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Giuseppe Felice Mangiatordi

national research council of italy

35H指数
146论文数
4.1K被引数
收录论文 82
发表时间
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Fatty acid amide hydrolase (FAAH) inhibitor design and preclinical studies: lessons learned from BIA 10–2474 and the challenges ahead脂肪酸酰胺水解酶（FAAH）抑制剂的设计与临床前研究：从BIA 10–2474中吸取的教训及面临的挑战
errExpert Opinion on Drug Discovery
IF4.9
err2026-08-19
err0
errOAAI
errAlessia Catalano; Filomena Fezza; Andrea Duranti; Maria Maddalena Cavalluzzi; Giovanni Lentini; Giuseppe Felice Mangiatordi; Marco Bruno Luigi Rocchi; Mauro Maccarrone
err分享
err收藏
A Reinforcement Learning-Guided Genetic Algorithm Integrating Medicinal Chemistry-Inspired Molecular Transformations强化学习引导的整合药物化学启发式分子转化的遗传算法
errJournal of Chemical Information and Modeling
IF5.3
err2026-04-16
err0
errOAAI
errDomenico Alberga; Vittoria Nanna; Maria Giovanna Eva Papadopoulos; Adolfo Ancona; Maria Cristina Lomuscio; Giuseppe Felice Mangiatordi
err分享
err收藏
Development of Second-Generation Phenoxyethylpiperidines as Potent Sigma-1 Receptor Agonists with Neuroprotective Potential for Alzheimer’s Disease
errJournal of Medicinal Chemistry
IF6.8
err2026-02-05
err0
PREAI
errFrancesco Mastropasqua; Anna Teresa Lisi; Lucie Crouzier; Gabriella Rosanna Musillo; Francesca Serena Abatematteo; Mauro Niso; Benjamin Delprat; Nicola Antonio Colabufo; Vittoria Nanna; Giuseppe Felice Mangiatordi; Pietro Delre; Tina Spalholz; Matilde Colella; Winnie Deuther-Conrad; Fulvio Loiodice; Tangui Maurice; Antonio Laghezza; Carmen Abate
err分享
err收藏
Structure-based identification of a non-covalent thioredoxin reductase inhibitor with proven ADMET suitability基于结构的非共价硫氧还蛋白还原酶抑制剂的鉴定，该抑制剂具有已证实的ADMET适用性
errJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
IF5.4
err2025-12-31
err0
PREAI
errLamanna, Giuseppe; Augello, Giuseppa; Ronga, Luisa; Tesauro, Diego; Silvestri, Ilaria; Azzolina, Antonina; Cervello, Melchiorre; Mangiatordi, Giuseppe Felice; Saviano, Michele
err分享
err收藏
Shedding light on the HSAB-guided sulfur–selenium antagonism in mercury coordination and reactivity toward biologically relevant systems: a DFT and MD study揭示HSAB指导下的汞配位和生物相关体系中的硫-硒拮抗作用及反应性：一项DFT和MD研究
errPhys. Chem. Chem. Phys.
