Thomas E. Prisinzano - Publications, H-index & Citations

Thomas E. Prisinzano

University of Kentucky

52H指数

288论文数

7.1K被引数

收录论文 126

发表时间

Novel 5-Phenylmorphans as Opioid Receptor Antagonists: Synthesis, Structure-Activity Relationship, Biological Evaluation and Computational Modeling 新型5-苯基吗啡烷作为阿片受体拮抗剂：合成、构效关系、生物评价和计算建模

Molecules

IF4.6

2026-10-02

OAAI

Zahra Hasanpour; Dan Luo; Thomas E. Prisinzano; Pranav Shah; Dana E. Selley; James C. Gillespie; Laurel A. Grisanti; Carmine Talarico; Davide Graziani; Xin Xu; Andrea R. Beccari; Kun-Eek Kil; Sung Won Kim; Arthur E. Jacobson; Kenner C. Rice; Agnieszka Sulima

Development and Application of an LC-MS Method for the Pharmacokinetics and Pharmacodynamics of Oral Therapeutic Efficacy of Nalfurafine

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

IF3.3

2026-01-01

PREAI

Sondhauss, Sven; Kiernan, Mackenzie; Morizzi, Julia; Wright, Phil; Prisinzano, Thomas E.; Kivell, Bronwyn M.; Robichon, Katharina; La Flamme, Anne Camille

Nalmefene enhances the remyelinating ability of nalfurafine when administered therapeutically at very low doses during experimental autoimmune encephalomyelitis 纳美芬在实验性自身免疫性脑脊髓炎中，以非常低的剂量进行治疗性给药时，能够增强纳呋拉啡的髓鞘再生能力。

Clinical & Translational Immunology

IF3.8

2025-12-11

OAAI

Lisa Denny; Katharina Robichon; Nikki Templeton; Mackenzie Kiernan; Thomas E Prisinzano; Bronwyn M Kivell; Anne Camille La Flamme

Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol β-Arrestin 2在吗啡及新型μ阿片受体激动剂kurkinorin和kurkinol的镇痛作用和副作用谱中的作用

Neuropsychopharmacology

IF7.1

2025-09-03

OAAI

Ross van de Wetering; Amy F. Alder; Andrew Biggerstaff; Katya Sellen; Dan Luo; Rachel S. Crowley; Thomas E. Prisinzano; Bronwyn M. Kivell

Stuffed Epimerase Domains of Pyochelin Biosynthesis are Defunct Methyltransferases 吡咯赤菌素生物合成中填充的表异构酶结构域是失活的甲基转移酶

BIOCHEMISTRY

IF3

2025-08-01

PREAI

Ronnebaum, Trey A.; Meneely, Kathleen M.; Horsman, Geoff P.; Prisinzano, Thomas E.; Lamb, Audrey L.

N-(3-Hydroxyphenyl)-3,8-diazabicyclooctanes as Opioid Receptors Probes. 1. Investigation of the Phenolic Hydroxyl Group N-(3-羟基苯基)-3,8-二氮杂双环辛烷作为阿片受体探针。1. 羟基酚基团的考察

European Journal of Medicinal Chemistry

IF5.9

2025-07-23

PREAI

Riya R. Trivedi; Dan Luo; Marissa C. Hessing; Emily Prantzalos; Warren J. Alilain; Jill R. Turner; Thomas E. Prisinzano

Transformation of a Potent C9-Substituted Phenylmorphan into MOR Partial Agonists with Improvement of Metabolic Stability: An In Vitro, In Vivo, and In Silico Study 将一种强效C9-取代的苯基吗喃转化为MOR部分激动剂并提高代谢稳定性：一项体外、体内和计算机模拟研究

ACS CHEMICAL NEUROSCIENCE

IF3.9

2025-05-20

PREAI

Hernandez, Delmis E.; Luo, Dan; Prisinzano, Thomas E.; Negus, S. Stevens; Nassehi, Nima; Selley, Dana E.; Shah, Pranav; Kato, Rintaro; Xu, Xin; Talarico, Carmine; Graziani, Davide; Beccari, Andrea R.; Jacobson, Arthur E.; Rice, Kenner C.; Sulima, Agnieszka

Ligand Recognition and G Protein Signaling Diversification in the Kappa Opioid Receptor κ阿片受体配体识别与G蛋白信号多样化

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2025-03-01

PREAI

Jiang, Qianru; Adediwura, Victor Ayo; Han, Jianming; Luo, Dan; Wang, Jinan; Prisinzano, Thomas E.; Fay, Jonathan F.; Miao, Yinglong; Che, Tao

Novel Compounds EO-139 and YZ-166 as Potential Countermeasures for Reversing Fentanyl-Induced Antinociception, Motor Incapacitation and Respiratory Depression

DRUG AND ALCOHOL DEPENDENCE

IF3.6

2025-02-01

PREAI

Martin, Jocelyn; Shaykin, Jakob; Denehy, Emily; Songrady, Judy; Luo, Dan; Alilain, Warren; Turner, Jill; Bardo, Michael; Prisinzano, Thomas

Effects of Biased Analogues of the Kappa Opioid Receptor Agonist, U50,488, in Preclinical Models of Pain and Side Effects Kappa阿片受体激动剂U50，488的偏倚类似物在疼痛和副作用的临床前模型中的作用

MOLECULES

IF4.6

2025-01-29

OAAI

van de Wetering, Ross; Vu, Loan Y.; Kornberger, Lindsay D.; Luo, Dan; Scouller, Brittany; Hong, Sheein; Paton, Kelly; Prisinzano, Thomas E.; Kivell, Bronwyn M.

