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朱

朱孔凯 (Kongkai Zhu)

shandong university

23H指数
80论文数
1.5K被引数
收录论文 29
发表时间
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Novel indole-based indoleamine 2,3-dioxygenase-1 (IDO1) inhibitors: design, synthesis, and antidepressant evaluation新型吲哚基色胺胺2,3-加氧酶-1（IDO1）抑制剂：设计、合成及抗抑郁活性评价
errBioorganic & Medicinal Chemistry
IF3
err2025-12-02
err0
PREAI
errJuan Zhang; Wen-Jing Gao; Yu-Xi Zheng; Jia-Dong Shao; Nai-Yu Zhang; Wei Guo; Shuai Wang; Qing Zhao; Kongkai Zhu; Ming Gao; Jin-Hai Yu; Ning Meng; Cheng-Shi Jiang
err分享
err收藏
The force-sensing GPCR LPHN2 is indispensable for normal auditory function力传感GPCR LPHN2对于正常的听觉功能至关重要。
errCell Reports
IF6.9
err2025-11-04
err0
errOAAI
errShu-Hua Zhou; Ming-Wei Wang; Zhi-Chen Song; Zhao Yang; Kong-Kai Zhu; Xin Wen; Qi-Yue Zhang; Ying Guan; Jia-Rui Gao; Xiao-Hui Wang; Ya-Qi Wang; Wen-Wen Liu; Lei Xu; Wei Xiong; Ren-Jie Chai; Chuan Wang; Zhi-Gang Xu; Xiao Yu; Jin-Peng Sun
err分享
err收藏
Discovery of a novel potent tubulin inhibitor through virtual screening and target validation for cancer chemotherapy通过虚拟筛选和靶点验证发现一种新型强效微管抑制剂，用于癌症化疗。
errCell Death Discovery
IF7
err2025-08-19
err0
errOAAI
errPeipei Shan; Kai-Lu Liu; Xiu Jiang; Guangzhao Zhou; Kongkai Zhu; Hua Zhang
err分享
err收藏
LigDockTailor: Ligand-specific docking tool matching using multidimensional descriptorsLigDockTailor：一种基于多维描述符的配体特异性对接工具匹配方法
errcomputational chemistry
IF3.1
err2025-06-15
err0
PREAI
errKai Zhang; Yunmei Zhu; Wei Zhang; Yanghan Sun; Ziheng Zhang; Yueyang Wang; Yixian Tan; Linyu Yu; Sirui Chen; Shiyong Ma; Kongkai Zhu; Bowen Ke; Jiaxue Wu; Zufeng Guo; Ling Zhang; Yongjun Dang; Junchi Hu
err分享
err收藏
Bisabolane-type sesquiterpenoids and cyclic tetrapeptide from the marine fungus Aspergillus sp. WHUF05242桉叶烷型倍半萜类化合物和环四肽，源自海洋真菌Aspergillus sp. WHUF05242
errFITOTERAPIA
IF2.6
err2025-06-01
err0
PREAI
errZhong, Yu-Ting; Zhao, Zi-Fang; Chen, Wei-Chen; Edjah, Philomina Panin; Zhu, Kong-Kai; Tian, Cong-Kui; Hong, Kui; Tao, Wei-Xin; Zhang, Ke-Yong; Zhang, Meng-Ke; Wang, Fu-Qian; Cai, You-Sheng
err分享
err收藏
Structural basis and biased signaling of proton sensation by GPCRs mediated by extracellular histidine rearrangementGPCR介导的细胞外组氨酸重排感知质子的结构基础与偏向性信号传导
errMOLECULAR CELL
IF16.6
err2025-04-01
err2
errOAAI
errGuo, Lulu; Zhu, Kongkai; Zhong, Ya-Ni; Gao, Mingxin; Liu, Junyan; Qi, Zhimin; Liu, Zili; Rong, Naikang; Zhang, Minghui; Li, Dongfang; Zhang, Qiyue; Yang, Gongming; Zhang, Xinxin; Zhang, Mingyue; Ding, Ning; Ping, Yu-qi; Yang, Zhao; Xiao, Peng; Xia, Ming; Yu, Xiao; Sun, Jin-Peng
err分享
err收藏
Design and synthesis of N-(3-cyanothiophen-2-yl)-2-phenoxyacetamide-based α-glucosidase inhibitors基于N-(3-氰基硫代苯并噻吩-2-基)-2-苯氧基乙酰胺的α-葡萄糖苷酶抑制剂的设计与合成
errBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
IF2.2
err2025-03-01
err0
PREAI
