Gregory A. Newby - Publications, H-index & Citations

Gregory A. Newby

johns hopkins university

42H指数

117论文数

1.5W被引数

收录论文 56

发表时间

Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis 碱基编辑和纳米颗粒转染对囊性纤维化治疗至关重要的气道细胞类型

JCI Insight

IF6.1

2026-05-08

PREAI

Kavanagh, Erin W.; Joynt, Anya T.; Pion, Audrey R.; Eastman, Alice C.; Parr, Alianna I.; Starego, Katherine L.; Jain, Manav; Shannon, Sydney R.; Yoo, Edwin J.; Newby, Gregory A.; Tzeng, Stephany Y.; Sharma, Neeraj; Green, Jordan J.; Cutting, Garry R.

Mitochondrial DNA copy number reduction via in vitro TFAM knockout remodels the nuclear epigenome and transcriptome

EPIGENOMICS

IF2.6

2025-12-01

PREAI

Win, Phyo W.; Nguyen, Julia; Shin, Elly H.; Nagano, Tyler S.; Selimi, Brent; Hong, Katie; Meybodi, Anahita M.; Yates, Bradley P.; Burke, Emma V.; Carter, David E.; Newby, Gregory A.; Newcomb, Charles; Arking, Dan E.; Castellani, Christina A.

Comparative Analysis of CRISPR-Cas9, lentiviral transduction, and base editing for sickle cell disease in a murine model CRISPR-Cas9、慢病毒转导和碱基编辑技术在镰状细胞病小鼠模型中的比较分析

Blood Advances

IF7.1

2025-10-30

OAAI

Henna Butt; Shruti Sathish; Evan London; Anh Le; Quan Li; Bjorg Gudmundsdottir; Duck-Yeon Lee; Emma V. Burke; Bradley P. Yates; David R. Liu; Matthew Hsieh; Alexis Leonard; William A. Eaton; Naoya Uchida; Francis J. Pierciey; Gregory A. Newby; John F. Tisdale; Selami Demirci

Engraftment and persistence of HBB base-edited hematopoietic stem cells in nonhuman primates HBB碱基编辑造血干细胞的植入与持久性在非人灵长类动物中的研究

Science Translational Medicine

IF14.6

2025-08-13

PREAI

Stefan Radtke; Emily Fields; Kyle Swing; Greta Kanestrom; Jonathan S. Yen; Dnyanada Pande; Mark R. Enstrom; Olivier Humbert; Mitchell J. Weiss; David R. Liu; Gregory A. Newby; Hans-Peter Kiem

GFP-on mouse model for interrogation of in vivo gene editing GFP-on 小鼠模型用于体内基因编辑的探究

Nature Communications

IF15.7

2025-07-31

OAAI

Carla Dib; Jack A. Queenan; Leah Swartzrock; Hana Willner; Morgane Denis; Nouraiz Ahmed; Fareha Moulana Zada; Beltran Borges; Carsten T. Charlesworth; Tony Lum; Bradley P. Yates; Caleb Y. Kwon; Augustino V. Scorzo; Scott C. Davis; Jessie R. Davis; Ran He; Jun Xie; Guangping Gao; Tippi C. MacKenzie; David R. Liu; Gregory A. Newby; Agnieszka D. Czechowicz

Base editing of trinucleotide repeats that cause Huntington's disease and Friedreich's ataxia reduces somatic repeat expansions in patient cells and in mice 对引起亨廷顿病和弗里德赖希共济失调的三核苷酸重复序列进行碱基编辑，可降低患者细胞和小鼠中的体细胞重复序列扩增。

NATURE GENETICS

IF0

2025-05-26

OAAI

Matuszek, Zaneta; Arbab, Mandana; Kesavan, Maheswaran; Hsu, Alvin; Roy, Jennie C. L.; Zhao, Jing; Yu, Tian; Weisburd, Ben; Newby, Gregory A.; Doherty, Neil J.; Wu, Muzhou; Shibata, Shota; Cristian, Ana; Tao, Y. Allen; Fearnley, Liam G.; Bahlo, Melanie; Rehm, Heidi L.; Xie, Jun; Gao, Guangping; Mouro Pinto, Ricardo; Liu, David R.

