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A

Ashique Rafique

Regeneron
H指数:33
被引数:7,214

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Anticoagulation with mechanistically distinct FXI/FXIa antibodies amrecibart (REGN9933A2) and cenvacibart (REGN7508Cat)

使用作用机制不同的FXI/FXIa抗体amrecibart（REGN9933A2）和cenvacibart（REGN7508Cat）进行抗凝

Blood
IF23.1
2026-06-150
OAAI
Dan Chalothorn; Aaron Kithcart; Ethan Marin; Selin Somersan-Karakaya; KehDih Lai; Frederic Cauwberghs; Jon Ackroyd; Kusha Mohammadi; Anju Shrestha; George Ehrlich; Ashique Rafique; Ishita Chatterjee; Kei Saotome; Matthew C. Franklin; Andrew J. Murphy; William Olson; Benjamin A. Olenchock; Gary A. Herman; David E. Gutstein; Andres Sirulnik
VSIG4 interaction with heparan sulfates inhibits VSIG4-complement binding
GLYCOBIOLOGY
IF3.3
2023-06-212
OAAI
Ebstein, Sarah Y.; Rafique, Ashique; Zhou, Yi; Krasco, Amanda; Montalvo-Ortiz, Welby; Yu, Lola; Custodio, Luisaidy; Adam, Rene C.; Bloch, Nicolin; Lee, Ken; Adewale, Funmilola; Vergata, Dominic; Luz, Antonio; Coquery, Sebastien; Daniel, Benjamin; Ullman, Erica; Franklin, Matthew C.; Hermann, Aynur; Huang, Tammy; Olson, William; Davis, Samuel; Murphy, Andrew J.; Sleeman, Matthew A.; Wei, Joyce; Skokos, Dimitris
A PD-1-targeted, receptor-masked IL-2 immunocytokine with maintained potential to engage endogenous IL-2Ra drives selective stimulation of PD-1+ T cells and robust anti-tumor efficacy
CANCER RESEARCH
IF16.6
2023-04-041
PRE
Wu, Jiaxi; Bloch, Nicolin; Chang, Aaron; Bhavsar, Ramandeep; Patel, Supriya; Wang, Qingqing; Ahmed, Hassan Shakil; Garg, Vidur; Amatulli, Michael; Yan, Yuetian; Wang, Shunhai; Dudgeon, Drew; Ramos, Willy; Krueger, Pamela; Rafique, Ashique; Huang, Tammy; Ullman, Erica; Hermann, Aynur; Olson, William; Lin, John; Smith, Eric; Zhang, Tong
Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning

通过CD3亲和力调节产生具有细胞因子释放和生物分布的分化特征的T细胞重定向双特异性抗体

SCIENTIFIC REPORTS
IF3.9
2021-07-1364
OAAI
Haber, Lauric; Olson, Kara; Kelly, Marcus P.; Crawford, Alison; DiLillo, David J.; Tavare, Richard; Ullman, Erica; Mao, Shu; Canova, Lauren; Sineshchekova, Olga; Finney, Jennifer; Pawashe, Arpita; Patel, Supriya; McKay, Ryan; Rizvi, Sahar; Damko, Ermelinda; Chiu, Danica; Vazzana, Kristin; Ram, Priyanka; Mohrs, Katja; D'Orvilliers, Amanda; Xiao, Jenny; Makonnen, Sosina; Hickey, Carlos; Arnold, Cody; Giurleo, Jason; Chen, Ya Ping; Thwaites, Courtney; Dudgeon, Drew; Bray, Kevin; Rafique, Ashique; Huang, Tammy; Delfino, Frank; Hermann, Aynur; Kirshner, Jessica R.; Retter, Marc W.; Babb, Robert; MacDonald, Douglas; Chen, Gang; Olson, William C.; Thurston, Gavin; Davis, Samuel; Lin, John C.; Smith, Eric
Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy
SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2020-06-2466
PREAI
Waite, Janelle C.; Wang, Bei; Haber, Lauric; Hermann, Aynur; Ullman, Erica; Ye, Xuan; Dudgeon, Drew; Slim, Rabih; Ajithdoss, Dharani K.; Godin, Stephen J.; Ramos, Ilyssa; Wu, Qi; Oswald, Erin; Poon, Patrick; Golubov, Jacquelynn; Grote, Devon; Stella, Jennifer; Pawashe, Arpita; Finney, Jennifer; Herlihy, Evan; Ahmed, Hassan; Kamat, Vishal; Dorvilliers, Amanda; Navarro, Elizabeth; Xiao, Jenny; Kim, Julie; Yang, Shao Ning; Warsaw, Jacqueline; Lett, Clarissa; Canova, Lauren; Schulenburg, Teresa; Foster, Randi; Krueger, Pamela; Garnova, Elena; Rafique, Ashique; Babb, Robert; Chen, Gang; Oristian, Nicole Stokes; Siao, Chia-Jen; Daly, Christopher; Gurer, Cagan; Martin, Joel; Macdonald, Lynn; MacDonald, Douglas; Poueymirou, William; Smith, Eric; Lowy, Israel; Thurston, Gavin; Olson, William; Lin, John C.; Sleeman, Matthew A.; Yancopoulos, George D.; Murphy, Andrew J.; Skokos, Dimitris
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
ELIFE
IF0
2020-06-0953
OA
Aykul, Senem; Corpina, Richard A.; Goebel, Erich J.; Cunanan, Camille J.; Dimitriou, Alexandra; Kim, Hyon Jong; Zhang, Qian; Rafique, Ashique; Leidich, Raymond; Wang, Xin; McClain, Joyce; Jimenez, Johanna; Nannuru, Kalyan C.; Rothman, Nyanza J.; Lees-Shepard, John B.; Martinez-Hackert, Erik; Murphy, Andrew J.; Thompson, Thomas B.; Economides, Aris N.; Idonel, Vincent
A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

一类增强CD3-bispecific抗体抗肿瘤活性的共刺激CD28-bispecific抗体

SCIENCE TRANSLATIONAL MEDICINE
IF14.6
2020-01-0894
OAAI
Skokos, Dimitris; Waite, Janelle C.; Haber, Lauric; Crawford, Alison; Hermann, Aynur; Ullman, Erica; Slim, Rabih; Godin, Stephen; Ajithdoss, Dharani; Ye, Xuan; Wang, Bei; Wu, Qi; Ramos, Ilyssa; Pawashe, Arpita; Canova, Lauren; Vazzana, Kristin; Ram, Priyanka; Herlihy, Evan; Ahmed, Hassan; Oswald, Erin; Golubov, Jacquelynn; Poon, Patrick; Havel, Lauren; Chiu, Danica; Lazo, Miguel; Provoncha, Kathleen; Yu, Kevin; Kim, Julie; Warsaw, Jacqueline J.; Oristian, Nicole Stokes; Siao, Chia-Jen; Dudgeon, Drew; Huang, Tammy; Potocky, Terra; Martin, Joel; MacDonald, Douglas; Oyejide, Adelekan; Rafique, Ashique; Poueymirou, William; Kirshner, Jessica R.; Smith, Eric; Olson, William; Lin, John; Thurston, Gavin; Sleeman, Matthew A.; Murphy, Andrew J.; Yancopoulos, George D.
Dual blockade of IL-4 and IL-13 with dupilumab, an IL-4Rα antibody, is required to broadly inhibit type 2 inflammation

