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E

Elsie C. Yu

merck and co inc
H指数:7
被引数:317

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Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease (vol. 69, pg. 8548, 2026)

发现强效、选择性、中枢神经系统穿透性大环LRRK2抑制剂用于帕金森病的治疗（vol. 69, pg. 8548, 2026）

Journal of Medicinal Chemistry
IF6.8
2026-04-010
PRE
Yu, Elsie C.; Zhou, Hua; Yan, Xin; Logan, Kaitlyn M.; Li, Derun; Gulati, Anmol; Poremba, Kelsey E.; Ardolino, Michael J.; Su, Jing; Xiao, Dong; Palte, Rachel L.; McMinn, Spencer E.; Nogle, Lisa M.; Adpressa, Donovon A.; Burgess, Samantha A.; Xiong, Tina; Otte, Karin M.; Chobanian, Harry R.; Bass, Alan; Lee, Susi; Pearson, Kara; Messina, Eric; Parisi, Michael; Barnum, John; Sobol, Zhanna; Ciaccio, Paul J.; DiMauro, Erin F.; Fell, Matthew J.; Fuller, Peter H.
Discovery of Potent; Selective; CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson’s Disease

发现强效、选择性、能穿透中枢神经系统的环状LRRK2抑制剂，用于帕金森病的治疗

Journal of Medicinal Chemistry
IF6.8
2026-03-290
PRE
Elsie C. Yu; Hua Zhou; Xin Yan; Kaitlyn M. Logan; Derun Li; Anmol Gulati; Kelsey E. Poremba; Michael J. Ardolino; Jing Su; Dong Xiao; Rachel L. Palte; Spencer E. McMinn; Lisa M. Nogle; Donovon A. Adpressa; Samantha A. Burgess; Tina Xiong; Karin M. Otte; Harry R. Chobanian; Alan Bass; Susi Lee; Kara Pearson; Eric Messina; Michael Parisi; John Barnum; Zhanna Sobol; Paul J. Ciaccio; Erin F. DiMauro; Matthew J. Fell; Peter H. Fuller

研究方向

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R
Richard R. Schrock
H 指数:120论文数:1,186被引数:5.7万
A
Amir H. Hoveyda
H 指数:118论文数:865被引数:4.1万
D
Dustin Smith
H 指数:16论文数:56被引数:1,283
D
Donovon A. Adpressa
H 指数:16论文数:41被引数:864
S
Samantha A. Burgess
H 指数:12论文数:54被引数:1,064
A
Alexander Pasternak
H 指数:36论文数:172被引数:4,294
E
Erin F. DiMauro
H 指数:28论文数:113被引数:2,142
S
Spencer E. McMinn
H 指数:9论文数:19被引数:301
A
Anmol Gulati
H 指数:8论文数:14被引数:443
D
Dong Xiao
H 指数:17论文数:70被引数:721