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K

K. Huber

university of oxford

40H指数
297论文数
7.4K被引数
收录论文 69
发表时间
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High-resolution structures of human NHE6 and NHE9 elucidate endosomal ion and lipid interactions人源NHE6和NHE9的高分辨率结构阐明了内体离子和脂质相互作用
errNature Communications
IF15.7
err2026-09-03
err0
errOAAI
errJesper S. Hansen; Ashley C. W. Pike; Gamma Chi; Gernot Wolf; Jeppe Tranberg-Jensen; Hannah Lichtmannegger; David Speedman; Alvaro Ingles-Prieto; Fabian Goericke; Helena Batoulis; Hartmut Beck; Rajini Rao; Tooraj Mirshahi; David B. Sauer; Giulio Superti-Furga; Kilian V. M. Huber
err分享
err收藏
Multiomic profiling of responses to clinical and novel bisphosphonates reveals extraskeletal effects on ageing related signatures对临床和新双膦酸盐反应的多组学分析揭示了其对与年龄相关标志物的骨骼外影响
errSignal Transduction and Targeted Therapy
IF52.7
err2026-07-15
err0
errOAAI
errJinsen Lu; Srinivasa Rao Rao; Helen Knowles; Haoqun Zhan; Beatriz Gamez; Mingyu Qin; Eleanor Platt; Lucy R. Frost; Tiffany-Jayne Allen; Gayle Marshall; Kilian V. M. Huber; Ludwig G. Bauer; Iolanda Vendrell; Darragh P. O’Brien; Benedikt Kessler; Anne Horne; Ian R. Reid; Chas Bountra; James L. Kirkland; Sundeep Khosla; Frank H. Ebetino; Emilio Roldan; R. Graham G. Russell; James R. Edwards
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Targeted Protein Degradation of NUDT5 Dissociates Catalytic Inhibition from Protein Loss in 6-Thioguanine Response靶向NUDT5蛋白降解在6-硫鸟嘌呤反应中将催化抑制与蛋白质丢失分离
errNature Communications
IF15.7
err2026-06-30
err0
errOAAI
errAnne-Sophie M. C. Marques; Ludwig G. Bauer; Tuan-Anh Nguyen; Alejandro Gonzalez Orta; Jan-Lennart Venne; Carol Cheng; Esra Balıkçı; Yusi Liu; Barr Tivon; Alena Kroupova; Alessio Ciulli; Nir London; Stefan Kubicek; Kilian V. M. Huber
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Advances in BRET probes for intracellular target engagement studiesBRET探针在细胞内靶点结合研究方面的进展
errNature Chemical Biology
IF13.7
err2026-01-06
err0
PREAI
errJacob L. Capener; Martin P. Schwalm; James D. Vasta; Ani Michaud; Kelly A. Teske; William M. Marsiglia; Kilian V. M. Huber; Arvin C. Dar; Stefan Knapp; Alison D. Axtman; Matthew B. Robers
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A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells一种用于测量细胞中PRMT5复合物非竞争性结合的BRET生物传感器
errNature Communications
IF15.7
err2025-12-03
err0
errOAAI
errElisabeth M. Rothweiler; Ani Michaud; Jakub Stefaniak; Usha Singh; Brynwood B. Mikulsky; James D. Vasta; Michael T. Beck; Jennifer Wilkinson; Jennifer A. Ward; Catherine M. Rogers; Esra Balıkçı; Jeppe Tranberg-Jensen; Jesper S. Hansen; Peter Loppnau; Adrian Whitty; Paul E. Brennan; Peter J. Tonge; Matthew B. Robers; Kilian V. M. Huber
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A non-enzymatic role of Nudix hydrolase 5 in repressing purine de novo synthesisNudix水解酶5在抑制嘌呤从头合成中的非酶促作用
errScience
IF45.8
err2025-11-06
err0
PREAI
errTuan-Anh Nguyen; Jung-Ming G. Lin; Anne-Sophie M. C. Marques; Maximilian Fottner; Ludwig G. Bauer; Andreas Reicher; Diana Daum; Lorenzo Scrofani; Yusi Liu; Carol Cheng; Luna D’Angelo L.d.D.; Juan Sanchez; Christoph Bueschl; Nara Marella; Pisanu Buphamalai; Florian Traversi; Maša Bereš; Herwig P. Moll; Marton Siklos; Jakob-Wendelin Genger; Gerald Hofstaetter; Ludovica Villanti; Monika Malik; Christoph Klimek; Kathrin Runggatscher; Bettina Guertl; Jesper S. Hansen; Sarah Dobner; Olga Babosova; Tina Becirovic; Laura P. M. H. de Rooij; Emilio Casanova; Anna Koren; D. Sean Froese; David S. Rosenblatt; Kristaps Klavins; Andreas Bergthaler; Jörg Menche; J. Thomas Hannich; Miriam Abele; Sara Sdelci; Kathrin Lang; Kilian V. M. Huber; Stefan Kubicek
