未登录 Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions Chu, Jessica; Panfen, Erika; Wang, Linna; Marino, Anthony; Chen, Xue-Qing; Fancher, R. Marcus; Landage, Raviraj; Patil, Omprakash; Desai, Salil Dileep; Shah, Devang; Xue, Yongjun; Sinz, Michael; Shen, Hong 分享 收藏
Bicyclic Ligand-Biased Agonists of S1P1: Exploring Side Chain Modifications to Modulate the PK, PD, and Safety Profiles Gilmore, John L.; Xiao, Hai-Yun; Dhar, T. G. Murali; Yang, Michael; Xiao, Zili; Yang, Xiaoxia; Taylor, Tracy L.; McIntyre, Kim W.; Warrack, Bethanne M.; Shi, Hong; Levesque, Paul C.; Marino, Anthony M.; Cornelius, Georgia; Mathur, Arvind; Shen, Ding Ren; Pang, Jian; Cvijic, Mary Ellen; Lehman-McKeeman, Lois D.; Sun, Huadong; Xie, Jenny; Salter-Cid, Luisa; Carter, Percy H.; Dyckman, Alaric J. 分享 收藏
Aryl Ether-Derived Sphingosine-1-Phosphate Receptor (S1P1) Modulators: Optimization of the PK, PD, and Safety Profiles Xiao, Zili; Yang, Michael G.; Dhar, T. G. Murali; Xiao, Hai-Yun; Gilmore, John L.; Marcoux, David; McIntyre, Kim W.; Taylor, Tracy L.; Shi, Hong; Levesque, Paul C.; Marino, Anthony M.; Cornelius, Georgia; Mathur, Arvind; Shen, Ding Ren; Cvijic, Mary Ellen; Lehman-McKeeman, Lois D.; Sun, Huadong; Xie, Jenny H.; Carter, Percy H.; Dyckman, Alaric J. 分享 收藏
Identification and Preclinical Pharmacology of ((1R,3S)-1-Amino-3-((S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P1) Modulator Advanced into Clinical Trials Gilmore, John L.; Xiao, Hai-Yun; Dhar, T. G. Murali; Yang, Michael G.; Xiao, Zili; Xie, Jenny; Lehman-McKeeman, Lois D.; Gong, Lei; Sun, Huadong; Lecureux, Lloyd; Chen, Cliff; Wu, Dauh-Rurng; Dabros, Marta; Yang, Xiaoxia; Taylor, Tracy L.; Zhou, Xia D.; Heimrich, Elizabeth M.; Thomas, Rochelle; McIntyre, Kim W.; Borowski, Virna; Warrack, Bethanne M.; Li, Yuwen; Shi, Hong; Levesque, Paul C.; Yang, Zheng; Marino, Anthony M.; Cornelius, Georgia; D'Arienzo, Celia J.; Mathur, Arvind; Rampulla, Richard; Gupta, Anuradha; Pragalathan, Bala; Shen, Ding Ren; Cvijic, Mary Ellen; Salter-Cid, Luisa M.; Carter, Percy H.; Dyckman, Alaric J. 分享 收藏
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Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus Monkeys Morse, Bridget L.; MacGuire, Jamus G.; Marino, Anthony M.; Zhao, Yue; Fox, Maxine; Zhang, Yueping; Shen, Hong; Humphreys, W. Griffith; Marathe, Punit; Lai, Yurong 分享 收藏
Asymmetric Hydroboration Approach to the Scalable Synthesis of ((1R,3S)-1-Amino-34(R)-6-hexy1-5,6,7,8-tetrahydronaphthalen-2yl)cyclopentyl)methanol (BMS-986104) as a Potent S1P1 Receptor Modulator Yang, Michael G.; Xiao, Zili; Dhar, T. G. Murali; Xiao, Hai-Yun; Gilmore, John L.; Marcoux, David; Xie, Jenny H.; McIntyre, Kim W.; Taylor, Tracy L.; Borowski, Virna; Heimrich, Elizabeth; Li, Yu-Wen; Feng, Jianlin; Fernandes, Alda; Yang, Zheng; Balimane, Praveen; Marino, Anthony M.; Cornelius, Georgia; Warrack, Bethanne M.; Mathur, Arvind; Wu, Dauh-Rurng; Li, Peng; Gupta, Anuradha; Pragalathan, Bala; Shen, Ding Ren; Cvijic, Mary Ellen; Lehman-McKeeman, Lois D.; Salter-Cid, Luisa; Barrish, Joel C.; Carter, Percy H.; Dyckman, Alaric J. 分享 收藏
Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design Xiao, Hai-Yun; Watterson, Scott H.; Langevine, Charles M.; Srivastava, Anurag S.; Ko, Soo S.; Zhang, Yanlei; Cherney, Robert J.; Guo, Wei-Wei; Gilmore, John L.; II, James E. Sheppeck; Wu, Dauh-Rurng; Li, Peng; Ramasamy, Duraisamy; Arunachalam, Piramanayagam; Mathur, Arvind; Taylor, Tracy L.; Shuster, David J.; McIntyre, Kim W.; Shen, Ding-Ren; Yarde, Melissa; Cvijic, Mary Ellen; Marino, Anthony M.; Balimane, Praveen V.; Yang, Zheng; Banas, Dana M.; Cornelius, Georgia; D'Arienzo, Celia J.; Warrack, Bethanne M.; Lehman-McKeeman, Lois; Salter-Cid, Luisa M.; Xie, Jenny; Barrish, Joel C.; Carter, Percy H.; Dyckman, Alaric J.; Dhar, T. G. Murali 分享 收藏
