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Z

Zifu Zhong

Ghent University
H指数:20
被引数:1,554

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Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the pKa of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo

硫代酰胺位于可质子化脂质的可质子化胺头基附近，可降低脂质纳米粒的pKa，并增强体外和体内的mRNA转染效率。

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2025-05-190
PRE
Yong Chen; Emily De Lombaerde; Aimée Bugler-Lamb; Zifu Zhong; Martijn J. Schuijs; Claudia M. Brenis Gomez; Jamie De Baere; Mark Gontsarik
A Fentanyl Hapten-Displaying Lipid Nanoparticle Vaccine that Non-Covalently Encapsulates a TLR7/8 Agonist and T-Helper Epitope Induces Protective Anti-Fentanyl Immunity
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2024-11-211
PRE
Zhong, Zifu; Deventer, Marie H.; Chen, Yong; Vanhee, Stijn; Lammens, Ines; Deswarte, Kim; Huang, Yi; Ye, Tingting; Wang, Haixiu; Nuhn, Lutz; Vandeputte, Marthe M.; Gontsarik, Mark; Cui, Xiaole; Sanders, Niek N.; Lienenklaus, Stefan; Lambrecht, Bart N.; Baptista, Antonio P.; Stove, Christophe P.; G. De Geest, Bruno
Amplification of Protein Expression by Self-Amplifying mRNA Delivered in Lipid Nanoparticles Containing a β-Aminoester Ionizable Lipid Correlates with Reduced Innate Immune Activation

通过在含有 β-氨基酯可电离脂质的脂质纳米颗粒中递送的自我扩增mRNA来扩增蛋白质表达与降低的先天免疫激活相关

ACS NANO
IF16
2024-10-010
PRE
De Lombaerde, Emily; Cui, Xiaole; Chen, Yong; Zhong, Zifu; Deckers, Julie; Mencarelli, Giulia; Opsomer, Lisa; Wang, Haixiu; De Baere, Jamie; Lienenklaus, Stefan; Lambrecht, Bart N.; Sanders, Niek N.; De Geest, Bruno G.
Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery

双氨基甲酸酯可电离脂质的组合筛选确定了用于脂质纳米颗粒mRNA递送的低反应原性脂质

ADVANCED FUNCTIONAL MATERIALS
IF19
2024-02-016
OA
De Lombaerde, Emily; Chen, Yong; Ye, Tingting; Deckers, Julie; Mencarelli, Giulia; De Swarte, Kim; Lauwers, Heleen; De Coen, Ruben; Kasmi, Sabah; Bevers, Sanne; Kuchmiy, Anna; Bogaert, Bram; Baekens, Lies; Zhong, Zifu; Lamoot, Alexander; Sanders, Niek N.; Lambrecht, Bart N.; Baptista, Antonio P.; De Koker, Stefaan; De Geest, Bruno G.
Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity
SMALL
IF12.1
2023-10-229
OA
Lamoot, Alexander; Jangra, Sonia; Laghlali, Gabriel; Warang, Prajakta; Singh, Gagandeep; Chang, Lauren A.; Park, Seok-Chan; De Swarte, Kim; Zhong, Zifu; Louage, Benoit; De Lombaerde, Emily; Ye, Tingting; Chen, Yong; Cuadrado-Castano, Sara; Lienenklaus, Stefan; Sanders, Niek N.; Lambrecht, Bart N.; Garcia-Sastre, Adolfo; Schotsaert, Michael; De Geest, Bruno G.

研究方向

暂未获取到该数据
N
Niek N. Sanders
H 指数:58论文数:225被引数:1.2万
B
Bruno G. De Geest
H 指数:65论文数:313被引数:1.5万
B
Bart N. Lambrecht
H 指数:123论文数:763被引数:6.3万
S
Stefan Lienenklaus
H 指数:49论文数:167被引数:8,485
K
Kim Deswarte
H 指数:33论文数:85被引数:6,972
Y
Yong Chen
H 指数:15论文数:60被引数:835
L
Lutz Nuhn
H 指数:39论文数:154被引数:3,807
S
Sunil A. David
H 指数:44论文数:111被引数:4,509
F
Francis Combes
H 指数:15论文数:30被引数:826
S
Stefaan De Koker
H 指数:40论文数:114被引数:5,748