未登录 分享 收藏
CAR T cells based on fully human T cell receptor-mimetic antibodies exhibit potent antitumor activity in vivo 基于全人源T细胞受体模拟抗体的CAR T细胞在体内表现出强大的抗肿瘤活性。 Salzler, Robert; Dilillo, David J.; Saotome, Kei; Bray, Kevin; Mohrs, Katja; Hwang, Haun; Cygan, Kamil J.; Shah, Darshit; Rye-Weller, Anna; Kundu, Kunal; Badithe, Ashok; Zhang, Xiaoqin; Garnova, Elena; Torres, Marcela; Dhanik, Ankur; Babb, Robert; Delfino, Frank J.; Thwaites, Courtney; Dudgeon, Drew; Moore, Michael J.; Meagher, Thomas Craig; Decker, Corinne E.; Owczarek, Tomasz; Gleason, John A.; Yang, Xiaoran; Suh, David; Lee, Wen-Yi; Welsh, Richard; Macdonald, Douglas; Hansen, Johanna; Guo, Chunguang; Kirshner, Jessica R.; Thurston, Gavin; Huang, Tammy; Franklin, Matthew C.; Yancopoulos, George D.; Lin, John C.; Macdonald, Lynn E.; Murphy, Andrew J.; Chen, Gang; Olsen, Olav; Olson, William C. 分享 收藏
Angiopoietin-2 blockade suppresses growth of liver metastases from pancreatic neuroendocrine tumors by promoting T cell recruitment Lee, Eunhyeong; O'Keefe, Sophie; Leong, Alessandra; Park, Ha-Ram; Varadarajan, Janani; Chowdhury, Subrata; Hiner, Shannon; Kim, Sungsoo; Shiva, Anahita; Friedman, Richard A.; Remotti, Helen; Fojo, Tito; Yang, Hee Won; Thurston, Gavin; Kim, Minah 分享 收藏
Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates Tkachev, Victor; Vanderbeck, Ashley; Perkey, Eric; Furlan, Scott N.; McGuckin, Connor; Atria, Daniela Gomez; Gerdemann, Ulrike; Rui, Xianliang; Lane, Jennifer; Hunt, Daniel J.; Zheng, Hengqi; Colonna, Lucrezia; Hoffman, Michelle; Yu, Alison; Outen, Riley; Kelly, Samantha; Allman, Anneka; Koch, Ute; Radtke, Freddy; Ludewig, Burkhard; Burbach, Brandon; Shimizu, Yoji; Panoskaltsis-Mortari, Angela; Chen, Guoying; Carpenter, Stephen M.; Harari, Olivier; Kuhnert, Frank; Thurston, Gavin; Blazar, Bruce R.; Kean, Leslie S.; Maillard, Ivan 分享 收藏
Intratumoral dendritic cell-CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma 肝癌PD-1阻断后，肿瘤内树突状cell-CD4 T辅助细胞壁ni使CD8 T细胞分化 Magen, Assaf; Hamon, Pauline; Fiaschi, Nathalie; Soong, Brian Y.; Park, Matthew D.; Mattiuz, Raphael; Humblin, Etienne; Troncoso, Leanna; D'souza, Darwin; Dawson, Travis; Kim, Joel; Hamel, Steven; Buckup, Mark; Chang, Christie; Tabachnikova, Alexandra; Schwartz, Hara; Malissen, Nausicaa; Lavin, Yonit; Soares-Schanoski, Alessandra; Giotti, Bruno; Hegde, Samarth; Ioannou, Giorgio; Gonzalez-Kozlova, Edgar; Hennequin, Clotilde; Le Berichel, Jessica; Zhao, Zhen; Ward, Stephen C.; Fiel, Isabel; Kou, Baijun; Dobosz, Michael; Li, Lianjie; Adler, Christina; Ni, Min; Wei, Yi; Wang, Wei; Atwal, Gurinder S.; Kundu, Kunal; Cygan, Kamil J.; Tsankov, Alexander M.; Rahman, Adeeb; Price, Colles; Fernandez, Nicolas; He, Jiang; Gupta, Namita T.; Kim-Schulze, Seunghee; Gnjatic, Sacha; Kenigsberg, Ephraim; Deering, Raquel P.; Schwartz, Myron; Marron, Thomas U.; Thurston, Gavin; Kamphorst, Alice O.; Merad, Miriam 分享 收藏