IF2.9
err2025-08-11
err0
PREAI
errPietro Delre; Ali Chahine; Giuseppe Felice Mangiatordi; Domenico Alberga; Michele Saviano; Germain Valverdu; Luisa Ronga; Karinne Miqueu; Panaghiotis Karamanis
err分享
err收藏
Structural Implications of Missense Point Mutations in Shwachman–Bodian–Diamond Syndrome Protein (SBDS): A Combined SAXS/MD InvestigationShwachman–Bodian–Diamond综合征蛋白（SBDS）中错义点突变的结构影响：一项结合SAXS/MD的研究
errACS Omega
IF4.3
err2025-08-01
err0
errOAAI
errGiovanni Mattiotti; Vittoria Nanna; Marco Giulini; Domenico Alberga; Giuseppe Felice Mangiatordi; Nuria Sánchez-Puig; Michele Saviano; Luca Tubiana; Raffaello Potestio; Gianluca Lattanzi; Dritan Siliqi
err分享
err收藏
Hunting for lubeluzole analogues as antimyotonic agents with reduced cardiac liability寻找具有降低心脏毒性的抗肌强直剂鲁贝鲁唑类似物
errEuropean Journal of Medicinal Chemistry
IF5.9
err2025-07-10
err0
errOAAI
errMaria Maddalena Cavalluzzi; Roberta Gualdani; Alessandro Farinato; Concetta Altamura; Sabata Pierno; Natalie Paola Rotondo; Francesco Terlizzi; Laura Beatrice Mattioli; Maria Grazia Perrone; Maria Cristina Lomuscio; Giuseppe Felice Mangiatordi; Nicola Antonio Colabufo; Antonio Carrieri; Roberta Budriesi; Peter Gmeiner; Harald Huebner; Jean-François Desaphy; Giovanni Lentini
err分享
err收藏
In Vitro Evaluation of Novel Furo[3,2-c]coumarins as Cholinesterases and Monoamine Oxidases Inhibitors
errMOLECULES
IF4.6
err2025-04-18
err0
errOAAI
errRullo, Mariagrazia; Benzi, Alice; Bianchi, Lara; Maccagno, Massimo; Taddei, Guglielmo Marcantoni; Miniero, Daniela Valeria; Mangiatordi, Giuseppe Felice; Lentini, Giovanni; Pisani, Leonardo; Petrillo, Giovanni; Tavani, Cinzia
err分享
err收藏
Identification of a Cannabinoid Receptor 2 Allosteric Site Using Computational Modeling and Pharmacological Analysis利用计算建模和药理学分析鉴定大麻素受体2的别构位点
errACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
IF3.7
err2025-01-28
err0
errOAAI
errFarooq, Z; Delre, P; Iliadis, S; Mangiatordi, GF; Contino, M; Howell, LA; Mccormick, PJ
err分享
err收藏
Transformer Decoder Learns from a Pretrained Protein Language Model to Generate Ligands with High Affinity
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2025-01-28
err0
PREAI
errCreanza, Teresa Maria; Alberga, Domenico; Patruno, Cosimo; Mangiatordi, Giuseppe Felice; Ancona, Nicola
err分享
err收藏
SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity prediction
errRSC MEDICINAL CHEMISTRY
IF3.6
err2025-01-01
err0
errOAAI
errLomuscio, Maria Cristina; Corriero, Nicola; Nanna, Vittoria; Piccinno, Antonio; Saviano, Michele; Lanzilotti, Rosa; Abate, Carmen; Alberga, Domenico; Mangiatordi, Giuseppe Felice
err分享
err收藏
A CD Study of a Structure-Based Selection of N-Heterocyclic Bis-Carbene Gold(I) Complexes as Potential Ligands of the G-Quadruplex-Forming Human Telomeric hTel23 Sequence
errMOLECULES
IF4.6
err2024-11-19
err2
errOAAI
errMarzano, Maria; Prencipe, Filippo; Delre, Pietro; Mangiatordi, Giuseppe Felice; Travagliante, Gabriele; Ronga, Luisa; Piccialli, Gennaro; Saviano, Michele; D'Errico, Stefano; Tesauro, Diego; Oliviero, Giorgia
err分享
err收藏
Structure-based design of multitargeting ChEs-MAO B inhibitors based on phenyl ring bioisosteres: AChE/BChE selectivity switch and drug-like characterization
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-08-01
err1
errOAAI
