未登录Phosphorylation of a-synuclein at T64 results in distinct oligomers and exerts toxicity in models of Parkinson's diseasea-突触核蛋白在T64的磷酸化导致不同的寡聚体，并在帕金森病模型中发挥毒性
Matsui, Hideaki; Ito, Shinji; Matsui, Hideki; Ito, Junko; Gabdulkhaev, Ramil; Hirose, Mika; Yamanaka, Tomoyuki; Koyama, Akihide; Kato, Taisuke; Tanaka, Maiko; Uemura, Norihito; Matsui, Noriko; Hirokawa, Sachiko; Yoshihama, Maki; Shimozawa, Aki; Kubo, Shin-ichiro; Iwasaki, Kenji; Hasegawa, Masato; Takahashi, Ryosuke; Hirai, Keisuke; Kakita, Akiyoshi; Onodera, Osamu .png)
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收藏Efficacy of catheter ablation from the noncoronary aortic cusp of verapamil-sensitive atrial tachycardia arising near the atrioventricular nodeYamabe, Hiroshige; Soejima, Toshiya; Kajiyama, Kimihiro; Fukami, Yurie; Haraguchi, Kazuki; Okonogi, Taichi; Hirai, Keisuke; Fukuoka, Ryota; Umeji, Kyoko; Orita, Yoshiya; Koga, Hisashi; Kawasaki, Tomohiro 分享 收藏 分享 收藏 分享 收藏 Nucleus accumbens pathways control cell-specific gene expression in the medial prefrontal cortexHikida, Takatoshi; Yao, Shuhei; Macpherson, Tom; Fukakusa, Ayumi; Morita, Makiko; Kimura, Haruhide; Hirai, Keisuke; Ando, Tatsuya; Toyoshiba, Hiroyoshi; Sawa, Akira 分享 收藏 Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia介导神经退行性痴呆的进化保守基因网络的鉴定Swarup, Vivek; Hinz, Flora I.; Rexach, Jessica E.; Noguchi, Ken-ichi; Toyoshiba, Hiroyoshi; Oda, Akira; Hirai, Keisuke; Sarkar, Arjun; Seyfried, Nicholas T.; Cheng, Chialin; Haggarty, Stephen J.; Ferrari, Raffaele; Rohrer, Jonathan D.; Ramasamy, Adaikalavan; Hardy, John; Hernandez, Dena G.; Nalls, Michael A.; Singleton, Andrew B.; Kwok, John B. J.; Dobson-Stone, Carol; Brooks, William S.; Schofield, Peter R.; Halliday, Glenda M.; Hodges, John R.; Piguet, Olivier; Bartley, Lauren; Thompson, Elizabeth; Haan, Eric; Hernandez, Isabel; Ruiz, Agustin; Boada, Merce; Borroni, Barbara; Padovani, Alessandro; Cairns, Nigel J.; Cruchaga, Carlos; Binetti, Giuliano; Ghidoni, Roberta; Benussi, Luisa; Forloni, Gianluigi; Albani, Diego; Galimberti, Daniela; Fenoglio, Chiara; Serpente, Maria; Scarpini, Elio; Clarimon, Jordi; Lleo, Alberto; Blesa, Rafael; Waldo, Maria Landqvist; Nilsson, Karin; Nilsson, Christer; Mackenzie, Ian R. A.; Hsiung, Ging-Yuek R.; Mann, David M. A.; Grafman, Jordan; Morris, Christopher M.; Attems, Johannes; Griffiths, Timothy D.; McKeith, Ian G.; Thomas, Alan J.; Jaros, Evelyn; Pietrini, Pietro; Huey, Edward D.; Wassermann, Eric M.; Tierney, Michael C.; Baborie, Atik; Pastor, Pau; Ortega-Cubero, Sara; Razquin, Cristina; Alonso, Elena; Perneczky, Robert; Diehl-Schmid, Janine; Alexopoulos, Panagiotis; Kurz, Alexander; Rainero, Innocenzo; Rubino, Elisa; Pinessi, Lorenzo; Rogaeva, Ekaterina; St George-Hyslop, Peter; Rossi, Giacomina; Tagliavini, Fabrizio; Giaccone, Giorgio; Rowe, James B.; Schlachetzki, Johannes C. M.; Uphill, James; Collinge, John; Mead, Simon; Danek, Adrian; Van Deerlin, Vivianna M.; Grossman, Murray; Trojanowski, John Q.; Pickering-Brown, Stuart; Momeni, Parastoo; van der Zee, Julie; Cruts, Marc; Van Broeckhoven, Christine; Cappa, Stefano F.; Leber, Isabelle; Brice, Alexis; Hannequin, Didier; Golfier, Veronique; Vercelletto, Martine; Nacmias, Benedetta; Sorbi, Sandro; Bagnoli, Silvia; Piaceri, Irene; Nielsen, Jorgen E.; Hjermind, Lena E.; Riemenschneider, Matthias; Mayhaus, Manuel; Gasparoni, Gilles; Pichler, Sabrina; Ibach, Bernd; Rossor, Martin N.; Fox, Nick C.; Warren, Jason D.; Spillantini, Maria Grazia; Morris, Huw R.; Rizzu, Patrizia; Heutink, Peter; Snowden, Julie S.; Rollinson, Sara; Gerhard, Alexander; Richardson, Anna; Bruni, Amalia