Rapid TCR:Epitope Ranker (RAPTER): a primary human T cell reactivity screening assay pairing epitope and TCR at single cell resolution Deering, Raquel P.; Blumenberg, Lili; Li, Lianjie; Dhanik, Ankur; Jeong, Se; Pourpe, Stephane; Song, Hang; Boucher, Lauren; Ragunathan, Shoba; Li, Yanxia; Zhong, Maggie; Kuhnert, Jessica; Adler, Christina; Hawkins, Peter; Gupta, Namita T.; Moore, Michael; Ni, Min; Hansen, Johanna; Wei, Yi; Thurston, Gavin 分享 收藏
Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice Lin, Wen; Singh, Varan; Springer, Raynel; Choonoo, Gabrielle; Gupta, Namita; Patel, Aditi; Frleta, Davor; Zhong, Jun; Owczarek, Tomasz; Decker, Corinne; Macdonald, Lynn; Murphy, Andrew; Thurston, Gavin; Mohrs, Markus; Ioffe, Ella; Lu, Yi-Fen 分享 收藏
Angiopoietin-2-Dependent Spatial Vascular Destabilization Promotes T-cell Exclusion and Limits in Melanoma Park, Ha -Ram; Shiva, Anahita; Cummings, Portia; Kim, Seoyeon; Kim, Sungsoo; Lee, Eunhyeong; Leong, Alessandra; Chowdhury, Subrata; Shawber, Carrie; Carvajal, Richard; Thurston, Gavin; An, Joon-Yong; Lund, Amanda W.; Yang, Hee Won; Kim, Minah 分享 收藏
Spontaneous tumor regression mediated by human T cells in a humanized immune system mouse model Patel, A. K.; Dhanik, Ankur; Lim, Wei Keat; Adler, Christina; Ni, Min; Wei, Yi; Zhong, Maggie; Nguyen, Cindy; Zhong, Jun; Lu, Yi-Fen; Thurston, Gavin; Macdonald, Lynn; Murphy, Andrew; Gurer, Cagan; Frleta, Davor 分享 收藏
IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models Carbonaro, Marisa; Wang, Kehui; Huang, Hui; Frleta, Davor; Patel, Aditi; Pennington, Alexander; Desclaux, Mathieu; Moller-Tank, Sven; Grindley, Justin; Altarejos, Judith; Zhong, Jun; Polites, Greg; Poueymirou, William; Jaspers, Stephen; Kyratsous, Christos; Zambrowicz, Brian; Murphy, Andrew; Lin, John C.; Macdonald, Lynn E.; Daly, Christopher; Sleeman, Mark; Thurston, Gavin; Li, Zhe 分享 收藏
Boosting anti-tumor immunity by promoting high endothelial venule and tertiary lymphoid structure formation in solid tumors via LTBR agonism An, Disi; Chen, Guoying; Wang, Wei; Mohrs, Katja; DiLillo, David; Daly, Christopher; Thurston, Gavin; Lin, John; Gupta, Namita; Atwal, Mickey; Kuhnert, Frank 分享 收藏
Development of novel human hepatocellular carcinoma models using genetically modified human hepatocytes in FSRG humanized liver mice Carbonaro, Marisa; Bonetti, Ciro; Huang, Hui; Wang, Kehui; Desclaux, Mathieu; Gong, Guochun; Lin, John C.; Daly, Christopher; Thurston, Gavin; Li, Zhe 分享 收藏
TCR-T and CAR-T cells targeting HLA-A2/MAGEA4 demonstrate differential tumor control, reflecting co-stimulatory signaling requirements Decker, Corinne E.; Idun, Jacqueline; Mohrs, Katja; Meagher, Thomas; Bray, Kevin; Petriv, Iryna; Golas, Jonathon; Helms, Timothy; Ajithdoss, Dharani; Thurston, Gavin; Lin, John; Kirshner, Jessica R.; DiLillo, David J. 分享 收藏
