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收藏A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule
Hosseini, Iraj; Fleisher, Brett; Getz, Jennifer; Decalf, Jeremie; Kwong, Mandy; Ovacik, Meric; Bainbridge, Travis W.; Moussion, Christine; Rao, Gautham K.; Gadkar, Kapil; Kamath, Amrita V.; Ramanujan, Saroja 分享 收藏 The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial resultsLewis, Gail D.; Li, Guangmin; Guo, Jun; Yu, Shang-Fan; Fields, Carter T.; Lee, Genee; Zhang, Donglu; Dragovich, Peter S.; Pillow, Thomas; Wei, Binqing; Sadowsky, Jack; Leipold, Douglas; Wilson, Tim; Kamath, Amrita; Mamounas, Michael; Lee, M. Violet; Saad, Ola; Choeurng, Voleak; Ungewickell, Alexander; Monemi, Sharareh; Crocker, Lisa; Kalinsky, Kevin; Modi, Shanu; Jung, Kyung Hae; Hamilton, Erika; LoRusso, Patricia; Krop, Ian; Schutten, Melissa M.; Commerford, Renee; Sliwkowski, Mark X.; Cho, Eunpi 分享 收藏 A Bispecific Modeling Framework Enables the Prediction of Efficacy, Toxicity, and Optimal Molecular Design of Bispecific Antibodies Targeting MerTKLi, Ran; Dere, Edward; Kwong, Mandy; Fei, Mingjian; Dave, Rutwij; Masih, Shabkhaiz; Wang, Joy; Mcnamara, Erin; Huang, Haochu; Liang, Wei-Ching; Schutt, Leah; Kamath, Amrita V.; Ovacik, Meric A. 分享 收藏 Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGF,B3 Antibody for the Treatment of Fibrotic DiseasesYadav, Rajbharan; Sukumaran, Siddharth; Lutman, Jeff; Mitra, Mayur S.; Halpern, Wendy; Sun, Tianhe; Setiadi, Francesca; Neighbors, Margaret; Sheng, X. Rebecca; Yip, Victor; Shen, Ben-Quan; Liu, Chang; Han, Lyrialle; Ovacik, Ayse Meric; Wu, Yan; Glickstein, Sara; Kunder, Rebecca; Arron, Joseph R.; Pan, Lin; V. Kamath, Amrita; Stefanich, Eric G. 分享 收藏 分享 收藏 Non-human primates in the PKPD evaluation of biologics: Needs and options to reduce, refine, and replace. A BioSafe White PaperMenochet, Karelle; Yu, Hongbin; Wang, Bonnie; Tibbitts, Jay; Hsu, Cheng-Pang; Kamath, Amrita, V; Richter, Wolfgang F.; Baumann, Andreas 分享 收藏 Nonclinical Pharmacokinetics, Pharmacodynamics, and Translational Model of RO7297089, A Novel Anti-BCMA/CD16A Bispecific Tetravalent Antibody for the Treatment of Multiple MyelomaCai, Hao; Kakiuchi-Kiyota, Satoko; Hendricks, Robert; Zhong, Shelly; Liu, Luna; Adedeji, Adeyemi O.; Chan, Pamela; Schutten, Melissa M.; Kamath, Amrita, V; Ovacik, Meric A. 分享 收藏 分享 收藏 Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell MalignanciesYadav, Rajbharan; Sukumaran, Siddharth; Zabka, Tanja S.; Li, Jinze; Oldendorp, Amy; Morrow, Gary; Reyes, Arthur; Cheu, Melissa; Li, Jessica; Wallin, Jeffrey J.; Tsai, Siao; Sun, Laura; Wang, Peiyin; Ellerman, Diego; Spiess, Christoph; Polson, Andy; Stefanich, Eric G.; Kamath, Amrita, V; Ovacik, Meric A. 分享 收藏 分享 收藏 A homogeneous high-DAR antibody-drug conjugate platform combining THIOMAB antibodies and XTEN polypeptidesZacharias, Neelie; Podust, Vladimir N.; Kajihara, Kimberly K.; Leipold, Douglas; Del Rosario, Geoffrey; Thayer, Desiree; Dong, Emily; Paluch, Maciej; Fischer, David; Zheng, Kai; Lei, Corinna; He, Jintang; Ng, Carl; Su, Dian; Liu, Luna; Masih, Shabkhaiz; Sawyer, William; Tinianow, Jeff; Marik, Jan; Yip, Victor; Li, Guangmin; Chuh, Josefa; Morisaki, J. Hiroshi; Park, Summer; Zheng, Bing; Hernandez-Barry, Hilda; Loyet, Kelly