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M

Matthew J. Hesse

Novartis
H指数:15
被引数:1,226

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Discovery of EGT710; an Oral Nonpeptidomimetic Reversible Covalent SARS-CoV-2 Main Protease Inhibitor

EGT710的发现：一种口服非肽类拟似可逆共价SARS-CoV-2主蛋白酶抑制剂

Journal of Medicinal Chemistry
IF6.8
2026-02-090
PRE
Julien P. N. Papillon; Jun Yuan; Matthew J. Hesse; Lei Zhang; Richard I. Robinson; Nathaniel F. Ware; Viktor Hornak; Rajeshri G. Karki; Tom Kirrane; Keira Garland; Sajan Joseph; Stephanie A. Moquin; Suresh B. Lakshminarayana; Laura Tandeske; Dustin Dovala; Mark Knapp; Elizabeth Ornelas; Daniel Fuller; Pei-i Ho; Xuping Xie; Katarina Vulic; Suzanne M. Skolnik; Jinhai Gao; Mark Zambrowski; Meike Spiess; José S. Duca; Scott A. Busby; Markus Schirle; Michael Robinson; Pei-Yong Shi; Heinz E. Moser; Christopher Sarko; James E. Bradner; Thierry T. Diagana; John A. Tallarico
Discovery and Optimization of a Novel Series of Influenza A Virus Replication Inhibitors Targeting the Nucleoprotein Protein–Protein Interaction

发现并优化靶向核蛋白蛋白-蛋白相互作用的新型甲型流感病毒复制抑制剂系列

Journal of Medicinal Chemistry
IF6.8
2025-07-230
PRE
Benjamin R. Taft; Matthew J. Hesse; Mulugeta Mamo; Dirksen E. Bussiere; Richard Huang; Patrick S. Lee; Laura Wedel; Ellena Growcott; Karen C. Wolff; Kelli Kuhen; Johanna Abend; Kelly A. Wong; Don Ganem; Vincent H. J. Leonard; David C. Tully
Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2024-09-270
OAAI
Barkan, David T.; Garland, Keira; Zhang, Lei; Eastman, Richard T.; Hesse, Matthew; Knapp, Mark; Ornelas, Elizabeth; Tang, Jenny; Cortopassi, Wilian Augusto; Wang, Yu; King, Frederick; Jia, Weiping; Nguyen, Zachary; Frank, Andreas O.; Chan, Ryan; Fang, Eric; Fuller, Daniel; Busby, Scott; Carias, Heidi; Donahue, Kristine; Tandeske, Laura; Diagana, Thierry T.; Jarrousse, Nadine; Moser, Heinz; Sarko, Christopher; Dovala, Dustin; Moquin, Stephanie; Marx, Vanessa M.
Rational Chemical Design of Molecular Glue Degraders

分子胶降解剂的合理化学设计

ACS CENTRAL SCIENCE
IF10.4
2023-04-1158
OAAI
Toriki, Ethan S.; Papatzimas, James W.; Nishikawa, Kaila; Dovala, Dustin; Frank, Andreas O.; Hesse, Matthew J.; Dankova, Daniela; Song, Jae-Geun; Bruce-Smythe, Megan; Struble, Heidi; Garcia, Francisco J.; Brittain, Scott M.; Kile, Andrew C.; McGregor, Lynn M.; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
Deubiquitinase-targeting chimeras for targeted protein stabilization

用于靶向蛋白质稳定的去泛素酶靶向嵌合体

NATURE CHEMICAL BIOLOGY
IF13.7
2022-02-24160
OA
Henning, Nathaniel J.; Boike, Lydia; Spradlin, Jessica N.; Ward, Carl C.; Liu, Gang; Zhang, Erika; Belcher, Bridget P.; Brittain, Scott M.; Hesse, Matthew J.; Dovala, Dustin; McGregor, Lynn M.; Misiolek, Rachel Valdez; Plasschaert, Lindsey W.; Rowlands, David J.; Wang, Feng; Frank, Andreas O.; Fuller, Daniel; Estes, Abigail R.; Randal, Katelyn L.; Panidapu, Anoohya; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.

研究方向

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D
Dustin Dovala
H 指数:19论文数:63被引数:1,701
J
John A. Tallarico
H 指数:49论文数:126被引数:1.1万
M
Markus Schirle
H 指数:52论文数:143被引数:1.9万
A
Andreas O. Frank
H 指数:30论文数:156被引数:2,999
J
Jeffrey M. McKenna
H 指数:28论文数:88被引数:4,309
V
Varinder K. Aggarwal
H 指数:96论文数:1,107被引数:3.3万
D
Daniel K. Nomura
H 指数:80论文数:294被引数:2.5万
C
Christine L. Willis
H 指数:44论文数:312被引数:6,086
D
Daniel Fuller
H 指数:4论文数:8被引数:352
L
Lynn M. McGregor
H 指数:16论文数:33被引数:1,861