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K

Karin Reif

Genentech
H指数:30
被引数:4,253

个人简介

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教育背景

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工作经历

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荣誉奖项

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Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-02-19211
OAAI
Crawford, James J. y; Johnson, Adam R.; Misner, Dinah L.; Belmont, Lisa D.; Castanedo, Georgette; Choy, Regina; Coraggio, Melis; Doug, Liming; Eigenbrot, Charles; Erickson, Rebecca; Ghilardi, Nico; Hau, Jonathan; Katewa, Arna; Kohli, Pawan Bir; Lee, Wendy; Lubach, Joseph W.; McKenzie, Brent S.; Ortwine, Daniel F.; Schutt, Leah; Tay, Suzanne; Wei, BinQing; Reif, Karin; Liu, Lichuan; Wong, Harvey; Young, Wendy B.
Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties

发现具有改善的药物样特性的布鲁顿酪氨酸激酶的有效和选择性三环抑制剂

ACS MEDICINAL CHEMISTRY LETTERS
IF4
2017-05-1629
OAAI
Wang, Xiaojing; Barbosa, James; Blomgren, Peter; Bremer, Meire C.; Chen, Jacob; Crawford, James J.; Deng, Wei; Dong, Liming; Eigenbrot, Charles; Gallion, Steve; Hau, Jonathon; Hu, Huiyong; Johnson, Adam R.; Katewa, Arna; Kropf, Jeffrey E.; Lee, Seung H.; Liu, Lichuan; Lubach, Joseph W.; Macaluso, Jen; Maciejewski, Pat; Mitchell, Scott A.; Ortwine, Daniel F.; DiPaolo, Julie; Reif, Karin; Scheerens, Heleen; Schmitt, Aaron; Wong, Harvey; Xiong, Jin-Ming; Xu, Jianjun; Zhao, Zhongdong; Zhou, Fusheng; Currie, Kevin S.; Young, Wendy B.
Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFNa-driven lupus nephritis
JCI INSIGHT
IF6.1
2017-04-0658
OAAI
Katewa, Arna; Wang, Yugang; Hackney, Jason A.; Huang, Tao; Suto, Eric; Ramamoorthi, Nandhini; Austin, Cary D.; Bremer, Meire; Chen, Jacob Zhi; Crawford, James J.; Currie, Kevin S.; Blomgren, Peter; DeVoss, Jason; DiPaolo, Julie A.; Hau, Jonathan; Johnson, Adam; Lesch, Justin; DeForge, Laura E.; Lin, Zhonghua; Liimatta, Marya; Lubach, Joseph W.; McVay, Sami; Modrusan, Zora; Nguyen, Allen; Poon, Chungkee; Wang, Jianyong; Liu, Lichuan; Lee, Wyne P.; Wong, Harvey; Young, Wendy B.; Townsend, Michael J.; Reif, Karin
Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
IF3.8
2017-01-0115
OAAI
Erickson, Rebecca I.; Schutt, Leah K.; Tarrant, Jacqueline M.; McDowell, Michelle; Liu, Lichuan; Johnson, Adam R.; Lewin-Koh, Sock-Cheng; Hedehus, Maj; Ross, Jed; Carano, Richard A. D.; Staflin, Karin; Zhong, Fiona; Crawford, James J.; Zhong, Shelly; Reif, Karin; Katewa, Arna; Wong, Harvey; Young, Wendy B.; Dambach, Donna M.; Misner, Dinah L.
Depletion of major pathogenic cells in asthma by targeting CRTh2
JCI INSIGHT
IF6.1
2016-05-1927
OA
