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Discovery of NLX-266, an Orally Available and Metabolically Stable ERK1/2-Biased 5-HT1AR Agonist with Superior Antidepressant and Antiparkinsonian Activity 发现NLX-266，一种口服可用且代谢稳定的ERK1/2偏向性5-HT1AR激动剂，具有优越的抗抑郁和抗帕金森活性。 Sniecikowska, Joanna; Gluch-Lutwin, Monika; Bucki, Adam; Gryzlo, Beata; Wieckowski, Krzysztof; Godyn, Justyna; Wieckowska, Anna; Siwek, Agata; Cios, Agnieszka; Wesolowska, Anna; Newman-Tancredi, Adrian; Kolaczkowski, Marcin 分享 收藏
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Preferential Synaptic Type of GABA-A Receptor Ligands Enhancing Neuronal Survival and Facilitating Functional Recovery After Ischemic Stroke Mordyl, Barbara; Fajkis-Zajaczkowska, Nikola; Szafranska, Katarzyna; Siwek, Agata; Gluch-Lutwin, Monika; Zmudzki, Pawel; Jonczyk, Jakub; Karcz, Tadeusz; Sloczynska, Karolina; Pekala, Elzbieta; Pomierny, Bartosz; Krzyzanowska, Weronika; Jurczyk, Jakub; Skorkowska, Alicja; Salach, Aleksandra; Jastrzebska-Wiesek, Magdalena; Walczak, Maria; Gawlik, Maciej Tadeusz; Smolik, Magdalena; Kolaczkowski, Marcin; Marcinkowska, Monika 分享 收藏
Guanidine Derivative ADS1017, a Potent Histamine H3 Receptor Antagonist with Promising Analgesic Activity and Satisfactory Safety Profile Karcz, Tadeusz; Szczepanska, Katarzyna; Mogilski, Szczepan; Moroz, Aleksandra; Olejarz-Maciej, Agnieszka; Humphrys, Laura J.; Pockes, Steffen; Siwek, Agata; Dubiel, Krzysztof; Staszewski, Marek; Calmels, Thierry; Waczynski, Krzysztof; Kiec-Kononowicz, Katarzyna 分享 收藏
Multifunctional, Fluorene-Based Modulator of Cholinergic and GABAergic Neurotransmission as a Novel Drug Candidate for Palliative Treatment of Alzheimer's Disease Panek, Dawid; Pasieka, Anna; Jonczyk, Jakub; Gawlinska, Milena; Zareba, Paula; Siwek, Agata; Wolak, Malgorzata; Mordyl, Barbara; Gluch-Lutwin, Monika; Latacz, Gniewomir; Brazzolotto, Xavier; Chantegreil, Fabien; Nachon, Florian; Zdarova Karasova, Jana; Pejchal, Jaroslav; Mzik, Martin; Sestak, Vit; Prchal, Lukas; Odvarkova, Jitka; Soukup, Ondrej; Korabecny, Jan; Sorf, Ales; Hamsikova, Marie; Zemanova, Lucie; Muckova, Lubica; Vanova, Nela; Dryja, Pola; Salat, Kinga; Hoefner, Georg; Wanner, Klaus; Wieckowska, Anna; Malawska, Barbara 分享 收藏
Rational Search for Betaine/GABA Transporter 1 Inhibitors-In Vitro Evaluation of Selected Hit Compound Latka, Kamil; Kickinger, Stefanie; Rzepka, Zuzanna; Zareba, Paula; Latacz, Gniewomir; Siwek, Agata; Wolak, Malgorzata; Stary, Dorota; Marcinkowska, Monika; Wellendorph, Petrine; Wrzesniok, Dorota; Bajda, Marek 分享 收藏
Contilisant plus Tubastatin A Hybrids: Polyfunctionalized Indole Derivatives as New HDAC Inhibitor-Based Multitarget Small Molecules with In Vitro and In Vivo Activity in Neurodegenerative Diseases Toledano-Pinedo, Mireia; Porro-Perez, Alicia; Schaeker-Huebner, Linda; Romero, Fernando; Dong, Min; Samadi, Abdelouahid; Almendros, Pedro; Iriepa, Isabel; Bautista-Aguilera, Oscar M.; Rodriguez-Fernandez, M. Mercedes; Solana-Manrique, Cristina; Sanchis, Inmaculada; Mora-Morell, Alba; Rodriguez, Ania Canseco; Sanchez-Perez, Ana M.; Knez, Damijan; Gobec, Stanislav; Bellver-Sanchis, Aina; Perez, Belen; Dobrydnev, Alexey V.; Artetxe-Zurutuza, Aizpea; Matheu, Ander; Siwek, Agata; Wolak, Malgorzata; Satala, Grzegorz; Bojarski, Andrzej J.; Doroz-Plonka, Agata; Handzlik, Jadwiga; Godyn, Justyna; Wieckowska, Anna; Paricio, Nuria; Grinan-Ferre, Christian; Hansen, Finn K.; Marco-Contelles, Jose 分享 收藏
Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties Siwek, Agata; Marcinkowska, Monika; Gluch-Lutwin, Monika; Mordyl, Barbara; Wolak, Malgorzata; Jastrzebska-Wiesek, Magdalena; Wilczynska-Zawal, Natalia; Wyska, Elzbieta; Szafranska, Katarzyna; Karcz, Tadeusz; Ostrowska, Olga; Bucki, Adam; Kolaczkowski, Marcin 分享 收藏
Discovery of New Highly Potent Histamine H3 Receptor Antagonists, Calcium Channel Blockers, and Acetylcholinesterase Inhibitors Malek, Rim; Salat, Kinga; Totoson, Perle; Karcz, Tadeusz; Refouvelet, Bernard; Skrzypczak-Wiercioch, Anna; Maj, Maciej; Simakov, Alexey; Martin, Helene; Siwek, Agata; Szalaj, Natalia; Godyn, Justyna; Panek, Dawid; Wieckowska, Anna; Jozwiak, Krzysztof; Demougeot, Celine; Kiec-Kononowicz, Katarzyna; Chabchoub, Fakher; Iriepa, Isabel; Marco-Contelles, Jose; Ismaili, Lhassane 分享 收藏
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First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease Pyka, Patryk; Haberek, Wawrzyniec; Wiecek, Malgorzata; Szymanska, Ewa; Ali, Wesam; Cios, Agnieszka; Jastrzebska-Wiesek, Magdalena; Satala, Grzegorz; Podlewska, Sabina; Di Giacomo, Silvia; Di Sotto, Antonella; Garbo, Sabrina; Karcz, Tadeusz; Lambona, Chiara; Marocco, Francesco; Latacz, Gniewomir; Sudol-Talaj, Sylwia; Mordyl, Barbara; Gluch-Lutwin, Monika; Siwek, Agata; Czarnota-Lydka, Kinga; Gogola, Dawid; Olejarz-Maciej, Agnieszka; Wilczynska-Zawal, Natalia; Honkisz-Orzechowska, Ewelina; Starek, Malgorzata; Dabrowska, Monika; Kucwaj-Brysz, Katarzyna; Fioravanti, Rossella; Nasim, Muhammad Jawad; Hittinger, Marius; Partyka, Anna; Wesolowska, Anna; Battistelli, Cecilia; Zwergel, Clemens; Handzlik, Jadwiga 分享 收藏
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Synthesis, relative configuration and CB1 receptor affinity studies for a set of 1,2,3-triazole derivatives Szafranski, Przemyslaw W.; Siwek, Agata; Smaga-Maslanka, Irena; Pomierny-Chamiolo, Lucyna; Ilnicki, Piotr; Zuchowski, Grzegorz; Nevalainen, Tapio; Filip, Malgorzata; Zajdel, Pawel; Cegla, Marek T. 分享 收藏
Dual Molecules Targeting 5-HT6 and GABA-A Receptors as a New Approach to Combat Depression Associated with Neuroinflammation Marcinkowska, Monika; Mordyl, Barbara; Siwek, Agata; Gluch-Lutwin, Monika; Karcz, Tadeusz; Gawalska, Alicja; Sapa, Michal; Bucki, Adam; Szafranska, Katarzyna; Pomierny, Bartosz; Pytka, Karolina; Kotanska, Magdalena; Mika, Kamil; Kolaczkowski, Marcin 分享 收藏
Potential Anti-Amnesic Activity of a Novel Multimodal Derivative of Salicylamide, JJGW08, in Mice Zmudzka, Elzbieta; Lustyk, Klaudia; Salaciak, Kinga; Siwek, Agata; Jaskowska, Jolanta; Kolaczkowski, Marcin; Sapa, Jacek; Pytka, Karolina 分享 收藏
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