Philippe P. Roux - Publications, H-index & Citations

Philippe P. Roux

university of montreal

56H指数

242论文数

2.1W被引数

收录论文 38

发表时间

The deubiquitinase USP17 regulates the expression and activity of the oncogenic driver β-catenin in colorectal cancer 去泛素化酶USP17调控结直肠癌中癌基因驱动因子β-catenin的表达和活性

Oncogene

IF7.3

2026-02-19

PREAI

Mariana Acevedo; Florence Dô; Firas El-Mortada; Pierre-Luc Tanguay; Laure Voisin; Thibault Houles; Geneviève Lavoie; David Allard; Philippe P. Roux; John Stagg; Samuel Doré; Logan Walsh; Jimmy Fourtounis; Eric Bonneil; Sylvain Meloche; Marc J. Servant

CDK12 inhibition reveals melanoma dependence on the RUNX1/CBFβ complex for genomic stability CDK12抑制揭示了黑色素瘤对RUNX1/CBFβ复合物维持基因组稳定性的依赖性

Cell Reports

IF6.9

2025-11-01

OAAI

Jonathan Boucher; Thibault Houles; Elsa Berliocchi; Geneviève Lavoie; Graham MacLeod; Marc K. Saba-El-Leil; Stephane Angers; Sylvain Meloche; Philippe P. Roux

mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport mTOR抑制通过诱导替代性脂质摄取和促进胆固醇转运来重编程细胞脂质稳态

Molecular Cell

IF16.6

2025-09-18

PREAI

Sejeong Shin; Min-Joon Han; Ishika Patel; Alia M. Welsh; Maria Sverdlov; Wonhwa Cho; Stephanie M. Cologna; Philippe P. Roux; Sang-Oh Yoon

The expanding landscape of canonical and non-canonical protein phosphorylation

TRENDS IN BIOCHEMICAL SCIENCES

IF11

2024-11-01

PREAI

Houles, Thibault; Yoon, Sang-Oh; Roux, Philippe P.

Identification of RSK substrates using an analog-sensitive kinase approach 使用类似物敏感的激酶方法鉴定RSK底物

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-03-01

OAAI

Lizcano-Perret, Belen; Vertommen, Didier; Herinckx, Gaetan; Calabrese, Viviane; Gatto, Laurent; Roux, Philippe P.; Michiels, Thomas

CBFA2T3::GLIS2 pediatric acute megakaryoblastic leukemia is sensitive to BCL-XL inhibition by navitoclax and DT2216

BLOOD ADVANCES

IF7.1

2023-12-28

OAAI

Gress, Verena; Roussy, Mathieu; Boulianne, Luc; Bilodeau, Melanie; Cardin, Sophie; El-Hachem, Nehme; Lisi, Veronique; Khakipoor, Banafsheh; Rouette, Alexandre; Farah, Azer; Theret, Louis; Aubert, Leo; Fatima, Furat; Audemard, Eric; Thibault, Pierre; Bonneil, Eric; Chagraoui, Jalila; Laramee, Louise; Gendron, Patrick; Jouan, Loubna; Jammali, Safa; Pare, Bastien; Simpson, Shawn M.; Tran, Thai Hoa; Duval, Michel; Teira, Pierre; Bittencourt, Henrique; Santiago, Raoul; Barab, Frederic; Sauvageau, Guy; Smith, Martin A.; Hebert, Josee; Roux, Philippe P.; Gruber, Tanja A.; Lavallee, Vincent -Philippe; Wilhelm, Brian T.; Cellot, Sonia

The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma

CELL DEATH DISCOVERY

IF7

2023-12-16

OAAI

Houles, Thibault; Boucher, Jonathan; Lavoie, Genevieve; MacLeod, Graham; Lin, Sichun; Angers, Stephane; Roux, Philippe P.

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer (vol 14, 3150, 2023)

NATURE COMMUNICATIONS

IF15.7

2023-09-05

OAAI

Dervovic, Dzana; Malik, Ahmad A.; Chen, Edward L. Y.; Narimatsu, Masahiro; Adler, Nina; Afiuni-Zadeh, Somaieh; Krenbek, Dagmar; Martinez, Sebastien; Tsai, Ricky; Boucher, Jonathan; Berman, Jacob M.; Teng, Katie; Ayyaz, Arshad; Lu, Yiqing; Mbamalu, Geraldine; Loganathan, Sampath K.; Lee, Jongbok; Zhang, Li; Guidos, Cynthia; Wrana, Jeffrey; Valipour, Arschang; Roux, Philippe P.; Reimand, Juri; Jackson, Hartland W.; Schramek, Daniel