errChen, Yi-Tong; Wan, Bo-Wen; Wang, Kai-Ming; Zhu, Kong-Kai; Meng, Ning; Jiang, Cheng-Shi; Zhang, Juan
err分享
err收藏
Discovery of anti-tumor small molecule lead compounds targeting the SH3 domain of c-Src protein through virtual screening and biological evaluation
errARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
IF3
err2025-02-01
err0
PREAI
errHao, Haifang; Bian, Yuan; Yang, Na; Ji, Xingzhao; Bao, Jie; Zhu, Kongkai
err分享
err收藏
Aculeapyridones A-Q, Pyranopyridone Alkaloids with Protective Effects against Acetaminophen-Induced Acute Liver Injury Discovered from a Coculture of Aspergillus aculeatinus WHUF0198 and a Penicillium sp.Aculeapyridones A-Q，具有对乙酰氨基酚诱导急性肝损伤保护作用的吡喃吡啶酮生物碱，来源于Aspergillus aculeatinus WHUF0198与一种Penicillium sp.的共培养。
errJOURNAL OF NATURAL PRODUCTS
IF3.6
err2025-01-28
err0
PREAI
errChen, Wei-Chen; Song, Xin; Wu, Jun; Zhong, Yu-Ting; Edjah, Philomina Panin; Zhang, Qin-Yong; Li, Mu; Zhu, Kong-Kai; Tian, Congkui; Yuan, Rui-Ying; Wu, Xiao-Yan; Gao, Ping; Hong, Kui; Cai, You-Sheng
err分享
err收藏
First total synthesis, antitumor evaluation and target identification of mornaphthoate E: A new tubulin inhibitor template acting on PI3K/Akt signaling pathway
errACTA PHARMACEUTICA SINICA B
IF14.6
err2024-05-01
err5
errOAAI
errShan, Peipei; Ye, Tao; Tang, Ying-De; Song, Hui; Wang, Chao; Zhu, Kongkai; Yang, Feifei; Zhang, Shi-Lei; Su, Pei-Wen; Gao, Shuanhu; Zhang, Hua
err分享
err收藏
Synthesis and biological evaluation of 1-phenyl-tetrahydro-β-carboline-based first dual PRMT5/EGFR inhibitors as potential anticancer agents
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-04-01
err7
PREAI
errZhang, Juan; Liu, Xuliang; Sa, Na; Zhang, Jin-He; Cai, Yong-Si; Wang, Kai-Ming; Xu, Wei; Jiang, Cheng-Shi; Zhu, Kong-Kai
err分享
err收藏
Structure of GPR101-Gs enables identification of ligands with rejuvenating potential
errNATURE CHEMICAL BIOLOGY
IF13.7
err2023-11-09
err9
PREAI
errYang, Zhao; Wang, Jun-Yan; Yang, Fan; Zhu, Kong-Kai; Wang, Guo-Peng; Guan, Ying; Ning, Shang-Lei; Lu, Yan; Li, Yu; Zhang, Chao; Zheng, Yuan; Zhou, Shu-Hua; Wang, Xin-Wen; Wang, Ming-Wei; Xiao, Peng; Yi, Fan; Zhang, Cheng; Zhang, Peng-Ju; Xu, Fei; Liu, Bao-Hua; Zhang, Hua; Yu, Xiao; Gao, Ning; Sun, Jin-Peng
err分享
err收藏
Ligand recognition and G protein coupling of the human itch receptor MRGPRX1
errNATURE COMMUNICATIONS
IF15.7
err2023-08-17
err4
errOAAI
errGuo, Lulu; Zhang, Yumu; Fang, Guoxing; Tie, Lu; Zhuang, Yuming; Xue, Chenyang; Liu, Qi; Zhang, Minghui; Zhu, Kongkai; You, Chongzhao; Xu, Peiyu; Yuan, Qingning; Zhang, Chao; Liu, Lei; Rong, Naikang; Peng, Shengxuan; Liu, Yuan; Wang, Chuanzheng; Luo, Xin; Lv, Zongyao; Kang, Dongwei; Yu, Xiao; Zhang, Cheng; Jiang, Yi; Dong, Xinzhong; Zhou, Jiuyao; Liu, Zhongmin; Yang, Fan; Eric Xu, H.; Sun, Jin-Peng
err分享
err收藏
An overview of the development of EED inhibitors to disable the PRC2 function
errRSC MEDICINAL CHEMISTRY
IF3.6
