Wai‐Keung Chui - Publications, H-index & Citations

Wai‐Keung Chui

National University of Singapore

29H指数

91论文数

1.8K被引数

收录论文 24

发表时间

Novel dual-targeting anti-proliferative dihydrotriazine-chalcone derivatives display suppression of cancer cell invasion and inflammation by inhibiting the NF-κB signaling pathway

FOOD AND CHEMICAL TOXICOLOGY

IF3.5

2018-06-01

PREAI

Gan, Fei-Fei; Zhang, Ruirui; Ng, Hui-Li; Karuppasamy, Muthukumar; Seah, Waygene; Yeap, Wei Hseun; Ong, Siew-Min; Hadadi, Eva; Wong, Siew-Cheng; Chui, Wai-Keung; Chew, Eng-Hui

1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2018-01-01

PREAI

Yang, Xuan; Wedajo, Wassihun; Yamada, Yoshiyuki; Dahlroth, Sue-Li; Neo, Jason Jun-Long; Dick, Thomas; Chui, Wai-Keung

Design, Synthesis, and Biological Evaluation of Coupled Bioactive Scaffolds as Potential Anticancer Agents for Dual Targeting of Dihydrofolate Reductase and Thioredoxin Reductase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-02-24

PREAI

Ng, Hui-Li; Ma, Xiang; Chew, Eng-Hui; Chui, Wai-Keung

Design, synthesis, docking studies and biological evaluation of novel dihydro-1,3,5-triazines as human DHFR inhibitors

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2017-01-01

PREAI

Zhou, Xiaotian; Lin, Kuaile; Ma, Xiang; Chui, Wai-Keung; Zhou, Weicheng

Biological Characterization of the Anti-Tumor Properties of Novel Dual-Target Inhibitors of Dihydrofolate Reductase and Thioredoxin Reductase

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2016-11-01

PREAI

Chew, Eng-Hui; Ng, Hui-Li; Kjellander, Matilda; Karuppasamy, Muthukumar; Chong, Adrina Swee-Yue; Chui, Wai-Keung; Ungerstedt, Johanna

Applying the designed multiple ligands approach to inhibit dihydrofolate reductase and thioredoxin reductase for antiproliferative activity

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2016-06-01

PREAI

Ng, Hu-Li; Chen, Shangying; Chew, Eng-Hui; Chui, Wai-Keung

Sulforaphane and its methylcarbonyl analogs inhibit the LPS-stimulated inflammatory response in human monocytes through modulating cytokine production, suppressing chemotactic migration and phagocytosis in a NF-κB- and MAPK-dependent manner

INTERNATIONAL IMMUNOPHARMACOLOGY

IF4.7

2015-02-01

PREAI

Reddy, Shridhivya A.; Shelar, Sandeep B.; Truong-Minh Dang; Lee, Baxter Neng-Cun; Yang, Hong; Ong, Siew-Min; Ng, Hui-Li; Chui, Wai-Keung; Wong, Siew-Cheng; Chew, Eng-Hui

Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: Synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2014-05-01

PREAI

Bera, Hriday; Ojha, Probir Kumar; Tan, Bee Jen; Sun, Lingyi; Dolzhenko, Anton V.; Chui, Wai-Keung; Chiu, Gigi Ngar Chee

A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

TOXICOLOGY AND APPLIED PHARMACOLOGY

IF3.4

2013-11-01

PREAI

Gan, Fei-Fei; Ling, Hui; Ang, Xiaohui; Reddy, Shridhivya A.; Lee, Stephanie S-H.; Yang, Hong; Tan, Sock-Hoon; Hayes, John D.; Chui, Wai-Keung; Chew, Eng-Hui

Identification of Michael Acceptor-Centric Pharmacophores with Substituents That Yield Strong Thioredoxin Reductase Inhibitory Character Correlated to Antiproliferative Activity

ANTIOXIDANTS & REDOX SIGNALING

IF6.1

2013-10-10

OAAI

Gan, Fei-Fei; Kaminska, Kamila K.; Yang, Hong; Liew, Chin-Yee; Leow, Pay-Chin; So, Choon-Leng; Tu, Lan N. L.; Roy, Amrita; Yap, Chun-Wei; Kang, Tse-Siang; Chui, Wai-Keung; Chew, Eng-Hui

A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2013-09-01

PREAI

Bera, Hriday; Tan, Bee Jen; Sun, Lingyi; Dolzhenko, Anton V.; Chui, Wai-Keung; Chiu, Gigi Nagar Chee

Synthesis and in vitro Evaluation of 1,2,4-Triazolo[1,5-a][1,3,5]triazine Derivatives as Thymidine Phosphorylase Inhibitors 胸苷磷酸化酶抑制剂1,2，4-三唑并 [1，5-a][1,3，5] 三嗪衍生物的合成及体外评价

CHEMICAL BIOLOGY & DRUG DESIGN

IF3.3

2013-08-22

PREAI

Bera, Hriday; Dolzhenko, Anton V.; Sun, Lingyi; Gupta, Sayan Dutta; Chui, Wai-Keung