Modulating Collagen I Expression in Fibroblasts by CRISPR-Cas9 Base Editing of the Collagen 1A1 Promoter 通过CRISPR-Cas9碱基编辑胶原1A1启动子调节成纤维细胞中胶原蛋白I的表达

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

IF4.9

2025-03-26

OAAI

Daliri, Karim; Hescheler, Juergen; Newby, Gregory A.; Liu, David R.; Pfannkuche, Kurt

Safer and efficient base editing and prime editing via ribonucleoproteins delivered through optimized lipid-nanoparticle formulations

NATURE BIOMEDICAL ENGINEERING

IF26.6

2024-11-28

OAAI

Holubowicz, Rafal; Du, Samuel W.; Felgner, Jiin; Smidak, Roman; Choi, Elliot H.; Palczewska, Grazyna; Menezes, Carolline Rodrigues; Dong, Zhiqian; Gao, Fangyuan; Medani, Omar; Yan, Alexander L.; Holubowicz, Maria W.; Chen, Paul Z.; Bassetto, Marco; Risaliti, Eleonora; Salom, David; Workman, J. Noah; Kiser, Philip D.; Foik, Andrzej T.; Lyon, David C.; Newby, Gregory A.; Liu, David R.; Felgner, Philip L.; Palczewski, Krzysztof

In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal- recessive retinitis pigmentosa in mice 体内光感受器碱基编辑可改善小鼠rhodopsin-E150K常染色体隐性视网膜色素变性

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IF9.1

2024-11-18

OAAI

Du, Samuel W.; Newby, Gregory A.; Salom, David; Gao, Fangyuan; Menezes, Carolline Rodrigues; Suh, Susie; Choi, Elliot H.; Chen, Paul Z.; Liu, David R.; Palczewski, Krzysztof

Amphiphilic shuttle peptide delivers base editor ribonucleoprotein to correct the CFTR R553X mutation in well-differentiated airway epithelial cells

NUCLEIC ACIDS RESEARCH

IF13.1

2024-09-24

OAAI

Kulhankova, Katarina; Cheng, Anna X.; Traore, Soumba; Auger, Maud; Pelletier, Mia; Hervault, Maxime; Wells, Kevin D.; Green, Jonathan A.; Byrne, Addison; Nelson, Benjamin; Sponchiado, Mariana; Boosani, Chandra; Heffner, Caleb S.; Snow, Kathy J.; Murray, Stephen A.; Villacreses, Raul A.; Rector, Michael, V; Gansemer, Nicholas D.; Stoltz, David A.; Allamargot, Chantal; Couture, Frederic; Hemez, Colin; Hallee, Stephanie; Barbeau, Xavier; Harvey, Mario; Lauvaux, Coraline; Gaillet, Bruno; Newby, Gregory A.; Liu, David R.; McCray Jr, Paul B.; Guay, David

Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells

NATURE BIOMEDICAL ENGINEERING

IF26.6

2024-07-10

OAAI

Sousa, Alexander A.; Hemez, Colin; Lei, Lei; Traore, Soumba; Kulhankova, Katarina; Newby, Gregory A.; Doman, Jordan L.; Oye, Keyede; Pandey, Smriti; Karp, Philip H.; McCray Jr, Paul B.; Liu, David R.

Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells 骨髓归巢脂质纳米颗粒用于患病和恶性造血干细胞的基因组编辑

NATURE NANOTECHNOLOGY

IF34.9

2024-05-23

PREAI

Lian, Xizhen; Chatterjee, Sumanta; Sun, Yehui; Dilliard, Sean A.; Moore, Stephen; Xiao, Yufen; Bian, Xiaoyan; Yamada, Kohki; Sung, Yun-Chieh; Levine, Rachel M.; Mayberry, Kalin; John, Samuel; Liu, Xiaoye; Smith, Caroline; Johnson, Lindsay T.; Wang, Xu; Zhang, Cheng Cheng; Liu, David R.; Newby, Gregory A.; Weiss, Mitchell J.; Yen, Jonathan S.; Siegwart, Daniel J.

Post-translational modification-centric base editor screens to assess phosphorylation site functionality in high throughput 以翻译后修饰为中心的碱基编辑器筛选以评估高通量的磷酸化位点功能

NATURE METHODS

IF32.1

2024-04-29

PREAI

Kennedy, Patrick H.; Sheikh, Amin Alborzian Deh; Balakar, Matthew; Jones, Alexander C.; Olive, Meagan E.; Hegde, Mudra; Matias, Maria I.; Pirete, Natan; Burt, Rajan; Levy, Jonathan; Little, Tamia; Hogan, Patrick G.; Liu, David R.; Doench, John G.; Newton, Alexandra C.; Gottschalk, Rachel A.; de Boer, Carl G.; Alarcon, Suzie; Newby, Gregory A.; Myers, Samuel A.

Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo 工程病毒样颗粒在体内瞬时递送prime编辑核糖核蛋白复合物

NATURE BIOTECHNOLOGY

IF41.7

2024-01-08

OAAI

An, Meirui; Raguram, Aditya; Du, Samuel W.; Banskota, Samagya; Davis, Jessie R.; Newby, Gregory A.; Chen, Paul Z.; Palczewski, Krzysztof; Liu, David R.

Highly efficient biallelic correction of homozygous COL7A1 mutation using ABE8e adenine base editor

BRITISH JOURNAL OF DERMATOLOGY

IF9.6

2023-12-27

OAAI

Brooks, Imogen R.; Alrokh, Yara; Kazemizadeh, Aidin; Balon, Katarzyna; Newby, Gregory; Liu, David R.; Laczmanski, Lukasz; Mcgrath, John A.; Jackow-Malinowska, Joanna

Shuttle peptide delivers base editor RNPs to rhesus monkey airway epithelial cells in vivo

NATURE COMMUNICATIONS

IF15.7

2023-12-05

OAAI

Kulhankova, Katarina; Traore, Soumba; Cheng, Xue; Benk-Fortin, Hadrien; Hallee, Stephanie; Harvey, Mario; Roberge, Joannie; Couture, Frederic; Kohli, Sajeev; Gross, Thomas J.; Meyerholz, David K.; Rettig, Garrett R.; Thommandru, Bernice; Kurgan, Gavin; Wohlford-Lenane, Christine; Hartigan-O'Connor, Dennis J.; Yates, Bradley P.; Newby, Gregory A.; Liu, David R.; Tarantal, Alice F.; Guay, David; McCray, Paul B., Jr.

Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo

NUCLEIC ACIDS RESEARCH

IF13.1

2023-11-30

OAAI

Zhang, Han; Kelly, Karen; Lee, Jonathan; Echeverria, Dimas; Cooper, David; Panwala, Rebecca; Amrani, Nadia; Chen, Zexiang; Gaston, Nicholas; Wagh, Atish; Newby, Gregory A.; Xie, Jun; Liu, David R.; Gao, Guangping; Wolfe, Scot A.; Khvorova, Anastasia; Watts, Jonathan K.; Sontheimer, Erik J.

Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning

NATURE BIOTECHNOLOGY

IF41.7

2023-10-18

OAAI

Koblan, Luke W.; Arbab, Mandana; Shen, Max W.; Hussmann, Jeffrey A.; Anzalone, Andrew V.; Doman, Jordan L.; Newby, Gregory A.; Yang, Dian; Mok, Beverly; Replogle, Joseph M.; Xu, Albert; Sisley, Tyler A.; Weissman, Jonathan S.; Adamson, Britt; Liu, David R.

Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2023-10-02

OAAI

Kabra, Meha; Shahi, Pawan K.; Wang, Yuyuan; Sinha, Divya; Spillane, Allison; Newby, Gregory A.; Saxena, Shivani; Tong, Yao; Chang, Yu; Abdeen, Amr A.; Edwards, Kimberly L.; Theisen, Cole O.; Liu, David R.; Gamm, David M.; Gong, Shaoqin; Saha, Krishanu; Pattnaik, Bikash R.

Protospacer modification improves base editing of a canonical splice site variant and recovery of CFTR function in human airway epithelial cells 原型间隔子修饰可改善典型剪接位点变体的碱基编辑和人气道上皮细胞中CFTR功能的恢复

MOLECULAR THERAPY-NUCLEIC ACIDS

IF0

2023-09-01

OAAI

Joynt, Anya T.; Kavanagh, Erin W.; Newby, Gregory A.; Mitchell, Shakela; Eastman, Alice C.; Paul, Kathleen C.; Bowling, Alyssa D.; Osorio, Derek L.; Merlo, Christian A.; Patel, Shivani U.; Raraigh, Karen S.; Liu, David R.; Sharma, Neeraj; Cutting, Garry R.

研究方向