err2022-01-01
err18
errOAAI
errLiu, Kai-Lu; Zhu, Kongkai; Zhang, Hua
err分享
err收藏
Structure-Guided Development of Small-Molecule PRC2 Inhibitors Targeting EZH2-EED Interaction
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2021-06-02
err26
PREAI
errDu, Daohai; Xu, Dandan; Zhu, Licheng; Stazi, Giulia; Zwergel, Clemens; Liu, Yanli; Luo, Zhongyuan; Li, Yuanqing; Zhang, Yuanyuan; Zhu, Kongkai; Ding, Yiluan; Liu, Jingqiu; Fan, Shijie; Zhao, Kaiyan; Zhang, Naixia; Kong, Xiangqian; Jiang, Hualiang; Chen, Kaixian; Zhao, Kehao; Valente, Sergio; Min, Jinrong; Duan, Wenhu; Luo, Cheng
err分享
err收藏
A highly sensitive endoplasmic reticulum-targeting fluorescent probe for the imaging of endogenous H2S in live cells
errSPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
IF4.6
err2020-10-01
err31
PREAI
errZhou, Lei; Cheng, Zhi-Qiang; Li, Ning; Ge, Yong-Xi; Xie, Hong-Xu; Zhu, Kongkai; Zhou, Aiqin; Zhang, Juan; Wang, Kai-Ming; Jiang, Cheng-Shi
err分享
err收藏
DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe
errNATURE COMMUNICATIONS
IF15.7
err2020-09-25
err34
errOAAI
errLiu, Qi; He, Qing-tao; Lyu, Xiaoxuan; Yang, Fan; Zhu, Zhong-liang; Xiao, Peng; Yang, Zhao; Zhang, Feng; Yang, Zhao-ya; Wang, Xiao-yan; Sun, Peng; Wang, Qian-wen; Qu, Chang-xiu; Gong, Zheng; Lin, Jing-yu; Xu, Zhen; Song, Shao-le; Huang, Shen-ming; Guo, Sheng-chao; Han, Ming-jie; Zhu, Kong-kai; Chen, Xin; Kahsai, Alem W.; Xiao, Kun-Hong; Kong, Wei; Li, Fa-hui; Ruan, Ke; Li, Zi-jian; Yu, Xiao; Niu, Xiao-gang; Jin, Chang-wen; Wang, Jiangyun; Sun, Jin-peng
err分享
err收藏
Rational Design of a High-Performance Quinoxalinone-Based AIE Photosensitizer for Image-Guided Photodynamic Therapy用于图像引导光动力治疗的高性能喹喔啉酮类AIE光敏剂的合理设计
errACS APPLIED MATERIALS & INTERFACES
IF8.2
err2020-08-31
err38
PREAI
errZhang, Peng; Kuang, Haizhu; Xu, Yingying; Shi, Leilei; Cao, Weiling; Zhu, Kongkai; Xu, Li; Ma, Jing
err分享
err收藏
Octahydro-Protoberberine and Protoemetine-Type Alkaloids from the Stems of Alangium salviifolium and Their Cytotoxicity
errJOURNAL OF NATURAL PRODUCTS
IF3.6
err2019-09-12
err20
PREAI
errCai, You-Sheng; Wang, Cong; Tian, Congkui; Sun, Wen-Tin; Chen, Ling; Xiao, Di; Zhou, Si-Yuan; Qiu, Guofu; Yu, Jianqing; Zhu, Kongkai; Yang, Sheng-Ping
err分享
err收藏
Rational Design, synthesis and biological evaluation of novel triazole derivatives as potent and selective PRMT5 inhibitors with antitumor activity
errJOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN
IF3.1
err2019-07-16
err17
PREAI
errZhu, Kongkai; Shao, Jingwei; Tao, Hongrui; Yan, Xue; Luo, Cheng; Zhang, Hua; Duan, Wenhu
err分享
err收藏

研究方向

理论模拟驱动的创新药/靶发现与作用机制研究
合作学者
合作期刊
蒋
蒋华良 (Hualiang Jiang)
H 指数: 101 · 论文数: 983
H
H. Eric Xu
H 指数: 100 · 论文数: 625
X
Xinzhong Dong
H 指数: 70 · 论文数: 280
吴骏 封面图
吴骏 (Jun Wu)
H 指数: 68 · 论文数: 279
张凯 封面图
张凯 (Kai Zhang)
H 指数: 67 · 论文数: 857
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