M.; Xu, Min; Kozak, Katherine R.; Phillips, Gail Lewis; Shen, Ben-Quan; Wu, Cong; Xu, Keyang; Yu, Shang-Fan; Kamath, Amrita; Rowntree, Rebecca K.; Reilly, Dorothea; Pillow, Thomas; Polson, Andrew; Schellenberger, Volker; Hazenbos, Wouter L. W.; Sadowsky, Jack 分享 收藏 Imaging Reveals Importance of Shape and Flexibility for Glomerular Filtration of BiologicsRafidi, Hanine; Estevez, Alberto; Ferl, Gregory Z.; Mandikian, Danielle; Stainton, Shannon; Sermeno, Lauren; Williams, Simon P.; Kamath, Amrita, V; Koerber, James T.; Boswell, C. Andrew 分享 收藏 Valency of HER2 Targeting Antibodies Influences Tumor Cell Internalization and PenetrationRamos, Madeleine K.; Mandikian, Danielle; Sermeno, Lauren N.; King, Anna; Dent, Alecia T.; Ho, Jason; Ulufatu, Sheila; Lombana, T. Noelle; Spiess, Christoph; Go, Mary Ann T.; Yu, Shang-Fan; Kamath, Amrita, V; Ferl, Gregory Z.; Boswell, C. Andrew 分享 收藏 Calicheamicin Antibody-Drug Conjugates with Improved PropertiesVollmar, Breanna S.; Frantz, Chris; Schutten, Melissa M.; Zhong, Fiona; Rosario, Geoffrey del; Go, Mary Ann T.; Yu, Shang-Fan; Leipold, Douglas D.; Kamath, Amrita, V; Ng, Carl; Xu, Keyang; Cruz-Chuh, Josefa Dela; Kozak, Katherine R.; Chen, Jinhua; Xu, Zijin; Wai, John; Adhikari, Pragya; Erickson, Hans K.; Dragovich, Peter S.; Polson, Andrew G.; Pillow, Thomas H. 分享 收藏 Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity嵌合BET降解剂的抗体偶联可实现体内活性Pillow, Thomas H.; Adhikari, Pragya; Blake, Robert A.; Chen, Jinhua; Del Rosario, Geoffrey; Deshmukh, Gauri; Figueroa, Isabel; Gascoigne, Karen E.; Kamath, Amrita, V; Kaufman, Susan; Kleinheinz, Tracy; Kozak, Katherine R.; Latifi, Brandon; Leipold, Douglas D.; Li, Chun Sing; Li, Ruina; Mulvihill, Melinda M.; O'Donohue, Aimee; Rowntree, Rebecca K.; Sadowsky, Jack D.; Wai, John; Wang, Xinxin; Wu, Cong; Xu, Zijin; Yao, Hui; Yu, Shang-Fan; Zhang, Donglu; Zang, Richard; Zhang, Hongyan; Zhou, Hao; Zhu, Xiaoyu; Dragovich, Peter S. 分享 收藏 Hyaluronic Acid-Antibody Fragment Bioconjugates for Extended Ocular PharmacokineticsFamili, Amin; Crowell, Susan R.; Loyet, Kelly M.; Mandikian, Danielle; Boswell, C. Andrew; Cain, David; Chan, Joyce; Comps-Agrar, Laetitia; Kamath, Amrita; Rajagopal, Karthikan 分享 收藏 Preclinical and translational pharmacokinetics of a novel THIOMAB™ antibody-antibiotic conjugate against Staphylococcus aureusDeng, Rong; Zhou, Chenguang; Li, Dongwei; Cai, Hao; Sukumaran, Siddharth; Carrasco-Triguero, Montserrat; Saad, Ola; Nazzal, Denise; Lowe, Christopher; Ramanujan, Saroja; Kamath, Amrita V. 分享 收藏 Prediction of Human Pharmacokinetics of Antibody-Drug Conjugates From Nonclinical DataLi, Chunze; Zhang, Cindy; Deng, Rong; Leipold, Douglas; Li, Dongwei; Latifi, Brandon; Gao, Yuying; Zhang, Crystal; Li, Zao; Miles, Dale; Chen, Shang-Chiung; Samineni, Divya; Wang, Bei; Agarwal, Priya; Lu, Dan; Prabhu, Saileta; Girish, Sandhya; Kamath, Amrita V. 分享 收藏 A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti-Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy VolunteersPeck, Melicent; Rothenberg, Michael E.; Deng, Rong; Lewin-Koh, Nicholas; She, Gaohong; Kamath, Amrita V.; Carrasco-Triguero, Montserrat; Saad, Ola; Castro, Aide; Teufel, Lisa; Dickerson, Daniel S.; Leonardelli, Marisa; Tavel, Jorge A. 分享 收藏 
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