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V

Vinod Khetarpal

chdi foundation, inc.
H指数:17
被引数:728

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In Vivo PET Imaging of [18F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington DiseaseDisease

[18F]CHDI-385的体内PET成像，该放射性配体用于亨廷顿病小鼠模型中突变亨廷顿蛋白聚集物的检测

Journal of Nuclear Medicine
IF9.1
2026-02-010
PRE
Zajicek, Franziska; Elvas, Filipe; Miranda, Alan; Akkermans, Jordy; Verhaeghe, Jeroen; Dominguez, Celia; Doot, Robert; Khetarpal, Vinod; Bard, Jonathan; Liu, Longbin; Staelens, Steven; Bertoglio, Daniele
Isoindolinone-Based PET Tracers for Imaging Mutant Huntingtin Aggregates

异吲哚酮类PET示踪剂用于成像突变亨廷蛋白聚集物

Journal of Medicinal Chemistry
IF6.8
2025-07-070
PRE
Longbin Liu; Peter D. Johnson; Matthew R. Mills; Penelope A. Turner; Michael E. Prime; Christopher J. Brown; Adrian Kotey; Samuel Coe; Paul R. Giles; Catherine Lloyd; Sarah Hayes; Frederic J. Marlin; Filippo Rota; Frank Herrmann; Manuela Heßmann; Sabine Schaertl; Franziska Zajicek; Stef De Lombaerde; Filipe Elvas; Jeroen Verhaeghe; Steven Staelens; Daniele Bertoglio; Xuemei Chen; Michael P. Conlon; Randall Davis; Samantha F. Ensor; James Haber; Kathryn C. Haber; Ming Min Hsai; John E. Mangette; William F. Penniman; Luca Anzillotti; Simone Esposito; Angelo Lembo; Laura Orsatti; Davide Ventre; Maria Veneziano; Christine Sandiego; Scott Haller; Gwendolyn A. Marriner; Ignacio Munoz-Sanjuan; Vinod Khetarpal; Jonathan A. Bard; Celia Dominguez
Identification and Optimization of RNA-Splicing Modulators as Huntingtin Protein-Lowering Agents for the Treatment of Huntington's Disease
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-09-154
PRE
Liu, Longbin; Malagu, Karine; Haughan, Alan F.; Khetarpal, Vinod; Stott, Andrew J.; Esmieu, William; Vater, Huw D.; Webster, Stephen J.; van de Poel, Amanda J.; Clissold, Cole; Cosgrove, Brett; Sutton, Benjamin; Spencer, Jonathan A.; Breccia, Perla; Gancia, Emanuela; Bonomo, Silvia; Ladduwahetty, Tammy; Lazari, Ovadia; Patel, Hiral; Atton, Helen C.; Clifton, Steve; Mota, Daniel M.; Magnani, Dario; O'Neill, Amy; Stebbeds, Marta; Macabuag, Natsuko; Todd, Daniel; Herva, Maria E.; Mitchell, Philip; Visser, Mijke; Compte Sancerni, Sara; Grand Moursel, Laure; da Silva, Marta; Kritikou, Eva; Heikkinen, Taneli T.; Bolkvadze, Tamuna; Fodale, Valentina; Spadafora, Debora; Daldin, Manuel; Bresciani, Alberto; Mangette, John E.; Doherty, Elizabeth M.; Lee, Matthew R.; Herbst, Todd; Monteagudo, Edith; Macdonald, Douglas; Plotnikov, Nikolay V.; Chambers, Mark; Mcallister, George; Munoz-Sanjuan, Ignacio; Dominguez, Celia
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-12-2211
PRE
Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Brown, Christopher J.; Anzillotti, Luca; Bertoglio, Daniele; Chen, Xuemei; Coe, Samuel; Davis, Randall; Dickie, Anthony P.; Esposito, Simone; Gadouleau, Elise; Giles, Paul R.; Greenaway, Catherine; Haber, James; Halldin, Christer; Haller, Scott; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Hessmann, Manuela; Hsai, Ming Min; Khani, Yaser; Kotey, Adrian; Lembo, Angelo; Mangette, John E.; Marriner, Gwendolyn A.; Marston, Richard W.; Mills, Matthew R.; Monteagudo, Edith; Forsberg-Moren, Anton; Nag, Sangram; Orsatti, Laura; Sandiego, Christine; Schaertl, Sabine; Sproston, Joanne; Staelens, Steven; Tookey, Jack; Turner, Penelope A.; Vecchi, Andrea; Veneziano, Maria; Munoz-Sanjuan, Ignacio; Bard, Jonathan; Dominguez, Celia
Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model
JCI INSIGHT
IF6.1
2022-10-244
OA
Marchionini, Deanna M.; Liu, Jeh-Ping; Ambesi-Impiombato, Alberto; Kerker, Kimberly; Cirillo, Kim; Bansal, Mukesh; Mushlin, Rich; Brunner, Daniela; Ramboz, Sylvie; Kwan, Mei; Kuhlbrodt, Kirsten; Tillack, Karsten; Peters, Finn; Rauhala, Leena; Obenauer, John; Greene, Jonathan R.; Hartl, Christopher; Khetarpal, Vinod; Lager, Brenda; Rosinski, Jim; Aaronson, Jeff; Alam, Morshed; Signer, Ethan; Munoz-Sanjuan, Ignacio; Howland, David; Zeitlin, Scott O.
Biodistribution and dosimetry in human healthy volunteers of the PET radioligands [11C]CHDI-00485180-R and [11C]CHDI-00485626, designed for quantification of cerebral aggregated mutant huntingtin
European Journal of Nuclear Medicine and Molecular Imaging
IF7.6
