未登录 2-aminobenzophenones as a novel class of bradykinin B1 receptor antagonists Su, Dai-Shi; Lim, John L.; Tinney, Elizabeth; Wan, Bang-Lin; Murphy, Kathy L.; Reiss, Duane R.; Harrell, C. Meacham; O'Malley, Stacy S.; Ransom, Rick W.; Chang, Raymond S. L.; Pettibone, Douglas J.; Yu, Jian; Tang, Cuyue; Prueksaritanont, Thomayant; Freidinger, Roger M.; Bock, Mark G.; Anthony, Neville J. 分享 收藏
Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists Kuduk, Scott D.; Di Marco, Christina N.; Chang, Ronald K.; Wood, Michael R.; Schirripa, Kathy M.; Kim, June J.; Wai, Jenny M. C.; DiPardo, Robert M.; Murphy, Kathy L.; Ransom, Richard W.; Harrell, C. Meacham; Reiss, Duane R.; Holahan, Marie A.; Cook, Jacquelynn; Hess, J. Fred; Sain, Nova; Urban, Mark O.; Tang, Cuyue; Prueksaritanont, Thomayant; Pettibone, Douglas J.; Bock, Mark G. 分享 收藏
Design, synthesis, and in vivo efficacy of glycine transporter-1 (GlyT1) inhibitors derived from a series of [4-phenyl-1(propylsulfonyl)piperidin-4-yl]lmethyl benzamides Lindsley, Craig W.; Zhao, Zhijian; Leister, William H.; O'Brien, Julie; Lemaire, Wei; Williams, David L., Jr.; Chen, Tsing-Bau; Chang, Raymond S. L.; Burno, Maryann; Jacobson, Marlene A.; Sur, Cyrille; Kinney, Gene G.; Pettibone, Douglas J.; Tiller, Philip R.; Smith, Sheri; Tsou, Nancy N.; Duggan, Mark E.; Conn, P. Jeffrey; Hartman, George D. 分享 收藏
Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine.: Application to the design of novel bradykinin B1 receptor antagonists Wood, MR; Schirripa, KM; Kim, JJ; Wan, BL; Murphy, KL; Ransom, RW; Chang, RSL; Tang, CY; Prueksaritanont, T; Detwiler, TJ; Hettrick, LA; Landis, ER; Leonard, YM; Krueger, JA; Lewis, SD; Pettibone, DJ; Freidinger, RM; Bock, MG 分享 收藏
Difference in mGluR5 interaction between positive allosteric modulators from two structural classes 来自两个结构课程的正变构调节剂之间mGluR5相互作用的差异 Williams, DL; O'Brien, JA; Lemaire, W; Chen, TB; Chang, RSL; Jacobson, MA; Ha, SN; Wisnoski, DD; Lindsley, CW; Sur, C; Duggan, ME; Pettibone, DJ; Conn, PJ 分享 收藏
A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models Kinney, GG; O'Brien, JA; Lemaire, W; Burno, M; Bickel, DJ; Clements, MK; Chen, TB; Wisnoski, DD; Lindsley, CW; Tiller, PR; Smith, S; Jacobson, MA; Sur, C; Duggan, ME; Pettibone, DJ; Conn, PJ; Williams, DL 分享 收藏
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2,3-diaminopyridine bradykinin B1 receptor antagonists Kuduk, SD; Ng, C; Feng, DM; Wai, JMC; Chang, RSL; Harrell, CM; Murphy, KL; Ransom, RW; Reiss, D; Ivarsson, M; Mason, G; Boyce, S; Tang, CY; Prueksaritanont, T; Freidinger, RM; Pettibone, DJ; Bock, MG 分享 收藏
Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist Ransom, RW; Harrell, CM; Reiss, DR; Murphy, KL; Chang, RSL; Hess, JF; Miller, PJ; O'Malley, SS; Hey, PJ; Kunapuli, P; Su, DS; Markowitz, MK; Wallace, MA; Raab, CE; Jones, AN; Dean, DC; Pettibone, DJ; Freidinger, RM; Bock, MG 分享 收藏
Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model Hess, JF; Ransom, RW; Zeng, ZZ; Chang, RSL; Hey, PJ; Warren, L; Harrell, CM; Murphy, KL; Chen, TB; Miller, PJ; Lis, E; Reiss, D; Gibson, RE; Markowitz, MK; DiPardo, RM; Su, DS; Bock, MG; Gould, RJ; Pettibone, DJ 分享 收藏
A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain O'Brien, JA; Lemaire, W; Wittmann, M; Jacobson, MA; Ha, SN; Wisnoski, DD; Lindsley, CW; Schaffhauser, HJ; Rowe, B; Sur, C; Duggan, ME; Pettibone, DJ; Conn, PJ; Williams, DL 分享 收藏
N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity Sur, C; Mallorga, PJ; Wittmann, M; Jacobson, MA; Pascarella, D; Williams, JB; Brandish, PE; Pettibone, DJ; Scolnick, EM; Conn, PJ 分享 收藏
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5 O'Brien, JA; Lemaire, W; Chen, TB; Chang, RSL; Jacobson, MA; Ha, SN; Lindsley, CW; Schaffhauser, HJ; Sur, C; Pettibone, DJ; Conn, PJ; Williams, DL 分享 收藏
Discovery of a potent, non-peptide bradykinin B1 receptor antagonist Su, DS; Markowitz, MK; DiPardo, RM; Murphy, KL; Harrell, CM; O'Malley, SS; Ransom, RW; Chang, RSL; Ha, S; Hess, FJ; Pettibone, DJ; Mason, GS; Boyce, S; Freidinger, RM; Bock, MG 分享 收藏
Benzodiazepines as potent and selective bradykinin B1 antagonists Wood, MR; Kim, JJ; Han, W; Dorsey, BD; Homnick, CF; DiPardo, RM; Kuduk, SD; MacNeil, T; Murphy, KL; Lis, EV; Ransom, RW; Stump, GL; Lynch, JJ; O'Malley, SS; Miller, PJ; Chen, TB; Harrell, CM; Chang, RSL; Sandhu, P; Ellis, JD; Bondiskey, PJ; Pettibone, DJ; Freidinger, RM; Bock, MG 分享 收藏
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The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin Pettibone, DJ; Hess, JF; Hey, PJ; Jacobson, MA; Leviten, M; Lis, EV; Mallorga, PJ; Pascarella, DM; Snyder, MA; Williams, JB; Zeng, ZZ 分享 收藏
In vitro studies on L-771,688 (SNAP 6383), a new potent and selective α1A-adrenoceptor antagonist Chang, RSL; Chen, TB; O'Malley, SS; Pettibone, DJ; DiSalvo, J; Francis, B; Bock, MG; Freidinger, R; Nagarathnam, D; Miao, SW; Shen, QR; Lagu, B; Dhar, TGM; Tyagarajan, S; Marzabadi, MR; Wong, WC; Gluchowski, C; Forray, C 分享 收藏
De novo design of a novel oxazolidinone analogue as a potent and selective α1A adrenergic receptor antagonist with high oral bioavailability Lagu, B; Tian, D; Jeon, Y; Li, C; Wetzel, JM; Nagarathnam, D; Shen, QR; Forray, C; Chang, RSL; Broten, TP; Ransom, RW; Chan, TB; O'Malley, SS; Schorn, TW; Rodrigues, AD; Kassahun, K; Pettibone, DJ; Freidinger, R; Gluchowski, C 分享 收藏
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