Jacob C. Ulirsch - Publications, H-index & Citations

Jacob C. Ulirsch

Broad Institute of MIT and Harvard

46H指数

118论文数

1.3W被引数

收录论文 46

发表时间

An encyclopedia of human enhancer–gene regulatory interactions 人类增强子-基因调控互作百科全书

Nature

IF48.5

2026-07-15

OAAI

Andreas R. Gschwind; Kristy S. Mualim; Alireza Karbalayghareh; Maya U. Sheth; Kushal K. Dey; Evelyn Jagoda; Ramil N. Nurtdinov; Wang Xi; Anthony S. Tan; James Galante; Hank Jones; X. Rosa Ma; David Yao; Dulguun Amgalan; Judhajeet Ray; Chad J. Munger; Joseph Nasser; Žiga Avsec; Benjamin T. James; Muhammad S. Shamim; Neva C. Durand; Suhas S. P. Rao; Ragini Mahajan; Benjamin R. Doughty; Kalina Andreeva; Jacob C. Ulirsch; Kaili Fan; Elizabeth M. Perez; Tri C. Nguyen; David R. Kelley; Hilary K. Finucane; Jill E. Moore; Zhiping Weng; Manolis Kellis; Michael C. Bassik; Berk Ustun; Alkes L. Price; Michael A. Beer; Roderic Guigó; John A. Stamatoyannopoulos; Erez Lieberman Aiden; William J. Greenleaf; Christina S. Leslie; Lars M. Steinmetz; Anshul Kundaje; Jesse M. Engreitz

Functional dissection of complex trait variants at single-nucleotide resolution 在单核苷酸分辨率下对复杂性状变异的功能解析

Nature

IF48.5

2026-02-25

OAAI

Layla Siraj; Rodrigo I. Castro; Hannah B. Dewey; Susan Kales; John C. Butts; Thanh Thanh L. Nguyen; Masahiro Kanai; Daniel Berenzy; Kousuke Mouri; Qingbo S. Wang; Petko P. Fiziev; Kristin Tsuo; Zachary R. McCaw; Sager J. Gosai; François Aguet; Ran Cui; Irfahan Kassam; Jeremy McRae; Christopher M. Vockley; Caleb A. Lareau; Sergey Abramov; Alexandr Boystov; Jeff Vierstra; Yukinori Okada; Alexander Gusev; Thouis R. Jones; Eric S. Lander; Pardis C. Sabeti; Hilary K. Finucane; Steven K. Reilly; Jacob C. Ulirsch; Ryan Tewhey

Predicting expression-altering promoter mutations with deep learning 利用深度学习预测改变表达量的启动子突变

Science

IF45.8

2025-05-29

PREAI

Kishore Jaganathan; Nicole Ersaro; Gherman Novakovsky; Yuchuan Wang; Terena James; Jeremy Schwartzentruber; Petko Fiziev; Irfahan Kassam; Fan Cao; Johann Hawe; Henry Cavanagh; Ashley Lim; Grace Png; Jeremy McRae; Abhimanyu Banerjee; Arvind Kumar; Jacob Ulirsch; Yan Zhang; Francois Aguet; Pierrick Wainschtein; Laksshman Sundaram; Adriana Salcedo; Sofia Kyriazopoulou Panagiotopoulou; Delasa Aghamirzaie; Evin Padhi; Ziming Weng; Shan Dong; Damian Smedley; Mark Caulfield; Anne O’Donnell-Luria; Heidi L. Rehm; Stephan J. Sanders; Anshul Kundaje; Stephen B. Montgomery; Mark T. Ross; Kyle Kai-How Farh

Massively Parallel Characterization of Thousands of Type 2 Diabetes-Associated Variants in Multiple Cell Types Nominates Candidate Causal Regulatory Alleles and Mechanisms

DIABETES

IF7.5

2024-06-14

PREAI

Kothari, Madhav; Bhuiyan, Redwan M.; Ulirsch, Jacob C.; Dewey, Hannah; Nerurkar, Niketa; Kursawe, Romy; Kales, Susan; Berenzy, Daniel; Tewhey, Ryan; Stitzel, Michael L.

