Huizhen Wen

southern medical university - china

7H指数

14论文数

179被引数

收录论文 5

发表时间

PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of synapses by microglia and depressive-like behaviors in mice PDE4 抑制通过减轻小胶质细胞介导的 HMGB1/C1q/C3 依赖性过度吞噬修剪突触及抑郁样行为，发挥缓解作用。

BRAIN BEHAVIOR AND IMMUNITY

IF7.6

2025-05-01

PREAI

Zhao, Qian; Zeng, Chunyuan; Luo, Fulan; Xian, Zihong; Wen, Huizhen; Tu, Xingxing; Yang, Rifang; Sun, Yijun; Zheng, Xiangling; Xu, Jiangping; Wang, Haitao

Discovery of 7-alkoxybenzofurans as PDE4 inhibitors with hepatoprotective activity in D-GalN/LPS-induced hepatic sepsis

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2024-09-01

PREAI

Xia, Chuang; Wen, Huizhen; Zheng, Lei; Ni, Yujie; Bi, Huichang; Wang, Haitao; Xu, Jiangping; Zhou, Zhong-Zhen

Inhibition of PDE4 Attenuates TNF-α-Triggered Cell Death Through Suppressing NF-κB and JNK Activation in HT-22 Neuronal Cells

CELLULAR AND MOLECULAR NEUROBIOLOGY

IF4.8

2019-10-28

PREAI

Xiao, Jiao; Yao, Rumeng; Xu, Bingtian; Wen, Huizhen; Zhong, Jiahong; Li, Dan; Zhou, Zhongzhen; Xu, Jiangping; Wang, Haitao

Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP+-induced oxidative insult

FREE RADICAL BIOLOGY AND MEDICINE

IF8.2

2019-05-01

PREAI

Zhong, Jiahong; Xie, Jinfeng; Xiao, Jiao; Li, Dan; Xu, Bingtian; Wang, Xinyi; Wen, Huizhen; Zhou, Zhongzhen; Cheng, Yufang; Xu, Jiangping; Wang, Haitao

FCPR03, a novel phosphodiesterase 4 inhibitor, alleviates cerebral ischemia/reperfusion injury through activation of the AKT/GSK313/ β-catenin signaling pathway

BIOCHEMICAL PHARMACOLOGY

IF5.6

2019-05-01

PREAI

Xu, Bingtian; Wang, Tiantian; Xiao, Jiao; Dong, Wenli; Wen, Hui-zhen; Wang, Xinyi; Qin, Yunyun; Cai, Ningbo; Zhou, Zhongzhen; Xu, Jiangping; Wang, Haitao

研究方向