Elizabeth A. Dierks

bristol myers squibb

H指数:18

被引数:1,274

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From Lead to Clinical Candidate: Discovery of BMS-986331 as a Potent and Selective N-Formyl Peptide Receptor 2 Agonist

从先导化合物到临床候选药物：BMS-986331作为强效且选择性N-甲酰肽受体2激动剂的发现

Journal of Medicinal Chemistry

IF6.8

2026-02-170

PRE

Pravin S. Shirude; Daniel Cheney; Amit K. Chattopadhyay; Balaji Seshadri; Vishweshwaraiah Baligar; Chandrasekhar Rachamreddy; Sudhakara Madduri; Prakash Anjanappa; Andrew Viet; Meriah N. Valente; Karen Rossi; Mojgan Abousleiman; Mei-Yin Hsu; Gerry Everlof; Volodymyr Gali; Yongnian Sun; John Allocco; Rongan Zhang; Stéphane St-Onge; John Lupisella; Xue-Qing Chen; Sanket Sarodaya; Madhu Sudhan Ravindran; Debarati M. Tagore; Jignesh Nagar; Shailesh Dudhgaonkar; Sivaprasad Putlur; Madeleine Héroux; Michel Bouvier; Ruth R. Wexler; Elizabeth Dierks; Ricardo A. Garcia; Ellen K. Kick; Nicholas R. Wurtz

Design; Synthesis; and T Cell Checkpoint Combination Potential Of First-In-Class DGKα/ζ Inhibitor BMS-986408

设计；合成；以及第一类DGKα/ζ抑制剂的T细胞检查点组合潜力 BMS-986408

Journal of Medicinal Chemistry

IF6.8

2025-10-140

PRE

Denise C. Grünenfelder; Upender Velaparthi; Jayakumar S. Warrier; Louis Chupak; Chetan Padmakar Darne; Bireshwar Dasgupta; T. G. Murali Dhar; Min Ding; Robert Gentles; Yazhong Huang; Prasada R. Jalagam; Manjunatha Narayana Rao Kamble; Raju Mannoori; Scott Martin; Shana L. Posy; Hasibur Rahaman; Thiruvenkadam Raja; Kotha Rathnakar Reddy; Saumya Roy; Amy Sarjeant; John S. Tokarski; Gopikishan Tonukunuru; Sivasudar Velaiah; Xiaofan Zheng; Aravind Anandam; Gopal Dhar; Shailesh Dudhgaonkar; R. Marcus Fancher; Siddheshwar Layane; Si-Qi Liu; Swagatam Ray; Hongchen Qiu; Susan Wee; Sagnik Chatterjee; Myrtle Davis; Elizabeth Dierks; Anoop Kumar; Thanga Mariappan; Robin Moore; Bokka Venkata Murali; Ramola Sane; Dana Banas; Deepa Calambur; Erica Cook; Priya Dehal; Hua Fang; Gregory Locke; Joseph G. Naglich; Madhu Sudhan Ravindran; Lumelle Schneeweis; Debarati M. Tagore; Mark Witmer; Abigail E. Witt; Dianlin Xie; Emma Lees; Michael Wichroski; Nicholas A. Meanwell; Robert Borzilleri; Richard E. Olson

Prodrug Strategy to Address Impaired Oral Absorption of a Weakly Basic TYK2 Inhibitor Caused by a Gastric Acid-Reducing Agent

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-11-190

PRE

Discovery and Optimization of Aryl Piperidinone Ureas as Selective Formyl Peptide Receptor 2 Agonists

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2024-08-120

PRE

Discovery of 12 (BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2023-09-191

PRE

Meng, Wei; Brigance, Robert; Mignone, James; Negash, Lidet; Zhao, Guohua; Ahmad, Saleem; Wang, Wei; Moore, Fang; Ye, Xiang-Yang; Sun, Jung-Hui; Mathur, Arvind; Li, Yi-Xin; Azzara, Anthony; Ma, Zhengping; Chu, Ching-Hsuen; Cullen, Mary Jane; Rooney, Suzanne; Harvey, Susan; Kopcho, Lisa; Abell, Lynn; O'Malley, Kevin; Keim, William; Dierks, Elizabeth A.; Chang, Shu; Foster, Kimberly A.; Harden, David; Dabros, Marta; Goti, Vineet; De Oliveira, Claudia; Krishna, Gopal; Pelleymounter, Mary Ann; Whaley, Jean; Robl, Jeffrey A.; Cheng, Dong; Devasthale, Pratik

