Jeffrey M. Witkin - Publications, H-index & Citations

Jeffrey M. Witkin

University of Wisconsin System

56H指数

544论文数

9.7K被引数

收录论文 113

发表时间

Antipsychotic-like pharmacological profile of the low impact ampakine CX691 (farampator): Implications for the use of low impact ampakines in the treatment of schizophrenia 低影响AMPA受体激动剂CX691（farampator）的抗精神病样药理学特征：对低影响AMPA受体激动剂在精神分裂症治疗中应用的启示

JOURNAL OF PSYCHIATRIC RESEARCH

IF3.2

2025-06-01

PREAI

Radin, Daniel P.; Cerne, Rok; Smith, Jodi L.; Witkin, Jeffrey M.; Lippa, Arnold

Safety, tolerability and pharmacokinetic profile of the low-impact ampakine CX717 in young healthy male subjects and elderly healthy male and female subjects

EUROPEAN JOURNAL OF PHARMACOLOGY

IF4.7

2025-04-01

PREAI

Radin, Daniel P.; Cerne, Rok; Smith, Jodi L.; Witkin, Jeffrey M.; Lippa, Arnold

Amplification of the therapeutic potential of AMPA receptor potentiators from the nootropic era to today

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

IF2.5

2025-03-01

PREAI

Radin, Daniel P.; Lippa, Arnold; Rana, Sabhya; Fuller, David D.; Smith, Jodi L.; Cerne, Rok; Witkin, Jeffrey M.

ANXIOLYTICS: Origins, drug discovery, and mechanisms

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

IF2.5

2024-12-01

PREAI

Witkin, Jeffrey M.; Barrett, James E.

Traumatic brain injury: molecular biomarkers, genetics, secondary consequences, and medical management

FRONTIERS IN NEUROSCIENCE

IF3.2

2024-10-04

OAAI

Lipsky, Robert H.; Witkin, Jeffrey M.; Shafique, Hana; Smith, Jodi L.; Cerne, Rok; Marini, Ann M.

AMPA receptors play an important role in the biological consequences of spinal cord injury: Implications for AMPA receptor modulators for therapeutic benefit AMPA受体在脊髓损伤的生物学后果中起重要作用: AMPA受体调节剂对治疗益处的影响

BIOCHEMICAL PHARMACOLOGY

IF5.6

2024-10-01

PREAI

Witkin, Jeffrey M.; Radin, Daniel P.; Rana, Sabhya; Fuller, David D.; Fusco, Anna F.; Demers, Julie C.; Thakre, Prajwal Pradeep; Smith, Jodi L.; Lippa, Arnold; Cerne, Rok

Preclinical characterization of a water-soluble low-impact ampakine prodrug, CX1942 and its active moiety, CX1763

FUTURE MEDICINAL CHEMISTRY

IF3.4

2024-09-20

PREAI

Radin, Daniel P.; Zhong, Sheng; Cerne, Rok; Shoaib, Mohammed; Witkin, Jeffrey M.; Lippa, Arnold

Is there a biochemical basis for purinergic P2X3 and P2X4 receptor antagonists to be considered as anti-seizure medications?

BIOCHEMICAL PHARMACOLOGY

IF5.6

2024-04-01

PREAI

Witkin, Jeffrey M.; Shafique, Hana; Smith, Jodi L.; Cerne, Rok

Mechanistic and therapeutic relationships of traumatic brain injury and γ-amino-butyric acid (GABA)创伤性脑损伤与 γ-氨基丁酸 (GABA) 的机理和治疗关系

PHARMACOLOGY & THERAPEUTICS

IF12.5

2024-04-01

PREAI

Witkin, Jeffrey M.; Shafique, Hana; Cerne, Rok; Smith, Jodi L.; Marini, Ann M.; Lipsky, Robert H.; Delery, Elizabeth

Low-Impact Ampakine CX1739 Exerts Pro-Cognitive Effects and Reverses Opiate-Induced Respiratory Depression in Rodents

FUTURE PHARMACOLOGY

IF2.7

2024-02-26

OAAI

Radin, Daniel Pierce; Zhong, Sheng; Cerne, Rok; Shoaib, Mohammed; Witkin, Jeffrey M.; Lippa, Arnold

New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy

ACS CHEMICAL NEUROSCIENCE

IF3.9

2024-01-04

PREAI

Sharmin, Dishary; Divovic, Branka; Ping, Xingjie; Cerne, Rok; Smith, Jodi L.; Rezvanian, Sepideh; Mondal, Prithu; Meyer, Michelle Jean; Kiley, Molly E.; Arnold, Leggy A.; Mian, Md Yeunus; Pandey, Kamal P.; Jin, Xiaoming; Mitrovic, Jelena R.; Djorovic, Djordje; Lippa, Arnold; Cook, James M.; Golani, Lalit K.; Scholze, Petra; Savic, Miroslav M.; Witkin, Jeffrey M.

