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J

José Brea

University of Santiago de Compostela

36H指数
268论文数
4.9K被引数
收录论文 153
发表时间
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N-Adamantyl-1-Pentyl-4-Oxo-1,4-Dihydroquinoline-3-Carboxamide and N-(Adamantan-1-Yl)-2-(Alkyloxy)benzamide Derivatives as Fluorescent Probes for Selective CB2R TargetingN-金刚烷基-1-戊基-4-氧代-1,4-二氢喹啉-3-甲酰胺和N-(金刚烷-1-基)-2-(烷氧基)苯甲酰胺衍生物作为选择性靶向CB2R的荧光探针
errPharmaceuticals
IF4.8
err2026-10-07
err0
errOAAI
errGabriella Rosanna Musillo; Giovanni Graziano; Mariachiara Mammone; Francesco Mastropasqua; Maria Majellaro; Claudia Gioè-Gallo; Jose Brea; Maria Isabel Loza; Anselma Liturri; Morena Miciaccia; Maria Grazia Perrone; Angela Stefanachi; Matilde Colella; Domenico Alberga; Eddy Sotelo; Nicola Antonio Colabufo; Marialessandra Contino; Carmen Abate
err分享
err收藏
Leveraging multitargeting BChE-MAO B inhibitors against microglia-related neuroinflammation: in vitro biological evaluation, structure-activity relationships, drug-like properties, and X-ray crystal complexes利用多靶点BChE-MAO B抑制剂对抗小胶质细胞相关神经炎症：体外生物评价、构效关系、类药性以及X射线晶体复合物
errEuropean Journal of Medicinal Chemistry
IF5.9
err2026-09-29
err1
PREAI
errRullo, Mariagrazia; La Spada, Gabriella; Brazzolotto, Xavier; Marchese, Sara; El Idrissi, Imane Ghafir; Miciaccia, Morena; Colella, Marco; Brea, Jose M.; Macchia, Eleonora; Loza, Maria I.; Gottinger, Andrea; Scilimati, Antonio; Perrone, Maria Grazia; Stefanachi, Angela; Binda, Claudia; Leonetti, Francesco; Pisani, Leonardo
err分享
err收藏
Rebuilding pneumococcal protection after Venezuela's 2026 earthquake doublet: A call for vaccination preparedness委内瑞拉2026年地震双震后重建肺炎球菌保护：呼吁疫苗接种准备
errEnfermedades Infecciosas y Microbiologia Clinica
IF2.5
err2026-09-28
err0
PREAI
errClaudia Beltrán-Arroyave; Alejandro Risquez; Maria Graciela López-Garcia; Manuela Merida; Andreina Yanes-Rojas; Jaime R. Torres; Rolando Ulloa-Gutierrez; Jose Brea; Maria L. Avila-Aguero; Roberto Debbag; Alfonso J. Rodriguez-Morales
err分享
err收藏
Topliss-Guided Optimization of Acetanilide-Based Soluble Epoxide Hydrolase Inhibitors: Exploring the Pentafluorosulfanyl Group as a Potency-Enhancing Motif托普利斯指导下的乙酰苯胺类可溶性环氧水解酶抑制剂的优化：探索五氟硫基团作为增强活性的基序
errChemMedChem
IF3.4
err2026-09-07
err0
errOAAI
errAlba López-Ruiz; Eugènia Pujol; Cristian Ramos; Valeria Rizzo; Christophe Morisseau; Cristina Val; Tiziana Ginex; Javier Vázquez; Sandra Codony; Andreea L. Turcu; Belén Pérez; Elena Sáez; Antonio Pineda-Lucena; Bruce D. Hammock; F. Javier Luque; M. Isabel Loza; José Brea; Santiago Vázquez
err分享
err收藏
Unveiling the molecular crosstalk between the purinergic P2X7 receptor and cannabinoid subtype 2 receptor in human microglial HMC3 cells: New insights for multitarget therapies in neuroinflammation揭示嘌呤能P2X7受体与大麻素2型受体在人类小胶质细胞HMC3细胞中的分子串扰：神经炎症多靶点治疗的新见解
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2026-06-17
err0
errOAAI
errImane Ghafir El Idrissi; David Moreira Alvarez; Rocío Piña Márquez; Elena Adinolfi; Anna Pegoraro; Rosaria Volpini; Michela Buccioni; Beatrice Francucci; Ciro Leonardo Pierri; Carmen Abate; Marcello Leopoldo; Josè Brea; Marialessandra Contino; Maria Isabel Loza; Enza Lacivita
err分享
err收藏
Synthesis and Biological Profiling of New 1,2,3,4-Tetrahydrobenzo[h]naphthyridine-Based Hybrids as Dual Inhibitors of β-Amyloid and Tau Aggregation with Anticholinesterase Activity基于1,2,3,4-四氢苯并[h]萘啶的新型杂合物的合成及其生物表征：作为具有抗胆碱酯酶活性的β-淀粉样蛋白和Tau聚集的双抑制剂
errBiomolecules
IF4.8
err2026-04-16
err0
errOAAI