C.; Maletta, Raffaele; Frangipane, Francesca; Cupidi, Chiara; Bernardi, Livia; Anfossi, Maria; Gallo, Maura; Conidi, Maria Elena; Smirne, Nicoletta; Rademakers, Rosa; Baker, Matt; Dickson, Dennis W.; Graff-Radford, Neill R.; Petersen, Ronald C.; Knopman, David; Josephs, Keith A.; Boeve, Bradley F.; Parisi, Joseph E.; Miller, Bruce L.; Karydas, Anna M.; Rosen, Howard; Seeley, William W.; van Swieten, John C.; Dopper, Elise G. P.; Seelaar, Harro; Pijnenburg, Yolande A. L.; Scheltens, Philip; Logroscino, Giancarlo; Capozzo, Rosa; Novelli, Valeria; Puca, Annibale A.; Franceschi, Massimo; Postiglione, Alfredo; Milan, Graziella; Sorrentino, Paolo; Kristiansen, Mark; Chiang, Huei-Hsin; Graff, Caroline; Pasquier, Florence; Rollin, Adeline; Deramecourt, Vincent; Lebouvier, Thibaud; Ferrucci, Luigi; Kapogiannis, Dimitrios; Grossman, Murray; Van Deerlin, Vivianna M.; Trojanowski, John Q.; Lah, James J.; Levey, Allan I.; Kondou, Shinichi; Geschwind, Daniel H. 分享 收藏 Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the eTreatment of Benign Prostatic HyperplasiaTerakado, Masahiko; Suzuki, Hidehiro; Hashimura, Kazuya; Tanaka, Motoyuki; Ueda, Hideyuki; Hirai, Keisuke; Asada, Masaki; Ikura, Masahiro; Matsunaga, Naoki; Saga, Hiroshi; Shinozaki, Koji; Karakawa, Naoko; Takada, Yuka; Minami, Masashi; Egashira, Hiromu; Sugiura, Yoshihiro; Yamada, Masanori; Nakade, Shinji; Takaoka, Yoshikazu 分享 收藏 分享 收藏 Synthesis of a Novel Series of Tricyclic Dihydrofuran Derivatives: Discovery of 8,9-Dihydrofuro[3,2-c]pyrazolo[1,5-a]pyridines as Melatonin Receptor (MT1/MT2) LigandsKoike, Tatsuki; Takai, Takafumi; Hoashi, Yasutaka; Nakayama, Masaharu; Kosugi, Yohei; Nakashima, Masato; Yoshikubo, Shin-ichi; Hirai, Keisuke; Uchikawa, Osamu 分享 收藏 1,6-Dihydro-2H-indeno[5,4-b]furan Derivatives: Design, Synthesis, and Pharmacological Characterization of a Novel Class of Highly Potent MT2-Selective AgonistsKoike, Tatsuki; Hoashi, Yasutaka; Takai, Takafumi; Nakayama, Masaharu; Yukuhiro, Nobuhito; Ishikawa, Takashi; Hirai, Keisuke; Uchikawa, Osamu 分享 收藏 Discovery of orally available spirodiketopiperazine-based CCR5 antagonistsNishizawa, Rena; Nishiyama, Toshihiko; Hisaichi, Katsuya; Hirai, Keisuke; Habashita, Hiromu; Takaoka, Yoshikazu; Tada, Hideaki; Sagawa, Kenji; Shibayama, Shiro; Maeda, Kenji; Mitsuya, Hiroaki; Nakai, Hisao; Fukushima, Daikichi; Toda, Masaaki 分享 收藏 分享 收藏 分享 收藏 分享 收藏 分享 收藏 Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Identification of 2-azabicyclo[4.1.0]heptan-3-iminesKawanaka, Y; Kobayashi, K; Kusuda, S; Tatsumi, T; Murota, M; Nishiyama, T; Hisaichi, K; Fujii, A; Hirai, K; Naka, M; Komeno, M; Odagaki, Y; Nakai, H; Toda, M 分享 收藏 Oxidative stress and predominant Aβ42(43) deposition in myopathies with rimmed vacuolesTateyama, M; Takeda, A; Onodera, Y; Matsuzaki, M; Hasegawa, T; Nunomura, A; Hirai, K; Perry, G; Smith, MA; Itoyama, Y 分享 收藏 Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailabilityKawanaka, Y; Kobayashi, K; Kusuda, S; Tatsumi, T; Murota, M; Nishiyama, T; Hisaichi, K; Fujii, A; Hirai, K; Naka, M; Komeno, M; Nakai, H; Toda, M 分享 收藏 Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase.: Synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-iminesKawanaka, Y; Kobayashi, K; Kusuda, S; Tatsumi, T; Murota, M; Nishiyama, T; Hisaichi, K; Fujii, A; Hirai, K; Nishizaki, M; Naka, M; Komeno, M; Nakai, H; Toda, M 分享 收藏 Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?氧化损伤是阿尔茨海默病和其他神经退行性疾病的基本致病机制吗？Perry, G; Nunomura, A; Hirai, K; Zhu, XW; Pérez, M; Avila, J; Castellani, RJ; Atwood, CS; Aliev, G; Sayre, LM; Takeda, A; Smith, MA 分享 收藏 
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