J. Keith Joung - Publications, H-index & Citations

J. Keith Joung

Harvard University

91H指数

221论文数

5.6W被引数

收录论文 116

发表时间

Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene editing for genetic hyperinflammation 基因毒性分析揭示了在治疗性基因编辑治疗遗传性高炎症中的平台特异性和细胞类型特异性效应

Cell Stem Cell

IF20.4

2026-05-13

OAAI

Lei Lei; Masako M. Kaufmann; Jessica Lao; Gudrun Thoulass; Sandra Ammann; Hui Xiao; Manuel Rhiel; Viviane Dettmer-Monaco; Julian Grünewald; Geoffroy Andrieux; Jamal Alzubi; Bret R. Miller; Kristoffer Weißert; Linda Gräßel; Christoph Schell; Anna L. Illert; J. Keith Joung; Melanie Boerries; Tatjana I. Cornu; Stephan Ehl

High-resolution CTCF footprinting reveals impact of chromatin state on cohesin extrusion 高分辨率CTCF足迹分析揭示了染色质状态对cohesin外推的影响

NATURE COMMUNICATIONS

IF15.7

2025-05-15

OAAI

Sept, Corriene E.; Tak, Y. Esther; Goel, Viraat; Bhakta, Mital S.; Cerda-Smith, Christian G.; Hutchinson, Haley M.; Blanchette, Marco; Eyler, Christine E.; Johnstone, Sarah E.; Joung, J. Keith; Hansen, Anders S.

Enhancing CRISPR prime editing by reducing misfolded pegRNA interactions

ELIFE

IF0

2024-06-06

OAAI

Zhang, Weiting; Petri, Karl; Ma, Junyan; Lee, Hyunho; Tsai, Chia-Lun; Joung, J. Keith; Yeh, Jing-Ruey Joanna

A Zebrafish Model of Myelodysplastic Syndrome Produced through tet2 Genomic Editing

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-20

OAAI

Gjini, Evisa; Mansour, Marc R.; Sander, Jeffry D.; Moritz, Nadine; Nguyen, Ashley T.; Kesarsing, Michiel; Gans, Emma; He, Shuning; Chen, Si; Ko, Myunggon; Kuang, You-Yi; Yang, Song; Zhou, Yi; Rodig, Scott; Zon, Leonard I.; Joung, J. Keith; Rao, Anjana; Look, A. Thomas

Engineered CRISPR prime editors with compact, untethered reverse transcriptases 具有紧凑，不受限制的逆转录酶的工程化CRISPR prime编辑器

NATURE BIOTECHNOLOGY

IF41.7

2022-09-26

OAAI

Gruenewald, Julian; Miller, Bret R.; Szalay, Regan N.; Cabeceiras, Peter K.; Woodilla, Christopher J.; Holtz, Eliza Jane B.; Petri, Karl; Joung, J. Keith

Augmenting and directing long-range CRISPR-mediated activation in human cells (vol 18, pg 1075, 2021)

NATURE METHODS

IF32.1

2022-06-27

OAAI

Tak, Y. Esther; Horng, Joy E.; Perry, Nicholas T.; Schultz, Hayley T.; Iyer, Sowmya; Yao, Qiuming; Zou, Luli S.; Aryee, Martin J.; Pinello, Luca; Joung, J. Keith

CRISPR-Cas9 treatment partially restores amyloid-β 42/40 in human fibroblasts with the Alzheimer's disease PSEN1 M146L mutation

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2022-06-01

OAAI

Konstantinidis, Evangelos; Molisak, Agnieszka; Perrin, Florian; Streubel-Gallasch, Linn; Fayad, Sarah; Kim, Daniel Y.; Petri, Karl; Aryee, Martin J.; Aguilar, Ximena; Gyorgy, Bence; Giedraitis, Vilmantas; Joung, J. Keith; Pattanayak, Vikram; Essand, Magnus; Erlandsson, Anna; Berezovska, Oksana; Ingelsson, Martin

Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors

CELL GENOMICS

IF9

2022-04-01

OAAI

Tak, Y. Esther; Boulay, Gaylor; Lee, Lukuo; Iyer, Sowmya; Perry, Nicholas T.; Schultz, Hayley T.; Garcia, Sara P.; Broye, Liliane; Horng, Joy E.; Rengarajan, Shruthi; Naigles, Beverly; Volorio, Angela; Sander, Jeffry D.; Gong, Jingyi; Riggi, Nicolo; Joung, J. Keith; Rivera, Miguel N.

Defining genome-wide CRISPR-Cas genome-editing nuclease activity with GUIDE-seq

NATURE PROTOCOLS

IF16

2021-11-12

OAAI

Malinin, Nikolay L.; Lee, GaHyun; Lazzarotto, Cicera R.; Li, Yichao; Zheng, Zongli; Nguyen, Nhu T.; Liebers, Matthew; Topkar, Ved V.; Iafrate, A. John; Le, Long P.; Aryee, Martin J.; Joung, J. Keith; Tsai, Shengdar Q.