Improving fine-mapping by modeling infinitesimal effects 通过对无穷小效应建模来改善精细映射

NATURE GENETICS

IF31.8

2023-11-30

OAAI

Cui, Ran; Elzur, Roy A.; Kanai, Masahiro; Ulirsch, Jacob C.; Weissbrod, Omer; Daly, Mark J.; Neale, Benjamin M.; Fan, Zhou; Finucane, Hilary K.

RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation RNA聚合酶II暂时暂停协调细胞周期进程和红系分化

DEVELOPMENTAL CELL

IF8.7

2023-10-01

OAAI

Martell, Danya J.; Merens, Hope E.; Caulier, Alexis; Fiorini, Claudia; Ulirsch, Jacob C.; Ietswaart, Robert; Choquet, Karine; Graziadei, Giovanna; Brancaleoni, Valentina; Cappellini, Maria Domenica; Scott, Caroline; Roberts, Nigel; Proven, Melanie; Roy, Noemi B. A.; Babbs, Christian; Higgs, Douglas R.; Sankarsn, Vijay G.; Churchman, L. Stirling

eQTL Catalogue 2023: New datasets, X chromosome QTLs, and improved detection and visualisation of transcript-level QTLs

PLOS GENETICS

IF3.7

2023-09-18

OAAI

Kerimov, Nurlan; Tambets, Ralf; Hayhurst, James D.; Rahu, Ida; Kolberg, Peep; Raudvere, Uku; Kuzmin, Ivan; Chowdhary, Anshika; Vija, Andreas; Teras, Hans J.; Kanai, Masahiro; Ulirsch, Jacob; Ryten, Mina; Hardy, John; Guelfi, Sebastian; Trabzuni, Daniah; Kim-Hellmuth, Sarah; Rayner, William; Finucane, Hilary; Peterson, Hedi; Mosaku, Abayomi; Parkinson, Helen; Alasoo, Kaur

Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases 利用基因特征的多基因富集来预测复杂性状和疾病背后的基因

NATURE GENETICS

IF31.8

2023-07-13

OAAI

Weeks, Elle M. M.; Ulirsch, Jacob C. C.; Cheng, Nathan Y. Y.; Trippe, Brian L. L.; Fine, Rebecca S. S.; Miao, Jenkai; Patwardhan, Tejal A. A.; Kanai, Masahiro; Nasser, Joseph; Fulco, Charles P. P.; Tashman, Katherine C. C.; Aguet, Francois; Li, Taibo; Ordovas-Montanes, Jose; Smillie, Christopher S. S.; Biton, Moshe; Shalek, Alex K. K.; Ananthakrishnan, Ashwin N. N.; Xavier, Ramnik J. J.; Regev, Aviv; Gupta, Rajat M. M.; Lage, Kasper; Ardlie, Kristin G. G.; Hirschhorn, Joel N. N.; Lander, Eric S. S.; Engreitz, Jesse M. M.; Finucane, Hilary K. K.

Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants 超过一百万参与者的冠状动脉疾病风险变异和基因的发现和系统表征