errAldrick B. Verano; Anna Sampietro; Ana Mallo-Abreu; Rosaria Spagnuolo; Belén Pérez; Manuela Bartolini; María Isabel Loza; José Brea; Jordi Juárez-Jiménez; Raimon Sabate; Carles Galdeano; Diego Muñoz-Torrero
err分享
err收藏
Voltage-gated calcium channels as key regulators of neuronal differentiation in the immortalized dorsal root ganglion neuronal cell line F11电压门控钙通道作为永生化的背根神经节神经元细胞系F11中神经元分化的关键调节因子
errScientific Reports
IF3.9
err2026-03-01
err0
PREAI
errLopez, D.; Brea, J.; Barro, M.; Loza, M. I.; Martinez, A. L.
err分享
err收藏
First-in-Class SAM-Competitive G9a Inhibitor FLAV-27 as a Disease-Modifying Therapy for Alzheimer’s DiseaseFirst-in-Class SAM-Competitive G9a Inhibitor FLAV-27作为阿尔茨海默病的疾病修正疗法
errMolecular Therapy
IF12
err2025-12-24
err0
errOAAI
errAina Bellver-Sanchis; David Valle-Garcia; Carla Barbaraci; Fernando Romero-Becerra; Rohit Kumar Singh; Júlia Jarne-Ferrer; Foteini Vasilopoulou; Alba Irisarri; Carmen Martínez-Fernández; Juan A. Fafián-Labora; María C. Arufe; Carolin Wüst; Aida Castellanos; David Soto; Núria Casals; Rut Fadó; Jennifer M. Pocock; Gemma Navarro; Cristina Val; José Brea
err分享
err收藏
Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex结构相似的5-HT2A受体配体ketanserin和altanserin在人前额皮质中诱导的G蛋白偶联特异性模式
errMolecular Pharmacology
IF3
err2025-09-24
err0
errOAAI
errPatricia Miranda-Azpiazu; Carolina Muguruza; Tomasz Maciej Stepniewski; Itziar Muneta-Arrate; David Moreira; José Brea; Luis F. Callado; María Isabel Loza; Javier González-Maeso; Jana Selent; Rebeca Diez-Alarcia; J.Javier Meana
err分享
err收藏
Proline Homologation in Melanostatin Neuropeptide: Discovery of Potent Modulators of the Dopamine D2 Receptors黑色素释放激素神经肽中的脯氨酸同系化：发现多巴胺D2受体的强效调节剂
errACS Medicinal Chemistry Letters
IF4
err2025-07-24
err0
PREAI
errIvo E. Sampaio-Dias; Hugo F. Costa-Almeida; Xavier C. Correia; Sara C. Silva-Reis; Vera M. Costa; José Brea; María I. Loza; José E. Rodríguez-Borges; Xerardo García-Mera
err分享
err收藏
Synthesis of 2-(3-aminopropyl)benzopyrans as potential antipsychotic agents targeting D2/D3 and 5-HT2A receptors2-(3-氨基丙基)苯并吡喃的合成及其作为靶向D2/D3和5-HT2A受体的潜在抗精神病药物的研究
errBioorganic & Medicinal Chemistry
IF3
err2025-07-03
err0
errOAAI
errÁlvaro Bernabeu-Sanchis; María José Varela; Ainhoa García; Carlos Villarroel-Vicente; Laura Vila; María Isabel Loza; José Brea; Diego Cortes; Nuria Cabedo
err分享
err收藏
Exploring Trisubstituted adenine derivatives as adenosine A1 receptor ligands with antagonist activity: Synthesis, biological evaluation and molecular modelling探索三取代腺嘌呤衍生物作为具有拮抗剂活性的腺苷A1受体配体的研究：合成、生物评价与分子模拟
errBIOORGANIC CHEMISTRY
IF4.7
err2025-06-01
err0
PREAI
errCordoba-Gomez, Laura B.; Lorente-Macias, Alvaro; Loza, Maria Isabel; Brea, Jose; Martinez, Anton Leandro; Mok, Jonathon; King, Ben; Franco-Montalban, Francisco; Garcia, Antonio Gonzalez; Guardia-Monteagudo, Juan Jose; Matos, Maria J.; Unciti-Broceta, Asier; Diaz-Mochon, Juan Jose; de Las Infantas, Maria Jose Pineda
err分享
err收藏
Morphological profiling data resource enables prediction of chemical compound properties形态学分析数据资源能够预测化学化合物的性质
errISCIENCE
IF4.1
err2025-05-01
err0
errOAAI
errWolff, Christopher; Neuenschwander, Martin; Beese, Carsten Jorn; Sitani, Divya; Ramos, Maria C.; Srovnalova, Alzbeta; Varela, Maria Jose; Polishchuk, Pavel; Skopelitou, Katholiki E.; Skuta, Ctibor; Stechmann, Bahne; Brea, Jose; Clausen, Mads Hartvig; Dzubak, Petr; Fernandez-Godino, Rosario; Genilloud, Olga; Hajduch, Marian; Loza, Maria Isabel; Lehmann, Martin; von Kries, Jens Peter; Sun, Han; Schmied, Christopher
err分享
err收藏
Copper(II) Cyclopeptides with High ROS-Mediated Cytotoxicity