Targeting α1- and α2-adrenergic receptors as a countermeasure for fentanyl-induced locomotor and ventilatory depression

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

IF4.2

2024-09-01

PREAI

Shaykin, Jakob D.; Denehy, Emily D.; Martin, Jocelyn R.; Chandler, Cassie M.; Luo, Dan; Taylor, Chase E.; Sunshine, Michael D.; Turner, Jill R.; Alilain, Warren J.; Prisinzano, Thomas E.; Bardo, Michael T.

ALPHA 1 AND 2 NORADRENERGIC RECEPTORS AS TARGETS FOR REVERSING FENTANYL-INDUCED RESPIRATORY DEPRESSION

DRUG AND ALCOHOL DEPENDENCE

IF3.6

2024-07-01

PREAI

Shaykin, Jakob; Martin, Jocelyn; Chandler, Cassie; Denehy, Emily; Turner, Jill; Alilain, Warren; Prisinzano, Thomas; Bardo, Michael

XYLAZINE REDUCES INTRAVENOUS FENTANYL CONSUMPTION BUT DOES NOT IMPAIR LEVER DISCRIMINATION IN MALE AND FEMALE RATS

DRUG AND ALCOHOL DEPENDENCE

IF3.6

2024-07-01

PREAI

Khatri, Shailesh; Bondy, Emma; Kendrick, Percell; Hong, Mei; Hinds, Terry, Jr.; Prisinzano, Thomas; Dunn, Kelly; Gipson-Reichard, Cassandra

Nalfurafine promotes myelination in vitro and facilitates recovery from cuprizone plus rapamycin-induced demyelination in mice

GLIA

IF5.1

2024-06-20

PREAI

van de Wetering, Ross; Bibi, Rabia; Biggerstaff, Andy; Hong, Sheein; Pengelly, Bria; Prisinzano, Thomas E.; La Flamme, Anne C.; Kivell, Bronwyn M.

Searching for Synthetic Opioid Rescue Agents: Identification of a Potent Opioid Agonist with Reduced Respiratory Depression

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2024-05-29

PREAI

Vu, Loan Y.; Luo, Dan; Johnson, Kai; Denehy, Emily D.; Songrady, Judy C.; Martin, Jocelyn; Trivedi, Riya; Alsum, Alexia R.; Shaykin, Jakob D.; Chaudhary, Chhabi L.; Woloshin, Eric J.; Kornberger, Lindsay; Bhuiyan, Nazmul; Parkin, Sean; Jiang, Qianru; Che, Tao; Alilain, Warren; Turner, Jill R.; Bardo, Michael T.; Prisinzano, Thomas E.

Functional Activity of Enantiomeric Oximes and Diastereomeric Amines and Cyano Substituents at C9 in 3-Hydroxy-N-phenethyl-5-phenylmorphans

MOLECULES

IF4.6

2024-04-23

OAAI

Roth, Hudson G.; Das, Madhurima; Sulima, Agnieszka; Luo, Dan; Kaska, Sophia; Prisinzano, Thomas E.; Kerr, Andrew T.; Jacobson, Arthur E.; Rice, Kenner C.

Stuffed Epimerase Domains in Pyochelin-like Natural Product Biosynthesis may be Defunct Methyltransferases and not Catalytically Required for Activity

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-03-01

PREAI

Meneely, Kathleen; Ronnebaum, Trey; Horsman, Geoff; Prisinzano, Thomas; Lamb, Audrey

Targeting EWS-FLI1 with mithramycin analogues for Ewing sarcoma treatment

MOLECULAR CANCER THERAPEUTICS

IF5.5

2023-12-01

PREAI

Leggas, Markos; Niloy, Kumar K.; Yetijaram, Rajesh; Horn, Jamie; Kazuto, Yasuda; Prisinzano, Thomas; Thorson, Jon S.; Tsoikov, Oleg; Rohr, Jurgen

Potent MOR Agonists from 2′-Hydroxy-5,9-dimethyl-N-phenethyl Substituted-6,7-benzomorphans and from C8-Hydroxy, Methylene and Methyl Derivatives of N-Phenethylnormetazocine 来自2 ′-Hydroxy-5，9-二甲基-N-苯乙基取代的-6，7-苯并吗啉和N-苯乙基去甲甲佐辛的C8-Hydroxy，亚甲基和甲基衍生物的有效MOR激动剂

MOLECULES

IF4.6

2023-11-22

OAAI

Das, Madhurima; Ward, George W.; Sulima, Agnieszka; Luo, Dan; Prisinzano, Thomas Edward; Imler, Gregory H.; Kerr, Andrew T.; Jacobson, Arthur E.; Rice, Kenner C.

Quantification of observable behaviors following oral administration of oxycodone and nalfurafine in male rhesus monkeys 在雄性恒河猴中口服羟考酮和nalfurafine后可观察到的行为的量化

DRUG AND ALCOHOL DEPENDENCE

IF3.6

2023-11-01

OAAI

Huskinson, Sally L.; Platt, Donna M.; Smith, Zachary R.; Doyle, William S.; Zamarripa, C. Austin; Dunaway, Kristen; Prisinzano, Thomas E.; Freeman, Kevin B.

研究方向