In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer

NATURE COMMUNICATIONS

IF15.7

2023-05-31

OAAI

Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

189

OAAI

Roux, PP; Richards, SA; Blenis, J

Proteomics Screen Identifies Class I Rab11 Family Interacting Proteins as Key Regulators of Cytokinesis

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-17

OAAI

Laflamme, Carl; Galan, Jacob A.; Ben El Kadhi, Khaled; Meant, Antoine; Zeledon, Carlos; Carreno, Sebastien; Roux, Philippe P.; Emery, Gregory

CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma

NATURE COMMUNICATIONS

IF15.7

2022-10-29

OAAI

Houles, Thibault; Lavoie, Genevieve; Nourreddine, Sami; Cheung, Winnie; Vaillancourt-Jean, Eric; Guerin, Celia M.; Bouttier, Mathieu; Grondin, Benoit; Lin, Sichun; Saba-El-Leil, Marc K.; Angers, Stephane; Meloche, Sylvain; Roux, Philippe P.

Proteomic analysis of the actin cortex in interphase and mitosis

JOURNAL OF CELL SCIENCE

IF3.6

2022-08-26

OAAI

Vadnjal, Neza; Nourreddine, Sami; Lavoie, Genevieve; Serres, Murielle; Roux, Philippe P.; Paluch, Ewa K.

CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells

BLOOD ADVANCES

IF7.1

2022-06-20

OAAI

Ansari, Unain; Tomellini, Elisa; Chagraoui, Jalila; Lehnertz, Bernhard; Mayotte, Nadine; Bordeleau, Marie-Eve; Roux, Philippe P.; Sauvageau, Guy

Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation

JCI INSIGHT

IF6.1

2022-03-22

OAAI

Heckel, Emilie; Cagnone, Gael; Agnihotri, Tapan; Cakir, Bertan; Das, Ashim; Kim, Jin Sung; Kim, Nicholas; Lavoie, Genevieve; Situ, Anu; Pundir, Sheetal; Sun, Ye; Wunnemann, Florian; Pierce, Kerry A.; Dennis, Courtney; Mitchell, Grant A.; Chemtob, Sylvain; Rezende, Flavio A.; Andelfinger, Gregor; Clish, Clary B.; Roux, Philippe P.; Sapieha, Przemyslaw; Smith, Lois Eh; Joyal, Jean-Sebastien

RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit

PLOS GENETICS

IF3.7

2021-06-14

OAAI

Cerezo, Emilie L.; Houles, Thibault; Lie, Oriane; Sarthou, Marie-Kerguelen; Audoynaud, Charlotte; Lavoie, Genevieve; Halladjian, Maral; Cantaloube, Sylvain; Froment, Carine; Burlet-Schiltz, Odile; Henry, Yves; Roux, Philippe P.; Henras, Anthony K.; Romeo, Yves

Sustained ERK1/2 signaling is necessary for follicular rupture during ovulation in mice

REPRODUCTION

IF3.7

2021-02-01

PREAI

Madogwe, Ejimedo; Schuermann, Yasmin; Siddappa, Dayananda; Bordignon, Vilceu; Roux, Philippe P.; Duggavathi, Raj

STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity

JOURNAL OF CELL BIOLOGY

IF6.4

2020-09-22

OAAI

De Jamblinne, Camille Valerie; Decelle, Barbara; Dehghani, Mehrnoush; Joseph, Mathieu; Sriskandarajah, Neera; Leguay, Kevin; Rambaud, Basile; Lemieux, Sebastien; Roux, Philippe P.; Hipfner, David R.; Carreno, Sebastien

An ErbB2 splice variant lacking exon 16 drives lung carcinoma

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2020-07-29

OAAI

Smith, Harvey W.; Yang, Lei; Ling, Chen; Walsh, Arlan; Martinez, Victor D.; Boucher, Jonathan; Zuo, Dongmei; Sokol, Ethan S.; Pavlick, Dean C.; Frampton, Garrett M.; Chmielecki, Juliann; Jones, Laura M.; Roux, Philippe P.; Lockwood, William W.; Muller, William J.

Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer

NATURE COMMUNICATIONS

IF15.7

2020-07-24

146

OAAI

Aubert, Leo; Nandagopal, Neethi; Steinhart, Zachary; Lavoie, Genevieve; Nourreddine, Sami; Berman, Jacob; Saba-El-Leil, Marc K.; Papadopoli, David; Lin, Sichun; Hart, Traver; Macleod, Graham; Topisirovic, Ivan; Gaboury, Louis; Fahrni, Christoph J.; Schramek, Daniel; Meloche, Sylvain; Angers, Stephane; Roux, Philippe P.

研究方向