errLa Spada, Gabriella; Miniero, Daniela Valeria; Rullo, Mariagrazia; Cipolloni, Marco; Delre, Pietro; Colliva, Carolina; Colella, Marco; Leonetti, Francesco; Liuzzi, Grazia Maria; Mangiatordi, Giuseppe Felice; Giacche, Nicola; Pisani, Leonardo
err分享
err收藏
N-Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R)
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-06-27
err0
PREAI
errIntranuovo, Francesca; Majellaro, Maria; Mastropasqua, Francesco; Delre, Pietro; Abatematteo, Francesca Serena; Mangiatordi, Giuseppe Felice; Stefanachi, Angela; Brea, Jose; Loza, Maria Isabel; Riganti, Chiara; Ligresti, Alessia; Kumar, Poulami; Esposito, Daniela; Cristino, Luigia; Nicois, Alessandro; Gonzalez, Lucia; Perrone, Maria Grazia; Colabufo, Nicola Antonio; Sotelo, Eddy; Abate, Carmen; Contino, Marialessandra
err分享
err收藏
Structural basis for specific inhibition of salicylate synthase from Mycobacterium abscessus脓肿分枝杆菌水杨酸合酶特异性抑制的结构基础
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2024-02-01
err0
errOAAI
errMori, Matteo; Cocorullo, Mario; Tresoldi, Andrea; Cazzaniga, Giulia; Gelain, Arianna; Stelitano, Giovanni; Chiarelli, Laurent R.; Tomaiuolo, Martina; Delre, Pietro; Mangiatordi, Giuseppe F.; Garofalo, Mariangela; Cassetta, Alberto; Covaceuszach, Sonia; Villa, Stefania; Meneghetti, Fiorella
err分享
err收藏
ALPACA: A machine Learning Platform for Affinity and selectivity profiling of CAnnabinoids receptors modulators羊驼: 大麻素受体调节剂亲和力和选择性分析的机器学习平台
errCOMPUTERS IN BIOLOGY AND MEDICINE
IF6.3
err2023-09-01
err3
errOAAI
errDelre, Pietro; Contino, Marialessandra; Alberga, Domenico; Saviano, Michele; Corriero, Nicola; Mangiatordi, Giuseppe Felice
err分享
err收藏
GENERA: A Combined Genetic/Deep-Learning Algorithm for Multiobjective Target-Oriented De Novo Design
errJOURNAL OF CHEMICAL INFORMATION AND MODELING
IF5.3
err2023-08-09
err11
errOAAI
errLamanna, Giuseppe; Delre, Pietro; Marcou, Gilles; Saviano, Michele; Varnek, Alexandre; Horvath, Dragos; Mangiatordi, Giuseppe Felice
err分享
err收藏
A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach
errSCIENTIFIC REPORTS
IF3.9
err2023-08-07
err3
errOAAI
errAbatematteo, Francesca Serena; Delre, Pietro; Mercurio, Ivan; Rezelj, Veronica V. V.; Siliqi, Dritan; Beaucourt, Stephanie; Lattanzi, Gianluca; Colabufo, Nicola Antonio; Leopoldo, Marcello; Saviano, Michele; Vignuzzi, Marco; Mangiatordi, Giuseppe Felice; Abate, Carmen
err分享
err收藏
Bioisosteric replacement based on 1,2,4-oxadiazoles in the discovery of 1H-indazole-bearing neuroprotective MAO B inhibitors
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2023-07-01
err12
PREAI
errRullo, Mariagrazia; La Spada, Gabriella; Miniero, Daniela Valeria; Gottinger, Andrea; Catto, Marco; Delre, Pietro; Mastromarino, Margherita; Latronico, Tiziana; Marchese, Sara; Mangiatordi, Giuseppe Felice; Binda, Claudia; Linusson, Anna; Liuzzi, Grazia Maria; Pisani, Leonardo
err分享
err收藏
Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2023-06-23
err2
PREAI
errFarinato, Alessandro; Cavalluzzi, Maria Maddalena; Altamura, Concetta; Campanale, Carmen; Laghetti, Paola; Saltarella, Ilaria; Delre, Pietro; Barbault, Arthur; Tarantino, Nancy; Milani, Gualtiero; Rotondo, Natalie Paola; Mannelli, Lorenzo Di Cesare; Ghelardini, Carla; Pierno, Sabata; Mangiatordi, Giuseppe Felice; Lentini, Giovanni; Desaphy, Jean-Francois
err分享
err收藏

研究方向

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