Optimization of physicochemical properties of pyrrolidine GPR40 AgoPAMs results in a differentiated profile with improved pharmacokinetics and reduced off-target activities

BIOORGANIC & MEDICINAL CHEMISTRY

IF3

2023-05-011

PRE

Jurica, Elizabeth A.; Wu, Ximao; Williams, Kristin N.; Haque, Lauren E.; Rampulla, Richard A.; Mathur, Arvind; Zhou, Min; Cao, Gary; Cai, Hong; Wang, Tao; Liu, Heng; Xu, Carrie; Kunselman, Lori K.; Antrilli, Thomas M.; Hicks, Michael B.; Sun, Qin; Dierks, Elizabeth A.; Apedo, Atsu; Moore, Douglas B.; Foster, Kimberly A.; Cvijic, Mary Ellen; Panemangalore, Reshma; Khandelwal, Purnima; Wilkes, Jason J.; Zinker, Bradley A.; Robertson, Donald G.; Janovitz, Evan B.; Galella, Michael; Li, Yi-Xin; Li, Julia; Ramar, Thangeswaran; Jalagam, Prasada Rao; Jayaram, Ramya; Whaley, Jean M.; Barrish, Joel C.; Robl, Jeffrey A.; Ewing, William R.; Ellsworth, Bruce A.

MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity

MGAT2抑制剂可减少小鼠NASH模型中的肝纤维化和炎症，并降低肥胖成人的体重

CELL METABOLISM

IF30.9

2022-11-0117

OAAI

Discovery of Heteroaryl Urea Isosteres for Formyl Peptide Receptor 2 Agonists

甲酰基肽受体2激动剂的杂芳基脲等排物的发现

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2022-05-252

Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-10-068

PREAI

Turdi, Huji; Chao, Hannguang; Hangeland, Jon J.; Ahmad, Saleem; Meng, Wei; Brigance, Robert; Zhao, Guohua; Wang, Wei; Moore, Fang; Ye, Xiang-Yang; Mathur, Arvind; Hou, Xiaoping; Kempson, James; Wu, Dauh-Rurng; Li, Yi-Xin; Azzara, Anthony, V; Ma, Zhengping; Chu, Ching-Hsuen; Chen, Luping; Cullen, Mary Jane; Rooney, Suzanne; Harvey, Susan; Kopcho, Lisa; Panemangelor, Reshma; Abell, Lynn; O'Malley, Kevin; Keim, William J.; Dierks, Elizabeth; Chang, Shu; Foster, Kimberly; Apedo, Atsu; Harden, David; Dabros, Marta; Gao, Qi; Pelleymounter, Mary Ann; Whaley, Jean M.; Robl, Jeffrey A.; Cheng, Dong; Lawrence, R. Michael; Devasthale, Pratik

Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-09-0853

PRE

Dilger, Andrew K.; Pabbisetty, Kumar B.; Corte, James R.; De Lucca, Indawati; Fang, Tianan; Yang, Wu; Pinto, Donald J. P.; Wang, Yufeng; Zhu, Yeheng; Mathur, Arvind; Li, Jianqing; Hou, Xiaoping; Smith, Daniel; Sun, Dawn; Zhang, Huiping; Krishnananthan, Subramaniam; Wu, Dauh-Rurng; Myers, Joseph E., Jr.; Sheriff, Steven; Rossi, Karen A.; Chacko, Silvi; Zheng, Joanna J.; Galella, Michael A.; Ziemba, Theresa; Dierks, Elizabeth A.; Bozarth, Jeffrey M.; Wu, Yiming; Crain, Earl; Wong, Pancras C.; Luettgen, Joseph M.; Wexler, Ruth R.; Ewing, William R.

Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction

选择性FPR2激动作用可促进重组巨噬细胞表型并改善心肌梗塞后的心脏结构功能

JACC-BASIC TO TRANSLATIONAL SCIENCE

IF7.2

2021-08-0135

Garcia, Ricardo A.; Lupisella, John A.; Ito, Bruce R.; Hsu, Mei-Yin; Fernando, Gayani; Carson, Nancy L.; Allocco, John J.; Ryan, Carol S.; Zhang, Rongan; Wang, Zhaoqing; Heroux, Madeleine; Carrier, Marilyn; St-Onge, Stephane; Bouvier, Michel; Dudhgaonkar, Shailesh; Nagar, Jignesh; Bustamante-Pozo, Moises M.; Garate-Carrillo, Alejandra; Chen, Jian; Ma, Xiuying; Search, Debra J.; Dierks, Elizabeth A.; Kick, Ellen K.; Wexler, Ruth R.; Gordon, David A.; Ostrowski, Jacek; Wurtz, Nicholas R.; Villarreal, Francisco

Preservation of Post-Infarction Cardiac Structure and Function via Long-Term Oral Formyl Peptide Receptor Agonist Treatment

JACC-BASIC TO TRANSLATIONAL SCIENCE

IF7.2

2019-12-0139

OAAI

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2018-01-2724

PREAI

Shi, Jun; Gu, Zhengxiang; Jurica, Elizabeth Anne; Wu, Ximao; Haque, Lauren E.; Williams, Kristin N.; Hernandez, Andres S.; Hong, Zhenqiu; Gao, Qi; Dabros, Marta; Davulcu, Akin H.; Mathur, Arvind; Rampulla, Richard A.; Gupta, Arun Kumar; Jayaram, Ramya; Apedo, Atsu; Moore, Douglas B.; Liu, Heng; Kunselman, Lori K.; Brady, Edward J.; Wilkes, Jason J.; Zinker, Bradley A.; Cai, Hong; Shu, Yue-Zhong; Sun, Qin; Dierks, Elizabeth A.; Foster, Kimberly A.; Xu, Carrie; Wang, Tao; Panemangalore, Reshma; Cvijic, Mary Ellen; Xie, Chunshan; Cao, Gary G.; Zhou, Min; Krupinski, John; Whaley, Jean M.; Robl, Jeffrey A.; Ewing, William R.; Ellsworth, Bruce Alan

Discovery of Pyrrolidine-Containing GPR40 Agonists: Stereochemistry Effects a Change in Binding Mode

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-02-0925

PREAI

Jurica, Elizabeth A.; Wu, Ximao; Williams, Kristin N.; Hernandez, Andres S.; Nirschl, David S.; Rampulla, Richard A.; Mathur, Arvind; Zhou, Min; Cao, Gary; Xie, Chunshan; Jacob, Biji; Cai, Hong; Wang, Tao; Murphy, Brian J.; Liu, Heng; Xu, Carrie; Kunselman, Lori K.; Hicks, Michael B.; Sun, Qin; Schnur, Dora M.; Sitkoff, Doree F.; Dierks, Elizabeth A.; Apedo, Atsu; Moore, Douglas B.; Foster, Kimberly A.; Cvijic, Mary Ellen; Panemangalore, Reshma; Flynn, Neil A.; Maxwell, Brad D.; Hong, Yang; Tian, Yuan; Wilkes, Jason J.; Zinker, Bradley A.; Whaley, Jean M.; Barrish, Joel C.; Robl, Jeffrey A.; Ewing, William R.; Ellsworth, Bruce A.

Optimization of a dihydropyrrolopyrazole series of transforming growth factor-β type I receptor kinase domain inhibitors:: Discovery of an orally bioavailable transforming growth factor-β receptor type I inhibitor as antitumor agent

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-03-0462

PREAI

The catalytic site of cytochrome P4504A11 (CYP4A11) and its L131F mutant

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

1998-09-0135

OAAI

The deactivation of soluble guanylyl cyclase by redox-active agents

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS