David K. Leahy - Publications, H-index & Citations

David K. Leahy

Biohaven Pharmaceuticals

20H指数

54论文数

1.8K被引数

收录论文 32

发表时间

Transmetallation by Halogen-Cyanide Metathesis in Water: Application to Cyanide Ion-Free Palladium Catalyzed Cyanation 水相中卤素-氰化物交换引发的金属转移：在无氰化物离子钯催化氰化中的应用

ACS Catalysis

IF13.1

2026-05-13

OAAI

Ashish Dusunge; Ramesh Hiralal Choudhary; Jacek B. Jasinski; Wilfried M. Braje; David K. Leahy; Sachin Handa

Flash Communication: Cobalt-Catalyzed Asymmetric Hydrogenation of a Fluorinated Cyclobutenoic Acid Derivative 闪光通讯：钴催化的氟代环丁烯酸衍生物的不对称氢化

Organometallics

IF2.9

2025-10-28

PREAI

Katherine L. Moffa; Lauren N. Mendelsohn; Connor S. MacNeil; Matthew V. Pecoraro; Ian W. Davies; David K. Leahy; Paul J. Chirik

AshPhos Ligand: Facilitating Challenging Aminations in Five- and Six-Membered Heteroaryl Halides Using Cyclic Secondary and Bulky Amines

JACS AU

IF8.7

2024-12-19

OAAI

Dusunge, Ashish; Leahy, David K.; Handa, Sachin

Asymmetric Hydrogenation of Indazole-Containing Enamides Relevant to the Synthesis of Zavegepant Using Neutral and Cationic Cobalt Precatalysts

ORGANIC LETTERS

IF5

2023-06-04

PREAI

Mendelsohn, Lauren N.; MacNeil, Connor S.; Esposito, Madison R.; Pabst, Tyler P.; Leahy, David K.; Davies, Ian W.; Chirik, Paul J.

Editorial overview-Nanocatalysis

CURRENT OPINION IN GREEN AND SUSTAINABLE CHEMISTRY

IF9.4

2023-06-01

PREAI

Leahy, David K.; Handa, Sachin

Trichloromethyl Carbanion in Aqueous Micelles: Mechanistic Insights and Access to Carboxylic Acids from (Hetero)aryl Halides

ACS CATALYSIS

IF13.1

2022-12-06

PREAI

Ansari, Tharique N.; Sharma, Sudripet; Hazra, Susanta; Hicks, Frederick; Leahy, David K.; Handa, Sachin

Bisulfite Addition Compounds as Substrates for Reductive Aminations in Water

ORGANIC LETTERS

IF5

2021-09-02

OAAI

Li, Xiaohan; Iyer, Karthik S.; Thakore, Ruchita R.; Leahy, David K.; Bailey, J. Daniel; Lipshutz, Bruce H.

Improved iGAL 2.0 Metric Empowers Pharmaceutical Scientists to Make Meaningful Contributions to United Nations Sustainable Development Goal 12

ACS SUSTAINABLE CHEMISTRY & ENGINEERING

IF7.3

2021-08-12

OAAI

Roschangar, Frank; Li, Jun; Zhou, Yanyan; Aelterman, Wim; Borovika, Alina; Colberg, Juan; Dickson, David P.; Gallou, Fabrice; Hayler, John D.; Koenig, Stefan G.; Kopach, Michael E.; Kosjek, Birgit; Leahy, David K.; O'Brien, Erin; Smith, Austin G.; Henry, Manuel; Cook, Jutta; Sheldon, Roger A.

Shielding Effect of Nanomicelles: Stable and Catalytically Active Oxidizable Pd(0) Nanoparticle Catalyst Compatible for Cross-Couplings of Water-Sensitive Acid Chlorides in Water

JACS AU

IF8.7

2021-07-20

OAAI

Ansari, Tharique N.; Sharma, Sudripet; Hazra, Susanta; Jasinski, Jacek B.; Wilson, Andrew J.; Hicks, Frederick; Leahy, David K.; Handa, Sachin

Metal-Micelle Cooperativity: Phosphine Ligand-Free Ultrasmall Palladium(II) Nanoparticles for Oxidative Mizoroki-Heck-type Couplings in Water at Room Temperature

JACS AU

IF8.7

2021-01-14

OAAI

Ansari, Tharique N.; Jasinski, Jacek B.; Leahy, David K.; Handa, Sachin

Beyond organic solvents: synthesis of a 5-HT4 receptor agonist in water

GREEN CHEMISTRY

IF9.2

2021-01-01

PREAI

Bailey, J. Daniel; Helbling, Edward; Mankar, Amey; Stirling, Matthew; Hicks, Fred; Leahy, David K.

