未登录 Field Study and Correlative Studies of Factor IX Variant FIX-R338L in Participants Treated with Fidanacogene Elaparvovec Pittman, Debra D.; Carrieri, Charles; Soares, Holly; McKay, John; Tan, Charles Y.; Liang, John Z.; Rakhe, Swapnil; Marshall, Jean-Claude; Murphy, John E.; Gaitonde, Puneet; Rupon, Jeremy 分享 收藏
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Investigating the clearance of VWF A-domains using site-directed PEGylation and novel N-linked glycosylation Fazavana, Judicael; Brophy, Teresa M.; Chion, Alain; Cooke, Niamh; Terraube, Virginie; Cohen, Justin; Parng, Chuenlei; Pittman, Debra; Cunningham, Orla; Lambert, Matthew; O'Donnell, James S.; O'Sullivan, Jamie M. 分享 收藏
Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas Patel-Hett, Sunita; Martin, Erika J.; Mohammed, Bassem M.; Rakhe, Swapnil; Sun, Pengling; Barrett, John C.; Nolte, Melinda E.; Kuhn, Janice; Pittman, Debra D.; Murphy, John E.; Brophy, Donald F. 分享 收藏
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PF-04447943, a Phosphodiesterase 9A Inhibitor, in Stable Sickle Cell Disease Patients: A Phase Ib Randomized, Placebo-Controlled Study Charnigo, Robert J.; Beidler, David; Rybin, Denis; Pittman, Debra D.; Tan, Beesan; Howard, Jo; Michelson, Alan D.; Frelinger, Andrew L., III; Clarke, Nicholas 分享 收藏
A first-in-human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of PF-06741086, an anti-tissue factor pathway inhibitor mAb, in healthy volunteers Cardinal, M.; Kantaridis, C.; Zhu, T.; Sun, P.; Pittman, D. D.; Murphy, J. E.; Arkin, S. 分享 收藏
Translational Pharmacokinetic/Pharmacodynamic Characterization and Target-Mediated Drug Disposition Modeling of an Anti-Tissue Factor Pathway Inhibitor Antibody, PF-06741086 Parng, Chuenlei; Singh, Pratap; Pittman, Debra D.; Wright, Katherine; Leary, Beth; Patel-Hett, Sunita; Rakhe, Swapnil; Stejskal, James; Peraza, Marjorie; Dufield, Dawn; Murphy, John E.; Webster, Rob 分享 收藏
Preclinical Pharmacokinetics, Pharmacodynamics, Tissue Distribution, and Interspecies Scaling of Recombinant Human Coagulation Factor XaI16L Parng, Chuenlei; Markiewicz, Victoria; Chen, Jianqing; Leary, Beth; Duriga, Nicole; Dyleski, Lisa; Caiazzo, Teresa; Bolt, Michael; Joyce, Alison; Gorovits, Boris; Pittman, Debra D.; Webster, Robert 分享 收藏
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A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia Ivanciu, Lacramioara; Toso, Raffaella; Margaritis, Paris; Pavani, Giulia; Kim, Haein; Schlachterman, Alexander; Liu, Jian-Hua; Clerin, Valerie; Pittman, Debra D.; Rose-Miranda, Rosalind; Shields, Kathleen M.; Erbe, David V.; Tobin, James F.; Arruda, Valder R.; Camire, Rodney M. 分享 收藏
IL-22 Induces an Acute-Phase Response Liang, Spencer C.; Nickerson-Nutter, Cheryl; Pittman, Debra D.; Carrier, Yijun; Goodwin, Debra G.; Shields, Kathleen M.; Lambert, Andre-Jean; Schelling, Scott H.; Medley, Quintus G.; Ma, Hak-Ling; Collins, Mary; Dunussi-Joannopoulos, Kyriaki; Fouser, Lynette A. 分享 收藏
Complement C3a, CpG Oligos, and DNA/C3a Complex Stimulate IFN-α Production in a Receptor for Advanced Glycation End Product-Dependent Manner Ruan, Benfang Helen; Li, Xin; Winkler, Aaron R.; Cunningham, Kristina M.; Kuai, Jun; Greco, Rita M.; Nocka, Karl H.; Fitz, Lori J.; Wright, Jill F.; Pittman, Debra D.; Tan, Xiang-Yang; Paulsen, Janet E.; Lin, Lih Ling; Winkler, David G. 分享 收藏
Advanced molecular profiling in vivo detects novel function of dickkopf-3 in the regulation of bone formation Aslan, Hadi; Ravid-Amir, Osnat; Clancy, Brian M.; Rezvankhah, Saeid; Pittman, Debra; Pelled, Gadi; Turgeman, Gadi; Zilberman, Yoram; Gazit, Zulma; Hoffmann, Andrea; Gross, Gerhard; Domany, Eytan; Gazit, Dan 分享 收藏
IL-22, A Th17 Cytokine, induces a systemic acute phase response Liang, Spencer C.; Pittman, Debra; Carrier, Yijun; Goodwin, Debra G.; Shields, Kathleen; Lambert, Andre-Jean; Schelling, Scott H.; Medley, Quint; Ma, Hak-Ling; Collins, Mary; Nickerson-Nutter, Cheryl; Dunussi-Joannopoulos, Kyriaki; Fouser, Lynette A. 分享 收藏
Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis Clerin, Valerie; Shih, Heather H.; Deng, Nanhua; Hebert, Gustave; Resmini, Christine; Shields, Kathleen M.; Feldman, Jeffrey L.; Winkler, Aaron; Albert, Leo; Maganti, Vasu; Wong, Anthony; Paulsen, Janet E.; Keith, James C., Jr.; Vlasuk, George P.; Pittman, Debra D. 分享 收藏
TREM-1 expression is increased in the Synovium of Rheumatoid Arthritis patients and induces the expression of pro-inflammatory cytokines Kuai, Jun; Gregory, Bernard; Hill, Andrew; Pittman, Debra D.; Feldman, Jeffrey L.; Brown, Tom; Carito, Brenda; OToole, Margot; Ramsey, Renee; Shields, Kathleen M.; Beech, Jonathan T.; Nanchahal, Jagdeep; Feldmann, Marc; Foxwell, Brian M.; Brennan, Fionula M. 分享 收藏
Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection Lutterloh, Emily C.; Opal, Steven M.; Pittman, Debra D.; Keith, James C., Jr.; Tan, Xiang-Yang; Clancy, Brian M.; Palmer, Helen; Milarski, Kim; Sun, Ying; Palardy, John E.; Parejo, Nicholas A.; Kessimian, Noubar 分享 收藏
IL-22, a TH17 and TH1 cytokine, regulates local tissue inflammation in the context of autoimmune disease Hegen, Martin; Ma, Hakling Margery; Liang, Spencer C.; Li, Jing; Pittman, Debra; Zollner, Richard; Olland, Stephane; Collins, Mary; Dunussi-Joannopoulos, Kyriaki; Gill, Davinder; Young, Debbie; Nickerson-Nutter, Cheryl; Fouser, Lynette A. 分享 收藏
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