Xue‐hai Liang - Publications, H-index & Citations

Xue‐hai Liang

arnatar therapeutics, inc.

47H指数

103论文数

7.5K被引数

收录论文 75

发表时间

Antisense oligonucleotide-mediated upregulation of Jag1 ameliorates liver disease phenotypes in a mouse model of Alagille syndrome 反义寡核苷酸介导的Jag1上调改善了Alagille综合征小鼠模型中的肝脏疾病表型

Molecular Therapy Nucleic Acids

IF6.1

2025-08-23

OAAI

Lingdi Zhang; Nima Niknejad; Jian Li; Lansha Peng; Surendra Jain; Derek Steiner; Rich Thai; Xing Xian Yu; Yanfeng Wang; Xue-hai Liang

The helicase Has1p is required for snoRNA release from pre-rRNA

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Liang, Xue-hai; Fournier, Maurille J.

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'-O-Methyl in Selected Positions in the Antisense Oligonucleotide Enhances the Performance of RNaseH1 Active PS-ASOs

NUCLEIC ACID THERAPEUTICS

IF4.7

2022-10-01

OAAI

Zhang, Lingdi; Liang, Xue-hai; De Hoyos, Cheryl Li; Migawa, Michael; Nichols, Joshua G.; Freestone, Graeme; Tian, Jun; Seth, Punit P.; Crooke, Stanley T.

NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides

NUCLEIC ACID THERAPEUTICS

IF4.7

2022-08-01

OAAI

Zhang, Lingdi; Bernardo, Karla D.; Vickers, Timothy A.; Tian, Jun; Liang, Xue-hai; Crooke, Stanley T.

Insights into innate immune activation via PS-ASO-protein-TLR9 interactions

NUCLEIC ACIDS RESEARCH

IF13.1

2022-07-15

OAAI

Pollak, Adam J.; Zhao, Luyi; Vickers, Timothy A.; Huggins, Ian J.; Liang, Xue-Hai; Crooke, Stanley T.

RNA modifications can affect RNase H1-mediated PS-ASO activity

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2022-06-01

OAAI

Lacy, Katelyn A. Doxtader; Liang, Xue-hai; Zhang, Lingdi; Crooke, Stanley T.

Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1

NUCLEIC ACIDS RESEARCH

IF13.1

2021-12-14

OAAI

Knott, Gavin J.; Chong, Yee Seng; Passon, Daniel M.; Liang, Xue-Hai; Deplazes, Evelyne; Conte, Maria R.; Marshall, Andrew C.; Lee, Mihwa; Fox, Archa H.; Bond, Charles S.

Perinuclear positioning of endosomes can affect PS-ASO activities

NUCLEIC ACIDS RESEARCH

IF13.1

2021-12-08

OAAI

Liang, Xue-hai; Nichols, Joshua G.; Tejera, Dario; Crooke, Stanley T.

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

NUCLEIC ACIDS RESEARCH

IF13.1

2021-08-20

OAAI

Anderson, Brooke A.; Freestone, Graeme C.; Low, Audrey; De-Hoyos, Cheryl L.; Drury, William J., III; Ostergaard, Michael E.; Migawa, Michael T.; Fazio, Michael; Wan, W. Brad; Berdeja, Andres; Scandalis, Eli; Burel, Sebastien A.; Vickers, Timothy A.; Crooke, Stanley T.; Swayze, Eric E.; Liang, Xuehai; Seth, Punit P.

Hsc70 Facilitates Mannose-6-Phosphate Receptor-Mediated Intracellular Trafficking and Enhances Endosomal Release of Phosphorothioate-Modified Antisense Oligonucleotides

NUCLEIC ACID THERAPEUTICS

IF4.7

2021-08-01

PREAI

Liang, Xue-Hai; Nichols, Joshua G.; Hsu, Chih-Wei; Crooke, Stanley T.

Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs

NUCLEIC ACIDS RESEARCH

IF13.1

2021-07-09

OAAI

Liang, Xue-Hai; Nichols, Joshua G.; Hoyos, Cheryl Li De; Sun, Hong; Zhang, Lingdi; Crooke, Stanley T.

Antisense drug discovery and development technology considered in a pharmacological context

BIOCHEMICAL PHARMACOLOGY

IF5.6

2021-07-01

PREAI

Crooke, Stanley T.; Liang, Xue-hai; Crooke, Rosanne M.; Baker, Brenda F.; Geary, Richard S.

Site-specific Incorporation of 2′,5′-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2021-04-05

OAAI

Prakash, Thazha P.; Yu, Jinghua; Shen, Wen; De Hoyos, Cheryl Li; Berdeja, Andres; Gaus, Hans; Liang, Xue-hai; Crooke, Stanley T.; Seth, Punit P.

Solid-Phase Separation of Toxic Phosphorothioate Antisense Oligonucleotide-Protein Nucleolar Aggregates Is Cytoprotective

NUCLEIC ACID THERAPEUTICS

IF4.7

2021-04-01

PREAI

Liang, Xue-hai; De Hoyos, Cheryl Li; Shen, Wen; Zhang, Lingdi; Fazio, Michael; Crooke, Stanley T.

Antisense technology: an overview and prospectus

NATURE REVIEWS DRUG DISCOVERY

IF101.8

2021-03-24

426

PREAI

Crooke, Stanley T.; Baker, Brenda F.; Crooke, Rosanne M.; Liang, Xue-hai

Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins

NUCLEIC ACIDS RESEARCH

IF13.1

2021-02-12

OAAI

Zhang, Lingdi; Vickers, Timothy A.; Sun, Hong; Liang, Xue-hai; Crooke, Stanley T.

Site-specific incorporation of 5′-methyl DNA enhances the therapeutic profile of gapmer ASOs

NUCLEIC ACIDS RESEARCH

IF13.1

2021-02-05

OAAI

Vasquez, Guillermo; Freestone, Graeme C.; Wan, W. Brad; Low, Audrey; Li De Hoyos, Cheryl; Yu, Jinghua; Prakash, Thazha P.; Ostergaard, Michael E.; Liang, Xue-hai; Crooke, Stanley T.; Swayze, Eric E.; Migawa, Michael T.; Seth, Punit P.

Antisense technology: A review

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2021-01-01

165

OAAI

Crooke, Stanley T.; Liang, Xue-Hai; Baker, Brenda F.; Crooke, Rosanne M.

Gapmer Antisense Oligonucleotides Targeting 5S Ribosomal RNA Can Reduce Mature 5S Ribosomal RNA by Two Mechanisms

NUCLEIC ACID THERAPEUTICS

IF4.7

2020-10-01

PREAI