未登录 分享 收藏
分享 收藏
Single cell RNA sequencing of human and murine cancers demonstrates metastases-specific neutrophil phenotypes driven by the IL-1β/CXCR2 signaling axis - Disruption of this pathway abrogates neutrophil immunosuppressive effects and reduces tumor burden McLaren, Alistair S.; Fetit, Rana; White, Mark; Mills, Megan L.; Lannagan, Tamsin; Falconer, John; Cortes-Lavaud, Xabier; Gilroy, Kathryn; Ridgway, Rachel; Nixon, Colin; Naiker, Varushka; Njunge, Renee; Clarke, Cassie J.; Whyte, Declan; Kirschner, Kristina; Jackstadt, Rene; Norman, Jim C.; Carlin, Leo M.; Campbell, Andrew D.; Sansom, Owen J.; Steele, Colin W. 分享 收藏
Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalization via macropinocytosis Derby, Sarah J.; Dutton, Louise; Strathdee, Karen E.; Stevenson, Katrina; Koessinger, Anna; Jackson, Mark; Tian, Yuling; Yu, Wenxi; Mclay, Kathy; Misquitta, Josette; Alsharif, Sama; Clarke, Cassie J.; Gilmour, Lesley; Thomason, Peter; McGhee, Ewan; McGarrity-Cottrell, Connor L.; Vanderlinden, Aurelie; Collis, Spencer J.; Rominyi, Ola; Lemgruber, Leandro; Solecki, Gergely; Olson, Michael; Winkler, Frank; Carlin, Leo M.; Heiland, Dieter Henrik; Inman, Gareth J.; Chalmers, Anthony J.; Norman, Jim C.; Carruthers, Ross; Birch, Joanna L. 分享 收藏
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer Nikolatou, Konstantina; Sandilands, Emma; Roman-Fernandez, Alvaro; Cumming, Erin M.; Freckmann, Eva; Lilla, Sergio; Buetow, Lori; McGarry, Lynn; Neilson, Matthew; Shaw, Robin; Strachan, David; Miller, Crispin; Huang, Danny T.; McNeish, Iain A.; Norman, James C.; Zanivan, Sara; Bryant, David M. 分享 收藏
Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families Wilson, Beverley; Flett, Chloe; Gemperle, Jakub; Lawless, Craig; Hartshorn, Matthew; Hinde, Eleanor; Harrison, Tess; Chastney, Megan; Taylor, Sarah; Allen, Jennifer; Norman, Jim C.; Zacharchenko, Thomas; Caswell, Patrick T. 分享 收藏
Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness Koessinger, Dominik; Novo, David; Koessinger, Anna; Campos, America; Peters, Jasmine; Dutton, Louise; Paschke, Peggy; Zerbst, Desiree; Moore, Madeleine; Mitchell, Louise; Neilson, Matthew; Stevenson, Katrina; Chalmers, Anthony; Tait, Stephen; Birch, Joanna; Norman, Jim 分享 收藏
分享 收藏
分享 收藏
分享 收藏
Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function Roman-Fernandez, Alvaro; Mansour, Mohammed A.; Kugeratski, Fernanda G.; Anand, Jayanthi; Sandilands, Emma; Galbraith, Laura; Rakovic, Kai; Freckmann, Eva C.; Cumming, Erin M.; Park, Ji; Nikolatou, Konstantina; Lilla, Sergio; Shaw, Robin; Strachan, David; Mason, Susan; Patel, Rachana; McGarry, Lynn; Katoch, Archana; Campbell, Kirsteen J.; Nixon, Colin; Miller, Crispin J.; Leung, Hing Y.; Le Quesne, John; Norman, James C.; Zanivan, Sara; Blyth, Karen; Bryant, David M. 分享 收藏
Rab11FIP1-deficient mice develop spontaneous inflammation and show increased susceptibility to colon damage Rab11FIP1-deficient小鼠发生自发性炎症并显示对结肠损伤的易感性增加 Rathan-Kumar, Sudiksha; Roland, Joseph T.; Momoh, Michael; Goldstein, Anna; Lapierre, Lynne A.; Manning, Elizabeth; Mitchell, Louise; Norman, Jim; Kaji, Izumi; Goldenring, James R. 分享 收藏
Increased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics Koessinger, Anna L.; Cloix, Catherine; Koessinger, Dominik; Heiland, Dieter Henrik; Bock, Florian J.; Strathdee, Karen; Kinch, Kevin; Martinez-Escardo, Laura; Paul, Nikki R.; Nixon, Colin; Malviya, Gaurav; Jackson, Mark R.; Campbell, Kirsteen J.; Stevenson, Katrina; Davis, Sandeep; Elmasry, Yassmin; Ahmed, Asma; O'Prey, Jim; Ichim, Gabriel; Schnell, Oliver; Stewart, William; Blyth, Karen; Ryan, Kevin M.; Chalmers, Anthony J.; Norman, Jim C.; Tait, Stephen W. G. 分享 收藏
Identification of the first structurally validated covalent ligands of the small GTPase RAB27A Jamshidiha, Mostafa; Lanyon-Hogg, Thomas; Sutherell, Charlotte L.; Craven, Gregory B.; Tersa, Montse; De Vita, Elena; Brustur, Delia; Perez-Dorado, Inmaculada; Hassan, Sarah; Petracca, Rita; Morgan, Rhodri M.; Sanz-Hernandez, Maximo; Norman, Jim C.; Armstrong, Alan; Mann, David J.; Cota, Ernesto; Tate, Edward W. 分享 收藏
Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion 核内体的核捕获耗尽核G-肌动蛋白以促进SRF/MRTF活化和癌细胞侵袭 Marco, Sergi; Neilson, Matthew; Moore, Madeleine; Perez-Garcia, Arantxa; Hall, Holly; Mitchell, Louise; Lilla, Sergio; Blanco, Giovani R.; Hedley, Ann; Zanivan, Sara; Norman, Jim C. 分享 收藏
PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness Rabas, Nicolas; Palmer, Sarah; Mitchell, Louise; Ismail, Shehab; Gohlke, Andrea; Riley, Joel S.; Tait, Stephen W. G.; Gammage, Payam; Soares, Leandro Lemgruber; Macpherson, Iain R.; Norman, Jim C. 分享 收藏
RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis Naszai, Mate; Bellec, Karen; Yu, Yachuan; Roman-Fernandez, Alvaro; Sandilands, Emma; Johansson, Joel; Campbell, Andrew D.; Norman, Jim C.; Sansom, Owen J.; Bryant, David M.; Cordero, Julia B. 分享 收藏
分享 收藏
Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane 突变型p53促进RCP依赖性化学抗性，与P-糖蛋白向质膜的递送增加相吻合 Phatak, Vinaya; von Grabowiecki, Yannick; Janus, Justyna; Officer, Leah; Behan, Caron; Aschauer, Lydia; Pinon, Lucia; Mackay, Hannah; Zanivan, Sara; Norman, Jim C.; Kelly, Michael; Le Quesne, John; Muller, Patricia A. J. 分享 收藏
分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