Huang, Tao; Hazen, Meredith; Shang, Yonglei; Zhou, Meijuan; Wu, Xiumin; Yan, Donghong; Lin, Zhonghua; Solon, Margaret; Luis, Elizabeth; Ngu, Hai; Shi, Yongchang; Katewa, Arna; Choy, David F.; Ramamoorthi, Nandhini; Castellanos, Erick R.; Balazs, Mercedesz; Xu, Min; Lee, Wyne P.; Matsumoto, Marissa L.; Payandeh, Jian; Arron, Joseph R.; Hongo, Jo-Anne; Wang, Jianyong; Hotzel, Isidro; Austin, Cary D.; Reif, Karin
Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa
TOXICOLOGICAL SCIENCES
IF4.1
2016-04-216
OAAI
Rajapaksa, Kathila S.; Huang, Tao; Sharma, Neeraj; Liu, Shannon; Solon, Margaret; Reyes, Arthur; Paul, Sarah; Yee, Angie; Tao, Janet; Chalasani, Sreedevi; Bien-Ly, Nga; Barck, Kai; Carano, Richard A. D.; Wang, Jianyong; Rangell, Linda; Bremer, Meire; Danilenko, Dimitry M.; Katavolos, Paula; Hotzel, Isidro; Reif, Karin; Austin, Cary D.
Discovery of Novel PI3-Kinase δ Specific Inhibitors for the Treatment of Rheumatoid Arthritis: Taming CYP3A4 Time-Dependent Inhibition
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2012-06-1168
PREAI
Safina, Brian S.; Baker, Stewart; Baumgardner, Matt; Blaney, Paul M.; Chan, Bryan K.; Chen, Yung-Hsiang; Cartwright, Matthew W.; Castanedo, Georgette; Chabot, Christine; Cheguillaume, Arnaud J.; Goldsmith, Paul; Goldstein, David M.; Goyal, Bindu; Hancox, Timothy; Handa, Raj K.; Lyer, Pravin S.; Kaur, Jasmit; Kondru, Rama; Kenny, Jane R.; Krintel, Sussie L.; Li, Jun; Lesnick, John; Lucas, Matthew C.; Lewis, Cristina; Mukadam, Sophie; Murray, Jeremy; Nadin, Alan J.; Nonomiya, Jim; Padilla, Fernando; Palmer, Wylie S.; Pang, Jodie; Pegg, Neil; Price, Steve; Reif, Karin; Salphati, Laurent; Savy, Pascal A.; Seward, Eileen M.; Shuttleworth, Stephen; Sohal, Sukhjit; Sweeney, Zachary K.; Tay, Suzanne; Tivitmahaisoon, Parcharee; Waszkowycz, Bohdan; Wei, Binqing; Yue, Qin; Zhang, Chenghong; Sutherlin, Daniel P.
Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis
NATURE CHEMICAL BIOLOGY
IF13.7
2010-11-28330
OAAI
Di Paolo, Julie A.; Huang, Tao; Balazs, Mercedesz; Barbosa, James; Barck, Kai H.; Bravo, Brandon J.; Carano, Richard A. D.; Darrow, James; Davies, Douglas R.; DeForge, Laura E.; Diehl, Lauri; Ferrando, Ronald; Gallion, Steven L.; Giannetti, Anthony M.; Gribling, Peter; Hurez, Vincent; Hymowitz, Sarah G.; Jones, Randall; Kropf, Jeffrey E.; Lee, Wyne P.; Maciejewski, Patricia M.; Mitchell, Scott A.; Rong, Hong; Staker, Bart L.; Whitney, J. Andrew; Yeh, Sherry; Young, Wendy B.; Yu, Christine; Zhang, Juan; Reif, Karin; Currie, Kevin S.

研究方向

暂未获取到该数据
H
Harvey Wong
H 指数:38论文数:238被引数:4,571
A
Arna Katewa
H 指数:14论文数:17被引数:1,134
L
Lichuan Liu
H 指数:33论文数:212被引数:3,549
D
Doreen A. Cantrell
H 指数:90论文数:306被引数:2.6万
J
James J. Crawford
H 指数:41论文数:161被引数:6,314
A
Adam R. Johnson
H 指数:35论文数:93被引数:4,332
J
Joseph W. Lubach
H 指数:27论文数:74被引数:2,007
W
Wendy B. Young
H 指数:17论文数:34被引数:1,381
T
Tao Huang
H 指数:38论文数:197被引数:4,489
I
Isidro Hötzel
H 指数:26论文数:97被引数:2,685