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李国菠 封面图

李国菠 (Guo‐Bo Li)

sichuan university

32H指数
155论文数
3.2K被引数
收录论文 88
发表时间
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EGNN-Based Generative Models for 3D Molecular GenerationEGNN为基础的3D分子生成生成模型
errWiley Interdisciplinary Reviews-Computational Molecular Science
IF27
err2026-09-07
err0
PREAI
errSiliang Chen; Daihan Wang; Zhaoping Pan; Guobo Li; Gu He
err分享
err收藏
Fluoro-boronates for targeting and imaging β-lactamase-producing pathogens氟硼酸酯用于靶向和成像β-内酰胺酶产生病原体
errActa Pharmaceutica Sinica B
IF14.6
err2026-07-10
err0
errOAAI
errGuoqing Liang; Siqi Wei; Huan Liu; Chenglong Han; Zengbao Yang; Xiangmin Dong; Lili Pan; Kedian Guo; Xueli Hu; Xin Li; Rong Tian; Christopher J. Schofield; Xikun Zhou; Xiaoai Wu; Guo-Bo Li
err分享
err收藏
Correction to “Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence”对 “通过面向药效团的生成式人工智能合理设计广谱非核苷类逆转录酶抑制剂” 的更正
errJournal of Medicinal Chemistry
IF6.8
err2026-04-20
err0
errOAAI
errKun Zhang; Yuhan Lin; Ling Dong; Yuting Niu; Jian Peng; Christophe Pannecouque; Erik De Clercq; Phuong-Thao Tran; Guobo Li; Tiancong Zhao; Xudong Li; Shuo Su; Shuai Wang; Fen-Er Chen
err分享
err收藏
Discovery of cyanoguanidine-containing 2,4,5-trisubstituted pyrimidine derivatives as novel dual-competitive SIRT5 inhibitors含有氰胍基的2,4,5-三取代嘧啶衍生物作为新型双竞争性SIRT5抑制剂的发现
errJournal of Molecular Structure
IF4.7
err2026-03-26
err0
PREAI
errRui Xiong; Yingying Jiang; Zhiwen Yang; Hang Zhang; Meijun Yang; Wenyi Liu; Yichun Miu; Yanjun Wang; Hui Lei; Cuiting Zhong; Xindie Li; Lijiao Wang; Guo-Bo Li; Yuanyuan Zhang; Lingling Yang
err分享
err收藏
A Novel CSN5 Inhibitor Drives Tumor-Intrinsic PD-L1 Degradation and Exerts Direct Antitumor Efficacy in Triple-Negative Breast Cancer一种新型CSN5抑制剂可驱动肿瘤内源性的PD-L1降解，并直接在 triple-negative breast cancer 中发挥抗肿瘤功效
errJournal of Medicinal Chemistry
IF6.8
err2026-02-18
err0
PREAI
errYanjun Wang; Hui Lei; Wenyi Liu; Xindie Li; Siyi Jiang; Hang Zhang; Rui Xiong; Zhiwen Yang; Yu-Hang Yan; Yingying Jiang; Ming Lei; Guo-Bo Li; Hua-Li Wang; Lingling Yang
err分享
err收藏
Local electronic modulation by single-atom Cu for CO2 hydrogenation to light olefins单原子Cu对CO2加氢制低碳烯烃的局域电子调制
errApplied Catalysis B: Environment and Energy
IF0
err2025-11-17
err0
PREAI
errLizhi Zhang; Wenming Liu; Guobo Li; Jian Ji; Liang Ye; Yupeng Liu; Wei Wang; Peng Wu; Honggen Peng
err分享
err收藏
Design, synthesis and biological evaluation of novel glutaminyl cyclase inhibitors targeting the CD47-SIRPα axis in breast cancer cells新型瓜氨酸酶抑制剂的研发、合成及其在靶向乳腺癌细胞中CD47-SIRPα轴的生物活性评价
errBioorganic & Medicinal Chemistry
IF3
