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Y

Yong Chen

hubei key laboratory of natural products research and development, college of biological and pharmaceutical sciences, china three gorges university, yichang, p. r. china
H指数:15
被引数:836

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Next-Generation Bio-Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

下一代生物可还原脂质在疟疾和非人灵长类动物模型中增强了疫苗效果

Advanced Functional Materials
IF19
2025-09-160
OAAI
Ruben De Coen; Sabah Kasmi; Shrinivas Dumbre; Lies Baekens; Elise Seynaeve; Louise Van den Hauwe; Niccolò Cantini; Aello Garantoudi; Filipe Branco Madeira; Alain Marrot; Emma Tuypens; Sofie Seghers; Anna Kuchmiy; Elisabeth Brabants; Bart Vanderborght; Ine Maes; Sarah Vandenberghe; Jessica Filtjens; Alícia Gordún Peiró; Daliya Kancheva; Ayla Debraekeleer; Florence Lambolez; Emily De Lombaerde; Yong Chen; Rafael Miyazawa Martins; Pauline Formaglio; Damya Laoui; Sofie Deschoemaeker; Bruno G. De Geest; Rogerio Amino; Stefaan De Koker
Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the pKa of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo

硫代酰胺位于可质子化脂质的可质子化胺头基附近，可降低脂质纳米粒的pKa，并增强体外和体内的mRNA转染效率。

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2025-05-190
PRE
Yong Chen; Emily De Lombaerde; Aimée Bugler-Lamb; Zifu Zhong; Martijn J. Schuijs; Claudia M. Brenis Gomez; Jamie De Baere; Mark Gontsarik
A Fentanyl Hapten-Displaying Lipid Nanoparticle Vaccine that Non-Covalently Encapsulates a TLR7/8 Agonist and T-Helper Epitope Induces Protective Anti-Fentanyl Immunity
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2024-11-211
PRE
Zhong, Zifu; Deventer, Marie H.; Chen, Yong; Vanhee, Stijn; Lammens, Ines; Deswarte, Kim; Huang, Yi; Ye, Tingting; Wang, Haixiu; Nuhn, Lutz; Vandeputte, Marthe M.; Gontsarik, Mark; Cui, Xiaole; Sanders, Niek N.; Lienenklaus, Stefan; Lambrecht, Bart N.; Baptista, Antonio P.; Stove, Christophe P.; G. De Geest, Bruno
Amplification of Protein Expression by Self-Amplifying mRNA Delivered in Lipid Nanoparticles Containing a β-Aminoester Ionizable Lipid Correlates with Reduced Innate Immune Activation

通过在含有 β-氨基酯可电离脂质的脂质纳米颗粒中递送的自我扩增mRNA来扩增蛋白质表达与降低的先天免疫激活相关

ACS NANO
IF16
2024-10-010
PRE
De Lombaerde, Emily; Cui, Xiaole; Chen, Yong; Zhong, Zifu; Deckers, Julie; Mencarelli, Giulia; Opsomer, Lisa; Wang, Haixiu; De Baere, Jamie; Lienenklaus, Stefan; Lambrecht, Bart N.; Sanders, Niek N.; De Geest, Bruno G.
Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1
ACS MEDICINAL CHEMISTRY LETTERS
IF4
2024-09-032
PRE
Tellis, John C.; Wei, BinQing; Siu, Michael; An, Le; Chan, Grace Kayan; Chen, Yong; Du, Xiangnan; Gazzard, Lewis; Hu, Baihua; Kiefer, James; Kakiuchi-Kiyota, Satoko; Lainchbury, Michael; Linehan, Jonathan L.; Luo, Xifeng; Malhotra, Sushant; Mendonca, Rohan; Pang, Jodie; Ran, Yinqing; Sethuraman, Vijay; Seward, Eileen; Sneeringer, Chris; Su, Dian; Wang, Weiru; Wu, Ping; Moffat, John G.; Heffron, Timothy P.; Choo, Edna F.; Chan, Bryan K.
Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery

双氨基甲酸酯可电离脂质的组合筛选确定了用于脂质纳米颗粒mRNA递送的低反应原性脂质

ADVANCED FUNCTIONAL MATERIALS
IF19
2024-02-016
OA
De Lombaerde, Emily; Chen, Yong; Ye, Tingting; Deckers, Julie; Mencarelli, Giulia; De Swarte, Kim; Lauwers, Heleen; De Coen, Ruben; Kasmi, Sabah; Bevers, Sanne; Kuchmiy, Anna; Bogaert, Bram; Baekens, Lies; Zhong, Zifu; Lamoot, Alexander; Sanders, Niek N.; Lambrecht, Bart N.; Baptista, Antonio P.; De Koker, Stefaan; De Geest, Bruno G.

研究方向

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B
Bruno G. De Geest
H 指数:65论文数:313被引数:1.5万
Z
Zifu Zhong
H 指数:20论文数:60被引数:1,555
B
Bart N. Lambrecht
H 指数:123论文数:763被引数:6.3万
E
Emily De Lombaerde
H 指数:8论文数:23被引数:268
N
Niek N. Sanders
H 指数:58论文数:225被引数:1.2万
S
Stefan Lienenklaus
H 指数:49论文数:167被引数:8,487
K
Kim Deswarte
H 指数:33论文数:85被引数:6,972
S
Stefaan De Koker
H 指数:40论文数:114被引数:5,748
M
Mark Gontsarik
H 指数:16论文数:31被引数:823
T
Tingting Ye
H 指数:7论文数:20被引数:217