未登录 Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation 重新评估ICH S7A核心组中的安全性药理学呼吸研究：一项多公司评估，评估其非临床效用和临床转化 Kremer, John J.; Abernathy, Matt M.; Ackley, David; Clark, Matthew; Dasilva, Jamie K.; Foley, Michael C.; Greiter-Wilke, A.; Henderson-Park, Kim H.; Morimoto, Bruce H.; Paglialunga, Sabina; Pugsley, Michael K.; Regan, Chris P.; Rossman, Eric I.; Segretti, Jason A.; Traebert, Martin; Vargas, Hugo M.; Wisialowski, Todd A.; Friedrichs, Greg S. 分享 收藏
QT risk assessment for the development of oligonucleotide therapeutics - An industry survey sponsored by the Safety Pharmacology Society (SPS) ion channel working group and oligonucleotide safety working group 寡核苷酸治疗药物开发的QT风险评估——由安全药理学学会（SPS）离子通道工作组与寡核苷酸安全性工作组赞助的行业调查 Chaudhary, Khuram; Lagrutta, Armando; Melliti, Karim; Traebert, Martin; Brimecombe, Jessica; Pugsley, Michael; Qu, Yusheng; Hebeisen, Simon; Martin, Ruth; Stoelzle-Feix, Sonja; Foy, Jeff; Harper, Tod; Leishman, Derek; Valentin, Jean-Pierre; Vargas, Hugo 分享 收藏
Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation 重新评估ICH S7A核心电池内的安全药理学呼吸研究: 临床前效用和临床翻译的多公司评估 Friedrichs, G. S.; Abernathy, M. M.; Ackley, D.; Clark, M.; DaSilva, J. K.; Foley, C. M.; Greiter-Wilke, A.; Henderson, K. A.; Kremer, J. J.; Morimoto, B. H.; Paglialunga, S.; Pugsley, M. K.; Regan, C. P.; Rossman, E. I.; Segretti, J. A.; Traebert, M.; Vargas, H. M.; Wisialowski, T. A. 分享 收藏
GABAA receptor-mediated seizure liabilities: a mixed-methods screening approach Bampali, Konstantina; Koniuszewski, Filip; Vogel, Florian D.; Fabjan, Jure; Andronis, Christos; Lekka, Eftychia; Virvillis, Vassilis; Seidel, Thomas; Delaunois, Annie; Royer, Leandro; Rolf, Michael G.; Giuliano, Chiara; Traebert, Martin; Roussignol, Gautier; Fric-Bordat, Magali; Mazelin-Winum, Ludmilla; Bryant, Sharon D.; Langer, Thierry; Ernst, Margot 分享 收藏
Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors 一类二氢苯并呋喃类似物对口服有效的yap-tead蛋白-蛋白相互作用抑制剂的优化 Sellner, Holger; Chapeau, Emilie; Furet, Pascal; Voegtle, Markus; Salem, Bahaa; Le Douget, Mickael; Bordas, Vincent; Groell, Jean-Marc; Le Goff, Anne-Laure; Rouzet, Christine; Wietlisbach, Thomas; Zimmermann, Thomas; McKenna, Joseph; Brocklehurst, Cara E. E.; Chene, Patrick; Wartmann, Markus; Scheufler, Clemens; Kallen, Joerg; Williams, Gareth; Harlfinger, Stephanie; Traebert, Martin; Dumotier, Berengere M.; Schmelzle, Tobias; Soldermann, Nicolas 分享 收藏
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Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations Gintant, Gary; Kaushik, Emily Pfeiffer; Feaster, Tromondae; Stoelzle-Feix, Sonja; Kanda, Yasunari; Osada, Tomoharu; Smith, Godfrey; Czysz, Katherine; Kettenhofen, Ralf; Lu, Hua Rong; Cai, Beibei; Shi, Hong; Herron, Todd Joseph; Dang, Qianyu; Burton, Francis; Pang, Li; Traebert, Martin; Abassi, Yama; Pierson, Jennifer Beck; Blinova, Ksenia 分享 收藏
Time for a Fully Integrated Nonclinical-Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective Vargas, Hugo M.; Rolf, Michael G.; Wisialowski, Todd A.; Achanzar, William; Bahinski, Anthony; Bass, Alan; Benson, Charles T.; Chaudhary, Khuram W.; Couvreur, Nicolas; Dota, Corina; Engwall, Michael J.; Michael Foley, C.; Gallacher, David; Greiter-Wilke, Andrea; Guillon, Jean-Michel; Guth, Brian; Himmel, Herbert M.; Hegele-Hartung, Christa; Ito, Maki; Jenkinson, Stephen; Chiba, Katsuyoshi; Lagrutta, Armando; Levesque, Paul; Martel, Eric; Okai, Yoshiko; Peri, Ravikumar; Pointon, Amy; Qu, Yusheng; Teisman, Ard; Traebert, Martin; Yoshinaga, Takashi; Gintant, Gary A.; Leishman, Derek J.; Valentin, Jean-Pierre 分享 收藏
Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria 解决革兰氏阴性细菌中氟喹诺酮类耐药性的拓扑异构酶抑制剂 Skepper, Colin K.; Armstrong, Duncan; Balibar, Carl J.; Bauer, Daniel; Bellamacina, Cornelia; Benton, Bret M.; Bussiere, Dirksen; De Pascale, Gianfranco; De Vicente, Javier; Dean, Charles R.; Dhumale, Bhavesh; Fisher, L. Mark; Fuller, John; Fulsunder, Mangesh; Holder, Lauren M.; Hu, Cheng; Kantariya, Bhavin; Lapointe, Guillaume; Leeds, Jennifer A.; Li, Xiaolin; Lu, Peichao; Lvov, Anatoli; Ma, Sylvia; Madhavan, Shravanthi; Malekar, Swapnil; McKenney, David; Mergo, Wosenu; Metzger, Louis; Moser, Heinz E.; Mutnick, Daniel; Noeske, Jonas; Osborne, Colin; Patel, Ashish; Patel, Darshit; Patel, Tushar; Prajapati, Krunal; Prosen, Katherine R.; Reck, Folkert; Richie, Daryl L.; Rico, Alice; Sanderson, Mark R.; Satasia, Shailesh; Sawyer, William S.; Selvarajah, Jogitha; Shah, Nirav; Shanghavi, Kartik; Shu, Wei; Thompson, Katherine, V; Traebert, Martin; Vala, Anand; Vala, Lakhan; Veselkov, Dennis A.; Vo, Jason; Wang, Michael; Widya, Marcella; Williams, Sarah L.; Xu, Yongjin; Yue, Qin; Zang, Richard; Zhou, Bo; Rivkin, Alexey 分享 收藏
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Neurofunctional test batteries in safety pharmacology - Current and emerging considerations for the drug development process 安全药理学中的神经功能测试电池-药物开发过程的当前和新兴考虑因素 Jackson, Samuel J.; Authier, Simon; Brohmann, Henning; Goody, Susan M. G.; Jones, David; Prior, Helen; Rosch, Anke; Traebert, Martin; Tse, Karen; Valentin, Jean Pierre; Milne, Aileen 分享 收藏
Variability of non-clinical behavioral CNS safety assessment: An intercompany comparison 非临床行为中枢神经系统安全性评估的变异性: 公司间比较 Himmel, H. M.; Delaunois, A.; Deurinck, M.; Dinklo, T.; Faelker, Eriksson T. M.; Habermann, C.; Heers, C.; Hempel, K.; Lorenz, H.; Rosch, A.; Schauerte, H.; Teuns, G.; Traebert, M.; van Amsterdam, C.; van der Linde, H. 分享 收藏
Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae Mannhardt, Ingra; Eder, Alexandra; Dumotier, Berengere; Prondzynski, Maksymilian; Kraemer, Elisabeth; Traebert, Martin; Soehren, Klaus-Dieter; Flenner, Frederik; Stathopoulou, Konstantina; Lemoine, Marc D.; Carrier, Lucie; Christ, Torsten; Eschenhagen, Thomas; Hansen, Arne 分享 收藏
Assessing the predictive value of the rodent neurofunctional assessment for commonly reported adverse events in phase I clinical trials Mead, Andy N.; Amouzadeh, Hamid R.; Chapman, Kathryn; Ewart, Lorna; Giarola, Alessandra; Jackson, Samuel J.; Jarvis, Philip; Jordaan, Pierre; Redfern, Will; Traebert, Martin; Valentin, Jean-Pierre; Vargas, Hugo M. 分享 收藏
Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms Spence, Stan; Deurinck, Mark; Ju, Haisong; Traebert, Martin; McLean, LeeAnne; Marlowe, Jennifer; Emotte, Corinne; Tritto, Elaine; Tseng, Min; Shultz, Michael; Friedrichs, Gregory S. 分享 收藏
The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate Gergely, P.; Nuesslein-Hildesheim, B.; Guerini, D.; Brinkmann, V.; Traebert, M.; Bruns, C.; Pan, S.; Gray, N. S.; Hinterding, K.; Cooke, N. G.; Groenewegen, A.; Vitaliti, A.; Sing, T.; Luttringer, O.; Yang, J.; Gardin, A.; Wang, N.; Crumb, W. J., Jr.; Saltzman, M.; Rosenberg, M.; Wallstroem, E. 分享 收藏
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Optimization of the in Vitro Cardiac Safety of Hydroxamate-Based Histone Deacetylase Inhibitors Shultz, Michael D.; Cao, Xueying; Chen, Christine H.; Cho, Young Shin; Davis, Nicole R.; Eckman, Joe; Fan, Jianmei; Fekete, Alex; Firestone, Brant; Flynn, Julie; Green, Jack; Growney, Joseph D.; Holmqvist, Mats; Hsu, Meier; Jansson, Daniel; Jiang, Lei; Kwon, Paul; Liu, Gang; Lombardo, Franco; Lu, Qiang; Majumdar, Dyuti; Meta, Christopher; Perez, Lawrence; Pu, Minying; Ramsey, Tim; Remiszewski, Stacy; Skolnik, Suzanne; Traebert, Martin; Urban, Laszlo; Uttamsingh, Vinita; Wang, Ping; Whitebread, Steven; Whitehead, Lewis; Yan-Neale, Yan; Yao, Yung-Mae; Zhou, Liping; Atadja, Peter 分享 收藏
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