J. Michael McIntosh - Publications, H-index & Citations

J. Michael McIntosh

Utah System of Higher Education

81H指数

351论文数

2.2W被引数

收录论文 177

发表时间

Peptides containing SARS-CoV-2 spike-protein residues are antagonists of a7 and a9a10 nAChRs and modulate interleukin-1β release from human monocytic THP-1 cells 含SARS-CoV-2刺突蛋白残基的多肽是α7和α9α10 nAChR的拮抗剂，并调节人单核THP-1细胞中白细胞介素-1β的释放

Journal of Biological Chemistry

IF3.9

2026-09-01

PREAI

Hone, Arik J.; Richter, Katrin; Riaz, Zoha; Wakkuri, Joseph; Tekarli, Bassel; Gajewiak, Joanna; Grau, Veronika; McIntosh, J. Michael

The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors 巨噬细胞的ATP介导的细胞因子释放由非常规的α9*烟碱乙酰胆碱受体下调。

Frontiers in Immunology

IF5.9

2025-10-27

OAAI

Philipp M. K. Wolf†; Dominik Hanke†; Vijay K. Singh†; Hanno L. Keller†; Luca J. Ettischer; Laura Teppe; Anca-Laura Amati; Andreas Hecker; Faeq Husain-Syed; Marius Rohde; Ulrike A. Nuber; Kathrin Büttner; J. Michael McIntosh; Juliane Liese; Sybille Mazurek; Veronika Grau; Katrin Richter

Protein Science

IF5.2

2025-10-11

OAAI

Muhammad Saad Khilji; Celeste M. Hackney; Thomas L. Koch; Arik J. Hone; Aymeric Rogalski; Maren Watkins; Jortan Tun; J. Michael McIntosh; Baldomero Olivera; Helena Safavi-Hemami; Kaare Teilum; Lars Ellgaard

Selective Inhibition of Rat α7 Nicotinic Acetylcholine Receptors by LvID, a Newly Characterized α4/7-Conotoxin from Conus lividus LvID对大鼠α7烟碱乙酰胆碱受体的选择性抑制，LvID是一种从Conus lividus中鉴定出的新型α4/7-芋螺毒素。

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2025-04-10

PREAI

Guo, Man; Zhu, Xiaopeng; Ma, Tao; Xu, Chenxing; Zhangsun, Dongting; Yu, Jinpeng; Kaas, Quentin; Harvey, Peta J.; McIntosh, J. Michael; Craik, David J.; Luo, Sulan

Human o 10 nicotinic acetylcholine receptor subunits assemble to form functional receptors

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2025-02-01

OAAI

Tekarli, Bassel; Azam, Layla; Hone, Arik J.; Mcintosh, J. Michael

Aspartic acid mutagenesis of α O-Conotoxin GeXIVA isomers reveals arginine residues crucial for inhibition of the α 9 α 10 nicotinic acetylcholine receptor

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

IF8.5

2024-06-01

PREAI

Luo, An; He, Jie; Yu, Jinpeng; Wu, Yong; Harvey, Peta J.; Kasheverov, Igor E.; Kudryavtsev, Denis S.; McIntosh, J. Michael; Tsetlin, Victor I.; Craik, David J.; Zhangsun, Dongting; Luo, Sulan

Design, Synthesis, and Structure-Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-05-30

PREAI

Hone, Arik J.; Santiago, Ulises; Harvey, Peta J.; Tekarli, Bassel; Gajewiak, Joanna; Craik, David J.; Camacho, Carlos J.; Mcintosh, J. Michael

Catharanthine Modulates Mesolimbic Dopamine Transmission and Nicotine Psychomotor Effects via Inhibition of α6-Nicotinic Receptors and Dopamine Transporters

ACS CHEMICAL NEUROSCIENCE

IF3.9

2024-04-13

OAAI

Williams, Benjamin M.; Steed, Nathan D.; Woolley, Joel T.; Moedl, Aubrey A.; Nelson, Christina A.; Jones, Gavin C.; Burris, Matthew D.; Arias, Hugo R.; Kim, Oc-Hee; Jang, Eun Young; Hone, Arik J.; Mcintosh, J. Michael; Yorgason, Jordan T.; Steffensen, Scott C.

Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus

MARINE DRUGS

IF5.4

2024-02-29

OAAI

Neves, Jorge L. B.; Urcino, Cristoval; Chase, Kevin; Dowell, Cheryl; Hone, Arik J.; Morgenstern, David; Chua, Victor M.; Ramiro, Iris Bea L.; Imperial, Julita S.; Leavitt, Lee S.; Phan, Jasmine; Fisher, Fernando A.; Watkins, Maren; Raghuraman, Shrinivasan; Tun, Jortan O.; Ueberheide, Beatrix M.; McIntosh, J. Michael; Vasconcelos, Vitor; Olivera, Baldomero M.; Gajewiak, Joanna

αO-Conotoxin GeXIVA[1,2] Reduced Neuropathic Pain and Changed Gene Expression in Chronic Oxaliplatin-Induced Neuropathy Mice Model