需要用IL-4Rα 抗体dupilumab双重阻断IL-4和IL-13，以广泛抑制2型炎症

ALLERGY
IF12
2020-01-03269
OAAI
Le Floc'h, Audrey; Allinne, Jeanne; Nagashima, Kirsten; Scott, George; Birchard, Dylan; Asrat, Seblewongel; Bai, Yu; Lim, Wei Keat; Martin, Joel; Huang, Tammy; Potocky, Terra B.; Kim, Jee H.; Rafique, Ashique; Papadopoulos, Nicholas J.; Stahl, Neil; Yancopoulos, George D.; Murphy, Andrew J.; Sleeman, Matthew A.; Orengo, Jamie M.
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail
Science
IF45.8
2020-01-010
OAAI
Johanna K. Hansen; Alina Baum; Kristen E. Pascal; Vincenzo Russo; Stephanie Giordano; Elzbieta H Wloga; Benjamin O. Fulton; Ying Yan; Katrina Koon; Krunal Patel; Kyung Min Chung; Aynur Hermann; Erica Ullman; Jonathan W. Cruz; Ashique Rafique; Tammy T. Huang; Jeanette L. Fairhurst; Christen Libertiny; Marine Malbec; Wen‐Yi Lee; Richard Welsh; Glen A. Farr; Seth Pennington; Dipali Deshpande; Jemmie Cheng; Anke Watty; Pascal Bouffard; Robert Babb; Natasha Levenkova; Calvin R. Chen; Bojie Zhang; Annabel Romero Hernandez; Kei Saotome; Yi Zhou; Matthew C. Franklin; Sumathi Sivapalasingam; David Chien Lye; Stuart M. Weston; James Logue; Robert E. Haupt; Matthew B. Frieman; Gang Chen; William C. Olson; Andrew J. Murphy; Neil Stahl; George D. Yancopoulos; Christos A. Kyratsous
Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2019-12-264
OAAI
Macdonald, Lynn E.; Meagher, Karoline A.; Franklin, Matthew C.; Levenkova, Natasha; Hansen, Johanna; Badithe, Ashok T.; Zhong, Maggie; Krueger, Pamela; Rafique, Ashique; Tu, Naxin; Shevchuk, James; Wadhwa, Saurabh; Ehrlich, George; Bautista, Joannie; Grant, Craig; Esau, Lakeisha; Poueymirou, William T.; Auerbach, Wojtek; Morton, Lori; Babb, Robert; Chen, Gang; Huang, Tammy; MacDonald, Douglas; Graham, Kenneth; Gurer, Cagan; Voronina, Vera A.; McWhirter, John R.; Guo, Chunguang; Yancopoulos, George D.; Murphy, Andrew J.
Preclinical Development of the Anti-LAG-3 Antibody REGN3767: Characterization and Activity in Combination with the Anti-PD-1 Antibody Cemiplimab in Human PD-1xLAG-3-Knockin Mice
MOLECULAR CANCER THERAPEUTICS
IF5.5
2019-11-0164
OAAI
Burova, Elena; Hermann, Aynur; Dai, Jie; Ullman, Erica; Halasz, Gabor; Potocky, Terra; Hong, Seongwon; Liu, Matt; Allbritton, Omaira; Woodruff, Amy; Pei, Jerry; Rafique, Ashique; Poueymirou, William; Martin, Joel; MacDonald, Douglas; Olson, William C.; Murphy, Andrew; Ioffe, Ella; Thurston, Gavin; Mohrs, Markus
A novel bispecific antibody platform to direct complement activity for efficient lysis of target cells
SCIENTIFIC REPORTS
IF3.9
2019-08-1916
OAAI
Cruz, Jonathan W.; Damko, Ermelinda; Modi, Bhavika; Tu, Naxin; Meagher, Karoline; Voronina, Vera; Gartner, Hans; Ehrlich, George; Rafique, Ashique; Babb, Robert; Aneja, Priya; Potocky, Terra B.; Orvilliers, Amanda D'; Coppi, Alida; SookYen, E.; Qiu, Haibo; Williams, Courtney M.; Bennett, Brandy L.; Chen, Gang; Macdonald, Lynn; Olson, William; Lin, John C.; Stahl, Neil; Murphy, Andrew J.; Kyratsous, Christos A.; Prasad, Brinda C.

研究方向

暂未获取到该数据
A
Andrew Murphy
H 指数:81论文数:457被引数:3.1万
W
William C. Olson
H 指数:58论文数:379被引数:1.4万
T
Tammy Huang
H 指数:22论文数:106被引数:6,667
G
George D. Yancopoulos
H 指数:203论文数:945被引数:16.4万
J
Joel Martin
H 指数:20论文数:40被引数:3,049
T
Terra Potocky
H 指数:21论文数:94被引数:2,114
A
Aynur Hermann
H 指数:10论文数:71被引数:2,170
D
Douglas MacDonald
H 指数:25论文数:68被引数:2,688
G
Gavin Thurston
H 指数:79论文数:489被引数:3.0万
E
Erica Ullman
H 指数:12论文数:84被引数:2,130