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G

Gregory A. Michaud

novartis biomedical research
H指数:22
被引数:4,897

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A conformation-sensitive product inhibitor of HDAC1/2 potentiates WNT signaling

HDAC1/2的构象敏感型产物抑制剂可增强WNT信号通路

Nature Chemical Biology
IF13.7
2026-11-110
PRE
Olga Charlat; Ling Li; Zheng Zhou; Rohan EJ Beckwith; Lijian Feng; Liqing Geng; Aleem Fazal; Jason R. Thomas; Jason Murphy; Nicolas Pizzato; Fabian Wu; Judith Knehr; Sebastian Bergling; Helen T. Pham; Daniel Fuller; Deborah I. Scheffer; Zijun Chen; Jun Gao; Daniel S. Palacios; Stephen M. Canham; Gregory A. Michaud; Claude Shelton; Scott M. Brittain; Marc Hild; Kristie Wetzel; Paola Capodieci; Frederic Sigoillot; Jeremy L. Jenkins; Jeffery A. Porter; En Li; John A. Tallarico; Markus Schirle; Barna D. Fodor; Justin Gu; Feng Cong
A small-molecule VHL molecular glue degrader for cysteine dioxygenase 1

一种靶向半胱氨酸二氧合酶1的小分子VHL分子胶降解剂

Nature Chemical Biology
IF13.7
2025-06-240
OA
Antonin Tutter; Dennis Buckley; Andrei A. Golosov; Xiaolei Ma; Wei Shu; Daniel J. J. McKay; Veronique Darsigny; Dustin Dovala; Rohan Beckwith; Jonathan Solomon; Pasupuleti Rao; Lei Xu; Aleem Fazal; Andreas Lingel; Charles Wartchow; Jennifer S. Cobb; Amanda Hachey; Jennifer Tullai; Gregory A. Michaud
Identification and characterization of ternary complexes consisting of FKBP12, MAPRE1 and macrocyclic molecular glues

FKBP12、MAPRE1和环状分子胶组成的二元复合物的鉴定与表征

RSC CHEMICAL BIOLOGY
IF3.1
2025-01-011
OA
Salcius, Michael; Tutter, Antonin; Fouche, Marianne; Koc, Halil; King, Dan; Dhembi, Anxhela; Golosov, Andrei; Jahnke, Wolfgang; Henry, Chrystele; Argoti, Dayana; Jia, Weiping; Pedro, Liliana; Connor, Lauren; Piechon, Philippe; Fabbiani, Francesca; Denay, Regis; Sager, Emine; Kuehnoel, Juergen; Lozach, Marie-Anne; Lima, Fabio; Vitrey, Angela; Chen, Shu-Yu; Michaud, Gregory; Roth, Hans-Joerg
Activation of human STING by a molecular glue-like compound

