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C

Christopher J. Brown

evotec (u.k.) ltd, 114 innovation drive, milton park, abingdon ox14 4rz, u.k.
H指数:32
被引数:3,796

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Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin Aggregates

异吲哚酮类PET示踪剂用于成像突变亨廷蛋白聚集物

Journal of Medicinal Chemistry
IF6.8
2025-07-070
PRE
Longbin Liu; Peter D. Johnson; Matthew R. Mills; Penelope A. Turner; Michael E. Prime; Christopher J. Brown; Adrian Kotey; Samuel Coe; Paul R. Giles; Catherine Lloyd; Sarah Hayes; Frederic J. Marlin; Filippo Rota; Frank Herrmann; Manuela Heßmann; Sabine Schaertl; Franziska Zajicek; Stef De Lombaerde; Filipe Elvas; Jeroen Verhaeghe; Steven Staelens; Daniele Bertoglio; Xuemei Chen; Michael P. Conlon; Randall Davis; Samantha F. Ensor; James Haber; Kathryn C. Haber; Ming Min Hsai; John E. Mangette; William F. Penniman; Luca Anzillotti; Simone Esposito; Angelo Lembo; Laura Orsatti; Davide Ventre; Maria Veneziano; Christine Sandiego; Scott Haller; Gwendolyn A. Marriner; Ignacio Munoz-Sanjuan; Vinod Khetarpal; Jonathan A. Bard; Celia Dominguez
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists (vol 15, 489, 2024)

设计规则：具有体内活性的 stapled peptides 及其在 Mdm2/X 抗体中的应用（卷 15，489，2024）

NATURE COMMUNICATIONS
IF15.7
2025-02-130
OA
Chandramohan, Arun; Josien, Hubert; Yuen, Tsz Ying; Duggal, Ruchia; Spiegelberg, Diana; Yan, Lin; Juang, Yu-Chi Angela; Ge, Lan; Aronica, Pietro G.; Kaan, Hung Yi Kristal; Lim, Yee Hwee; Peier, Andrea; Sherborne, Brad; Hochman, Jerome; Lin, Songnian; Biswas, Kaustav; Nestor, Marika; Verma, Chandra S.; Lane, David P.; Sawyer, Tomi K.; Garbaccio, Robert; Henry, Brian; Kannan, Srinivasaraghavan; Brown, Christopher J.; Johannes, Charles W.; Partridge, Anthony W.
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
NATURE COMMUNICATIONS
IF15.7
2024-01-128
OAAI
Chandramohan, Arun; Josien, Hubert; Yuen, Tsz Ying; Duggal, Ruchia; Spiegelberg, Diana; Yan, Lin; Juang, Yu-Chi Angela; Ge, Lan; Aronica, Pietro G.; Kaan, Hung Yi Kristal; Lim, Yee Hwee; Peier, Andrea; Sherborne, Brad; Hochman, Jerome; Lin, Songnian; Biswas, Kaustav; Nestor, Marika; Verma, Chandra S.; Lane, David P.; Sawyer, Tomi K.; Garbaccio, Robert; Henry, Brian; Kannan, Srinivasaraghavan; Brown, Christopher J.; Johannes, Charles W.; Partridge, Anthony W.
A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays

一种高通量微流体机械加工平台，可在基于细胞的测定中实现环肽的细胞内递送

BIOENGINEERING & TRANSLATIONAL MEDICINE
IF5.7
2023-05-131
OAAI
Kasper, Stephen H.; Otten, Stephanie; Squadroni, Brian; Orr-Terry, Cionna; Kuang, Yi; Mussallem, Lily; Ge, Lan; Yan, Lin; Kannan, Srinivasaraghavan; Verma, Chandra S.; Brown, Christopher J.; Johannes, Charles W.; Lane, David P.; Chandramohan, Arun; Partridge, Anthony W.; Roberts, Lee R.; Josien, Hubert; Therien, Alex G.; Hett, Erik C.; Howell, Bonnie J.; Peier, Andrea; Ai, Xi; Cassaday, Jason
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-12-2211
PRE
Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Brown, Christopher J.; Anzillotti, Luca; Bertoglio, Daniele; Chen, Xuemei; Coe, Samuel; Davis, Randall; Dickie, Anthony P.; Esposito, Simone; Gadouleau, Elise; Giles, Paul R.; Greenaway, Catherine; Haber, James; Halldin, Christer; Haller, Scott; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Hessmann, Manuela; Hsai, Ming Min; Khani, Yaser; Kotey, Adrian; Lembo, Angelo; Mangette, John E.; Marriner, Gwendolyn A.; Marston, Richard W.; Mills, Matthew R.; Monteagudo, Edith; Forsberg-Moren, Anton; Nag, Sangram; Orsatti, Laura; Sandiego, Christine; Schaertl, Sabine; Sproston, Joanne; Staelens, Steven; Tookey, Jack; Turner, Penelope A.; Vecchi, Andrea; Veneziano, Maria; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Dominguez, Celia
Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2022-02-0217
OA
Bertoglio, Daniele; Bard, Jonathan; Hessmann, Manuela; Liu, Longbin; Gaertner, Annette; De Lombaerde, Stef; Huscher, Britta; Zajicek, Franziska; Miranda, Alan; Peters, Finn; Herrmann, Frank; Schaertl, Sabine; Vasilkovska, Tamara; Brown, Christopher J.; Johnson, Peter D.; Prime, Michael E.; Mills, Matthew R.; Van der Linden, Annemie; Mrzljak, Ladislav; Khetarpal, Vinod; Wang, Yuchuan; Marchionini, Deanna M.; Skinbjerg, Mette; Verhaeghe, Jeroen; Dominguez, Celia; Staelens, Steven; Munoz-Sanjuan, Ignacio
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
SCIENTIFIC REPORTS
IF3.9
2021-09-0920
OAAI
Herrmann, Frank; Hessmann, Manuela; Schaertl, Sabine; Berg-Rosseburg, Karola; Brown, Christopher J.; Bursow, Galina; Chiki, Anass; Ebneth, Andreas; Gehrmann, Miriam; Hoeschen, Nicole; Hotze, Madlen; Jahn, Stefanie; Johnson, Peter D.; Khetarpal, Vinod; Kiselyov, Alex; Kottig, Karsten; Ladewig, Stefanie; Lashuel, Hilal; Letschert, Sven; Mills, Matthew R.; Petersen, Kathrin; Prime, Michael E.; Scheich, Christoph; Schmiedel, Gerhard; Wityak, John; Liu, Longbin; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-08-0516
PREAI
Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Lee, Matthew R.; Brown, Christopher J.; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Conlon, Mike; Davis, Randall; Ensor, Samantha; Esposito, Simone; Moren, Anton Forsberg; Gai, Xinjie; Green, Samantha; Greenaway, Catherine; Haber, James; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; He-mann, Manuela; Hsai, Ming Min; Kotey, Adrian; Mangette, John E.; Mills, Matthew R.; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Varnas, Katarina; Varrone, Andrea; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.; Dominguez, Celia
NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay
ACS CHEMICAL BIOLOGY
IF3.8
2021-02-0434
PREAI
Peier, Andrea; Ge, Lan; Boyer, Nicolas; Frost, John; Duggal, Ruchia; Biswas, Kaustav; Edmondson, Scott; Hermes, Jeffrey D.; Yan, Lin; Zimprich, Chad; Sadruddin, Ahmad; Kaan, Hung Yi Kristal; Chandramohan, Arun; Brown, Christopher J.; Thean, Dawn; Lee, Xue Er; Yuen, Tsz Ying; Ferrer-Gago, Fernando J.; Johannes, Charles W.; Lane, David P.; Sherborne, Brad; Corona, Cesear; Robers, Matthew B.; Sawyer, Tomi K.; Partridge, Anthony W.
Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling
CHEMICAL SCIENCE
IF7.4
2021-01-0114
OAAI
Lim, Shuhui; Boyer, Nicolas; Boo, Nicole; Huang, Chunhui; Venkatachalam, Gireedhar; Juang, Yu-Chi Angela; Garrigou, Michael; Kaan, Kristal; Duggal, Ruchia; Peh, Khong Ming; Sadruddin, Ahmad; Gopal, Pooja; Yuen, Tsz Ying; Ng, Simon; Kannan, Srinivasaraghavan; Brown, Christopher J.; Verma, Chandra; Orth, Peter; Peier, Andrea; Ge, Lan; Yu, Xiang; Bhatt, Bhavana; Chen, Feifei; Wang, Erjia; Li, Nianyu Jason; Gonzales, Raymond J.; Stoeck, Alexander; Henry, Brian; Sawyer, Tomi K.; Lane, David; Johannes, Charles W.; Biswas, Kaustav; Partridge, Anthony W.
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-07-1426
PREAI
Liu, Longbin; Prime, Michael E.; Lee, Matt R.; Khetarpal, Vinod; Brown, Christopher J.; Johnson, Peter D.; Miranda-Azpiazu, Patricia; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Davis, Randall; Dickie, Anthony; Ebneth, Andreas; Esposito, Simone; Gadouleau, Elise; Gai, Xinjie; Galan, Sebastien; Green, Samantha; Greenaway, Catherine; Giles, Paul; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Hessmann, Manuela; Jia, Zhisheng; Kiselyov, Alexander; Kotey, Adrian; Krulle, Thomas; Mangette, John E.; Marston, Richard W.; Menta, Sergio; Mills, Matthew R.; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Svedberg, Marie; Takano, Akihiro; Taylor, Malcolm; Thomas, Wayne; Toth, Miklos; Vaidya, Darshan; Vanras, Katarina; Weddell, Derek; Wigginton, Ian; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.; Dominguez, Celia

研究方向

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D
David P. Lane
H 指数:136论文数:960被引数:7.8万
C
Chandra Verma
H 指数:62论文数:531被引数:1.5万
C
Charles W. Johannes
H 指数:26论文数:77被引数:1,951
A
Anthony W. Partridge
H 指数:28论文数:75被引数:3,501
S
Srinivasaraghavan Kannan
H 指数:31论文数:121被引数:2,880
T
Tsz Ying Yuen
H 指数:15论文数:39被引数:571
P
Peter Johnson
H 指数:36论文数:156被引数:3,872
M
Michael E. Prime
H 指数:17论文数:33被引数:730
I
Ignacio Muñoz-Sanjuán
H 指数:39论文数:137被引数:6,056
C
Celia Dominguez
H 指数:37论文数:145被引数:3,726