Lauren E. Sirois

Genentech

H指数:14

被引数:1,130

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Cyclization of Carbonyl Electrophiles via Dual HAT/Photoredox-Catalyzed Reductive Radical-Polar Crossover

通过双重HAT/光还原催化实现的羰基亲电试剂环化反应

European Journal of Organic Chemistry

IF2.7

2026-01-010

PRE

Investigating the Origin of Epimerization Attenuation during Pd-Catalyzed Cross-Coupling Reactions

ACS CATALYSIS

IF13.1

2024-08-031

OAAI

Fit-for-Purpose Synthesis of a KRASG12C Covalent Inhibitor, via a Diastereoselective Hayashi Arylation

通过非对映选择性Hayashi芳基化合成KRASG12C共价抑制剂

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-07-220

PRE

Streamlined Synthesis of SHP2 Inhibitor GDC-1971 Enhanced by a Telescoped Schotten-Baumann SNAr and Reactive Crystallization Cascade

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-06-270

PRE

Scalable Synthesis of 6-Chloro-1H-pyrazolo[3,4-b]pyrazine via a Continuous Flow Formylation/Hydrazine Cyclization Cascade

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2024-05-312

PRE

Umpolung Flow Chemistry for the Synthesis of a 3-Oxo-3H-spiro[benzofuran-2,4′-piperidine] Building Block

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2024-05-201

PRE

Data Science Guided Multiobjective Optimization of a Stereoconvergent Nickel-Catalyzed Reduction of Enol Tosylates to Access Trisubstituted Alkenes

ACS CATALYSIS

IF13.1

2024-03-132

PRE

Manufacturing Process for 6-Bromo-N,N-bis(4-methoxybenzyl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine, a Key Intermediate in the Synthesis of KRAS G12C Inhibitor Divarasib

合成KRAS G12C抑制剂Divarasib的关键中间体6-溴-N，N-双 (4-甲氧基苄基)-4-甲基-5-(三氟甲基) 吡啶-2-胺的制造工艺

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2023-12-295

PRE

Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036

第二代KRAS G12C共价抑制剂GDC-6036的选择性合成

ORGANIC LETTERS

IF5

2023-05-1012

PRE

Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2022-11-0326

PRE

Stereoselective Synthesis of the IDO Inhibitor Navoximod

JOURNAL OF ORGANIC CHEMISTRY

IF3.6

2022-03-235

PRE

Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2021-11-0454

Achiral-Chiral Two-Dimensional Liquid Chromatography Platform to Support Automated High-Throughput Experimentation in the Field of Drug Development

ANALYTICAL CHEMISTRY

IF6.7

2020-11-0310

PREAI

Practical Synthesis of a Stable Precursor for Positron Emission Tomography Imaging Agent 18F-GTP1

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-07-283

PREAI

Process Development Overcomes a Challenging Pd-Catalyzed C-N Coupling for the Synthesis of RORc Inhibitor GDC-0022

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2020-03-307

PREAI

Phosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2-a]pyrimidine Isomers

ORGANIC LETTERS

IF5

2019-11-1814

PREAI

Identification of an acetonitrile addition impurity formed during peptide disulfide bond reduction using dithiothreitol and Tris(2-carboxyethyl)phosphine

使用二硫苏醇和三 (2-羧乙基) 膦鉴定肽二硫键还原过程中形成的乙腈加成杂质

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

IF3.1

2019-09-011

PREAI

Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp3-sp2 Suzuki Coupling of a Benzyl Carbonate

利用碳酸苄酯的sp3-sp2铃木偶联，开发局部作用的SGLT1抑制剂LX2761的工艺

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2018-12-245

PREAI

Practical Synthesis of a 6-Triazolylazabicyclo[3.1.0]hexane

ORGANIC PROCESS RESEARCH & DEVELOPMENT

IF3.5

2018-06-015

PREAI

Characterization of Pharmaceutical Cocrystals and Salts by Dynamic Nuclear Polarization-Enhanced Solid-State NMR Spectroscopy

CRYSTAL GROWTH & DESIGN

IF3.4

2018-02-1566

OAAI

Lauren E. Sirois

个人简介

教育背景

工作经历

荣誉奖项

研究方向