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O

Olivia W. Rossanese

The Institute of Cancer Research
H指数:30
被引数:3,580

个人简介

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教育背景

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工作经历

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荣誉奖项

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Discovery of an In Vivo Chemical Probe for BCL6 Inhibition by Optimization of Tricyclic Quinolinones
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2023-04-072
OAAI
Harnden, Alice C.; Davis, Owen A.; Box, Gary M.; Hayes, Angela; Johnson, Louise D.; Henley, Alan T.; Brandon, Alexis K. de Haven; Valenti, Melanie; Cheung, Kwai-Ming J.; Brennan, Alfie; Huckvale, Rosemary; Pierrat, Olivier A.; Talbot, Rachel; Bright, Michael D.; Akpinar, Hafize Aysin; Miller, Daniel S. J.; Tarantino, Dalia; Gowan, Sharon; de Klerk, Selby; McAndrew, Peter Craig; Le Bihan, Yann-Vai; Meniconi, Mirco; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L. M.; Raynaud, Florence I.; Rossanese, Olivia W.; Bellenie, Benjamin R.; Hoelder, Swen
Discovering cell-active BCL6 inhibitors: effectively combining biochemical HTS with multiple biophysical techniques, X-ray crystallography and cell-based assays
SCIENTIFIC REPORTS
IF3.9
2022-11-037
OAAI
Pierrat, Olivier A.; Liu, Manjuan; Collie, Gavin W.; Shetty, Kartika; Rodrigues, Matthew J.; Le Bihan, Yann-Vai; Gunnell, Emma A.; McAndrew, P. Craig; Stubbs, Mark; Rowlands, Martin G.; Yahya, Norhakim; Shehu, Erald; Talbot, Rachel; Pickard, Lisa; Bellenie, Benjamin R.; Cheung, Kwai-Ming J.; Drouin, Ludovic; Innocenti, Paolo; Woodward, Hannah; Davis, Owen A.; Lloyd, Matthew G.; Varela, Ana; Huckvale, Rosemary; Broccatelli, Fabio; Carter, Michael; Galiwango, David; Hayes, Angela; Raynaud, Florence, I; Bryant, Christopher; Whittaker, Steven; Rossanese, Olivia W.; Hoelder, Swen; Burke, Rosemary; van Montfort, Rob L. M.
Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-06-0311
OAAI
Davis, Owen A.; Cheung, Kwai-Ming J.; Brennan, Alfie; Lloyd, Matthew G.; Rodrigues, Matthew J.; Pierrat, Olivier A.; Collie, Gavin W.; Le Bihan, Yann-Vai; Huckvale, Rosemary; Harnden, Alice C.; Varela, Ana; Bright, Michael D.; Eve, Paul; Hayes, Angela; Henley, Alan T.; Carter, Michael D.; McAndrew, P. Craig; Talbot, Rachel; Burke, Rosemary; van Montfort, Rob L. M.; Raynaud, Florence, I; Rossanese, Olivia W.; Meniconi, Mirco; Bellenie, Benjamin R.; Hoelder, Swen
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2022-06-026
OAAI
Huckvale, Rosemary; Harnden, Alice C.; Cheung, Kwai-Ming J.; Pierrat, Olivier A.; Talbot, Rachel; Box, Gary M.; Henley, Alan T.; Brandon, Alexis K. de Haven; Hallsworth, Albert E.; Bright, Michael D.; Akpinar, Hafize Aysin; Miller, Daniel S. J.; Tarantino, Dalia; Gowan, Sharon; Hayes, Angela; Gunnell, Emma A.; Brennan, Alfie; Davis, Owen A.; Johnson, Louise D.; de Klerk, Selby; McAndrew, Craig; Le Bihan, Yann-Vai; Meniconi, Mirco; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L. M.; Raynaud, Florence I.; Rossanese, Olivia W.; Bellenie, Benjamin R.; Hoelder, Swen
Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2021-11-3010
OAAI
Lloyd, Matthew G.; Huckvale, Rosemary; Cheung, Kwai-Ming J.; Rodrigues, Matthew J.; Collie, Gavin W.; Pierrat, Olivier A.; Iou, Mahad Gatti; Carter, Michael; Davis, Owen A.; McAndrew, P. Craig; Gunnell, Emma; Le Bihan, Yann-Vai; Talbot, Rachel; Henley, Alan T.; Johnson, Louise D.; Hayes, Angela; Bright, Michael D.; Raynaud, Florence, I; Meniconi, Mirco; Burke, Rosemary; van Montfort, Rob L. M.; Rossanese, Olivia W.; Bellenie, Benjamin R.; Hoelder, Swen
Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2020-04-1046
OAAI
Bellenie, Benjamin R.; Cheung, Kwai-Ming J.; Varela, Ana; Pierrat, Olivier A.; Collie, Gavin W.; Box, Gary M.; Bright, Michael D.; Gowan, Sharon; Hayes, Angela; Rodrigues, Matthew J.; Shetty, Kartika N.; Carter, Michael; Davis, Owen A.; Henley, Alan T.; Innocenti, Paolo; Johnson, Louise D.; Liu, Manjuan; de Klerk, Selby; Le Bihan, Yann-Vai; Lloyd, Matthew G.; McAndrew, P. Craig; Shehu, Erald; Talbot, Rachel; Woodward, Hannah L.; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L. M.; Raynaud, Florence, I; Rossanese, Olivia W.; Hoelder, Swen
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2019-11-1448
OAAI
Macdonald, Jonathan D.; Simon, Selena Chacon; Han, Changho; Wang, Fen; Shaw, J. Grace; Howes, Jennifer E.; Sai, Jiqing; Yuh, Joannes P.; Camper, Demarco; Alicie, Bethany M.; Alvarado, Joseph; Nikhar, Sameer; Payne, William; Aho, Erin R.; Bauer, Joshua A.; Zhao, Bin; Phan, Jason; Thomas, Lance R.; Rossanese, Olivia W.; Tansey, William P.; Waterson, Alex G.; Stauffer, Shaun R.; Fesik, Stephen W.
C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
IF5.9
2019-09-019
OAAI
Le Bihan, Yann-Vai; Lanigan, Rachel M.; Atrash, Butrus; McLaughlin, Mark G.; Velupillai, Srikannathasan; Malcolm, Andrew G.; England, Katherine S.; Ruda, Gian Filippo; Mok, N. Yi; Tumber, Anthony; Tomlin, Kathy; Saville, Harry; Shehu, Erald; McAndrew, Craig; Carmichael, LeAnne; Bennett, James M.; Jeganathan, Fiona; Eve, Paul; Donovan, Adam; Hayes, Angela; Wood, Francesca; Raynaud, Florence I.; Fedorov, Oleg; Brennan, Paul E.; Burke, Rosemary; van Montfort, Rob L. M.; Rossanese, Olivia W.; Blagg, Julian; Bavetsias, Vassilios
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS

RAS上SOS1-Mediated核苷酸交换的苯并咪唑衍生激活剂的发现和基于结构的优化

JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-09-1145
OAAI
Hodges, Timothy R.; Abbott, Jason R.; Little, Andrew J.; Sarkar, Dhruba; Salovich, James M.; Howes, Jennifer E.; Akan, Denis T.; Sai, Jiqing; Arnold, Allison L.; Browning, Carrie; Burns, Michael C.; Sobolik, Tammy; Sun, Qi; Beesetty, Yugandhar; Coker, Jesse A.; Scharn, Dirk; Stadtmueller, Heinz; Rossanese, Olivia W.; Phan, Jason; Waterson, Alex G.; McConnell, Darryl B.; Fesik, Stephen W.
Discovery of Potent 2-Aryl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design
JOURNAL OF MEDICINAL CHEMISTRY
IF6.8
2018-06-1158
OAAI
Wang, Feng; Jeon, Kyu Ok; Salovich, James M.; Macdonald, Jonathan D.; Alvarado, Joseph H.; Gogliotti, Rocco D.; Phan, Jason; Olejniczak, Edward T.; Sun, Qi; Wang, Shidong; Camper, DeMarco; Yuh, Joannes P.; Shaw, J. Grace; Sai, Jiqing; Rossanese, Olivia W.; Tansey, William P.; Stauffer, Shaun R.; Fesik, Stephen W.

研究方向

暂未获取到该数据
S
Stephen W. Fesik
H 指数:97论文数:432被引数:4.4万
A
Alex G. Waterson
H 指数:32论文数:134被引数:4,180
E
Edward T. Olejniczak
H 指数:63论文数:246被引数:1.3万
D
DeMarco V. Camper
H 指数:14论文数:39被引数:1,204
J
Jason Phan
H 指数:26论文数:83被引数:3,302
M
Michael C. Burns
H 指数:17论文数:64被引数:1,432
T
Taekyu Lee
H 指数:18论文数:76被引数:2,334
F
Florence I. Raynaud
H 指数:75论文数:775被引数:1.9万
M
Michael D. Feldkamp
H 指数:16论文数:75被引数:1,260
A
Andreas O. Frank
H 指数:30论文数:156被引数:2,983