errBIOCONJUGATE CHEMISTRY
IF3.9
err2025-03-01
err0
PREAI
errBoga, Sonia; Bouzada, David; Lopez-Blanco, Roi; Sarmiento, Axel; Salvado, Iria; Alvar Gil, David; Brea, Jose; Loza, Maria Isabel; Barreiro-Pineiro, Natalia; Martinez-Costas, Jose; Mena, Silvia; Guirado, Gonzalo; Santoro, Alice; Faller, Peter; Vazquez, M. Eugenio; Lopez, Miguel Vazquez
err分享
err收藏
Design, Synthesis, and Evaluation of a New Fluorescent Ligand for the M2 Muscarinic Acetylcholine Receptor
errACS MEDICINAL CHEMISTRY LETTERS
IF4
err2025-03-01
err0
errOAAI
errSzabo, Renata; Kovacs, Denes Szepesi; Kiss, Dora Judit; Yazdi, Zeinab Nezafat; Toth, Andras David; Brea, Jose; Loza, Maria Isabel; Meszena, Domokos; Wittner, Lucia; Ulbert, Istvan; Volk, Balazs; Hunyady, Laszlo; Keseru, Gyorgy Miklos
err分享
err收藏
Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties
errPHARMACEUTICS
IF5.5
err2024-07-25
err0
errOAAI
errPont, Caterina; Sampietro, Anna; Perez-Areales, F. Javier; Cristiano, Nunzia; Albalat, Agusti; Perez, Belen; Bartolini, Manuela; De Simone, Angela; Andrisano, Vincenza; Barenys, Marta; Teixido, Elisabet; Sabate, Raimon; Loza, M. Isabel; Brea, Jose; Munoz-Torrero, Diego
err分享
err收藏
N-Adamantyl-1-alkyl-4-oxo-1,4-dihydroquinoline-3-carboxamide Derivatives as Fluorescent Probes to Detect Microglia Activation through the Imaging of Cannabinoid Receptor Subtype 2 (CB2R)
errJOURNAL OF MEDICINAL CHEMISTRY
IF6.8
err2024-06-27
err0
PREAI
errIntranuovo, Francesca; Majellaro, Maria; Mastropasqua, Francesco; Delre, Pietro; Abatematteo, Francesca Serena; Mangiatordi, Giuseppe Felice; Stefanachi, Angela; Brea, Jose; Loza, Maria Isabel; Riganti, Chiara; Ligresti, Alessia; Kumar, Poulami; Esposito, Daniela; Cristino, Luigia; Nicois, Alessandro; Gonzalez, Lucia; Perrone, Maria Grazia; Colabufo, Nicola Antonio; Sotelo, Eddy; Abate, Carmen; Contino, Marialessandra
err分享
err收藏
G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits
errNATURE COMMUNICATIONS
IF15.7
err2024-05-29
err2
errOAAI
errKossatz, Elk; Diez-Alarcia, Rebeca; Gaitonde, Supriya A.; Ramon-Duaso, Carla; Stepniewski, Tomasz Maciej; Aranda-Garcia, David; Muneta-Arrate, Itziar; Tepaz, Elodie; Saen-Oon, Suwipa; Soliva, Robert; Shahraki, Aida; Moreira, David; Brea, Jose; Loza, Maria Isabel; de la Torre, Rafael; Kolb, Peter; Bouvier, Michel; Meana, J. Javier; Robledo, Patricia; Selent, Jana
err分享
err收藏
2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives
errMOLECULES
IF4.6
err2024-05-28
err0
errOAAI
errAreias, Filipe; Correia, Carla; Rocha, Ashly; Teixeira, Sofia; Castro, Marian; Brea, Jose; Hu, Huabin; Carlsson, Jens; Loza, Maria I.; Proenca, M. Fernanda; Carvalho, M. Alice
err分享
err收藏
Exploring Biginelli-based scaffolds as A2B adenosine receptor antagonists: Unveiling novel structure-activity relationship trends, lead compounds, and potent colorectal anticancer agents
errBIOMEDICINE & PHARMACOTHERAPY
IF7.5
err2024-04-01
err0
errOAAI
errPrieto-Diaz, Ruben; Fojo-Carballo, Hugo; Majellaro, Maria; Tandaric, Tana; Azuaje, Jhonny; Brea, Jose; Loza, Maria I.; Barbazan, Jorge; Salort, Gloria; Chotalia, Meera; Rodriguez-Pampin, Ivan; Mallo-Abreu, Ana; Paleo, M. Rita; Garcia-Mera, Xerardo; Ciruela, Francisco; Gutierrez-de-Teran, Hugo; Sotelo, Eddy
err分享
err收藏

研究方向

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合作学者
合作期刊
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Todd R. Golub
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H 指数: 127 · 论文数: 425
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