MARINE DRUGS

IF5.4

2024-01-19

OAAI

Wang, Huanbai; Li, Xiaodan; Qiao, Yamin; Wang, Meiting; Wang, Wen; Mcintosh, J. Michael; Zhangsun, Dongting; Luo, Sulan

Analogs of α-conotoxin PnIC selectively inhibit α7β2-over α7-only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism Α-芋螺毒素PnIC的类似物通过一种新的变构机制选择性地抑制 α7β2-而不是仅 α7-亚型烟碱乙酰胆碱受体

FASEB JOURNAL

IF4.2

2023-12-31

OAAI

George, Andrew A.; John, Sabin J.; Lucero, Linda M.; Eaton, J. Brek; Jaiswal, Ekta; Christensen, Sean B.; Gajewiak, Joanna; Watkins, Maren; Cao, Yiwei; Olivera, Baldomero M.; Im, Wonpil; Mcintosh, J. Michael; Whiteaker, Paul

Computational Design of α-Conotoxins to Target Specific Nicotinic Acetylcholine Receptor Subtypes

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2023-12-18

OAAI

Wu, Xiaosa; Hone, Arik J.; Huang, Yen-Hua; Clark, Richard J.; Mcintosh, J. Michael; Kaas, Quentin; Craik, David J.

DM506 (3-Methyl-1,2,3,4,5,6-hexahydroazepino[4,5-b]indole fumarate), a Novel Derivative of Ibogamine, Inhibits α7 and α9α10 Nicotinic Acetylcholine Receptors by Different Allosteric Mechanisms

ACS CHEMICAL NEUROSCIENCE

IF3.9

2023-06-30

PREAI

Tae, Han-Shen; Ortells, Marcelo O.; Tekarli, Bassel J.; Manetti, Dina; Romanelli, Maria Novella; McIntosh, J. Michael; Adams, David J.; Arias, Hugo R.

Nicotinic acetylcholine receptors: Therapeutic targets for novel ligands to treat pain and inflammation

PHARMACOLOGICAL RESEARCH

IF10.5

2023-04-01

OAAI

Hone, Arik J.; McIntosh, J. Michael

Conus regius-Derived Conotoxins: Novel Therapeutic Opportunities from a Marine Organism

MARINE DRUGS

IF5.4

2022-12-10

OAAI

Margiotta, Francesco; Micheli, Laura; Ciampi, Clara; Ghelardini, Carla; McIntosh, J. Michael; Di Cesare Mannelli, Lorenzo

RgIA4 Prevention of Acute Oxaliplatin-Induced Cold Allodynia Requires α9-Containing Nicotinic Acetylcholine Receptors and CD3+ T-Cells

CELLS

IF5.2

2022-11-11

OAAI

Huynh, Peter N.; Christensen, Sean B.; McIntosh, J. Michael

Comparison of the Anti-inflammatory Properties of Two Nicotinic Acetylcholine Receptor Ligands, Phosphocholine and pCF3-diEPP

FRONTIERS IN CELLULAR NEUROSCIENCE

IF4

2022-03-31

OAAI

Richter, Katrin; Papke, Roger L.; Stokes, Clare; Roy, Danika C.; Espinosa, Eduardo S.; Wolf, Philipp M. K.; Hecker, Andreas; Liese, Juliane; Singh, Vijay K.; Padberg, Winfried; Schluter, Klaus-Dieter; Rohde, Marius; McIntosh, J. Michael; Morley, Barbara J.; Horenstein, Nicole A.; Grau, Veronika; Simard, Alain R.

Application of alpha1-antitrypsin in a rat model of veno-arterial extracorporeal membrane oxygenation

SCIENTIFIC REPORTS

IF3.9

2021-08-04

OAAI

Edinger, Fabian; Schmitt, Christoph; Koch, Christian; McIntosh, J. Michael; Janciauskiene, Sabina; Markmann, Melanie; Sander, Michael; Padberg, Winfried; Grau, Veronika

Cy3-RgIA-5727 Labels and Inhibits α9-Containing nAChRs of Cochlear Hair Cells

FRONTIERS IN CELLULAR NEUROSCIENCE

IF4

2021-07-23

OAAI

Fisher, Fernando; Zhang, Yuanyuan; Vincent, Philippe F. Y.; Gajewiak, Joanna; Gordon, Thomas J.; Glowatzki, Elisabeth; Fuchs, Paul Albert; McIntosh, J. Michael

Nicotinic Acetylcholine Receptor Partial Antagonist Polyamides from Tunicates and Their Predatory Sea Slugs

ACS CHEMICAL NEUROSCIENCE

IF3.9

2021-07-02

OAAI

Paguigan, Noemi D.; Tun, Jortan O.; Leavitt, Lee S.; Lin, Zhenjian; Chase, Kevin; Dowell, Cheryl; Deering-Rice, Cassandra E.; Lim, Albebson L.; Karthikeyan, Manju; Hughen, Ronald W.; Zhang, Jie; Peterson, Randall T.; Reilly, Christopher A.; Light, Alan R.; Raghuraman, Shrinivasan; McIntosh, J. Michael; Olivera, Baldomero M.; Schmidt, Eric W.

研究方向