Discovery and Structure-Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P1) Gilmore, John L.; Sheppeck, James E., II; Watterson, Scott H.; Hague, Lauren; Mukhopadhyay, Parag; Tebben, Andrew J.; Galena, Michael A.; Shen, Ding Ren; Yarde, Melissa; Cvijic, Mary Ellen; Borowski, Virna; Gillooly, Kathleen; Taylor, Tracy; McIntyre, Kim W.; Warrack, Bethanne; Levesque, Paul C.; Li, Julia P.; Cornelius, Georgia; D'Arienzo, Celia; Marino, Anthony; Balimane, Praveen; Salter-Cid, Luisa; Barrish, Joel C.; Pitts, William J.; Carter, Percy H.; Xie, Jenny; Dyckman, Alaric J. 分享 收藏
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series Watterson, Scott H.; Guo, Junqing; Spergel, SteiTe H.; Langevine, Charles M.; Moquin, Robert V.; Shen, Ding Ren; Yarde, Melissa; Cvijic, Mary Ellen; Banas, Dana; Liu, Richard; Suchard, Suzanne J.; Gillooly, Kathleen; Taylor, Tracy; Rex-Rabe, Sandra; Shuster, David J.; McIntyre, Kim W.; Cornelius, Georgia; D'Arienzo, Celia; Marino, Anthony; Balimane, Praveen; Warrack, Bethanne; Salter-Cid, Luisa; McKinnon, Murray; Barrish, Joel C.; Carter, Percy H.; Pitts, William J.; Xie, Jenny; Dyckman, Alaric J. 分享 收藏
Identification and Preclinical Pharmacology of BMS-986104: A Differentiated S1P1 Receptor Modulator in Clinical Trials Dhar, T. G. Murali; Xiao, Hai-Yun; Xie, Jenny; Lehman-McKeeman, Lois D.; Wu, Dauh-Rurng; Dabros, Marta; Yang, Xiaoxia; Taylor, Tracy L.; Zhou, Xia D.; Heimrich, Elizabeth M.; Thomas, Rochelle; McIntyre, Kim W.; Warrack, Bethanne; Shi, Hong; Levesque, Paul C.; Zhu, Jia L.; Hennan, James; Balimane, Praveen; Yang, Zheng; Marino, Anthony M.; Cornelius, Georgia; D'Arienzo, Celia J.; Mathur, Arvind; Shen, Ding Ren; Cvijic, Mary Ellen; Salter-Cid, Luisa; Barrish, Joel C.; Carter, Percy H.; Dyckman, Alaric J. 分享 收藏
Utilization of In Vitro Caco-2 Permeability and Liver Microsomal Half-Life Screens in Discovering BMS-488043, a Novel HIV-1 Attachment Inhibitor with Improved Pharmacokinetic Properties Yang, Zheng; Zadjura, Lisa M.; Marino, Anthony M.; D'Arienz, Celia J.; Malinowski, Jacek; Gesenberg, Christoph; Lin, Pin-Fang; Colonno, Richard J.; Wang, Tao; Kadow, John F.; Meanwell, Nicholas A.; Hansel, Steven B. 分享 收藏
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Multiple pathways are involved in the oral absorption of BMS-262084, a tryptase inhibitor, in rats: Role of paracellular transport, binding to trypsin, and P-glycoprotein efflux Kamath, AV; Morrison, RA; Harper, TW; Lan, SJ; Marino, AM; Chong, SH 分享 收藏
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Biphenylsulfonamide endothelin receptor antagonists.: 4.: Discovery of N-[[2′-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1′-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ETA selective antagonist Murugesan, N; Gu, ZX; Spergel, S; Young, M; Chen, P; Mathur, A; Leith, L; Hermsmeier, M; Liu, ECK; Zhang, RA; Bird, E; Waldron, T; Marino, A; Koplowitz, B; Humphreys, WG; Chong, S; Morrison, RA; Webb, ML; Moreland, S; Trippodo, N; Barrish, JC 分享 收藏
Biphenylsulfonamide endothelin receptor antagonists.: 2.: Discovery of 4′-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ETA antagonists Murugesan, N; Gu, ZX; Stein, PD; Spergel, S; Mathur, A; Leith, L; Liu, ECK; Zhang, RA; Bird, E; Waldron, T; Marino, A; Morrison, RA; Webb, ML; Moreland, S; Barrish, JC 分享 收藏
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