Markus A. Seeliger - Publications, H-index & Citations

Markus A. Seeliger

Stony Brook University

37H指数

138论文数

6.0K被引数

收录论文 59

发表时间

A design approach for bitopic kinase inhibitors 双位点激酶抑制剂的构效关系设计方法

Nature

IF48.5

2026-09-23

OAAI

Jack W. Stevenson; Kevin Lou; Joshua A. Reynolds; Ian R. Outhwaite; Kenneth Huang; Ivan Sokirniy; Sky Y. J. Peterson; Amir Z. Munir; Celine D. Wang; Haider Inam; Emma L. Gebauer; Ariel Leyte-Vidal; Anastasiia Grynyova; Sydney M. Figueroa; Matthew G. Rees; Melissa M. Ronan; Fernando Salangsang; Yan Zeng; Veronica Steri; Jennifer A. Roth; Neil P. Shah; Ignacia Echeverria; Andrej Šali; Ziyang Zhang; Javid J. Moslehi; Markus A. Seeliger; Justin R. Pritchard; Kevan M. Shokat

Altered residence time as a cause of drug resistance 药物耐药性的原因是改变了的停留时间

Current Opinion in Structural Biology

IF7

2026-02-12

PREAI

Brian M. Farrell; Markus A. Seeliger

Resistance to Allosteric Inhibitors 对变构抑制剂的抗性

Journal of Molecular Biology

IF4.5

2025-04-10

PREAI

Ian R. Outhwaite; Isabelle Kwan; Ariel Leyte-Vidal; Neil P. Shah; Ivet Bahar; Markus A. Seeliger

Inhibiting p38α MAPK signaling: A balancing act in treating inflammation

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

IF3.8

2025-03-01

PREAI

Kwan, Isabelle; Karim, Raisa; Seeliger, Markus A.

Absence of ABL1 exon 2-encoded SH3 residues in BCR::ABL1 destabilizes the autoinhibited kinase conformation and confers resistance to asciminib

LEUKEMIA

IF13.4

2024-07-31

OAAI

Leyte-Vidal, Ariel; DeFilippis, Rosaanna; Outhwaite, Ian R.; Kwan, Isabelle; Lee, Ji Young; Leavitt, Carlyn; Miller, Kaeli B.; Rea, Delphine; Rangwala, Aziz M.; Lou, Kevin; Patel, Suhana; Alvarez, Ailin; Shokat, Kevan M.; Bahar, Ivet; Seeliger, Markus A.; Shah, Neil P.

Calculating Protein-Ligand Residence Times through State Predictive Information Bottleneck Based Enhanced Sampling

JOURNAL OF CHEMICAL THEORY AND COMPUTATION

IF5.5

2024-07-11

OAAI

Lee, Suemin; Wang, Dedi; Seeliger, Markus A.; Tiwary, Pratyush

SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis

NATURE COMMUNICATIONS

IF15.7

2024-07-04

OAAI

Chouhan, Surbhi; Sridaran, Dhivya; Weimholt, Cody; Luo, Jingqin; Li, Tiandao; Hodgson, Myles C.; Santos, Luana N.; Le Sommer, Samantha; Fang, Bin; Koomen, John M.; Seeliger, Markus; Qu, Cheng-Kui; Yart, Armelle; Kontaridis, Maria I.; Mahajan, Kiran; Mahajan, Nupam P.

Editorial overview: Molecular determinants, mechanisms, and state-of-the-art approaches in allostery

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2024-06-01

PREAI

Berezovsky, Igor N.; Seeliger, Markus A.

The C1q and gC1qR axis as a novel checkpoint inhibitor in cancer C1q和gC1qR轴作为癌症中的新型检查点抑制剂

FRONTIERS IN IMMUNOLOGY

IF5.9

2024-04-22

OAAI

Ghebrehiwet, Berhane; Zaniewski, Michal; Fernandez, Audrey; Digiovanni, Mathew; Reyes, Tiana N.; Ji, Ping; Savitt, Anne G.; Williams, Jennie L.; Seeliger, Markus A.; Peerschke, Ellinor I. B.

All the mutations that are fit to die

CELL CHEMICAL BIOLOGY

IF7.2

2024-02-01

OAAI

Gebauer, Emma; Seeliger, Markus A.

Allo-targeting of the kinase domain: Insights from in silico studies and comparison with experiments

CURRENT OPINION IN STRUCTURAL BIOLOGY

IF7

2024-02-01

OAAI

Lee, Ji Young; Gebauer, Emma; Seeliger, Markus A.; Bahar, Ivet

Death by a thousand cuts through kinase inhibitor combinations that maximize selectivity and enable rational multitargeting

ELIFE

IF0

2023-12-04

OAAI

Outhwaite, Ian R.; Singh, Sukrit; Berger, Benedict-Tilman; Knapp, Stefan; Chodera, John D.; Seeliger, Markus A.

Probing conformational dynamics to understand kinase inhibition

ELIFE

IF0

2023-10-18

OAAI

Outhwaite, Ian R.; Seeliger, Markus A.

Structural mechanism of a drug-binding process involving a large conformational change of the protein target 涉及蛋白质靶标大构象变化的药物结合过程的结构机制

NATURE COMMUNICATIONS

IF15.7

2023-04-05

OAAI

Ayaz, Pelin; Lyczek, Agatha; Paung, YiTing; Mingione, Victoria R.; Iacob, Roxana E.; de Waal, Parker W.; Engen, John R.; Seeliger, Markus A.; Shan, Yibing; Shaw, David E.

Good Things Take Time: Tiwary - Seeliger Collaboration for Predictive Pharmacodynamics

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2023-03-28

OAAI

Seeliger, Markus; Tiwary, Pratyush

Domain Architecture of the Nonreceptor Tyrosine Kinase Ack1

CELLS

IF5.2

2023-03-15

OAAI

Kan, Yagmur; Paung, YiTing; Seeliger, Markus A.; Miller, W. Todd

Allosteric regulation and inhibition of protein kinases

BIOCHEMICAL SOCIETY TRANSACTIONS

IF4.3

2023-02-16

OAAI

Mingione, Victoria R.; Paung, YiTing; Outhwaite, Ian R.; Seeliger, Markus A.

Inhibiting ACK1-mediated phosphorylation of C-terminal Src kinase counteracts prostate cancer immune checkpoint blockade resistance

NATURE COMMUNICATIONS

IF15.7

2022-11-14

OAAI

Sridaran, Dhivya; Chouhan, Surbhi; Mahajan, Kiran; Renganathan, Arun; Weimholt, Cody; Bhagwat, Shambhavi; Reimers, Melissa; Kim, Eric H.; Thakur, Manish K.; Saeed, Muhammad A.; Pachynski, Russell K.; Seeliger, Markus A.; Miller, W. Todd; Feng, Felix Y.; Mahajan, Nupam P.

Discovery and molecular basis of subtype-selective cyclophilin inhibitors

NATURE CHEMICAL BIOLOGY

IF13.7

2022-09-26

OAAI

Peterson, Alexander A.; Rangwala, Aziz M.; Thakur, Manish K.; Ward, Patrick S.; Hung, Christie; Outhwaite, Ian R.; Chan, Alix, I; Usanov, Dmitry L.; Mootha, Vamsi K.; Seeliger, Markus A.; Liu, David R.

Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2022-08-01

OAAI

Weinheimer, Alexandra S.; Paung, YiTing; Rageul, Julie; Khan, Arafat; Lo, Natalie; Ho, Brian; Tong, Michael; Alphonse, Sebastien; Kim, Hyungjin; Seeliger, Markus A.

研究方向