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M

Masahiro Hiratsuka

Tohoku University

44H指数
299论文数
8.2K被引数
收录论文 65
发表时间
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Functional Characterization of Rare DPYD Variants Identified in 8,380 Japanese Individuals: Implications for 5-Fluorouracil Metabolism8,380名日本个体中鉴定的稀有DPYD变异的功能表征：对5-氟尿嘧啶代谢的启示
errDrug Metabolism and Disposition
IF4
err2026-09-17
err0
PREAI
errKento Terauchi; Eiji Hishinuma; Akiko Ueda; Shota Nishihara; Sakae Saito; Shu Tadaka; Kengo Kinoshita; Masamitsu Maekawa; Nariyasu Mano; Yuu Miyauchi; Masahiro Hiratsuka
err分享
err收藏
A rare variant in DPYD c.812delT causes severe adverse events of S-1 in a patient with tongue cancerDPYD基因c.812delT罕见变异导致舌癌患者使用S-1药物产生严重不良反应
errCancer Chemotherapy and Pharmacology
IF2.3
err2026-08-03
err0
errOAAI
errHiroki Ishimura; Atsushi Suehiro; Daiki Hira; Eiji Hishinuma; Midori Kato; Masamitsu Maekawa; Taishi Yasuda; Yurie Katsube; Yoshiki Katada; Natsuki Imayoshi; Yuki Shigetsura; Shunsaku Nakagawa; Masahiro Tsuda; Masahiro Hiratsuka; Tomohiro Terada
err分享
err收藏
Differences in reactive metabolite formation and cytochrome P450 binding between acetaminophen and its bicyclo[1.1.1]pentane bioisostere乙酰氨基酚及其双环[1.1.1]戊烷生物电子等排体的反应性代谢物形成和细胞色素P450结合差异
errDrug Metabolism and Pharmacokinetics
IF2.2
err2026-04-15
err0
PREAI
errMinami Shibata; Ayato Mizuno; Tomoki Nakayoshi; Akifumi Oda; Masaya Nakajima; Masanobu Uchiyama; Masahiro Hiratsuka; Yoshihiro Yamanishi; Kouichi Yoshinari
err分享
err收藏
UDP-glucuronosyltransferase 1A9 function is mediated by the two C-terminal lysine residues and proper mobility/flexibility of the cytoplasmic tailUDP-葡糖醛酸基转移酶1A9的功能由其两个C末端赖氨酸残基以及细胞质尾部的适当移动性/柔韧性介导。
errBiochemical and Biophysical Research Communications
IF2.2
err2025-11-17
err0
PREAI
errYuu Miyauchi; Yume Sadato; Madoka Sawai; Shinji Takechi; Masahiro Hiratsuka; Peter I. Mackenzie; Yuji Ishii
err分享
err收藏
Comprehensive functional characterization of rare and known CYP2E1 allelic variants identified in a Japanese population对日本人群中鉴定出的罕见和已知CYP2E1等位基因变异的全面功能表征
errBiochemical Pharmacology
IF5.6
err2025-10-03
err0
errOAAI
errYuki Ohmori; Eiji Hishinuma; Yuma Suzuki; Akiko Ueda; Caroline Mwendwa Kijogi; Tomoki Nakayoshi; Akifumi Oda; Sakae Saito; Shu Tadaka; Kengo Kinoshita; Yu Sato; Masahiro Hiratsuka
err分享
err收藏
Evaluation of the functional impact of rare CYP2C19 missense variants identified in understudied Populations: An Integrated in silico and in vitro analysis评估在研究不足人群中鉴定出的罕见CYP2C19错义变异的功能影响：一项整合的计算机模拟和体外分析
errBiochemical Pharmacology
IF5.6
err2025-09-20
err0
PREAI
errReema Saleous; Eiji Hishinuma; Zeina N. Al-Mahayri; Akiko Ueda; Yuma Suzuki; Mohammad A. Ghattas; Radwa E. Mahgoub; Masahiro Hiratsuka; Bassam R. Ali
