Dustin J. Maly - Publications, H-index & Citations

Dustin J. Maly

university of washington

48H指数

320论文数

6.7K被引数

收录论文 104

发表时间

MEK interactions tune RAF kinase sensitivity to conformation-selective inhibition MEK相互作用调节RAF激酶对构象选择性抑制的敏感性

Nature Chemical Biology

IF13.7

2026-05-01

PREAI

Stoddard, Ethan G.; Perera, B. Gayani K.; Fang, Linglan; Brush, Daniel S.; Zhong, Yuhao; Potter, Zachary E.; Simon, Jessica J.; Golkowski, Martin; Maly, Dustin J.

Identification of affinity-optimized peptide binders of a viral protease for chemical genetic applications 鉴定用于化学遗传学应用的亲和力优化病毒蛋白酶肽结合物

Bioorganic & Medicinal Chemistry Letters

IF2.2

2025-11-05

PREAI

Fernando Banales-Mejia; Emily M. Dieter; Kyler J. Radmall; Glenna W. Foight; Douglas M. Fowler; Dustin J. Maly

Pharmacologic inhibition of IRE1α-dependent decay protects alveolar epithelial identity and prevents pulmonary fibrosis in mice IRE1α依赖性降解的药理抑制保护肺泡上皮的表型特性并预防小鼠的肺纤维化

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2025-10-15

PREAI

Auyeung, Vincent C.; Steinberg, Tavienne L.; Olivier, Alina; Suzuki, Luka; Moreno, Mary E.; Khan, Imran S.; Downey, Michael S.; Thamsen, Maike; Guo, Lu; Maly, Dustin J.; Backes, Bradley J.; Sheppard, Dean; Papa, Feroz R.

Multiplexed profiling of intracellular protein abundance, activity, interactions and druggability with LABEL-seq 使用labe-seq对细胞内蛋白质丰度，活性，相互作用和药物性能进行多重分析

NATURE METHODS

IF32.1

2024-10-21

PREAI

Simon, Jessica J.; Fowler, Douglas M.; Maly, Dustin J.

Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance 单细胞传感器分析揭示了能够Ras-G12C耐药性的信号传导程序

NATURE CHEMICAL BIOLOGY

IF13.7

2024-08-05

OAAI

Zhang, Jason Z.; Ong, Shao-En; Baker, David; Maly, Dustin J.

A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

MOLECULAR CANCER THERAPEUTICS

IF5.5

2024-06-12

OAAI

Uo, Takuma; Ojo, Kayode K.; Sprenger, Cynthia C. T.; Epilepsia, Kathryn S.; Perera, B. Gayani K.; Damodarasamy, Mamatha; Sun, Shihua; Kim, Soojin; Hogan, Hannah H.; Hulverson, Matthew A.; Choi, Ryan; Whitman, Grant R.; Barrett, Lynn K.; Michaels, Samantha A.; Xu, Linda H.; Sun, Vicky L.; Arnold, Samuel L. M.; Pang, Haley J.; Nguyen, Matthew M.; Vigil, Anna-Lena B. G.; Kamat, Varun; Sullivan, Lucas B.; Sweet, Ian R.; Vidadala, Ram; Maly, Dustin J.; Van Voorhis, Wesley C.; Plymate, Stephen R.

Single-cell signaling analysis reveals that major vault protein facilitates RasG12C inhibitor resistance

CANCER RESEARCH

IF16.6

2024-03-22

PREAI

Zhang, Jason Z.; Ong, Shao-En; Baker, David; Maly, Dustin J.

Identifying Conformation-Dependent Ligandable Regions of Lck Using Parallel Chemoselective Profiling

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2024-03-01

OAAI

Graves, Amber; Potter, Zachary; Maly, Dustin

Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics

CELL CHEMICAL BIOLOGY

IF7.2

2024-02-01

PREAI

Chakraborty, Sujata; Ahler, Ethan; Simon, Jessica J.; Fang, Linglan; Potter, Zachary E.; Sitko, Katherine A.; Stephany, Jason J.; Guttman, Miklos; Fowler, Douglas M.; Maly, Dustin J.

Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution 计算设计的传感器在亚细胞分辨率下检测内源性Ras活性和信号传导效应子

NATURE BIOTECHNOLOGY

IF41.7

2024-01-25

OAAI

Zhang, Jason Z.; Nguyen, William H.; Greenwood, Nathan; Rose, John C.; Ong, Shao-En; Maly, Dustin J.; Baker, David

Inhibition of androgen receptor signaling in castrate resistant prostate cancer in association with inhibition of glycolysis by targeting hexokinase 2 activity with pyrrolopyrimidine-based small molecules

CANCER RESEARCH

IF16.6

2023-06-02

PREAI

Uo, Takuma; Sprenger, Cynthia; Sweet, Ian; Maly, Dustin; Coleman, Ilsa; Sun, Shihua; Ojo, Kayode; Munari, Mika; Kim, Soojin; Epilepsia, Kathryn; Perera, Gayani; Han, Wanting; Nelson, Peter; Choi, Ryan; Nguyen, Matt; Hulverson, Matt; van Voorhis, Wesley; Plymate, Stephen

Designed sensors reveal normal and oncogenic Ras signaling in endomembranes and condensates

MOLECULAR CANCER RESEARCH

IF4.7

2023-05-01

PREAI

Zhang, Jason Z.; Nguyen, William H.; Rose, John C.; Ong, Shao-En; Maly, Dustin J.; Baker, David

Designed sensors reveal normal and oncogenic Ras signaling in endomembranes and condensates

CANCER RESEARCH

IF16.6

2023-04-04

PREAI

Zhang, Jason Z.; Nguyen, William H.; Rose, John C.; Ong, Shao-En; Maly, Dustin J.; Baker, David

A chemically controlled Cas9 switch enables temporal modulation of diverse effectors

NATURE CHEMICAL BIOLOGY

IF13.7

2023-03-06

OAAI

Wei, Cindy T. T.; Popp, Nicholas A. A.; Peleg, Omri; Powell, Rachel L. L.; Borenstein, Elhanan; Maly, Dustin J. J.; Fowler, Douglas M. M.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

MOLECULAR CELL

IF16.6

2023-03-01

OAAI

Golkowski, Martin; Lius, Andrea; Sapre, Tanmay; Lau, Ho-Tak; Moreno, Taylor; Maly, Dustin J.; Ong, Shao-En

Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics

ACS CHEMICAL BIOLOGY

IF3.8

2023-02-01

OAAI

Tambo, Carrie S.; Tripathi, Sarvind; Perera, B. Gayani K.; Maly, Dustin J.; Bridges, Alexander J.; Kiss, Gert; Rubin, Seth M.

Designed sensors reveals normal and oncogenic Ras signaling in endomembranes and condensates

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-01-01

OAAI

Zhang, Jason; Nguyen, Will; Ong, Shao-En; Maly, Dustin; Baker, David

Kinobead competition and correlation analysis (kiCCA) for rapid, sensitive, and high-throughput profiling of kinase interactomes in native cells and tissues

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-01-01

PREAI

Lius, Andrea; Golkowski, Martin; Sapre, Tanmay; Lau, Ho-Tak; Moreno, Taylor; Maly, Dustin; Ong, Shao-En

ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR

NATURE CHEMICAL BIOLOGY

IF13.7

2021-09-23

OAAI

Feldman, Hannah C.; Ghosh, Rajarshi; Auyeung, Vincent C.; Mueller, James L.; Kim, Jae-Hong; Potter, Zachary E.; Vidadala, Venkata N.; Perera, B. Gayani K.; Olivier, Alina; Backes, Bradley J.; Zikherman, Julie; Papa, Feroz R.; Maly, Dustin J.

Pyrrolopyrimidine Bumped Kinase Inhibitors for the Treatment of Cryptosporidiosis

ACS INFECTIOUS DISEASES

IF3.8

2021-02-10

OAAI

Hulverson, Matthew A.; Choi, Ryan; Vidadala, Rama S. R.; Whitman, Grant R.; Vidadala, Venkata Narayana; Ojo, Kayode K.; Barrett, Lynn K.; Lynch, James J.; Marsh, Kennan; Kempf, Dale J.; Maly, Dustin J.; Van Voorhis, Wesley C.

研究方向