Michael E. Prime

evotec (u.k.) ltd, 114 innovation drive, milton park, abingdon ox14 4rz, u.k.

H指数:17

被引数:730

个人简介

暂无内容

教育背景

暂无内容

工作经历

暂无内容

荣誉奖项

暂无内容

Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin Aggregates

异吲哚酮类PET示踪剂用于成像突变亨廷蛋白聚集物

Journal of Medicinal Chemistry

IF6.8

2025-07-070

PRE

Longbin Liu; Peter D. Johnson; Matthew R. Mills; Penelope A. Turner; Michael E. Prime; Christopher J. Brown; Adrian Kotey; Samuel Coe; Paul R. Giles; Catherine Lloyd; Sarah Hayes; Frederic J. Marlin; Filippo Rota; Frank Herrmann; Manuela Heßmann; Sabine Schaertl; Franziska Zajicek; Stef De Lombaerde; Filipe Elvas; Jeroen Verhaeghe; Steven Staelens; Daniele Bertoglio; Xuemei Chen; Michael P. Conlon; Randall Davis; Samantha F. Ensor; James Haber; Kathryn C. Haber; Ming Min Hsai; John E. Mangette; William F. Penniman; Luca Anzillotti; Simone Esposito; Angelo Lembo; Laura Orsatti; Davide Ventre; Maria Veneziano; Christine Sandiego; Scott Haller; Gwendolyn A. Marriner; Ignacio Munoz-Sanjuan; Vinod Khetarpal; Jonathan A. Bard; Celia Dominguez

Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2022-12-2211

PRE

Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Brown, Christopher J.; Anzillotti, Luca; Bertoglio, Daniele; Chen, Xuemei; Coe, Samuel; Davis, Randall; Dickie, Anthony P.; Esposito, Simone; Gadouleau, Elise; Giles, Paul R.; Greenaway, Catherine; Haber, James; Halldin, Christer; Haller, Scott; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Hessmann, Manuela; Hsai, Ming Min; Khani, Yaser; Kotey, Adrian; Lembo, Angelo; Mangette, John E.; Marriner, Gwendolyn A.; Marston, Richard W.; Mills, Matthew R.; Monteagudo, Edith; Forsberg-Moren, Anton; Nag, Sangram; Orsatti, Laura; Sandiego, Christine; Schaertl, Sabine; Sproston, Joanne; Staelens, Steven; Tookey, Jack; Turner, Penelope A.; Vecchi, Andrea; Veneziano, Maria; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Dominguez, Celia

Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease

SCIENCE TRANSLATIONAL MEDICINE

IF14.6

2022-02-0217

Bertoglio, Daniele; Bard, Jonathan; Hessmann, Manuela; Liu, Longbin; Gaertner, Annette; De Lombaerde, Stef; Huscher, Britta; Zajicek, Franziska; Miranda, Alan; Peters, Finn; Herrmann, Frank; Schaertl, Sabine; Vasilkovska, Tamara; Brown, Christopher J.; Johnson, Peter D.; Prime, Michael E.; Mills, Matthew R.; Van der Linden, Annemie; Mrzljak, Ladislav; Khetarpal, Vinod; Wang, Yuchuan; Marchionini, Deanna M.; Skinbjerg, Mette; Verhaeghe, Jeroen; Dominguez, Celia; Staelens, Steven; Munoz-Sanjuan, Ignacio

Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates

SCIENTIFIC REPORTS

IF3.9

2021-09-0920

OAAI

Herrmann, Frank; Hessmann, Manuela; Schaertl, Sabine; Berg-Rosseburg, Karola; Brown, Christopher J.; Bursow, Galina; Chiki, Anass; Ebneth, Andreas; Gehrmann, Miriam; Hoeschen, Nicole; Hotze, Madlen; Jahn, Stefanie; Johnson, Peter D.; Khetarpal, Vinod; Kiselyov, Alex; Kottig, Karsten; Ladewig, Stefanie; Lashuel, Hilal; Letschert, Sven; Mills, Matthew R.; Petersen, Kathrin; Prime, Michael E.; Scheich, Christoph; Schmiedel, Gerhard; Wityak, John; Liu, Longbin; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.