err分享
err收藏
Disulfide bond-mediated stabilization of the oligomers of UDP-glucuronosyltransferase 2B7二硫键介导的UDP-葡糖基转移酶2B7寡聚体稳定化
errJournal of Biological Chemistry
IF3.9
err2025-07-21
err0
errOAAI
errYuu Miyauchi; Haruna Koba; Madoka Sawai; Hisao Kansui; Shinji Takechi; Eiji Hishinuma; Naomi Matsukawa; Masahiro Hiratsuka; Peter I. Mackenzie; Yuji Ishii
err分享
err收藏
Carbon-Based Particles Inhibit Antigen Penetration Into the Skin by Adsorbing the Antigen
errEXPERIMENTAL DERMATOLOGY
IF3.1
err2025-02-16
err0
errOAAI
errIchinohe, Rin; Segawa, Ryosuke; Nakajo, Takahisa; Hiratsuka, Masahiro; Yoshii, Takeharu; Pirabul, Kritin; Pan, Zhen-Ze; Nishihara, Hirotomo; Hirasawa, Noriyasu
err分享
err收藏
Functional significance of CYP2B6 gene rare allelic variants identified in Japanese individuals
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2024-11-01
err0
errOAAI
errYamazaki, Shuki; Hishinuma, Eiji; Suzuki, Yuma; Ueda, Akiko; Kijogi, Caroline; Nakayoshi, Tomoki; Oda, Akifumi; Saito, Sakae; Tadaka, Shu; Kinoshita, Kengo; Maekawa, Masamitsu; Sato, Yu; Kumondai, Masaki; Mano, Nariyasu; Hirasawa, Noriyasu; Hiratsuka, Masahiro
err分享
err收藏
Caspases downregulate nickel and hydrogen peroxide-induced IL-8 production via modification of c-Jun N-terminal kinases
errTOXICOLOGY
IF4.6
err2024-01-01
err0
PREAI
errMaeyama, Ryusei; Segawa, Ryosuke; Onodera, Ryo; Hiratsuka, Masahiro; Hirasawa, Noriyasu
err分享
err收藏
jMorp: Japanese Multi-Omics Reference Panel update report 2023
errNUCLEIC ACIDS RESEARCH
IF13.1
err2023-11-01
err27
errOAAI
errTadaka, Shu; Kawashima, Junko; Hishinuma, Eiji; Saito, Sakae; Okamura, Yasunobu; Otsuki, Akihito; Kojima, Kaname; Komaki, Shohei; Aoki, Yuichi; Kanno, Takanari; Saigusa, Daisuke; Inoue, Jin; Shirota, Matsuyuki; Takayama, Jun; Katsuoka, Fumiki; Shimizu, Atsushi; Tamiya, Gen; Shimizu, Ritsuko; Hiratsuka, Masahiro; Motoike, Ikuko N.; Koshiba, Seizo; Sasaki, Makoto; Yamamoto, Masayuki; Kinoshita, Kengo
err分享
err收藏
Hypoxia-inducible factor prolyl hydroxylase inhibitors suppressed thymic stromal lymphopoietin production and allergic responses in a mouse air-pouch-type ovalbumin sensitization model
errINTERNATIONAL IMMUNOPHARMACOLOGY
IF4.7
err2023-05-01
err0
errOAAI
errSegawa, Ryosuke; Kyoda, Takuya; Yagisawa, Makiko; Muramatsu, Tadanobu; Hiratsuka, Masahiro; Hirasawa, Noriyasu
err分享
err收藏
Inhibition of thymic stromal lymphopoietin production by FK3453
errJOURNAL OF PHARMACOLOGICAL SCIENCES
IF2.9
err2022-08-01
err0
errOAAI
errSegawa, Ryosuke; Ishihara, Ryosuke; Hiratsuka, Masahiro; Hirasawa, Noriyasu
err分享
err收藏
Rapid Genetic Diagnosis for Okinawan Patients with Enlarged Vestibular Aqueduct Using Single-Stranded Tag Hybridization Chromatographic Printed-Array Strip