2022-08-247
PRE
Delva, Aline; Koole, Michel; Serdons, Kim; Bormans, Guy; Liu, Longbin; Bard, Jonathan; Khetarpal, Vinod; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Wood, Andrew; Skinbjerg, Mette; Wang, Yuchuan; Vandenberghe, Wim; Van Laere, Koen
Development of a ligand for in vivo imaging of mutant huntingtin in Huntington's disease
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2022-02-0217
OA
Bertoglio, Daniele; Bard, Jonathan; Hessmann, Manuela; Liu, Longbin; Gaertner, Annette; De Lombaerde, Stef; Huscher, Britta; Zajicek, Franziska; Miranda, Alan; Peters, Finn; Herrmann, Frank; Schaertl, Sabine; Vasilkovska, Tamara; Brown, Christopher J.; Johnson, Peter D.; Prime, Michael E.; Mills, Matthew R.; Van der Linden, Annemie; Mrzljak, Ladislav; Khetarpal, Vinod; Wang, Yuchuan; Marchionini, Deanna M.; Skinbjerg, Mette; Verhaeghe, Jeroen; Dominguez, Celia; Staelens, Steven; Munoz-Sanjuan, Ignacio
Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
SCIENTIFIC REPORTS
IF3.9
2021-09-0920
OAAI
Herrmann, Frank; Hessmann, Manuela; Schaertl, Sabine; Berg-Rosseburg, Karola; Brown, Christopher J.; Bursow, Galina; Chiki, Anass; Ebneth, Andreas; Gehrmann, Miriam; Hoeschen, Nicole; Hotze, Madlen; Jahn, Stefanie; Johnson, Peter D.; Khetarpal, Vinod; Kiselyov, Alex; Kottig, Karsten; Ladewig, Stefanie; Lashuel, Hilal; Letschert, Sven; Mills, Matthew R.; Petersen, Kathrin; Prime, Michael E.; Scheich, Christoph; Schmiedel, Gerhard; Wityak, John; Liu, Longbin; Dominguez, Celia; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.
[11C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-08-0516
PREAI
Liu, Longbin; Johnson, Peter D.; Prime, Michael E.; Khetarpal, Vinod; Lee, Matthew R.; Brown, Christopher J.; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Conlon, Mike; Davis, Randall; Ensor, Samantha; Esposito, Simone; Moren, Anton Forsberg; Gai, Xinjie; Green, Samantha; Greenaway, Catherine; Haber, James; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; He-mann, Manuela; Hsai, Ming Min; Kotey, Adrian; Mangette, John E.; Mills, Matthew R.; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Varnas, Katarina; Varrone, Andrea; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.; Dominguez, Celia
Imaging Mutant Huntingtin Aggregates: Development of a Potential PET Ligand
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-07-1426
PREAI
Liu, Longbin; Prime, Michael E.; Lee, Matt R.; Khetarpal, Vinod; Brown, Christopher J.; Johnson, Peter D.; Miranda-Azpiazu, Patricia; Chen, Xuemei; Clark-Frew, Daniel; Coe, Samuel; Davis, Randall; Dickie, Anthony; Ebneth, Andreas; Esposito, Simone; Gadouleau, Elise; Gai, Xinjie; Galan, Sebastien; Green, Samantha; Greenaway, Catherine; Giles, Paul; Halldin, Christer; Hayes, Sarah; Herbst, Todd; Herrmann, Frank; Hessmann, Manuela; Jia, Zhisheng; Kiselyov, Alexander; Kotey, Adrian; Krulle, Thomas; Mangette, John E.; Marston, Richard W.; Menta, Sergio; Mills, Matthew R.; Monteagudo, Edith; Nag, Sangram; Nibbio, Martina; Orsatti, Laura; Schaertl, Sabine; Scheich, Christoph; Sproston, Joanne; Stepanov, Vladimir; Svedberg, Marie; Takano, Akihiro; Taylor, Malcolm; Thomas, Wayne; Toth, Miklos; Vaidya, Darshan; Vanras, Katarina; Weddell, Derek; Wigginton, Ian; Wityak, John; Mrzljak, Ladislav; Munoz-Sanjuan, Ignacio; Bard, Jonathan A.; Dominguez, Celia
Establishment of an in Vitro Human Blood-Brain Barrier Model Derived from Induced Pluripotent Stem Cells and Comparison to a Porcine Cell-Based System
CELLS
IF5.2
2020-04-1627
OAAI
Di Marco, Annalise; Vignone, Domenico; Paz, Odalys Gonzalez; Fini, Ivan; Battista, Maria Rosaria; Cellucci, Antonella; Bracacel, Elena; Auciello, Giulio; Veneziano, Maria; Khetarpal, Vinod; Rose, Mark; Rosa, Alessandro; Gloaguen, Isabelle; Monteagudo, Edith; Herbst, Todd; Dominguez, Celia; Munoz-Sanjuan, Ignacio

研究方向

暂未获取到该数据
J
Jonathan Bard
H 指数:34论文数:98被引数:5,635
I
Ignacio Muñoz-Sanjuán
H 指数:39论文数:137被引数:6,075
L
Longbin Liu
H 指数:6论文数:32被引数:185
D
Daniele Bertoglio
H 指数:20论文数:82被引数:883
C
Celia Dominguez
H 指数:37论文数:145被引数:3,735
S
Steven Staelens
H 指数:39论文数:400被引数:7,818
J
Jeroen Verhaeghe
H 指数:31论文数:165被引数:2,832
A
Alan Miranda
H 指数:14论文数:64被引数:582
F
Franziska Zajicek
H 指数:5论文数:21被引数:147
P
Peter Johnson
H 指数:36论文数:156被引数:3,875