Matthew C. T. Fyfe - Publications, H-index & Citations

Matthew C. T. Fyfe

astellas pharmaceuticals

31H指数

100论文数

4.8K被引数

收录论文 30

发表时间

First-in-class inhibitors of the tRNA methyltransferase METTL1 for the treatment of cancer

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Sapetschnig, Alexandra; Thomas, Beth; Yankova, Eliza; Fischl, Harry; Azevedo, Aleksandra; Bucknell, Sarah; Fosbeary, Richard; Sawyer, Sapphire; Evans, Sian; Livi, Carmen; Andrews, Byron; Rogan, Jack; Webster, Natalie; Fyfe, Matthew; Tzelepis, Konstantinos; Rausch, Oliver

Narrow Spectrum Kinase Inhibitors Demonstrate Promise for the Treatment of Dry Eye Disease and Other Ocular Inflammatory Disorders

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

IF4.7

2018-03-15

OAAI

Hagan, Suzanne; Fyfe, Matthew C. T.; Ofori-Frimpong, Boatemaa; Oliver, Katherine; Foster, Martyn R.; Sirohi, Sameer; Solanke, Yemisi; Doughty, Michael; Rowley, Adele; Taylor, Mike; Webber, Steve; Walshe, Claire A.

THE PHARMACOLOGICAL PROFILE OF TOP1288, A NARROW SPECTRUM KINASE INHIBITOR (NSKI) IN CLINICAL DEVELOPMENT AS AN ANTI-INFLAMMATORY TREATMENT FOR ULCERATIVE COLITIS

GASTROENTEROLOGY

IF25.1

2017-04-01

PREAI

Foster, Martyn; Biancheri, Paolo; Fyfe, Matthew C.; MacDonald, Thomas T.; Rowley, Adele; Sirohi, Sameer; Solanke, Yemisi; Webber, Steve; Walshe, Claire A.

THE NARROW SPECTRUM KINASE INHIBITOR (NSKI) TOP1288 DEMONSTRATES POTENT ANTI-INFLAMMATORY EFFECTS IN A T CELL ADOPTIVE TRANSFER COLITIS MODEL THROUGH A TOPICAL MODE OF ACTION

GASTROENTEROLOGY

IF25.1

2017-04-01

PREAI

Solanke, Yemisi; Foster, Martyn; Fyfe, Matthew C.; Rowley, Adele; Sirohi, Sameer; Webber, Steve; Walshe, Claire A.

PHOSPHO-FLOW CYTOMETRY: A METHOD FOR INVESTIGATING EFFECTS OF NARROW SPECTRUM KINASE INHIBITORS ON KINASE PHOSPHORYLATION AS A CLINICAL BIOMARKER

GASTROENTEROLOGY

IF25.1

2017-04-01

PREAI

Sirohi, Sameer; Foster, Martyn; Fyfe, Matthew C.; Solanke, Yemisi; Webber, Steve; Walshe, Claire A.

TOP1210 NSKI Demonstrates Superior Activity and Improved Safety Profile Potential Compared to Corticosteroid and Immunomodulators in Preclinical Models of Colitis

GASTROENTEROLOGY

IF25.1

2016-04-01

PREAI

Walshe, Claire A.; Rowley, Adele; Foster, Martyn; Solanke, Yemisi; Sirohi, Sameer; Fyfe, Matthew C.; Webber, Steve

GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity

BRITISH JOURNAL OF PHARMACOLOGY

IF7.7

2009-01-29

258

OAAI

Overton, H. A.; Fyfe, M. C. T.; Reynet, C.

SAR, pharmacokinetics, safety, and efficacy of glucokinase activating 2-(4-sulfonylphenyl)-N-thiazol-2-ylacetamides:: Discovery of PSN-GK1

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2008-06-28

PREAI

Bertram, Lisa S.; Black, Daniel; Briner, Paul H.; Chatfield, Rosemary; Cooke, Andrew; Fyfe, Matthew C. T.; Murray, P. John; Naud, Frederic; Nawano, Masao; Procter, Martin J.; Rakipovski, Guenaj; Rasamison, Chrystelle M.; Reynet, Christine; Schofield, Karen L.; Shah, Vilas K.; Spindler, Felix; Taylor, Amanda; Turton, Roy; Williams, Geoffrey M.; Wong-Kai-In, Philippe; Yasuda, Kosuke

GPR119 agonists as potential new oral agents for the treatment of type 2 diabetes and obesity

EXPERT OPINION ON DRUG DISCOVERY

IF4.9

2008-03-26

PREAI

Fyfe, Matthew C. T.; McCormack, James G.; Overton, Hilary A.; Procter, Martin J.; Reynet, Christine

Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions

DIABETOLOGIA

IF10.2

2007-04-06

OAAI

Fyfe, M. C. T.; White, J. R.; Taylor, A.; Chatfield, R.; Wargent, E.; Printz, R. L.; Sulpice, T.; McCormack, J. G.; Procter, M. J.; Reynet, C.; Widdowson, P. S.; Wong-Kai-In, P.

Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents

CELL METABOLISM

IF30.9

2006-03-01

633

OAAI

Overton, HA; Babbs, AJ; Doel, SM; Fyfe, MCT; Gardner, LS; Griffin, G; Jackson, HC; Procter, MJ; Rasamison, CM; Tang-Christensen, M; Widdowson, PS; Williams, GM; Reynet, C

Practical synthesis of 2-amino-5-fluorothiazole hydrochloride

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2006-02-10

PREAI

Briner, PH; Fyfe, MCT; Martin, P; Murray, PJ; Naud, F; Procter, MJ

Molecular and supramolecular synthesis with dibenzofuran-containing systems

CHEMISTRY-A EUROPEAN JOURNAL

IF3.7

2006-01-20

PREAI

Asakawa, M; Ashton, PR; Brown, CL; Fyfe, MCT; Menzer, S; Pasini, D; Scheuer, C; Spencer, N; Stoddart, JF; White, AJP; Williams, DJ