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P

Peter J. Cossar

Eindhoven University of Technology

H指数:14

被引数:690

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Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC

通过14-3-3介导的分子胶-PROTAC诱导部分无序的雌激素受体α泛素化

Nature Communications

IF15.7

2026-07-150

OAAI

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

调节性ChREBP/14-3-3复合物的分子胶可保护β细胞免受糖脂毒性的影响。

NATURE COMMUNICATIONS

IF15.7

2025-03-020

OA

Modulation of Protein-Protein Interactions with Molecular Glues in a Synthetic Condensate Platform

利用分子胶在合成凝聚体平台中对蛋白质-蛋白质相互作用的调控

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2025-01-280

PRE

Site-specific molecular glues for the 14-3-3/Tau pS214 protein-protein interaction via reversible covalent imine tethering

RSC MEDICINAL CHEMISTRY

IF3.6

2025-01-010

OAAI

A simple method for developing lysine targeted covalent protein reagents

NATURE COMMUNICATIONS

IF15.7

2023-12-0111

OAAI

Molecular basis and dual ligand regulation of tetrameric estrogen receptor α/14-3-3ζ protein complex

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-07-015

OAAI

Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERR? Protein-Protein Interaction as a Molecular Glue Drug Discovery Approach

14-3-3/ERR的可逆双共价分子锁定？蛋白质-蛋白质相互作用作为分子胶药物发现方法

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2023-03-1620

OAAI

Wiskostatin and other carbazole scaffolds as off target inhibitors of dynamin I GTPase activity and endocytosis

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

IF5.9

2023-02-014

PRE

Novel piperazine-1,2,3-triazole leads for the potential treatment of pancreatic cancer

RSC MEDICINAL CHEMISTRY

IF3.6

2023-01-011

OA

Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry

CHEMICAL SCIENCE

IF7.4

2023-01-018

OAAI

Amino Alcohols as Potential Antibiotic and Antifungal Leads

IF4.6

2022-03-223

OAAI

Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues

CHEMICAL SCIENCE

IF7.4

2022-01-013

OAAI

Targeting the S100A2-p53 Interaction with a Series of 3,5-Bis(trifluoromethyl)benzene Sulfonamides: Synthesis and Cytotoxicity

IF3.4

2021-07-134

PREAI

Cytotoxic 1,2,3-Triazoles as Potential Leads Targeting the S100A2-p53 Complex: Synthesis and Cytotoxicity

IF3.4

2021-07-127

PREAI

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-06-0218

OAAI

Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2021-05-2830

OAAI

Structure-Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor γt

JOURNAL OF MEDICINAL CHEMISTRY

IF6.8

2021-05-1910

OAAI

Covalent flexible peptide docking in Rosetta

CHEMICAL SCIENCE

IF7.4

2021-01-0115

OAAI

Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2020-09-2550

OAAI

Protein-protein interactions as antibiotic targets: A medicinal chemistry perspective

MEDICINAL RESEARCH REVIEWS

IF11.6

2018-07-1339

OAAI