Development of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-07-02

PREAI

Vetrichelvan, Muthalagu; Rakshit, Souvik; Chandrasekaran, Sathishkumar; Chinnakalai, Karthikeyan; Darne, Chetan Padmakar; Doddalingappa, Dyamanna; Gopikumar, Indasi; Gupta, Anuradha; Gupta, Arun Kumar; Karmakar, Ananta; Lakshminarasimhan, Thirumalai; Leahy, David K.; Palani, Senthil; Radhakrishnan, Vignesh; Rampulla, Richard; Savarimuthu, Antony; Subramanian, Varadharajan; Velaparthi, Upender; Warrier, Jayakumar; Eastgate, Martin D.; Borzilleri, Robert M.; Mathur, Arvind; Vaidyanathan, Rajappa

Scalable α-Arylation of Nitriles in Aqueous Micelles using Ultrasmall Pd Nanoparticles: Surprising Formation of Carbanions in Water

ACS CATALYSIS

IF13.1

2020-04-22

PREAI

Bihani, Manisha; Ansari, Tharique N.; Finck, Lucie; Bora, Pranjal P.; Jasinski, Jacek B.; Pavuluri, Bhavana; Leahy, David K.; Handa, Sachin

Catalytic Sulfamoylation of Alcohols with Activated Aryl Sulfamates

ORGANIC LETTERS

IF5

2019-12-13

PREAI

Rapp, Peter B.; Murai, Koichi; Ichiishi, Naoko; Leahy, David K.; Miller, Scott J.

The PMI Predictor app to enable green-by-design chemical synthesis

NATURE SUSTAINABILITY

IF27.1

2019-10-28

PREAI

Borovika, Alina; Albrecht, Jacob; Li, Jun; Wells, Andrew S.; Briddell, Christiana; Dillon, Barry R.; Diorazio, Louis J.; Gage, James R.; Gallou, Fabrice; Koenig, Stefan G.; Kopach, Michael E.; Leahy, David K.; Martinez, Isamir; Olbrich, Martin; Piper, Jared L.; Roschangar, Frank; Sherer, Edward C.; Eastgate, Martin D.

Evaluating the Impact of a Decade of Funding from the Green Chemistry Institute Pharmaceutical Roundtable

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2018-09-20

PREAI

Koenig, Stefan G.; Leahy, David K.; Wells, Andrew S.

Leveraging a Catch-Release Logic Gate Process for the Synthesis and Nonchromatographic Purification of Thioether- or Amine-Bridged Macrocyclic Peptides

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2018-03-14

PREAI

Kheirabadi, Mahboubeh; Creech, Gardner S.; Qiao, Jennifer X.; Nirschl, David S.; Leahy, David K.; Boy, Kenneth M.; Carter, Percy H.; Eastgate, Martin D.

Inspiring process innovation via an improved green manufacturing metric: iGAL

GREEN CHEMISTRY

IF9.2

2018-01-01

PREAI

Roschangar, Frank; Zhou, Yanyan; Constable, David J. C.; Colberg, Juan; Dickson, David P.; Dunn, Peter J.; Eastgate, Martin D.; Gallou, Fabrice; Hayler, John D.; Koenig, Stefan G.; Kopach, Michael E.; Leahy, David K.; Mergelsberg, Ingrid; Scholz, Ulrich; Smith, Austin G.; Henry, Manuel; Mulder, Jason; Brandenburg, Joerg; Dehli, Juan R.; Fandrick, Daniel R.; Fandrick, Keith R.; Gnad-Badouin, Frieder; Zerban, Georg; Groll, Klaus; Anastas, Paul T.; Sheldon, Roger A.; Senanayake, Chris H.

Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3′-hydroxyazetidin-1-yl)ethanone [BMS-8163361, an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2017-06-05

PREAI

Ye, Xiang-Yang; Chen, Stephanie Y.; Wu, Shung; Yoon, David S.; Wang, Haixia; Hong, Zhenqiu; O'Connor, Stephen P.; Li, Jun; Li, James J.; Kennedy, Lawrence J.; Walker, Steven J.; Nayeem, Akbar; Sheriff, Steven; Camac, Daniel M.; Ramamurthy, Vidyhashankar; Morin, Paul E.; Zebo, Rachel; Taylor, Joseph R.; Morgan, Nathan N.; Ponticiello, Randolph P.; Harrity, Thomas; Apedo, Atsu; Golla, Rajasree; Seethala, Ramakrishna; Wang, Mengmeng; Harper, Timothy W.; Sleczka, Bogdan G.; He, Bin; Kirby, Mark; Leahy, David K.; Li, Jianqing; Hanson, Ronald L.; Guo, Zhiwei; Li, Yi-Xin; DiMarco, John D.; Scaringe, Raymond; Maxwell, Brad; Moulin, Frederick; Barrish, Joel C.; Gordon, David A.; Robl, Jeffrey A.

Design and evolution of the BMS process greenness scorecard

GREEN CHEMISTRY

IF9.2

2017-01-01

PREAI

Leahy, David K.; Simmons, Eric M.; Hung, Victor; Sweeney, Jason T.; Fleming, William F.; Miller, Melanie

研究方向