errJOURNAL OF CLINICAL MEDICINE
IF2.9
err2022-02-19
err0
errOAAI
errGanaha, Akira; Hishinuma, Eiji; Kaname, Tadashi; Hiratsuka, Masahiro; Kondo, Shunsuke; Tono, Tetsuya
err分享
err收藏
Identification and functional validation of novel pharmacogenomic variants using a next-generation sequencing-based approach for clinical pharmacogenomics
errPHARMACOLOGICAL RESEARCH
IF10.5
err2022-02-01
err11
errOAAI
errSiamoglou, Stavroula; Koromina, Maria; Hishinuma, Eiji; Yamazaki, Shuki; Tsermpini, Evangelia-Eirini; Kordou, Zoe; Fukunaga, Koya; Chantratita, Wasun; Zhou, Yitian; Lauschke, Volker M.; Mushiroda, Taisei; Hiratsuka, Masahiro; Patrinos, George P.
err分享
err收藏
A chalcone derivative suppresses TSLP induction in mice and human keratinocytes through binding to BET family proteins
errBIOCHEMICAL PHARMACOLOGY
IF5.6
err2021-12-01
err2
errOAAI
errSegawa, Ryosuke; Takeda, Hiroyuki; Yokoyama, Takeshi; Ishida, Momoha; Miyata, Chihiro; Saito, Taiji; Ishihara, Ryosuke; Nakagita, Tomoya; Sasano, Yusuke; Kanoh, Naoki; Iwabuchi, Yoshiharu; Mizuguchi, Mineyuki; Hiratsuka, Masahiro; Hirasawa, Noriyasu
err分享
err收藏
Functional Characterization of 21 Rare Allelic CYP1A2 Variants Identified in a Population of 4773 Japanese Individuals by Assessing Phenacetin O-Deethylation
errJOURNAL OF PERSONALIZED MEDICINE
IF3
err2021-07-22
err6
errOAAI
errKumondai, Masaki; Rico, Evelyn Gutierrez; Hishinuma, Eiji; Nakanishi, Yuya; Yamazaki, Shuki; Ueda, Akiko; Saito, Sakae; Tadaka, Shu; Kinoshita, Kengo; Saigusa, Daisuke; Nakayoshi, Tomoki; Oda, Akifumi; Hirasawa, Noriyasu; Hiratsuka, Masahiro
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err收藏
Lactate released from human fibroblasts enhances Ni elution from Ni plate
errTOXICOLOGY
IF4.6
err2021-04-01
err2
PREAI
errKasai, Koji; Segawa, Ryosuke; Onodera, Ryo; Asakawa, Sanki; Hiratsuka, Masahiro; Hirasawa, Noriyasu
err分享
err收藏
Functional Assessment of 12 Rare Allelic CYP2C9 Variants Identified in a Population of 4773 Japanese Individuals
errJOURNAL OF PERSONALIZED MEDICINE
IF3
err2021-02-02
err8
errOAAI
errKumondai, Masaki; Ito, Akio; Rico, Evelyn Marie Gutierrez; Hishinuma, Eiji; Ueda, Akiko; Saito, Sakae; Nakayoshi, Tomoki; Oda, Akifumi; Tadaka, Shu; Kinoshita, Kengo; Maekawa, Masamitsu; Mano, Nariyasu; Hirasawa, Noriyasu; Hiratsuka, Masahiro
err分享
err收藏
Heterologous expression of high-activity cytochrome P450 in mammalian cells
errSCIENTIFIC REPORTS
IF3.9
err2020-08-25
err20
errOAAI
errKumondai, Masaki; Hishinuma, Eiji; Rico, Evelyn Marie Gutierrez; Ito, Akio; Nakanishi, Yuya; Saigusa, Daisuke; Hirasawa, Noriyasu; Hiratsuka, Masahiro
err分享
err收藏

研究方向

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