未登录Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2
Ong, Han Wee; Yang, Xuan; Smith, Jeffery L.; Taft-Benz, Sharon; Howell, Stefanie; Dickmander, Rebekah J.; Havener, Tammy M.; Sanders, Marcia K.; Brown, Jason W.; Counago, Rafael M.; Chang, Edcon; Kraemer, Andreas; Moorman, Nathaniel J.; Heise, Mark; Axtman, Alison D.; Drewry, David H.; Willson, Timothy M. .png)
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收藏More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5-a]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus ReplicationOng, Han Wee; Yang, Xuan; Smith, Jeffery L.; Dickmander, Rebekah J.; Brown, Jason W.; Havener, Tammy M.; Taft-Benz, Sharon; Howell, Stefanie; Sanders, Marcia K.; Capener, Jacob L.; Counago, Rafael M.; Chang, Edcon; Kraemer, Andreas; Moorman, Nathaniel J.; Heise, Mark; Axtman, Alison D.; Drewry, David H.; Willson, Timothy M. 分享 收藏 Optimization of mTOR Inhibitors Using Property-Based Drug Design and Free-Wilson Analysis for Improved In Vivo EfficacyMurphy, Sean T.; Atienza, Joy; Brown, Jason W.; Cheruvallath, Zacharia S.; Cukierski, Matthew J.; Fabrey, Robyn; Keung, Walter; Kwok, Lily; O'Connell, Shawn; Tang, Mingnam; Vanderpool, Darin L.; Vincent, Patrick W.; Zhang, Lilly; Marx, Matthew A. 分享 收藏 Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5-a]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2AYang, Xuan; Ong, Han Wee; Dickmander, Rebekah J.; Smith, Jeffery L.; Brown, Jason W.; Tao, William; Chang, Edcon; Moorman, Nathaniel J.; Axtman, Alison D.; Willson, Timothy M. 分享 收藏 Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-CoronavirusesYang, Xuan; Dickmander, Rebekah J.; Bayati, Armin; Taft-Benz, Sharon A.; Smith, Jeffery L.; Wells, Carrow, I; Madden, Emily A.; Brown, Jason W.; Lenarcic, Erik M.; Yount, Boyd L., Jr.; Chang, Edcon; Axtman, Alison D.; Baric, Ralph S.; Heise, Mark T.; McPherson, Peter S.; Moorman, Nathaniel J.; Willson, Timothy M. 分享 收藏 First-Time Disclosure of CVN424, a Potent and Selective GPR6 Inverse Agonist for the Treatment of Parkinson's Disease: Discovery, Pharmacological Validation, and Identification of a Clinical CandidateSun, Huikai; Monenschein, Holger; Schiffer, Hans H.; Reichard, Holly A.; Kikuchi, Shota; Hopkins, Maria; Macklin, Todd K.; Hitchcock, Stephen; Adams, Mark; Green, Jason; Brown, Jason; Murphy, Sean T.; Kaushal, Nidhi; Collia, Deanna R.; Moore, Steve; Ray, William J.; English, Nicole Marion; Carlton, Mark Beresford Lewis; Brice, Nicola L. 分享 收藏 Language-specific grit: exploring psychometric properties, predictive validity, and differences across contextsSudina, Ekaterina; Brown, Jason; Datzman, Brien; Oki, Yukiko; Song, Katherine; Cavanaugh, Robert; Thiruchelvam, Bala; Plonsky, Luke 分享 收藏 分享 收藏 Discovery of novel benzo[b][1,4]oxazin-3(4H)-ones as poly(ADP-Ribose)polymerase inhibitorsGangloff, Anthony R.; Brown, Jason; De Jong, Ron; Erickson, Philip; Grimshaw, Charles; Hixon, Mark; Jennings, Andy; Kamran, Ruhi; Kiryanov, Andre; O'Connell, Shawn; Taylor, Ewan; Phong Vu 分享 收藏 分享 收藏 分享 收藏 
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