Helen Lenthall

Garvan Institute of Medical Research

H指数:11

被引数:510

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Affinity maturation endows potent activity onto class 6 SARS-CoV-2 broadly neutralizing antibodies

亲和力成熟赋予6类SARS-CoV-2广谱中和抗体强大的活性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2025-01-020

Mazigi, Ohan; Langley, David B.; Henry, Jake Y.; Burnett, Deborah L.; Sobti, Meghna; Walker, GregoryJ.; Rouet, Romain; Balachandran, Harikrishnan; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Schofield, Peter; Brown, Simon H. J.; Schulz, Sebastian R.; Hoffmann, Markus; Poehlmann, Stefan; Post, Jeffrey; Martinello, Marianne; Kelleher, Anthony; Rawlinson, William D.; Turville, Stuart G.; Bull, Rowena A.; Stewart, Alastair G.; Jaeck, Hans-Martin; Goodnow, Christopher C.; Christ, Daniel

Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse

SCIENCE ADVANCES

IF12.5

2023-04-281

OAAI

Conway, James R. W.; Warren, Sean C.; Lee, Young-Kyung; McCulloch, Andrew T.; Magenau, Astrid; Lee, Victoria; Metcalf, Xanthe L.; Stoehr, Janett; Haigh, Katharina; Abdulkhalek, Lea; Guaman, Cristian S.; Reed, Daniel A.; Murphy, Kendelle J.; Pereira, Brooke A.; Melenec, Pauline; Chambers, Cecilia; Latham, Sharissa L.; Lenthall, Helen; Deenick, Elissa K.; Ma, Yuanqing; Phan, Tri; Lim, Elgene; Joshua, Anthony M.; Walters, Stacey; Grey, Shane T.; Shi, Yan-Chuan; Zhang, Lei; Herzog, Herbert; Croucher, David R.; Philp, Andy; Scheele, Colinda L. G. J.; Herrmann, David; Sansom, Owen J.; Morton, Jennifer P.; Papa, Antonella; Haigh, Jody J.; Nobis, Max; Timpson, Paul

Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2023-03-2112

OAAI

Nguyen, Tina; Lau, Anthony; Bier, Julia; Cooke, Kristen C.; Lenthall, Helen; Ruiz-Diaz, Stephanie; Avery, Danielle T.; Brigden, Henry; Zahra, David; Sewell, William A.; Droney, Luke; Okada, Satoshi; Asano, Takaki; Abolhassani, Hassan; Chavoshzadeh, Zahra; Abraham, Roshini S.; Rajapakse, Nipunie; Klee, Eric W.; Church, Joseph A.; Williams, Andrew; Wong, Melanie; Burkhart, Christoph; Uzel, Gulbu; Croucher, David R.; James, David E.; Ma, Cindy S.; Brink, Robert; Tangye, Stuart G.; Deenick, Elissa K.

Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients

通过基于表位的选择从恢复期患者中广泛中和SARS-CoV-2抗体

NATURE COMMUNICATIONS

IF15.7

2023-02-0819

OAAI

Rouet, Romain; Henry, Jake Y.; Johansen, Matt D.; Sobti, Meghna; Balachandran, Harikrishnan; Langley, David B.; Walker, Gregory J.; Lenthall, Helen; Jackson, Jennifer; Ubiparipovic, Stephanie; Mazigi, Ohan; Schofield, Peter; Burnett, Deborah L.; Brown, Simon H. J.; Martinello, Marianne; Hudson, Bernard; Gilroy, Nicole; Post, Jeffrey J.; Kelleher, Anthony; Jaeck, Hans-Martin; Goodnow, Christopher C.; Turville, Stuart G.; Rawlinson, William D.; Bull, Rowena A.; Stewart, Alastair G.; Hansbro, Philip M.; Christ, Daniel

Immunizations with diverse sarbecovirus receptor-binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability

IMMUNITY

IF26.3

2021-12-0137

OAAI

Burnett, Deborah L.; Jackson, Katherine J. L.; Langley, David B.; Aggrawal, Anupria; Stella, Alberto Ospina; Johansen, Matt D.; Balachandran, Harikrishnan; Lenthall, Helen; Rouet, Romain; Walker, Gregory; Saunders, Bernadette M.; Singh, Mandeep; Li, Hui; Henry, Jake Y.; Jackson, Jennifer; Stewart, Alastair G.; Witthauer, Franka; Spence, Matthew A.; Hansbro, Nicole G.; Jackson, Colin; Schofield, Peter; Milthorpe, Claire; Martinello, Marianne; Schulz, Sebastian R.; Roth, Edith; Kelleher, Anthony; Emery, Sean; Britton, Warwick J.; Rawlinson, William D.; Karl, Rudolfo; Schaefer, Simon; Winkler, Thomas H.; Brink, Robert; Bull, Rowena A.; Hansbro, Philip M.; Jaeck, Hans-Martin; Turville, Stuart; Christ, Daniel; Goodnow, Christopher C.

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

MABS

IF7.3

2021-05-2416

OAAI

Activated PI3Kδ breaches multiple B cell tolerance checkpoints and causes autoantibody production

激活的PI3Kδ 破坏多个b细胞耐受检查点并导致自身抗体产生

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2019-12-1632

OAAI

Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4+ T cells

PIK3CD中的激活突变破坏人和鼠CD4 T细胞的分化和功能

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IF11.2

2019-07-0148

OAAI

B cell-intrinsic requirement for STK4 in humoral immunity in mice and human subjects

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IF11.2

2019-06-0116

OAAI

Germline-activating mutations in PIK3CD compromise B cell development and function

PIK3CD生殖系激活突变损害b细胞发育和功能

JOURNAL OF EXPERIMENTAL MEDICINE

IF10.6

2018-07-1782

OAAI

Avery, Danielle T.; Kane, Alisa; Nguyen, Tina; Lau, Anthony; Nguyen, Akira; Lenthall, Helen; Payne, Kathryn; Shi, Wei; Brigden, Henry; French, Elise; Bier, Julia; Hermes, Jana R.; Zahra, David; Sewell, William A.; Butt, Danyal; Elliott, Michael; Boztug, Kaan; Meyts, Isabelle; Choo, Sharon; Hsu, Peter; Wong, Melanie; Berglund, Lucinda J.; Gray, Paul; O'Sullivan, Michael; Cole, Theresa; Holland, Steven M.; Ma, Cindy S.; Burkhart, Christoph; Corcoran, Lynn M.; Phan, Tri Giang; Brink, Robert; Uzel, Gulbu; Deenick, Elissa K.; Tangye, Stuart G.

Elucidating the effects of disease-causing mutations on STAT3 function in autosomal-dominant hyper-IgE syndrome

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IF11.2

2016-10-0118

PREAI

Helen Lenthall

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