[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-08-0516

PREAI

Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Lee, Matthew R.; Brown, Christopher J.; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Conlon, Mike; Davis, Randall; Ensor, Samantha; Esposito, Simone; Moren, Anton Forsberg; Gai, Xinjie; Green, Samantha; Greenaway, Catherine; Haber, James; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; He-mann, Manuela; Hsai, Ming Min; Kotey, Adrian; Mangette, John E.; Mills, Matthew R.; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Varnas, Katarina; Varrone, Andrea; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.; Dominguez, Celia

Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2020-07-1426

PREAI

Liu, Longbin; Prime, Michael E.; Lee, Matt R.; Khetarpal, Vinod; Brown, Christopher J.; Johnson, Peter D.; Miranda-Azpiazu, Patricia; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Davis, Randall; Dickie, Anthony; Ebneth, Andreas; Esposito, Simone; Gadouleau, Elise; Gai, Xinjie; Galan, Sebastien; Green, Samantha; Greenaway, Catherine; Giles, Paul; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Hessmann, Manuela; Jia, Zhisheng; Kiselyov, Alexander; Kotey, Adrian; Krulle, Thomas; Mangette, John E.; Marston, Richard W.; Menta, Sergio; Mills, Matthew R.; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Svedberg, Marie; Takano, Akihiro; Taylor, Malcolm; Thomas, Wayne; Toth, Miklos; Vaidya, Darshan; Vanras, Katarina; Weddell, Derek; Wigginton, Ian; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.; Dominguez, Celia

Development of a Series of Aryl Pyrimidine Kynurenine Monooxygenase Inhibitors as Potential Therapeutic Agents for the Treatment of Huntington's Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2015-01-2359

PREAI

Toledo-Sherman, Leticia M.; Prime, Michael E.; Mrzljak, Ladislav; Beconi, Maria G.; Beresford, Alan; Brookfield, Frederick A.; Brown, Christopher J.; Cardaun, Isabell; Courtney, Stephen M.; Dijkman, Ulrike; Hamelin-Flegg, Estelle; Johnson, Peter D.; Kempf, Valerie; Lyons, Kathy; Matthews, Kimberly; Mitchell, William L.; O'Connell, Catherine; Pena, Paula; Powell, Kendall; Rassoulpour, Arash; Reed, Laura; Reindl, Wolfgang; Selvaratnam, Suganathan; Friley, Weslyn Ward; Weddell, Derek A.; Went, Naomi E.; Wheelan, Patricia; Winkler, Christin; Winkler, Dirk; Wityak, John; Yarnold, Christopher J.; Yates, Dawn; Munoz-Sanjuan, Ignacio; Dominguez, Celia

CHDI-00340246, A KYNURENINE MONOOXYGENASE INHIBITOR AS POTENTIAL THERAPEUTIC AGENT FOR THE TREATMENT OF HUNTINGTON'S DISEASE

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

IF7.5

2014-09-170

PREAI

SAR Development of Lysine-Based Irreversible Inhibitors of Transglutaminase 2 for Huntington's Disease

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2012-10-0832

OAAI

Irreversible 4-Aminopiperidine Transglutaminase 2 Inhibitors for Huntington's Disease

ACS MEDICINAL CHEMISTRY LETTERS

IF4

2012-08-1323

OAAI

Discovery and Structure-Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington's Disease

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2012-01-2770

PREAI

Prime, Michael E.; Andersen, Ole A.; Barker, John J.; Brooks, Mark A.; Cheng, Robert K. Y.; Toogood-Johnson, Ian; Courtney, Stephen M.; Brookfield, Frederick A.; Yarnold, Christopher J.; Marston, Richard W.; Johnson, Peter D.; Johnsen, Siw F.; Palfrey, Jordan J.; Vaidya, Darshan; Erfan, Sayeh; Ichihara, Osamu; Felicetti, Brunella; Palan, Shilpa; Pedret-Dunn, Anna; Schaertl, Sabine; Sternberger, Ina; Ebneth, Andreas; Scheel, Andreas; Winkler, Dirk; Toledo-Sherman, Leticia; Beconi, Maria; Macdonald, Douglas; Munoz-Sanjuan, Ignacio; Dominguez, Celia; Wityak, John

Phthalazinone Pyrazoles as Potent, Selective, and Orally Bioavailable Inhibitors of Aurora-A Kinase

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2010-12-0383

PREAI

A novel route to preussomerins via 2-arylacetal anions

ORGANIC LETTERS

IF5

2000-05-0231

PREAI

Concise syntheses of γ-oxo-β,β-difluorinated amino acids via chelated [3,3]-rearrangement of difluoroallylic alcohols

JOURNAL OF ORGANIC CHEMISTRY