未登录 Targeting Mediator Kinase Cyclin-Dependent Kinases 8/19 Potentiates Chemotherapeutic Responses, Reverses Tumor Growth, and Prolongs Survival from Ovarian Clear Cell Carcinoma 靶向中介激酶细胞周期依赖性蛋白激酶8/19可增强化疗反应、逆转肿瘤生长并延长卵巢透明细胞癌患者的生存期 Barton, Wade C.; Kumari, Asha; Mack, Zachary T.; Schools, Gary P.; Quintero, Liz Macias; Choi, Alex Seok; Rangavajhula, Karthik; Arend, Rebecca C.; Broude, Eugenia V.; Mythreye, Karthikeyan 分享 收藏
CDK8/19 inhibition attenuates G1 arrest induced by BCR-ABL antagonists and accelerates death of chronic myelogenous leukemia cells Khamidullina, Alvina I.; Yastrebova, Margarita A.; Bruter, Alexandra V.; Nuzhina, Julia V.; Vorobyeva, Nadezhda E.; Khrustaleva, Anastasia M.; Varlamova, Ekaterina A.; Tyakht, Alexander V.; Abramenko, Iaroslav E.; Ivanova, Ekaterina S.; Zamkova, Maria A.; Li, Jing; Lim, Chang-Uk; Chen, Mengqian; Broude, Eugenia V.; Roninson, Igor B.; Shtil, Alexander A.; Tatarskiy, Victor V. 分享 收藏
Mediator kinase inhibitors suppress triple- negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors 介质激酶抑制剂通过mTOR和AKT抑制剂抑制三阴性乳腺癌的生长并延长肿瘤抑制 Ding, Xiaokai; Liang, Jiaxin; Sharko, Amanda C.; Hilimire, Thomas A.; Li, Jing; Loskutov, Jurgen; Mack, Zachary T.; Ji, Hao; Schools, Gary P.; Cai, Chao; Pugacheva, Elena N.; Chen, Mengqian; Roninson, Igor B.; Broude, Eugenia V. 分享 收藏
Mediator kinase inhibition reverses castration resistance of advanced cancer Li, Jing; Hilimire, Thomas A.; Liu, Yueying; Wang, Lili; Liang, Jiaxin; Gyorffy, Balazs; Sikirzhytski, Vitali; Ji, Hao; Zhang, Li; Cheng, Chen; Ding, Xiaokai; Kerr, Kendall R.; Dowling, Charles E.; Chumanevich, Alexander A.; Mack, Zachary T.; Schools, Gary P.; Lim, Chang-uk; Ellis, Leigh; Zi, Xiaolin; Porter, Donald C.; Broude, Eugenia V.; McInnes, Campbell; Wilding, George; Lilly, Michael B.; Roninson, Igor B.; Chen, Mengqian 分享 收藏
Development of adaptive anoikis resistance promotes ovarian cancer metastasis that can be prevented by CDK8/19 Mediator kinase inhibition Monavarian, Mehri; Rajkarnikar, Resha; Page, Emily Faith; Kumari, Asha; Quintero, Liz Macias; Ianov, Lara; Sahoo, Sarthak; Jolly, Mohit Kumar; Worthey, Elizabeth; Hempel, Nadine; Singh, Abhyudai; Broude, Eugenia; Mythreye, Karthikeyan 分享 收藏
CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins Chen, Mengqian; Li, Jing; Zhang, Li; Wang, Lili; Cheng, Chen; Ji, Hao; Altilia, Serena; Ding, Xiaokai; Cai, Guoshuai; Altomare, Diego; Shtutman, Michael; Byrum, Stephanie D.; Mackintosh, Samuel G.; Feoktistov, Alexey; Soshnikova, Nataliya; Mogila, Vladislav A.; Tatarskiy, Victor; Erokhin, Maksim; Chetverina, Darya; Prawira, Angga; Ni, Yi; Urban, Stephan; McInnes, Campbell; Broude, Eugenia, V; Roninson, Igor B. 分享 收藏
Inhibition of Cyclin-Dependent Kinases 8/19 Restricts Bacterial and Virus-Induced Inflammatory Responses in Monocytes Kokinos, Elena K.; Tsymbal, Sergey A.; Galochkina, Anastasia V.; Bezlepkina, Svetlana A.; Nikolaeva, Julia V.; Vershinina, Sofia O.; Shtro, Anna A.; Tatarskiy, Victor V.; Shtil, Alexander A.; Broude, Eugenia V.; Roninson, Igor B.; Dukhinova, Marina 分享 收藏
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Dual therapeutic targeting of CDK8/19 and mTOR in triple negative breast cancer Ding, Xiaokai; Ji, Hao; Sharko, Amanda C.; Loskutov, Juergen; Mack, Zachary; Myers, Jadyn; Chen, Mengqian; Pugacheva, Elena; Roninson, Igor; Broude, Eugenia 分享 收藏
Depletion of COPI in cancer cells: the role of reactive oxygen species in the induction of lipid accumulation, noncanonical lipophagy and apoptosis Gasparian, A.; Aksenova, M.; Oliver, D.; Levina, E.; Doran, R.; Lucius, M.; Piroli, G.; Oleinik, N.; Ogretmen, B.; Mythreye, K.; Frizzell, N.; Broude, E.; Wyatt, M. D.; Shtutman, M. 分享 收藏
Inhibition of CDK8/19 Mediator kinase potentiates HER2-targeting drugs and bypasses resistance to these agents in vitro and in vivo Ding, Xiaokai; Sharko, Amanda C.; McDermott, Martina S. J.; Schools, Gary P.; Chumanevich, Alexander; Ji, Hao; Li, Jing; Zhang, Li; Mack, Zachary T.; Sikirzhytski, Vitali; Shtutman, Michael; Ivers, Laura; O'Donovan, Norma; Crown, John; Gyorffy, Balazs; Chen, Mengqian; Roninson, Igor B.; Broude, Eugenia, V 分享 收藏
Preventing adaptive therapeutic resistance to CDK4/6 inhibition with CDK8/19 inhibitors Mack, Zachary; Yastrebova, Margarita; Khamidullina, Alvina; Sharko, Amanda; Ding, Xiaokai; Bowe, Stephan; Sashi, Nikitha; Safa, Samantha; Digsby, Kaitlyn; Eckstrom, Amanda; Sikirzhitski, Vitali; Lim, Chang-Uk; Tatarskiy, Victor; Roninson, Igor; Broude, Eugenia 分享 收藏
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Pharmacological inhibition of DEAD-Box RNA Helicase 3 attenuates stress granule assembly DEAD-Box RNA解旋酶3的药理学抑制减弱应激颗粒组装 Cui, B. Celia; Sikirzhytski, Vitali; Aksenova, Marina; Lucius, Matthew D.; Levon, Gabrielle H.; Mack, Zachary T.; Pollack, Charlotte; Odhiambo, Diana; Broude, Eugenia; Lizarraga, Sofia B.; Wyatt, Michael D.; Shtutman, Michael 分享 收藏
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Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation Aksenova, Marina; Sybrandt, Justin; Cui, Biyun; Sikirzhytski, Vitali; Ji, Hao; Odhiambo, Diana; Lucius, Matthew D.; Turner, Jill R.; Broude, Eugenia; Pena, Edsel; Lizarraga, Sofia; Zhu, Jun; Safro, Ilya; Wyatt, Michael D.; Shtutman, Michael 分享 收藏
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