err2025-10-27
err0
PREAI
errRong Li; Wei-Feng Zhang; Hui Lei; Fan-Bo Meng; Wenyi Liu; Rui Xiong; Hang Zhang; Yanjun Wang; Yingying Jiang; Guo-Bo Li; Li-Jiao Wang; Lingling Yang; Hua-Li Wang
err分享
err收藏
Structural Optimization of Bicyclic Oxo-Boronates as Dual Metallo- and Serine-β-Lactamase Inhibitors双环氧硼酸酯作为双金属和丝氨酸-β-内酰胺酶抑制剂的构效优化
errJournal of Medicinal Chemistry
IF6.8
err2025-10-13
err0
PREAI
errZeng-Bao Yang; Si-Qi Wei; Yao-Geng Wang; Xiang-Min Dong; Hao-Xiang Xu; Xiao-Lan Li; Jian Peng; Rui-Chuan Yin; Guo-Bo Li
err分享
err收藏
Bacteriophage-mediated Antibacterial and Photodynamic Therapies细菌噬菌体介导的抗菌和光动力疗法
errRSC Med. Chem.
IF3.6
err2025-10-08
err0
PREAI
errRui Yu; Guo-Bo Li; Bengui Ye; Jong Seung Kim; Xuechuan Hong; Yuling Xiao; Xiaodong Zeng
err分享
err收藏
Pharmacophore-oriented 3D molecular generation toward efficient feature-customized drug discovery药效团导向的3D分子生成，用于高效特征定制的药物发现
errNature Computational Science
IF18.3
err2025-08-26
err0
PREAI
errJian Peng; Jun-Lin Yu; Zeng-Bao Yang; Yi-Ting Chen; Si-Qi Wei; Fan-Bo Meng; Yao-Geng Wang; Xiao-Tian Huang; Guo-Bo Li
err分享
err收藏
REaMA: Building Biomedical Relation Extraction Specialized Large Language Models Through Instruction TuningREaMA：通过指令调优构建生物医学关系抽取专用大型语言模型
errIEEE Transactions on Neural Networks and Learning Systems
IF8.9
err2025-08-20
err0
PREAI
errYidan Zhang; Junlin Yu; Guobo Li; Zhenan He; Gary G. Yen
err分享
err收藏
Co-delivery of SN38 and SR717 activates cGAS–STING for near-infrared II image-guided chemoimmunotherapy共递送SN38和SR717激活cGAS–STING，用于近红外II成像引导的化疗免疫疗法
errJournal of Controlled Release
IF11.5
err2025-08-14
err0
PREAI
errXiaowen Hou; Chunlin Ren; Xiaodong Zeng; Yukun Hu; Yicheng Zhao; Yuxin Cheng; Qiusi Luo; Taotao Ding; Xue Qiao; Yuqin Liao; Guo-Bo Li; Bengui Ye; Xuechuan Hong; Yuling Xiao
err分享
err收藏
Structural Properties, Pathophysiological Relevance and Synthetic Modulators of TRPC ChannelsTRPC通道的结构特性、病理生理相关性及其合成调节剂
errMedicinal Research Reviews
IF11.6
err2025-07-30
err0
PREAI
errXue Qiao; Chunlin Ren; Wumei Wang; Xiaofen Wang; Guo-Bo Li; Cheng Chen; Bengui Ye; Xiaodong Zeng; Yuling Xiao; Xuechuan Hong
err分享
err收藏
A 3D pocket-aware lead optimization model with knowledge guidance and its application for discovery of new glutaminyl cyclase inhibitors一种基于知识引导的3D口袋感知先导化合物优化模型及其在新谷氨酰胺环化酶抑制剂发现中的应用
errBriefings in Bioinformatics
IF7.7
err2025-07-02
err0
errOAAI
errAnjie Qiao; Yuting Chen; Junjie Xie; Weifeng Huang; Hao Zhang; Qirui Deng; Jiahua Rao; Ji Deng; Fanbo Meng; Zhen Wang; Mingyuan Xu; Hongming Chen; Jiancong Xie; Shuangjia Zheng; Yuedong Yang; Guo-Bo Li; Jinping Lei
err分享
err收藏