Circulating tumor DNA (ctDNA) correlates closely with tumor necrosis and relapsefree survival (RFS) in hepatocellular carcinoma (HCC) patients treated with perioperative cemiplimab Marron, Thomas U.; Brennan, Laura; Hamon, Pauline; Fiel, Maria Isabel; Ward, Stephen C.; Zhu, Yuan O.; Kim, Edward; Kamphorst, Alice O.; Thanigaimani, Pradeep; Uldrick, Thomas S.; Lucas, Natalie; Wu, Kathy; Hapanowicz, Olivia; King, Paula; Li, Siyu; Miller, Elizabeth; Bhardwaj, Nina; Thurston, Gavin; Lowy, Israel; Gnjatic, Sacha; Schwartz, Myron E.; Jankovic, Vladimir; Merad, Miriam 分享 收藏
分享 收藏
分享 收藏
A Bispecific METxMET Antibody-Drug Conjugate with Cleavable Linker Is Processed in Recycling and Late Endosomes Bay, Andres E. Perez; Faulkner, Devon; DaSilva, John O.; Young, Tara M.; Yang, Katie; Giurleo, Jason T.; Ma, Dangshe; Delfino, Frank J.; Olson, William C.; Thurston, Gavin; Daly, Christopher; Andreev, Julian 分享 收藏
CD22-targeted CD28 bispecific antibody enhances antitumor efficacy of odronextamab in refractory diffuse large B cell lymphoma models Wei, Joyce; Montalvo-Ortiz, Welby; Yu, Lola; Krasco, Amanda; Olson, Kara; Rizvi, Sahar; Fiaschi, Nathalie; Coetzee, Sandra; Wang, Fang; Ullman, Erica; Ahmed, Hassan Shakil; Herlihy, Evan; Lee, Ken; Havel, Lauren; Potocky, Terra; Ebstein, Sarah; Frleta, Davor; Khatri, Aditi; Godin, Stephen; Hamon, Sara; Brouwer-Visser, Jurriaan; Gorenc, Travis; MacDonald, Doug; Hermann, Aynur; Chaudhry, Aafia; Sirulnik, Andres; Olson, William; Lin, John; Thurston, Gavin; Lowy, Israel; Murphy, Andrew J.; Smith, Eric; Jankovic, Vladimir; Sleeman, Matthew A.; Skokos, Dimitris 分享 收藏
COMPREHENSIVE SINGLE CELL SEQUENCING ANALYSIS OF PAIRED TISSUE AND BLOOD SAMPLES FROM HCC PATIENTS TREATED WITH NEOADJUVANT ANTI-PD-1 THERAPY REVEALS TREATMENT-INDUCED CLONAL T CELL DYNAMICS Wang, Wei; Hawkins, Peter; Li, Lianjie; Fiaschi, Nathalie; Magen, Assaf; Jeong, Se; Boucher, Lauren; Adler, Christina; Ni, Min; James, Nicola; Schwartz, Myron; Marron, Thomas; Miller, Elizabeth; Lowy, Israel; Wei, Yi; Kamphorst, Alice; Merad, Miriam; Atwal, Gurinder; Thurston, Gavin; Gupta, Namita; Deering, Raquel 分享 收藏
Efficient engraftment and viral transduction of human hepatocytes in an FRG rat liver humanization model Carbonaro, Marisa; Lee, Jeffrey; Pefanis, Evangelos; Desclaux, Mathieu; Wang, Kehui; Pennington, Alexander; Huang, Hui; Mujica, Alejo; Rojas, Jose; Ally, Roxanne; Kennedy, Daniel; Brown, Michael; Rogulin, Vitaliy; Moller-Tank, Sven; Sabin, Leah; Zambrowicz, Brian; Thurston, Gavin; Li, Zhe 分享 收藏
.png){kind=icon}
未登录.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
.png){kind=icon}