KRM-II-81 suppresses epileptifom activity across the neural network of cortical tissue from a patient with pharmacoresistant epilepsy

HELIYON

IF3.6

2024-01-01

OAAI

Smith, Jodi L.; Wertz, Jeremy; Lippa, Arnold; Ping, Xingjie; Jin, Xiaoming; Cook, James M.; Witkin, Jeffrey M.; Cerne, Rok

Potentiation of AMPA receptors for rapid therapeutic gain in psychiatry has reached a new level of excitement

NEUROPSYCHOPHARMACOLOGY

IF7.1

2023-07-13

PREAI

Witkin, Jeffrey M.; Lippa, Arnold

Synthesis and Receptor Binding Studies of α5 GABAAR Selective Novel Imidazodiazepines Targeted for Psychiatric and Cognitive Disorders

MOLECULES

IF4.6

2023-06-14

OAAI

Sharmin, Dishary; Mian, Md Yeunus; Marcotte, Michael; Prevot, Thomas D.; Sibille, Etienne; Witkin, Jeffrey M.; Cook, James M.

Clinical pharmacological innovation in the treatment of depression 抑郁症治疗的临床药理学创新

EXPERT REVIEW OF CLINICAL PHARMACOLOGY

IF3

2023-04-06

PREAI

Witkin, Jeffrey M.; Golani, Lalit K.; Smith, Jodi L.

Structural Analogs of the GABAkine KRM-II-81 Are Orally Bioavailable Anticonvulsants without Sedation

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2023-04-01

OAAI

Pandey, Kamal P.; Divovic, Branka; Rashid, Farjana; Golani, Lalit K.; Cerne, Rok; Zahn, Nicolas M.; Meyer, Michelle Jean; Arnold, Leggy A.; Sharmin, Dishary; Mian, Md Yeunus; Smith, Jodi L.; Ping, Xingjie; Jin, Xiaoming; Lippa, Arnold; Tiruveedhula, V. V. N. Phani Babu; Cook, James M.; Savic, Miroslav M.; Witkin, Jeffrey M.

Comparative anticonvulsant activity of the GABAkine KRM-II-81 and a deuterated analog GABAkine KRM-II-81和氘代类似物的抗惊厥活性比较

DRUG DEVELOPMENT RESEARCH

IF4.2

2023-02-07

OAAI

Ping, Xingjie; Meyer, Michelle J.; Zahn, Nicolas M.; Golani, Lalit K.; Sharmin, Dishary; Pandey, Kamal P.; Revanian, Sepideh; Mondal, Prithu; Jin, Xiaoming; Arnold, Leggy A.; Cerne, Rok; Cook, James M.; Divovic, Branka; Savic, Miroslav M.; Lippa, Arnold; Smith, Jodi L.; Witkin, Jeffrey M.

Clinical investigations of compounds targeting metabotropic glutamate receptors

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

IF2.5

2022-09-01

PREAI

Witkin, Jeffrey M.; Pandey, Kamal P.; Smith, Jodi L.

Where do we go next in antidepressant drug discovery? A new generation of antidepressants: a pivotal role of AMPA receptor potentiation and mGlu2/3 receptor antagonism

EXPERT OPINION ON DRUG DISCOVERY

IF4.9

2022-08-22

PREAI

Pilc, Andrzej; Machaczka, Agata; Kawalec, Pawel; Smith, Jodi L.; Witkin, Jeffrey M.

Hydrochloride Salt of the GABAkine KRM-II-81

ACS OMEGA

IF4.3

2022-07-27

OAAI

Mian, Md Yeunus; Divovic, Branka; Sharmin, Dishary; Pandey, Kamal P.; Golani, Lalit K. .; Tiruveedhula, V. V. N. Phani Babu; Cerne, Rok; Smith, Jodi L.; Ping, Xingjie; Jin, Xiaoming; Imler, Gregory H.; Deschamps, Jeffrey R.; Lippa, Arnold; Cook, James M.; Savic, Miroslav M.; Rowlett, James; Witkin, Jeffrey M.

研究方向