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A

Agata Siwek

Jagiellonian University
H指数:33
被引数:4,340

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Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s Disease

多官能化N-芳基磺酰基吲哚：用于表观遗传学基础治疗帕金森病的(E)-N-羟基-3-{3-[(5-(3-(哌啶-1-基)丙氧基)-1H-吲哚-1-基)磺酰基]苯基}丙烯酰胺（MTP150）的鉴定

International Journal of Molecular Sciences
IF4.9
2026-03-310
OAAI
Mireia Toledano-Pinedo; Alicia Porro-Pérez; Linda Schäker-Hübner; Daniel Diez-Iriepa; Isabel Iriepa; Agata Siwek; Małgorzata Wolak; Grzegorz Satała; Andrzej J. Bojarski; Agata Doroz-Płonka; Jadwiga Handzlik; Justyna Godyń; Patrick Dallemagne; Christophe Rochais; Audrey Davis; Marc Since; Belén Pérez; Aina Bellver-Sanchis; Alba Irisarri; Mercè Pallàs; Cristina Solana-Manrique; Francisco López-Muñoz; Lhassane Ismaili; Christian Griñán-Ferré; Nuria Paricio; Finn K. Hansen; Anna Więckowska; José Marco-Contelles
Rational Design, Synthesis and Pharmacological Evaluation of Chalcones as Dual-Acting Compounds—Histamine H3 Receptor Ligands and MAO-B Inhibitors

理性设计、合成及药理学评价：作为双重作用化合物的查尔酮——组胺H3受体配体和MAO-B抑制剂

International Journal of Molecular Sciences
IF4.9
2026-01-060
OA
Dorota Łażewska; Agata Doroz-Płonka; Kamil Kuder; Agata Siwek; Waldemar Wagner; Joanna Karnafał-Ziembla; Agnieszka Olejarz-Maciej; Małgorzata Wolak; Monika Głuch-Lutwin; Barbara Mordyl
Simultaneous modulation of 5-HT6 and SERT by MM394: a dual-target ligand providing neuroprotection against amyloid-β toxicity, memory preservation, and alleviation of BPSD symptoms

MM394对5-HT6和SERT的同时调节：一种双靶点配体，可提供抗淀粉样β毒性、记忆保留和改善BPSD症状的神经保护作用

Pharmacology Biochemistry and Behavior
IF2.5
2025-11-100
PRE
Agata Siwek; Monika Marcinkowska; Barbara Mordyl; Monika Głuch-Lutwin; Małgorzata Wolak; Magdalena Jastrzębska-Więsek; Natalia Wilczyńska-Zawal; Elżbieta Wyska; Katarzyna Szafrańska; Anna Wesołowska; Marcin Kołaczkowski
JP-14: A Trace Amine-Associated Receptor 1 Agonist with Anti-Metabolic Disorder Potential

JP-14：一种 Trace Amine-Associated Receptor 1 激动剂，具有抗代谢紊乱的潜力

International Journal of Molecular Sciences 2025, Vol. 26, Page 10033
IF0
2025-10-150
OAAI
Monika Marcinkowska; Joanna Sniecikowska; Monika Głuch-Lutwin; Barbara Mordyl; Marek Bednarski; Adam Bucki; Michał Sapa; Monika Kubacka; Agata Siwek; Agnieszka Zagórska; Jacek Sapa; Marcin Kołaczkowski; Magdalena Kotańska
Discovery of NLX-266, an Orally Available and Metabolically Stable ERK1/2-Biased 5-HT1AR Agonist with Superior Antidepressant and Antiparkinsonian Activity