NATURE GENETICS

IF31.8

2022-12-06

200

OAAI

Aragam, Krishna G.; Jiang, Tao; Goel, Anuj; Kanoni, Stavroula; Wolford, Brooke N.; Atri, Deepak S.; Weeks, Elle M.; Wang, Minxian; Hindy, George; Zhou, Wei; Grace, Christopher; Roselli, Carolina; Marston, Nicholas A.; Kamanu, Frederick K.; Surakka, Ida; Venegas, Loreto Munoz; Sherliker, Paul; Koyama, Satoshi; Ishigaki, Kazuyoshi; Asvold, Bjorn O.; Brown, Michael R.; Brumpton, Ben; de Vries, Paul S.; Giannakopoulou, Olga; Giardoglou, Panagiota; Gudbjartsson, Daniel F.; Gueldener, Ulrich; Haider, Syed M. Ijlal; Helgadottir, Anna; Ibrahim, Maysson; Kastrati, Adnan; Kessler, Thorsten; Kyriakou, Theodosios; Konopka, Tomasz; Li, Ling; Ma, Lijiang; Meitinger, Thomas; Mucha, Soeren; Munz, Matthias; Murgia, Federico; Nielsen, Jonas B.; Noethen, Markus M.; Pang, Shichao; Reinberger, Tobias; Schnitzler, Gavin; Smedley, Damian; Thorleifsson, Gudmar; von Scheidt, Moritz; Ulirsch, Jacob C.; Arnar, David O.; Burtt, Noel P.; Costanzo, Maria C.; Flannick, Jason; Ito, Kaoru; Jang, Dong-Keun; Kamatani, Yoichiro; Khera, Amit V.; Komuro, Issei; Kullo, Iftikhar J.; Lotta, Luca A.; Nelson, Christopher P.; Roberts, Robert; Thorgeirsson, Gudmundur; Thorsteinsdottir, Unnur; Webb, Thomas R.; Baras, Aris; Bjoerkegren, Johan L. M.; Boerwinkle, Eric; Dedoussis, George; Holm, Hilma; Hveem, Kristian; Melander, Olle; Morrison, Alanna C.; Orho-Melander, Marju; Rallidis, Loukianos S.; Ruusalepp, Arno; Sabatine, Marc S.; Stefansson, Kari; Zalloua, Pierre; Ellinor, Patrick T.; Farrall, Martin; Danesh, John; Ruff, Christian T.; Finucane, Hilary K.; Hopewell, Jemma C.; Clarke, Robert; Gupta, Rajat M.; Erdmann, Jeanette; Samani, Nilesh J.; Schunkert, Heribert; Watkins, Hugh; Willer, Cristen J.; Deloukas, Panos; Kathiresan, Sekar; Butterworth, Adam S.

Functional characterization of T2D-associated SNP effects on baseline and ER stress-responsive β cell transcriptional activation

NATURE COMMUNICATIONS

IF15.7

2021-09-02

OAAI

Khetan, Shubham; Kales, Susan; Kursawe, Romy; Jillette, Alexandria; Ulirsch, Jacob C.; Reilly, Steven K.; Ucar, Duygu; Tewhey, Ryan; Stitzel, Michael L.

Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR-FlowFISH 使用hcr-flowfish直接表征顺式调节元件和复杂遗传关联的功能解剖

NATURE GENETICS

IF31.8

2021-07-29

OAAI

Reilly, Steven K.; Gosai, Sager J.; Gutierrez, Alan; Mackay-Smith, Ava; Ulirsch, Jacob C.; Kanai, Masahiro; Mouri, Kousuke; Berenzy, Daniel; Kales, Susan; Butler, Gina M.; Gladden-Young, Adrianne; Bhuiyan, Redwan M.; Stitzel, Michael L.; Finucane, Hilary K.; Sabeti, Pardis C.; Tewhey, Ryan

Leveraging supervised learning for functionally informed fine-mapping of cis-eQTLs identifies an additional 20,913 putative causal eQTLs 利用监督学习进行cis-eqtl的功能信息精细映射，可以识别额外的20,913个假定的因果eqtl

NATURE COMMUNICATIONS

IF15.7

2021-06-07

OAAI

Wang, Qingbo S.; Kelley, David R.; Ulirsch, Jacob; Kanai, Masahiro; Sadhuka, Shuvom; Cui, Ran; Albors, Carlos; Cheng, Nathan; Okada, Yukinori; Aguet, Francois; Ardlie, Kristin G.; MacArthur, Daniel G.; Finucane, Hilary K.

Tractor uses local ancestry to enable the inclusion of admixed individuals in GWAS and to boost power

NATURE GENETICS

IF31.8

2021-01-18

121

OAAI

Atkinson, Elizabeth G.; Maihofer, Adam X.; Kanai, Masahiro; Martin, Alicia R.; Karczewski, Konrad J.; Santoro, Marcos L.; Ulirsch, Jacob C.; Kamatani, Yoichiro; Okada, Yukinori; Finucane, Hilary K.; Koenen, Karestan C.; Nievergelt, Caroline M.; Daly, Mark J.; Neale, Benjamin M.

