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J

Jeffrey M. McKenna

novartis institutes of biomedical research
H指数:28
被引数:4,312

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Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC

亚砜基偶氮环丙烷作为致癌转录因子MYC的立体选择性共价失稳降解剂

Angewandte Chemie International Edition
IF0
2025-09-250
PRE
Hannah T. Rosen; Kelvin Li; Christian E. Stieger; Erin L. Li; Brynne Currier; Scott M. Brittain; Francisco J. Garcia; Diana C. Beard; Michael D. Jones; Sandra Haenni-Holzinger; Dustin Dovala; Jeffrey M. McKenna; Markus Schirle; Thomas J. Maimone; Daniel K. Nomura
Oxidative cyclization reagents reveal tryptophan cation–π interactions

氧化环化试剂揭示色氨酸阳离子-π 相互作用

Nature
IF48.5
2024-03-060
PRE
Xiao Xie; Patrick J. Moon; Steven W. M. Crossley; Amanda J. Bischoff; Dan He; Gen Li; Nam Dao; Angel Gonzalez-Valero; Audrey G. Reeves; Jeffrey M. McKenna; Susanna K. Elledge; James A. Wells; F. Dean Toste; Christopher J. Chang
Rational Chemical Design of Molecular Glue Degraders

分子胶降解剂的合理化学设计

ACS CENTRAL SCIENCE
IF10.4
2023-04-1158
OAAI
Toriki, Ethan S.; Papatzimas, James W.; Nishikawa, Kaila; Dovala, Dustin; Frank, Andreas O.; Hesse, Matthew J.; Dankova, Daniela; Song, Jae-Geun; Bruce-Smythe, Megan; Struble, Heidi; Garcia, Francisco J.; Brittain, Scott M.; Kile, Andrew C.; McGregor, Lynn M.; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.
An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
2022-12-0919
OA
Gonzalez-Valero, Angel; Reeves, Audrey G.; Page, Annika C. S.; Moon, Patrick J.; Miller, Edward; Coulonval, Katia; Crossley, Steven W. M.; Xie, Xiao; He, Dan; Musacchio, Patricia Z.; Christian, Alec H.; McKenna, Jeffrey M.; Lewis, Richard A.; Fang, Eric; Dovala, Dustin; Lu, Yipin; McGregor, Lynn M.; Schirle, Markus; Tallarico, John A.; Roger, Pierre P.; Toste, F. Dean; Chang, Christopher J.
Deubiquitinase-targeting chimeras for targeted protein stabilization

用于靶向蛋白质稳定的去泛素酶靶向嵌合体

NATURE CHEMICAL BIOLOGY
IF13.7
2022-02-24160
OA
Henning, Nathaniel J.; Boike, Lydia; Spradlin, Jessica N.; Ward, Carl C.; Liu, Gang; Zhang, Erika; Belcher, Bridget P.; Brittain, Scott M.; Hesse, Matthew J.; Dovala, Dustin; McGregor, Lynn M.; Misiolek, Rachel Valdez; Plasschaert, Lindsey W.; Rowlands, David J.; Wang, Feng; Frank, Andreas O.; Fuller, Daniel; Estes, Abigail R.; Randal, Katelyn L.; Panidapu, Anoohya; McKenna, Jeffrey M.; Tallarico, John A.; Schirle, Markus; Nomura, Daniel K.

研究方向

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J
John A. Tallarico
H 指数:49论文数:126被引数:1.1万
M
Markus Schirle
H 指数:52论文数:143被引数:1.9万
D
Daniel K. Nomura
H 指数:80论文数:294被引数:2.5万
S
Scott M. Brittain
H 指数:28论文数:87被引数:4,183
J
Jessica N. Spradlin
H 指数:18论文数:32被引数:2,109
D
Dustin Dovala
H 指数:19论文数:63被引数:1,703
F
F. Dean Toste
H 指数:141论文数:808被引数:5.6万
T
Thomas J. Maimone
H 指数:38论文数:221被引数:8,695
L
Lynn M. McGregor
H 指数:16论文数:33被引数:1,862
N
Nathaniel J. Henning
H 指数:12论文数:17被引数:1,746