发现NLX-266，一种口服可用且代谢稳定的ERK1/2偏向性5-HT1AR激动剂，具有优越的抗抑郁和抗帕金森活性。

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2025-04-230
OA
Sniecikowska, Joanna; Gluch-Lutwin, Monika; Bucki, Adam; Gryzlo, Beata; Wieckowski, Krzysztof; Godyn, Justyna; Wieckowska, Anna; Siwek, Agata; Cios, Agnieszka; Wesolowska, Anna; Newman-Tancredi, Adrian; Kolaczkowski, Marcin
Preferential Synaptic Type of GABA-A Receptor Ligands Enhancing Neuronal Survival and Facilitating Functional Recovery After Ischemic Stroke
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-12-130
PRE
Mordyl, Barbara; Fajkis-Zajaczkowska, Nikola; Szafranska, Katarzyna; Siwek, Agata; Gluch-Lutwin, Monika; Zmudzki, Pawel; Jonczyk, Jakub; Karcz, Tadeusz; Sloczynska, Karolina; Pekala, Elzbieta; Pomierny, Bartosz; Krzyzanowska, Weronika; Jurczyk, Jakub; Skorkowska, Alicja; Salach, Aleksandra; Jastrzebska-Wiesek, Magdalena; Walczak, Maria; Gawlik, Maciej Tadeusz; Smolik, Magdalena; Kolaczkowski, Marcin; Marcinkowska, Monika
Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
2024-11-220
OA
Panek, Dawid; Pasieka, Anna; Jonczyk, Jakub; Gawlinska, Milena; Zareba, Paula; Siwek, Agata; Wolak, Malgorzata; Mordyl, Barbara; Gluch-Lutwin, Monika; Latacz, Gniewomir; Brazzolotto, Xavier; Chantegreil, Fabien; Nachon, Florian; Zdarova Karasova, Jana; Pejchal, Jaroslav; Mzik, Martin; Sestak, Vit; Prchal, Lukas; Odvarkova, Jitka; Soukup, Ondrej; Korabecny, Jan; Sorf, Ales; Hamsikova, Marie; Zemanova, Lucie; Muckova, Lubica; Vanova, Nela; Dryja, Pola; Salat, Kinga; Hoefner, Georg; Wanner, Klaus; Wieckowska, Anna; Malawska, Barbara
Contilisant plus Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-09-100
PRE
Toledano-Pinedo, Mireia; Porro-Perez, Alicia; Schaeker-Huebner, Linda; Romero, Fernando; Dong, Min; Samadi, Abdelouahid; Almendros, Pedro; Iriepa, Isabel; Bautista-Aguilera, Oscar M.; Rodriguez-Fernandez, M. Mercedes; Solana-Manrique, Cristina; Sanchis, Inmaculada; Mora-Morell, Alba; Rodriguez, Ania Canseco; Sanchez-Perez, Ana M.; Knez, Damijan; Gobec, Stanislav; Bellver-Sanchis, Aina; Perez, Belen; Dobrydnev, Alexey V.; Artetxe-Zurutuza, Aizpea; Matheu, Ander; Siwek, Agata; Wolak, Malgorzata; Satala, Grzegorz; Bojarski, Andrzej J.; Doroz-Plonka, Agata; Handzlik, Jadwiga; Godyn, Justyna; Wieckowska, Anna; Paricio, Nuria; Grinan-Ferre, Christian; Hansen, Finn K.; Marco-Contelles, Jose
Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2024-09-011
PRE
Siwek, Agata; Marcinkowska, Monika; Gluch-Lutwin, Monika; Mordyl, Barbara; Wolak, Malgorzata; Jastrzebska-Wiesek, Magdalena; Wilczynska-Zawal, Natalia; Wyska, Elzbieta; Szafranska, Katarzyna; Karcz, Tadeusz; Ostrowska, Olga; Bucki, Adam; Kolaczkowski, Marcin
Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors
ACS CHEMICAL NEUROSCIENCE
IF3.9
2024-08-290
PRE
Malek, Rim; Salat, Kinga; Totoson, Perle; Karcz, Tadeusz; Refouvelet, Bernard; Skrzypczak-Wiercioch, Anna; Maj, Maciej; Simakov, Alexey; Martin, Helene; Siwek, Agata; Szalaj, Natalia; Godyn, Justyna; Panek, Dawid; Wieckowska, Anna; Jozwiak, Krzysztof; Demougeot, Celine; Kiec-Kononowicz, Katarzyna; Chabchoub, Fakher; Iriepa, Isabel; Marco-Contelles, Jose; Ismaili, Lhassane
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-01-089
OAAI
Pyka, Patryk; Haberek, Wawrzyniec; Wiecek, Malgorzata; Szymanska, Ewa; Ali, Wesam; Cios, Agnieszka; Jastrzebska-Wiesek, Magdalena; Satala, Grzegorz; Podlewska, Sabina; Di Giacomo, Silvia; Di Sotto, Antonella; Garbo, Sabrina; Karcz, Tadeusz; Lambona, Chiara; Marocco, Francesco; Latacz, Gniewomir; Sudol-Talaj, Sylwia; Mordyl, Barbara; Gluch-Lutwin, Monika; Siwek, Agata; Czarnota-Lydka, Kinga; Gogola, Dawid; Olejarz-Maciej, Agnieszka; Wilczynska-Zawal, Natalia; Honkisz-Orzechowska, Ewelina; Starek, Malgorzata; Dabrowska, Monika; Kucwaj-Brysz, Katarzyna; Fioravanti, Rossella; Nasim, Muhammad Jawad; Hittinger, Marius; Partyka, Anna; Wesolowska, Anna; Battistelli, Cecilia; Zwergel, Clemens; Handzlik, Jadwiga

研究方向

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M
Marcin Kołaczkowski
H 指数:34论文数:181被引数:4,072
M
Monika Głuch‐Lutwin
H 指数:22论文数:113被引数:1,309
G
Gabriel Nowak
H 指数:66论文数:405被引数:1.3万
A
Anna Wesołowska
H 指数:33论文数:201被引数:3,833
A
Adam Bucki
H 指数:25论文数:84被引数:1,449
A
Anna Partyka
H 指数:29论文数:162被引数:2,380
M
Monika Marcinkowska
H 指数:18论文数:72被引数:1,010
K
Katarzyna Kieć‐Kononowicz
H 指数:39论文数:400被引数:6,055
B
Barbara Mordyl
H 指数:16论文数:73被引数:747
M
Maciej Pawłowski
H 指数:30论文数:232被引数:3,151