Structure-activity relationship studies of 3,4-disubstitued indole-2-ketone derivatives identify a potent glutaminyl cyclase inhibitor with antitumor activity against breast cancer3,4-二取代吲哚-2-酮衍生物的结构-活性关系研究识别出一种强效的谷氨酰胺环化酶抑制剂，该抑制剂对乳腺癌具有抗肿瘤活性。
errChinese Chemical Letters
IF8.9
err2025-07-01
err0
PREAI
errHui Lei; Yingying Jiang; Jiayu Liu; Weifeng Zhang; Fanbo Meng; Jun Mou; Wenyi Liu; Pengcheng Lei; Rui Xiong; Zan Xu; Hang Zhang; Yanjun Wang; Guo-Bo Li; Lingling Yang; Hua-Li Wang
err分享
err收藏
Discovery of 3-methacylic acid substituted benzoxaboroles as dual metallo-and serine-(β-lactamase inhibitors3-甲酰基乙酸取代的苯并硼唑类化合物的发现作为双金属和丝氨酸(β-内酰胺酶抑制剂)
errEUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
err2025-05-28
err0
PREAI
errLiang, Guo-Qing; Jiang, Ying-Ying; Han, Cheng-Long; Wang, Yao; Wang, Si-Yao; Chen, Yi-Ting; Li, Gen; Li, Guo-Bo; Xiao, You-Cai
err分享
err收藏
Combination of Sodium Butyrate and Immunotherapy in Glioma: regulation of immunologically hot and cold tumors via gut microbiota and metabolites丁酸钠与免疫疗法在胶质瘤中的联合应用：通过肠道菌群及其代谢物调控免疫热肿瘤和免疫冷肿瘤
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2025-04-14
err0
errOAAI
errLi, Sui; Wang, Li; Han, Mingyu; Fan, Huali; Tang, Hailin; Gao, Huile; Li, Guobo; Xu, Zheng; Zhou, Zhaokai; Du, Junrong; Peng, Cheng; Peng, Fu
err分享
err收藏
Transcription factor addictions: exploring the potential Achilles' Heel of endometriosis转录因子依赖：探索子宫内膜异位症的潜在阿喀琉斯之踵
errSCIENCE CHINA-LIFE SCIENCES
IF9.5
err2025-03-27
err0
PREAI
errYang, Yang; Du, Yi; Ma, Xuelei; Yuan, Gang; Li, Guobo; Zhang, Qian; Zhou, Shengtao
err分享
err收藏
Enhanced BBB penetration and microglia-targeting nanomodulator for the two-pronged modulation of chronically activated microglia-mediated neuroinflammation in Alzheimer's disease增强血脑屏障穿透性和靶向小胶质细胞的纳米调节剂，用于阿尔茨海默病中慢性激活的小胶质细胞介导的神经炎症的双管齐下调控。
errACTA PHARMACEUTICA SINICA B
IF0
err2025-01-01
err1
errOAAI
errWei, Y; Xia, X; Wang, XR; Yang, WQ; He, SQ; Wang, LL; Chen, YK; Zhou, Y; Chen, F; Li, HM; Peng, F; Li, GB; Xu, Z; Fu, JT; Gao, HL
err分享
err收藏
Catalytic cycle network: Boosting CO2 hydrogenation to propane
errAPPLIED CATALYSIS B-ENVIRONMENT AND ENERGY
IF21.1
err2024-12-01
err0
PREAI
errZhang, Lizhi; Li, Miao; Li, Guobo; Liang, Wenming; Ye, Liang; Liu, Kun; Ma, Qingxiang; Peng, Honggen
err分享
err收藏

研究方向

创新药物研发药物设计靶标发现人工智能化学生物学金属酶结构生物学生物物理学分子生物学
合作学者
合作期刊
E
Erik De Clercq
H 指数: 162 · 论文数: 4.0K
陈豪 封面图
陈豪 (Hao Chen)
H 指数: 139 · 论文数: 5.6K
张
张礼智 (Lizhi Zhang)
H 指数: 135 · 论文数: 654
J
Jong Seung Kim
H 指数: 134 · 论文数: 1.2K
C
Christopher J. Schofield
H 指数: 112 · 论文数: 1.3K
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