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C

Christopher A. Gabel

nodthera

42H指数
108论文数
8.8K被引数
收录论文 30
发表时间
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CNS-targeted NLRP3 Inhibition by NT-0527 confers therapeutic advantage in a CAPS mouse modelNT-0527通过靶向中枢神经系统（CNS）抑制NLRP3，在CAPS小鼠模型中展现出治疗优势。
errJournal of Neuroinflammation
IF10.1
err2026-02-21
err0
errOAAI
errBeverly H. Koller; MyTrang Nguyen; John R. Doedens; David Harrison; Nicholas Clarke; Alan P. Watt; Christopher A. Gabel
err分享
err收藏
Ester Prodrug NLRP3 Inflammasome Inhibitor NT-0796 is Brain Active due to Activation by Local Expression of Carboxylesterase-1
errACS Chemical Neuroscience
IF3.9
err2026-01-26
err0
errOAAI
errZsofia Digby; Christine Diamond; Heather Wescott; Pam Smolak; Peter Thornton; Nicola Lindsay; Christopher A. Gabel; Nicholas Clarke; Alan P. Watt
err分享
err收藏
Profile of NT-0527; a brain penetrant NLRP3 Inflammasome inhibitor suitable as an in vivo tool compound for neuroinflammatory disordersNT-0527的概况；一种适合作为神经炎症疾病在体研究工具化合物的脑穿透性NLRP3炎性小体抑制剂
errRSC Med. Chem.
IF3.6
err2025-09-27
err0
PREAI
errDavid Harrison; Andy Billinton †; Mark G. Bock; Nicholas P. Clarke; Zsofia Digby; Christopher A. Gabel; Nicola Lindsay; Valérie Reader; Jane Scanlon ‡; Pamela Smolak; Peter Thornton; Heather Wescott; Alan P. Watt
err分享
err收藏
The ester-containing prodrug NT-0796 enhances delivery of the NLRP3 inflammasome inhibitor NDT-19795 to monocytic cells expressing carboxylesterase-1
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2024-09-01
err0
errOAAI
errDoedens, John R.; Diamond, Christine; Harrison, David; Bock, Mark G.; Clarke, Nicholas; Watt, Alan P.; Gabel, Christopher A.
err分享
err收藏
Species-specific NLRP3 regulation and its role in CNS autoinflammatory diseases
errCELL REPORTS
IF6.9
err2024-03-01
err2
errOAAI
errKoller, Beverly H.; Nguyen, MyTrang; Snouwaert, John N.; Gabel, Christopher A.; Ting, Jenny P. -Y.
err分享
err收藏
Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances PotencyS
errJOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
err2024-03-01
err5
errOAAI
errSmolak, Pamela; Nguyen, MyTrang; Diamond, Christine; Wescott, Heather; Doedens, John R.; Schooley, Kenneth; Snouwaert, John N.; Bock, Mark G.; Harrison, David; Watt, Alan P.; Koller, Beverly H.; Gabel, Christopher A.
err分享
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Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2023-10-24
err18
PREAI
errHarrison, David; Billinton, Andy; Bock, Mark G.; Doedens, John R.; Gabel, Christopher A.; Holloway, M. Katharine; Porter, Roderick A.; Reader, Valerie; Scanlon, Jane; Schooley, Kenneth; Watt, Alan P.
err分享
err收藏
Interleukin-36 (IL-36) Ligands Require Processing for Full Agonist (IL-36α, IL-36β, and IL-36γ) or Antagonist (IL-36Ra) Activity
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2011-12-01
err330
errOAAI
errTowne, Jennifer E.; Renshaw, Blair R.; Douangpanya, Jason; Lipsky, Brian P.; Shen, Min; Gabel, Christopher A.; Sims, John E.
err分享
err收藏
EVALUATION OF THE EFFICACY OF IL-1R ANTAGONISTS IN HUMAN CARTILAGE DEGRADATION EX VIVO
errOSTEOARTHRITIS AND CARTILAGE
IF9
err2011-09-01
err0
errOAAI
errHulme, J. T.; Merriam, K.; Rottman, J. B.; Virca, G. D.; Sims, J. E.; Gabel, C. A.
err分享
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MMP-13 INHIBITORS REDUCE NOCICEPTION IN A RAT MODEL OF OSTEOARTHRITIS
errOSTEOARTHRITIS AND CARTILAGE
IF9
err2010-10-01
err1
errOAAI