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Drug repurposing in amyotrophic lateral sclerosis (ALS)肌萎缩侧索硬化症（ALS）中的药物重定位
errEXPERT OPINION ON DRUG DISCOVERY
IF4.9
err2025-03-01
err0
errOAAI
errCarroll, Emily; Scaber, Jakub; Huber, Kilian V. M.; Brennan, Paul E.; Thompson, Alexander G.; Turner, Martin R.; Talbot, Kevin
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Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open迈向目标2035: EUbOPEN-一个公私合作伙伴关系，以开放和解锁生物学
errRSC MEDICINAL CHEMISTRY
IF3.6
err2025-01-01
err1
errOAAI
errTredup, Claudia; Ackloo, Suzanne; Beck, Hartmut; Brown, Peter J.; Bullock, Alex N.; Ciulli, Alessio; Dikic, Ivan; Edfeldt, Kristina; Edwards, Aled M.; Elkins, Jonathan M.; Farin, Henner F.; Fon, Edward A.; Gstaiger, Matthias; Guenther, Judith; Gustavsson, Anna-Lena; Haeberle, Sandra; Isigkeit, Laura; Huber, Kilian V. M.; Kotschy, Andras; Kraemer, Oliver; Leach, Andrew R.; Marsden, Brian D.; Matsui, Hisanori; Merk, Daniel; Montel, Florian; Mulder, Monique P. C.; Mueller, Susanne; Owen, Dafydd R.; Proschak, Ewgenij; Roehm, Sandra; Stolz, Alexandra; Sundstroem, Michael; von Delft, Frank; Willson, Timothy M.; Arrowsmith, Cheryl H.; Knapp, Stefan
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Covalent Inhibitors of KEAP1 with Exquisite Selectivity
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-11-21
err0
PREAI
errFejes, Imre; Markacz, Piroska; Tatai, Janos; Rudas, Monika; Dunkel, Petra; Gyuris, Mario; Nyerges, Miklos; Provost, Nicolas; Duvivier, Valerie; Delerive, Philippe; Martiny, Virginie; Bristiel, Alexandra; Vidal, Brice; Richardson, William; Rothweiler, Elisabeth M.; Tranberg-Jensen, Jeppe; Manning, Charlotte E.; Sweeney, Melissa N.; Chalk, Rod; Huber, Kilian V. M.; Bullock, Alex N.; Herner, Andras; Seedorf, Klaus; Vinson, Cedric; Weber, Csaba; Kotschy, Andras
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Discovery and characterization of potent inhibitors of the RNA editing enzyme ADAR1
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2024-10-01
err0
PREAI
errPollard, J.; Llorca-Cardenosa, M.; Joe, H.; Major, S.; Craggs, G.; Matthew, F.; Gross, F.; Guard-Levin, Z.; Huber, K.; Maloney, A.; O'Kane, P.; Simpson, I.
err分享
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Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300
errJACS AU
IF8.7
err2024-07-29
err1
errOAAI
errChen, Xuemin; Crawford, McKenna C.; Xiong, Ying; Shaik, Anver Basha; Suazo, Kiall F.; Bauer, Ludwig G.; Penikalapati, Manini S.; Williams, Joycelyn H.; Huber, Kilian V. M.; Andressen, Thorkell; Swenson, Rolf E.; Meier, Jordan L.
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A live cell PRMT5 NanoBRETT target engagement assay querying competitive and uncompetitive modes of inhibition
errMOLECULAR CANCER THERAPEUTICS
IF5.5
err2024-06-10
err0
PREAI
errTeske, Kelly A.; Michaud, Ani; Rothweiler, Elisabeth; Corona, Cesear; Hoffman, Kaitlin Dunn; Wilkinson, Jennifer; Beck, Michael; Vasta, James; Huber, Kilian; Robers, Matthew
err分享
err收藏
Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-04-18
err3
errOAAI
errBalikci, Esra; Marques, Anne-Sophie M. C.; Bauer, Ludwig G.; Seupel, Raina; Bennett, James; Raux, Brigitt; Buchan, Karly; Simelis, Klemensas; Singh, Usha; Rogers, Catherine; Ward, Jennifer; Cheng, Carol; Szommer, Tamas; Schutzenhofer, Kira; Elkins, Jonathan M.; Sloman, David L.; Ahel, Ivan; Fedorov, Oleg; Brennan, Paul E.; Huber, Kilian V. M.
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A live cell PRMT5 NanoBRET Target Engagement Assay querying competitive and uncompetitive modes of inhibition
errCANCER RESEARCH
IF16.6
err2024-03-22
err0
PREAI
errMichaud, Ani; Rothweiler, Elisabeth; Corona, Cesear; Beck, Michael; Wilkinson, Jennifer; Vasta, James; Huber, Kilian; Robers, Matthew
err分享
err收藏
Target deconvolution with matrix-augmented pooling strategy reveals cell-specific drug-protein interactions
errCELL CHEMICAL BIOLOGY
IF7.2
err2023-11-01
err7
errOAAI
errJi, Hongchao; Lu, Xue; Zhao, Shiji; Wang, Qiqi; Liao, Bin; Bauer, Ludwig G.; Huber, Kilian V. M.; Luo, Ray; Tian, Ruijun; Tan, Chris Soon Heng
err分享
err收藏
Open resources for chemical probes and their implications for future drug discovery
errEXPERT OPINION ON DRUG DISCOVERY
IF4.9
err2023-04-16
err3
errOAAI
errBalikci, Esra; Marques, Anne-Sophie M. C.; Hansen, Jesper S.; Huber, Kilian V. M.
err分享
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Discovery of a Chemical Probe to Study Implications of BPTF Bromodomain Inhibition in Cellular and in vivo Experiments
errCHEMMEDCHEM
IF3.4
err2023-02-06
err2
errOAAI
errMartinelli, Paola; Schaaf, Otmar; Mantoulidis, Andreas; Martin, Laetitia J.; Fuchs, Julian E.; Bader, Gerd; Gollner, Andreas; Wolkerstorfer, Bernhard; Rogers, Catherine; Balikci, Esra; Lipp, Jesse J.; Mischerikow, Nikolai; Doebel, Sandra; Gerstberger, Thomas; Sommergruber, Wolfgang; Huber, Kilian V. M.; Boettcher, Jark
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Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function
errCHEMICAL SCIENCE
IF7.4
err2023-01-01
err9
errOAAI
errColeman, Oliver D.; Macdonald, Jessica; Thomson, Ben; Ward, Jennifer A.; Stubbs, Christopher J.; McAllister, Tom E.; Clark, Shane; Amin, Siddique; Cao, Yimang; Abboud, Martine I.; Zhang, Yijia; Sanganee, Hitesh; Huber, Kilian V. M.; Claridge, Tim D. W.; Kawamura, Akane
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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2022-12-23
err11
PREAI
errLondregan, Allyn T.; Aitmakhanova, Karlygash; Bennett, James; Byrnes, Laura J.; Canterbury, Daniel P.; Cheng, Xiayun; Christott, Thomas; Clemens, Jennifer; Coffey, Steven B.; Dias, Joao M.; Dowling, Matthew S.; Farnie, Gillian; Fedorov, Oleg; Fennell, Kimberly F.; Gamble, Vicki; Gileadi, Carina; Giroud, Charline; Harris, Michael R.; Hollingshead, Brett D.; Huber, Kilian; Korczynska, Magdalena; Lapham, Kimberly; Loria, Paula M.; Narayanan, Arjun; Owen, Dafydd R. .; Raux, Brigitt; Sahasrabudhe, Parag, V; Ruggeri, Roger B.; Saez, Laura Diaz; Stock, Ingrid A. .; Thuma, Benjamin A. .; Tsai, Andy; Varghese, Alison E.
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DNA double-strand break-derived RNA drives TIRR/53BP1 complex dissociation br
errCELL REPORTS
IF6.9
err2022-10-01
err8
errOAAI
errKetley, Ruth F.; Battistini, Federica; Alagia, Adele; Mondielli, Clemence; Iehl, Florence; Balikci, Esra; Huber, Kilian V. M.; Orozco, Modesto; Gullerova, Monika
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研究方向

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合作学者
合作期刊
P
Peer Bork
H 指数: 233 · 论文数: 950
S
Stuart L. Schreiber
H 指数: 166 · 论文数: 1.3K
P
Philip Cohen
H 指数: 156 · 论文数: 581
N
Nathanael S. Gray
H 指数: 145 · 论文数: 1.5K
B
Bryan L. Roth
H 指数: 139 · 论文数: 971
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