Functionally informed fine-mapping and polygenic localization of complex trait heritability 复杂性状遗传力的功能信息精细定位和多基因定位

NATURE GENETICS

IF31.8

2020-11-16

149

OAAI

Weissbrod, Omer; Hormozdiari, Farhad; Benner, Christian; Cui, Ran; Ulirsch, Jacob; Gazal, Steven; Schoech, Armin P.; van de Geijn, Bryce; Reshef, Yakir; Marquez-Luna, Carla; O'Connor, Luke; Pirinen, Matti; Finucane, Hilary K.; Price, Alkes L.

Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features 使用功能和基因组特征对TNFAIP3基因座上的疾病和性状因果变异进行优先排序

NATURE COMMUNICATIONS

IF15.7

2020-03-06

OAAI

Ray, John P.; de Boer, Carl G.; Fulco, Charles P.; Lareau, Caleb A.; Kanai, Masahiro; Ulirsch, Jacob C.; Tewhey, Ryan; Ludwig, Leif S.; Reilly, Steven K.; Bergman, Drew T.; Engreitz, Jesse M.; Issner, Robbyn; Finucane, Hilary K.; Lander, Eric S.; Regev, Aviv; Hacohen, Nir

Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation 通过LIN28B-mediated调节BCL11A翻译来控制人类血红蛋白的转换

NATURE GENETICS

IF31.8

2020-01-20

OAAI

Basak, Anindita; Munschauer, Mathias; Lareau, Caleb A.; Montbleau, Kara E.; Ulirsch, Jacob C.; Hartigan, Christina R.; Schenone, Monica; Lian, John; Wang, Yaomei; Huang, Yumin; Wu, Xianfang; Gehrke, Lee; Rice, Charles M.; An, Xiuli; Christou, Helen A.; Mohandas, Narla; Carr, Steven A.; Chen, Jane-Jane; Orkin, Stuart H.; Lander, Eric S.; Sankaran, Vijay G.

X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation (vol 125, pg 1665, 2015)

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2020-01-02

OAAI

Sankaran, Vijay G.; Ulirsch, Jacob C.; Tchaikovskii, Vassili; Ludwig, Leif S.; Wakabayashi, Aoi; Kadirvel, Senkottuvelan; Lindsley, R. Coleman; Bejar, Rafael; Shi, Jiahai; Lovitch, Scott B.; Bishop, David F.; Steensma, David P.

Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis

CELL REPORTS

IF6.9

2019-06-01

110

OAAI

Ludwig, Leif S.; Lareau, Caleb A.; Bao, Erik L.; Nandakumar, Satish K.; Muus, Christoph; Ulirsch, Jacob C.; Chowdhary, Kaitavjeet; Buenrostro, Jason D.; Mohandas, Narla; An, Xiuli; Aryee, Martin J.; Regev, Aviv; Sankaran, Vijay G.

Gene-centric functional dissection of human genetic variation uncovers regulators of hematopoiesis

ELIFE

IF0

2019-05-09

OAAI

Nandakumar, Satish K.; McFarland, Sean K.; Mateyka, Laura M.; Lareau, Caleb A.; Ulirsch, Jacob C.; Ludwig, Leif S.; Agarwal, Gaurav; Engreitz, Jesse M.; Przychodzen, Bartlomiej; McConkey, Marie; Cowley, Glenn S.; Doench, John G.; Maciejewski, Jaroslaw P.; Ebert, Benjamin L.; Root, David E.; Sankaran, Vijay G.

HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis HRI协调红细胞生成中蛋白质稳态和线粒体功能所需的翻译

ELIFE

IF0

2019-04-29

OAAI

Zhang, Shuping; Macias-Garcia, Alejandra; Ulirsch, Jacob C.; Velazquez, Jason; Butty, Vincent L.; Levine, Stuart S.; Sankaran, Vijay G.; Chen, Jane-Jane

研究方向