通过分子胶样化合物激活人类STING

NATURE CHEMICAL BIOLOGY
IF13.7
2023-10-1211
OAAI
Li, Jie; Canham, Stephen M.; Wu, Hua; Henault, Martin; Chen, Lihao; Liu, Guoxun; Chen, Yu; Yu, Gary; Miller, Howard R.; Hornak, Viktor; Brittain, Scott M.; Michaud, Gregory A.; Tutter, Antonin; Broom, Wendy; Digan, Mary Ellen; Mcwhirter, Sarah M.; Sivick, Kelsey E.; Pham, Helen T.; Chen, Christine H.; Tria, George S.; Mckenna, Jeffery M.; Schirle, Markus; Mao, Xiaohong; Nicholson, Thomas B.; Wang, Yuan; Jenkins, Jeremy L.; Jain, Rishi K.; Tallarico, John A.; Patel, Sejal J.; Zheng, Lianxing; Ross, Nathan T.; Cho, Charles Y.; Zhang, Xuewu; Bai, Xiao-Chen; Feng, Yan
Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute kidney injury
CELL CHEMICAL BIOLOGY
IF7.2
2021-09-0116
OAAI
Larraufie, Marie-Helene; Gao, Xiaolin; Xia, Xiaobo; Devine, Patrick J.; Kallen, Joerg; Liu, Dong; Michaud, Gregory; Harsch, Andreas; Savage, Nik; Ding, Jian; Tan, Kian; Mihalic, Manuel; Roggo, Silvio; Canham, Stephen M.; Bushell, Simon M.; Krastel, Philipp; Gao, Jinhai; Izaac, Aude; Altinoglu, Erhan; Lustenberger, Philipp; Salcius, Michael; Harbinski, Fred; Williams, Eric T.; Zeng, Liling; Loureiro, Joseph; Cong, Feng; Fryer, Christy J.; Klickstein, Lloyd; Tallarico, John A.; Jain, Rishi K.; Rothman, Deborah M.; Wang, Shaowen
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma (vol 13, pg 465, 2019)
NATURE CHEMICAL BIOLOGY
IF13.7
2020-03-041
OAAI
Ross, Nathan T.; Lohmann, Felix; Carbonneau, Seth; Fazal, Aleem; Weihofen, Wilhelm A.; Gleim, Scott; Salcius, Michael; Sigoillot, Frederic; Henault, Martin; Carl, Sarah H.; Rodriguez-Molina, Juan B.; Miller, Howard R.; Brittain, Scott M.; Murphy, Jason; Zambrowski, Mark; Boynton, Geoffrey; Wang, Yuan; Chen, Aye; Molind, Gregory J.; Wilbertz, Johannes H.; Artus-Revel, Caroline G.; Jia, Min; Akinjiyan, Favour A.; Turner, Jonathan; Knehr, Judith; Carbone, Walter; Schuierer, Sven; Reece-Hoyes, John S.; Xie, Kevin; Saran, Chitra; Williams, Eric T.; Roma, Guglielmo; Spencer, Matt; Jenkins, Jeremy; George, Elizabeth L.; Thomas, Jason R.; Michaud, Gregory; Schirle, Markus; Tallarico, John; Passmore, Lori A.; Chao, Jeffrey A.; Beckwith, Rohan E. J.
CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma
NATURE CHEMICAL BIOLOGY
IF13.7
2019-12-0970
OAAI
Ross, Nathan T.; Lohmann, Felix; Carbonneau, Seth; Fazal, Aleem; Weihofen, Wilhelm A.; Gleim, Scott; Salcius, Michael; Sigoillot, Frederic; Henault, Martin; Carl, Sarah H.; Rodriguez-Molina, Juan B.; Miller, Howard R.; Brittain, Scott M.; Murphy, Jason; Zambrowski, Mark; Boynton, Geoffrey; Wang, Yuan; Chen, Aye; Molind, Gregory J.; Wilbertz, Johannes H.; Artus-Revel, Caroline G.; Jia, Min; Akinjiyan, Favour A.; Turner, Jonathan; Knehr, Judith; Carbone, Walter; Schuierer, Sven; Reece-Hoyes, John S.; Xie, Kevin; Saran, Chitra; Williams, Eric T.; Roma, Guglielmo; Spencer, Matt; Jenkins, Jeremy; George, Elizabeth L.; Thomas, Jason R.; Michaud, Gregory; Schirle, Markus; Tallarico, John; Passmore, Lori A.; Chao, Jeffrey A.; Beckwith, Rohan E. J.
A small-molecule inhibitor of C5 complement protein
NATURE CHEMICAL BIOLOGY
IF13.7
2019-06-1714
PREAI
Jendza, Keith; Kato, Mitsunori; Salcius, Michael; Srinivas, Honnappa; De Erkenez, Andrea; Nguyen, Anh; McLaughlin, Doug; Be, Celine; Wiesmann, Christian; Murphy, Jason; Bolduc, Philippe; Mogi, Muneto; Duca, Jose; Namil, Abdel; Capparelli, Michael; Darsigny, Veronique; Meredith, Erik; Tichkule, Ritesh; Ferrara, Luciana; Heyder, Jessica; Liu, Fang; Horton, Patricia A.; Romanowski, Michael J.; Schirle, Markus; Mainolfi, Nello; Anderson, Karen; Michaud, Gregory A.
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice (vol 11, pg 511, 2015)
NATURE CHEMICAL BIOLOGY
IF13.7
2016-03-182
OAAI
Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Caroline Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice (vol 11, pg 511, 2015)
NATURE CHEMICAL BIOLOGY
IF13.7
2015-08-184
OAAI
Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice
NATURE CHEMICAL BIOLOGY
IF13.7
2015-06-01375
PREAI
Palacino, James; Swalley, Susanne E.; Song, Cheng; Cheung, Atwood K.; Shu, Lei; Zhang, Xiaolu; Van Hoosear, Mailin; Shin, Youngah; Chin, Donovan N.; Keller, Caroline Gubser; Beibel, Martin; Renaud, Nicole A.; Smith, Thomas M.; Salcius, Michael; Shi, Xiaoying; Hild, Marc; Servais, Rebecca; Jain, Monish; Deng, Lin; Bullock, Caroline; McLellan, Michael; Schuierer, Sven; Murphy, Leo; Blommers, Marcel J. J.; Blaustein, Cecile; Berenshteyn, Frada; Lacoste, Arnaud; Thomas, Jason R.; Roma, Guglielmo; Michaud, Gregory A.; Tseng, Brian S.; Porter, Jeffery A.; Myer, Vic E.; Tallarico, John A.; Hamann, Lawrence G.; Curtis, Daniel; Fishman, Mark C.; Dietrich, William F.; Dales, Natalie A.; Sivasankaran, Rajeev
DcpS as a Therapeutic Target for Spinal Muscular Atrophy
ACS CHEMICAL BIOLOGY
IF3.8
2008-10-08121
OAAI
Singh, Jasbir; Salcius, Michael; Liu, Shin-Wu; Staker, Bart L.; Mishra, Rama; Thurmond, John; Michaud, Gregory; Mattoon, Dawn R.; Printen, John; Christensen, Jeffery; Bjornsson, Jon Mar; Pollok, Brian A.; Kiledjian, Megerditch; Stewart, Lance; Jarecki, Jill; Gurney, Mark E.

研究方向

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M
Michael Salcius
H 指数:12论文数:24被引数:1,401
J
John A. Tallarico
H 指数:49论文数:126被引数:1.1万
M
Markus Schirle
H 指数:52论文数:143被引数:1.9万
J
Jason R. Thomas
H 指数:25论文数:57被引数:4,075
S
Sven Schuierer
H 指数:29论文数:113被引数:3,788
G
Guglielmo Roma
H 指数:44论文数:174被引数:1.0万
M
Marc Hild
H 指数:27论文数:51被引数:1.0万
V
Vic E. Myer
H 指数:32论文数:67被引数:2.0万
F
Frederic Sigoillot
H 指数:25论文数:62被引数:2,769
J
Jeremy L. Jenkins
H 指数:46论文数:155被引数:8,606