Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target EngagementJOURNAL OF MEDICINAL CHEMISTRYIF6.82021-10-1415PREAI
Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological MalignanciesJOURNAL OF MEDICINAL CHEMISTRYIF6.82020-12-1165PREAI
Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM InhibitorsACS MEDICINAL CHEMISTRY LETTERSIF42018-07-1326OAAI
Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase (vol 59, pg 6281, 2016)JOURNAL OF MEDICINAL CHEMISTRYIF6.82018-07-030OAAI
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one)JOURNAL OF MEDICINAL CHEMISTRYIF6.82018-04-23101OAAI
Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) KinaseJOURNAL OF MEDICINAL CHEMISTRYIF6.82016-06-1678PREAI
Pyrimidinone Nicotinamide Mimetics as Selective Tankyrase and Wnt Pathway Inhibitors Suitable for in Vivo PharmacologyACS MEDICINAL CHEMISTRY LETTERSIF42015-01-1760OAAI
Synthesis and asymmetric hydrogenation of (3E)-1-benzyl-3-[(2-oxopyridin-1(2H)-yl)methylidene]piperidine-2,6-dioneCHEMICAL COMMUNICATIONSIF4.22012-01-0110OA
Rapid Generation of a High Quality Lead for Transforming Growth Factor-β (TGF-β) Type I Receptor (ALK5)JOURNAL OF MEDICINAL CHEMISTRYIF6.82009-09-0840PREAI