errBlack, R. A.; Gabel, C.; Lively, S.; Toteva, M.; Fan, P.; Tocker, J.; Hulme, J.; Bendele, A.; Whiteside, R.; Henry, J.
err分享
err收藏
IL-1F ligands require processing for full agonist (IL-1f6, IL-1f8 and IL-1f9) or antagonist (IL-1f5) activity
errCYTOKINE
IF3.7
err2010-10-01
err1
PREAI
errTowne, Jennifer E.; Renshaw, Blair R.; Douangpanya, Jason; Lipsky, Brian P.; Shen, Min; Gabel, Christopher A.; Sims, John E.
err分享
err收藏
Externalization of the Leaderless Cytokine IL-1F6 Occurs in Response to Lipopolysaccharide/ATP Activation of Transduced Bone Marrow Macrophages
errJOURNAL OF IMMUNOLOGY
IF3.4
err2009-09-15
err43
errOAAI
errMartin, Unja; Scholler, John; Gurgel, Jesse; Renshaw, Blair; Sims, John E.; Gabel, Christopher A.
err分享
err收藏
Periodate oxidized ATP (oATP) reduces hyperalgesia in mice: Involvement of P2X7 receptors and implications for therapy
errINTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
IF2.6
err2008-01-01
err32
PREAI
errFulgenzi, A.; Ticozzi, P.; Gabel, C. A.; Dell'Antonio, G.; Quattrini, A.; Franzone, J. S.; Ferrero, M. E.
err分享
err收藏
P2 purinergic receptor modulation of cytokine productionP2嘌呤受体调节细胞因子的产生
errPURINERGIC SIGNALLING
IF2.4
err2007-01-03
err49
errOAAI
errGabel, Christopher A.
err分享
err收藏
Theoretical and experimental design of atypical kinase inhibitors: Application to p38 MAP kinase
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2005-08-05
err80
PREAI
errMcClure, KF; Abramov, YA; Laird, ER; Barberia, JT; Cai, WL; Carty, TJ; Cortina, SR; Danley, DE; Dipesa, AJ; Donahue, KM; Dombroski, MA; Elliott, NC; Gabel, CA; Han, SG; Hynes, TR; LeMotte, PK; Mansour, MN; Marr, ES; Letavic, MA; Pandit, J; Ripin, DB; Sweeney, FJ; Tan, D; Tao, Y
err分享
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Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice
errJOURNAL OF INVESTIGATIVE DERMATOLOGY
IF5.7
err2005-06-01
err139
errOAAI
errKim, AL; Labasi, JM; Zhu, YC; Tang, XW; McClure, K; Gabel, CA; Athar, M; Bickers, DR
err分享
err收藏
Glutathione S-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1β posttranslational processing
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2003-05-01
err203
errOAAI
errLaliberte, RE; Perregaux, DG; Hoth, LR; Rosner, PJ; Jordan, CK; Peese, KM; Eggler, JF; Dombroski, MA; Geoghegan, KF; Gabel, CA
err分享
err收藏
Absence of the P2X7 receptor alters leukocyte function and attenuates an inflammatory response
errJOURNAL OF IMMUNOLOGY
IF3.4
err2002-06-15
err470
errOAAI
errLabasi, JM; Petrushova, N; Donovan, C; McCurdy, S; Lira, P; Payette, MM; Brissette, W; Wicks, JR; Audoly, L; Gabel, CA
err分享
err收藏
Antimicrobial peptides initiate IL-1β posttranslational processing:: A novel role beyond innate immunity
errJOURNAL OF IMMUNOLOGY
IF3.4
err2002-03-15
err66
PREAI
errPerregaux, DG; Bhavsar, K; Contillo, L; Shi, JS; Gabel, CA
err分享
err收藏
Interleukin-1β posttranslational processing -: Exploration of P2X7 receptor involvement
errDRUG DEVELOPMENT RESEARCH
IF4.2
err2001-08-28
err5
PREAI
errPerregaux, DG; Labasi, J; Laliberte, R; Stam, E; Solle, M; Koller, B; Griffiths, R; Gabel, CA
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研究方向

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合作学者
合作期刊
J
Jenny P.‐Y. Ting
H 指数: 84 · 论文数: 388
B
Beverly H. Koller
H 指数: 83 · 论文数: 296
K
Kurt Drickamer
H 指数: 75 · 论文数: 233
P
Philip G. Board
H 指数: 67 · 论文数: 344
J
John E. Sims
H 指数: 65 · 论文数: 136
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