Augmenting and directing long-range CRISPR-mediated activation in human cells

NATURE METHODS

IF32.1

2021-08-05

OAAI

Tak, Y. Esther; Horng, Joy E.; Perry, Nicholas T.; Schultz, Hayley T.; Iyer, Sowmya; Yao, Qiuming; Zou, Luli S.; Aryee, Martin J.; Pinello, Luca; Joung, J. Keith

CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells (vol 40, pg 189, 2021)

NATURE BIOTECHNOLOGY

IF41.7

2021-05-13

OAAI

Petri, Karl; Zhang, Weiting; Ma, Junyan; Schmidts, Andrea; Lee, Hyunho; Horng, Joy E.; Kim, Daniel Y.; Kurt, Ibrahim C.; Clement, Kendell; Hsu, Jonathan Y.; Pinello, Luca; Maus, Marcela V.; Joung, J. Keith; Yeh, Jing-Ruey Joanna

Analysis of off-target effects in CRISPR-based gene drives in the human malaria mosquito 人类疟疾蚊子中基于CRISPR的基因驱动的脱靶效应分析

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2021-04-30

OAAI

Garrood, William T.; Kranjc, Nace; Petri, Karl; Kim, Daniel Y.; Guo, Jimmy A.; Hammond, Andrew M.; Morianou, Ioanna; Pattanayak, Vikram; Joung, J. Keith; Crisanti, Andrea; Simoni, Alekos

CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells

NATURE BIOTECHNOLOGY

IF41.7

2021-04-29

144

OAAI

PrimeDesign software for rapid and simplified design of prime editing guide RNAs PrimeDesign软件，用于快速和简化设计prime编辑指南rna

NATURE COMMUNICATIONS

IF15.7

2021-02-15

115

OAAI

Hsu, Jonathan Y.; Grunewald, Julian; Szalay, Regan; Shih, Justine; Anzalone, Andrew, V; Lam, Kin Chung; Shen, Max W.; Petri, Karl; Liu, David R.; Joung, J. Keith; Pinello, Luca

Scalable characterization of the PAM requirements of CRISPR-Cas enzymes using HT-PAMDA

NATURE PROTOCOLS

IF16

2021-02-05

OAAI

Walton, Russell T.; Hsu, Jonathan Y.; Joung, J. Keith; Kleinstiver, Benjamin P.

A Code of Ethics for Gene Drive Research

CRISPR JOURNAL

IF4

2021-02-01

OAAI

Annas, George J.; Beisel, Chase L.; Clement, Kendell; Crisanti, Andrea; Francis, Stacy; Galardini, Marco; Galizi, Roberto; Grunewald, Julian; Immobile, Greta; Khalil, Ahmad S.; Mueller, Ruth; Pattanayak, Vikram; Petri, Karl; Paul, Ligi; Pinello, Luca; Simoni, Alekos; Taxiarchi, Chrysanthi; Joung, J. Keith

Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2020-09-01

OAAI

Cruz, Lilian; Gyorgy, Bence; Cheah, Pike See; Kleinstiver, Benjamin P.; Eimer, William A.; Garcia, Sara P.; Sharma, Nutan; Ozelius, Laurie J.; Bragg, D. Cristopher; Joung, J. Keith; de Souza, Osmar Norberto; Timmers, Luis Fernando Saraiva Macedo; Breakefield, Xandra O.

CRISPR C-to-G base editors for inducing targeted DNA transversions in human cells 用于诱导人类细胞中靶向DNA颠转的CRISPR c--g碱基编辑器

NATURE BIOTECHNOLOGY

IF41.7

2020-07-20

427

OAAI

Kurt, Ibrahim C.; Zhou, Ronghao; Iyer, Sowmya; Garcia, Sara P.; Miller, Bret R.; Langner, Lukas M.; Grunewald, Julian; Joung, J. Keith

Optimization of AsCas12a for combinatorial genetic screens in human cells

NATURE BIOTECHNOLOGY

IF41.7

2020-07-13

OAAI

DeWeirdt, Peter C.; Sanson, Kendall R.; Sangree, Annabel K.; Hegde, Mudra; Hanna, Ruth E.; Feeley, Marissa N.; Griffith, Audrey L.; Teng, Teng; Borys, Samantha M.; Strand, Christine; Joung, J. Keith; Kleinstiver, Benjamin P.; Pan, Xuewen; Huang, Alan; Doench, John G.

Technologies and Computational Analysis Strategies for CRISPR Applications

MOLECULAR CELL

IF16.6

2020-07-01

OAAI

Clement, Kendell; Hsu, Jonathan Y.; Canver, Matthew C.; Joung, J. Keith; Pinello, Luca

研究方向