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Efficacy of MEDI0618, a pH-dependent monoclonal antibody targeting PAR2, in preclinical models of migraine MEDI0618(一种pH依赖性的靶向PAR2的单克隆抗体)在偏头痛预临床模型中的疗效 Kopruszinski, Caroline M.; Linley, John E.; Thornton, Peter; Walker, Alison S.; Newton, Philip; Podichetty, Sadhana; Ruparel, Radhey Hemendra; de Souza, Luiz Henrique Moreira; Navratilova, Edita; Meno-Tetang, Guy; Gurrell, Ian; Dodick, David W.; Dobson, Claire; Chessell, Tharani; Porreca, Frank; Chessell, Iain 分享 收藏
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MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non-clinical species and Alzheimer's disease patients Lloyd, Christopher; Freskgard, Per-Ola; Newton, Philip; Lowne, David; Nickson, Adrian; Bogstedt, Anna; Eketjall, Susanna; Hoglund, Kina; Gustavsson, Susanne; Welsh, Fraser; Chessell, Tharani; McFarlane, Mary; Bhat, Ratan V.; Turner, Richard; Perkinton, Michael S.; Santisteban Valencia, Zulma; Lindqvist, Eva; Pomfret, Michael; Dudley, Amanda D.; Vaughan, Tristan J.; Groves, Maria T.; Natanegara, Fanni; Feng, Yingdong; Sims, John R.; Proctor, Nicholas Kyle; Dage, Jeffrey L.; Shering, Craig; Tan, Keith; Ostenfeld, Thor; Billinton, Andy; Chessell, Iain P. 分享 收藏
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Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries Boland, Brandon B.; Laker, Rhianna C.; O'Brien, Siobhan; Sitaula, Sadichha; Sermadiras, Isabelle; Nielsen, Jens Christian; Barkholt, Pernille; Roostalu, Urmas; Hecksher-Sorensen, Jacob; Sejthen, Sara Rubek; Thorbek, Ditte Dencker; Suckow, Arthur; Burmeister, Nicole; Oldham, Stephanie; Will, Sarah; Howard, Victor G.; Gill, Benji M.; Newton, Philip; Naylor, Jacqueline; Hornigold, David C.; Austin, Jotham; Lantier, Louise; McGuinness, Owen P.; Trevaskis, James L.; Grimsby, Joseph S.; Rhodes, Christopher J. 分享 收藏
Characterization and preclinical evaluation of a protease activated receptor 2 (PAR2) monoclonal antibody as a preventive therapy for migraine Kopruszinski, Caroline M.; Thornton, Peter; Arnold, Joanne; Newton, Philip; Lowne, David; Navratilova, Edita; Swiokla, Juliana; Dodick, David W.; Dobson, Claire; Gurrell, Ian; Chessell, Iain Patrick; Porreca, Frank 分享 收藏
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Discovery and characterisation of an antibody that selectively modulates the inhibitory activity of plasminogen activator inhibitor-1 Vousden, Katherine A.; Lundqvist, Tomas; Popovic, Bojana; Naiman, Brian; Carruthers, Alan M.; Newton, Philip; Johnson, Daniel J. D.; Pomowski, Anja; Wilkinson, Trevor; Dufner, Patrick; de Mendez, Isabelle; Mallinder, Philip R.; Murray, Clare; Strain, Martin; Connor, Jane; Murray, Lynne A.; Sleeman, Matthew A.; Lowe, David C.; Huntington, James A.; Vaughan, Tristan J. 分享 收藏
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